• Journal of Radiation Protection and Research
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• 제45권2호
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• pp.88-94
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• 2020

Background: The International Commission on Radiological Protection (ICRP) has recently published report series on the occupational intakes of radionuclides (OIR) for internal dosimetry of radiation workers. In this study, the optimized monitoring program including the monitoring interval and the minimum detectable activity (MDA) of major radionuclides was suggested to perform the routine individual monitoring of internal exposure based on the ICRP OIR. Materials and Methods: The derived recording levels and the critical monitoring quantities were reviewed from international standards or guidelines by the International Atomic Energy Agency (IAEA), the International Organization for Standardization (ISO), and the European Radiation Dosimetry Group (EURADOS). The OIR data viewer provided by ICRP was used to evaluate the monitoring intervals and the MDA, which are derived from the reference bioassay functions and the dose coefficients. Results and Discussion: The optimal monitoring intervals were determined taking account of two requirement conditions on the potential intake underestimation and the MDA values. The MDA requirement values of the selected radionuclides were calculated based on the committed effective dose from 0.1 mSv to 5 mSv. The optimized routine individual monitoring program was suggested including the optimal monitoring intervals and the MDA requirements. The optimal MDA values were evaluated based on the committed effective dose of 0.1 mSv. However, the MDA can be adjusted considering the practical operation of the routine individual monitoring program in the nuclear facilities. Conclusion: The monitoring intervals and the MDA as crucial factors for the routine monitoring were described to suggest the optimized routine individual monitoring program of the occupational intakes. Further study on the alpha/beta-emitting radionuclides as well as short lived gamma-emitting nuclides will be necessary in the future.

• 환경영향평가
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• 제22권1호
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• pp.89-97
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• 2013

RADCONS Ver. 1.0 (RADiological CONSequence Assessment Program) was developed for radiological risk assessment in this study. A Gaussian plume model was used to analyze the fate and transport of radionuclides released into the air in case of accidents. Both single meterological data and time series meterological data can be used in RADCONS. To assess the radiological risk of the early phase after an accident, ED (Effective Dose) estimated by both deterministic and probabilistic approaches are presented. These EDs by deterministic and probabilistic will be helpful to efficient decision making for decision makers. External doses from deposited materials by time are presented for quantifying the effects of mid and late phases of an accident. A radiological risk assessment was conducted using RADCONS for an accident scenario of 1 Ci of Cs-137. The maximum of ED for radii of 1,000 meters from the accident point was 8.51E-4 mSv. After Monte-Carlo simulation, considering the uncertainty of the breathing rate and dispersion parameters, the average ED was 8.49E-4, and the 95 percentile was 1.10E-3. A data base of the dose coefficients and a sampling module of the meteorological data will be modified to improve the user's convenience in the next version.

• Journal of Radiation Protection and Research
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• 제49권1호
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• pp.50-64
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• 2024

Background: The reference dose coefficients (DCs) of the International Commission on Radiological Protection (ICRP) have been widely used to estimate organ doses of individuals for risk assessments. This approach has been well accepted because individual anatomy data are usually unavailable, although dosimetric uncertainty exists due to the anatomical difference between the reference phantoms and the individuals. We attempted to quantify the individual variation of organ doses for photon external exposures by calculating and comparing organ DCs for 30 individuals against the ICRP reference DCs. Materials and Methods: We acquired computed tomography images from 30 patients in which eight organs (brain, breasts, liver, lungs, skeleton, skin, stomach, and urinary bladder) were segmented using the ImageJ software to create voxel phantoms. The phantoms were implemented into the Monte Carlo N-Particle 6 (MCNP6) code and then irradiated by broad parallel photon beams (10 keV to 10 MeV) at four directions (antero-posterior, postero-anterior, left-lateral, right-lateral) to calculate organ DCs. Results and Discussion: There was significant variation in organ doses due to the difference in anatomy among the individuals, especially in the kilovoltage region (e.g., <100 keV). For example, the red bone marrow doses at 0.01 MeV varied from 3 to 7 orders of the magnitude depending on the irradiation geometry. In contrast, in the megavoltage region (1-10 MeV), the individual variation of the organ doses was found to be negligibly small (differences <10%). It was also interesting to observe that the organ doses of the ICRP reference phantoms showed good agreement with the mean values of the organ doses among the patients in many cases. Conclusion: The results of this study would be informative to improve insights in individual-specific dosimetry. It should be extended to further studies in terms of many different aspects (e.g., other particles such as neutrons, other exposures such as internal exposures, and a larger number of individuals/patients) in the future.

• 한국의학물리학회지:의학물리
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• 제27권1호
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• pp.31-36
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• 2016

본 연구에서는 이중에너지 영상을 획득하는 방법으로, 구리판을 이용한 에너지 변조 필터를 사용하였을 때의 선량을 계산 및 측정하였고, 기존의 다른 방법들과 선량을 비교하였다. 몬테칼로 전산모사를 이용하여 에너지 변조 필터에 의한 선량 변화를 평가하기 위하여 MCNPX를 사용하였다. 두경부, 흉부, 복부 촬영에 주로 사용되는 관전압인 80, 120 kVp에 대한 스펙트럼을 SPEC78 프로그램으로 생성하여 선원을 모사하였고, 구리 물질로 이루어진 에너지 변조 필터(밀도: $8.96g/cm^3$)는 두께를 0.5 mm부터 2.0 mm까지 0.5 mm 간격으로 변화시켜가면서 선원으로부터 20.0 cm 거리에 X-선 창을 절반만 가리도록 모델링 하였다. 몬테칼로 전산모사 값과 실제 선량 값을 비교하기 위해서는 교정 상수가 필요하므로, Gafchromic EBT3 필름에 알고 있는 선량을 조사한 후 판독하여 선량 교정 곡선을 획득하였다. 실험과 동일한 조건으로 MCNPX의 f6 tally로 획득한 결과값과 측정값 간의 선량 환산 인자는 $7.2*10^4cGy/output$으로 구해졌으며, 관전압 80 kVp과 관전류 6 mA의 조건으로 콘빔 CT 촬영 시, 평균 10.1 cGy (표준편차 2.7 cGy) 조사됨을 알 수 있었다. 에너지 변조 필터에 기반한 이중 에너지 영상 획득 기술을 적용한 본 연구에서는 이중 에너지 콘빔 CT 시스템의 선량이 단일 에너지 CT 시스템의 선량보다 33~40% 감소함을 알 수 있다. 또한, 에너지 변조 필터에서 발생한 산란선에 의한 선량 증가 효과는 거의 없었다. 따라서, 인체 내 물질 분별력이 우수하여 임상에 널리 응용되었던 기존 이중 에너지 CT 시스템의 상대적으로 피폭선량이 높다는 단점을 효과적으로 개선할 수 있다.

• 대한방사선기술학회지:방사선기술과학
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• 제35권1호
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• pp.35-44
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• 2012

서울소재 'S'병원에서 근무중인 방사선사를 대상으로 병원 근무경력 및 CT검사실 근무 경험 유 무, 현재 사용하고 있는 방사선 선원의 종류에 따른 CT검사와 일반촬영검사의 방사선 선량과 위험성에 관한 인식도 조사를 통해 CT검사의 위험성에 대한 각성을 위한 기초자료로 활용하고자 한다. 영상의학과에 근무하는 방사선사 중 131명을 대상으로 설문지를 통해 연구가설 검정을 위한 자료를 수집하였고, 설문문항의 Cronbach @계수는0.825988과0.767161로 나타났으며, p-value의 기각률은<0.05로 하였다. 연구가설검정을 위해 SAS 9.1(SAS Institute Inc., Cary, NC, USA.)통계패키지를 이용하여 Mann-Whitney test와 Kruskai-Wallis test, Two sample T-test, Two sample T-test with Bonferroni's Correction, One-way ANOVA 통계분석방법 등을 이용하였다. CT검사와 일반촬영의 선량에 관한 가설의 각 p-value 값은 0.2291~0.9663의 범위로 나타났고, CT검사와 일반촬영검사의 위험성에 관한 가설의 각 p-value 값은 0.1924~1.0000의 범위로 나타났다. 모든 연구가설의 p-value값이 기각률(<0.05)을 상위하여 나타났으며, 현재 'S'병원에 근무중인 방사선사들은 근무경력 및 CT검사실 근무경력 유무, 현재 사용하는 방사선 선원의 종류에 관계없이 일반촬영 보다 CT검사가 선량이 많으며, 위험하다고 인식하고 있는 것으로 나타났다.

• 한국의학물리학회지:의학물리
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• 제24권1호
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• pp.41-47
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• 2013

부피효과를 가지는 2차원 배열형 이온함으로부터 측정된 세기조절방사선치료의 선량분포와 부피효과를 가지지 않는 장치로부터 측정된 선량분포를 비교함으로써 이 효과가 측정결과에 미치는 영향에 대해 평가하였다. 조사면 크기에 따라 총 5개의 세기조절방사선치료계획을 5문 조사방식으로 가상의 팬톰에 시행하였다. 선량분포 측정은 매트릭스 팬톰, 빔 영상시스템, 필름 등 총 3가지 측정장치를 이용하였다. 측정된 값은 분석프로그램을 이용하여 전산화치료계획 시스템을 통해 획득된 선량분포와 비교하였다. 비교된 선량분포는 분석프로그램 상에서 상관계수와 감마값을 통해 측정장치의 부피효과 유무에 따른 차이를 분석한 결과 매트릭스 팬톰에서 최대 1.3% 이상으로 나타났다. 매트릭스 팬톰은 조사면의 크기가 작아질수록 내부의 이온함에 의해 부피효과가 커지게 되므로 다른 측정장치에 비해 더 큰 측정오차를 가지는 것으로 판단되었다.

• Archives of Pharmacal Research
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• 제11권3호
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• pp.250-252
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• 1988

A sensitive and simplified HPLC assay of fluconazol is described. The calibration curve of fluconazol in plasma ranging $0-10\;{\mu}g/ml$ was linear with the correlation coefficients of 0.9900. The limit of detection was $0.3\;{\mu}g/ml$. The average recovery of the drug was $89.1\;{\pm}\;9.05%$. After oral administration of single dose(150mg) of fluconazol in man, $C_{max}\;and\;T_{max$ were $3\;{mu}g/ml$ and 4hr., respectively.

• Bulletin of the Korean Chemical Society
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• 제32권11호
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• pp.3967-3972
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• 2011

A whole body physiologically based pharmacokinetic (PBPK) model was applied to investigate absorption, distribution, and physiologic variations on pharmacokinetics of imatinib in human body. Previously published pharmacokinetic data of the drug after intravenous (i.v.) infusion and oral administration were simulated by the PBPK model. Oral dose absorption kinetics were analyzed by adopting a compartmental absorption and transit model in gut section. Tissue/plasma partition coefficients of drug after i.v. infusion were also used for oral administration. Sensitivity analysis of the PBPK model was carried out by taking parameters that were commonly subject to variation in human. Drug concentration in adipose tissue was found to be higher than those in other tissues, suggesting that adipose tissue plays a role as a storage tissue for the drug. Variations of metabolism in liver, body weight, and blood/plasma partition coefficient were found to be important factors affecting the plasma concentration profile of drug in human body.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2004년도 춘계 학술발표회 제16권1호
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• pp.446-449
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• 2004

Traditional prediction models have been developed with a fixed equation from based on the limited number of data and parameters. If new data is quite different from original data, then the model should update not only its coefficients but also its equation form. However, artificial neural network dose not need a specific equation form. Instead of that, it needs enough input-output data. Also, it can continuously re-train the new data, so that it can conveniently adapt to new data. Therefore, the purpose of this study is to verify faith and application of prediction system of concrete strength using artificial neural networks through mock-up test.

• Radiation Oncology Journal
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• 제7권1호
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• pp.81-83
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• 1989

This study, involving thirty-two patients with carcinoma of uterine cervix treated by high dose rate intracavitary irradiation using a remotely controlled afterloading system, compares the doss at point A and 8 with the Curie-minutes prescription. A linear least-square regression analysis was used to compare the two sets of date. Correlation coefficients between doses at points A and B and the Ci-min prescription are 0.92 (p<0.001) and 0.90 (p<0.001), respectively, and linear relationship is observed between these two system. The limitation and significance of the comparison of the two approaches to intracavitary dosimetry is discussed.