Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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A Sensitive and Simplified HPLC Analysis for the Determination of Fluconazol in Human Plasma

  • Kim, Eun-J. (Korea Research Institute of Chemical Technology (KRICT)) ;
  • Lee, Hye-S. (Korea Research Institute of Chemical Technology (KRICT)) ;
  • Zee, Ok-P. (Korea Research Institute of Chemical Technology (KRICT)) ;
  • Lee, Sung-T. (Department of Biology, Korea Institute of Technology (KIT))
  • Published : 1988.09.01
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Abstract

A sensitive and simplified HPLC assay of fluconazol is described. The calibration curve of fluconazol in plasma ranging $0-10\;{\mu}g/ml$ was linear with the correlation coefficients of 0.9900. The limit of detection was $0.3\;{\mu}g/ml$. The average recovery of the drug was $89.1\;{\pm}\;9.05%$. After oral administration of single dose(150mg) of fluconazol in man, $C_{max}\;and\;T_{max$ were $3\;{mu}g/ml$ and 4hr., respectively.

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