• Journal of Radiation Protection and Research
• /
• 제12권2호
• /
• pp.28-36
• /
• 1987

원자력 시설에서 대기중으로 방출되는 방사성 구름에 의한 환경선량계산에는 Gaussian plume model 주로 사용되고 있으나, 바람의 분포나 대기의 흐트러짐이 공간적으로 일정하지 않은 복잡 지형에의 적용에는 문제가 있다. 복잡 지형을 고려한 기류계산에는 MATTEW, WIND04 코드가 그 타당성을 인정받고 있다. 이러한 코드의 원리를 기초로 하여, 질량보존법칙을 만족하는 이류 확산 방정식을 유한차분법으로 계산하고 풍속장을 구하였다. 입자 농도와 피폭선량은 방사성 구름을 입자군으로 근사시키는 PIC model을 이용하여 계산하였으며, 입자의 대기 확산은 Random Walk법을 이용하였다. 계산 결과, 지형에 의한 풍속, 풍향의 변화를 알 수 있었으며, 피폭선량분포를 구할 수 있었다.

• 대한방사선치료학회지
• /
• 제9권1호
• /
• pp.40-45
• /
• 1997

When therapeutic irradiation is indicated for the orbital tumors, the greatest concern is the risk of radiation-induced cataract. Conjunctival lymphoma is one of the good examples. We would like to report the procedure of the lens shielding device(L.S.D) and the result of irradiated dose to the lens. L.S.D. consistes of two parts : load alloy to attenuate electron beam, and dental acryl which completely covers the lead alloy to avoid discomfort of cornea from contacting directly with cerrobend and side scattering by cerrobend. And for easy location and removal, side bars were made on each side. Radiation doses were meaured with TLD(TLD 3500 Hawshaw). Markus chamber in a polystyrene phantom. The phantom was irradiated with 9MeV electron beams from Clinac 2100C with $6{\times}6cm$ electron cone. The relative dose at 6mm depth where the lens is located was $4.2\%$ with TLD and $5.1\%$ with Markus chamber clinically when 2600 cGy are irradiated to the eyeball, the mapinary dose to the lens will be 109 cGy or 132 cGy, which will significently reduce the cataract.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
• /
• 한국우주과학회 2005년도 한국우주과학회보 제14권1호
• /
• pp.143-147
• /
• 2005

우주시스템 연구실에서 개발 중인 HAUSAT-2의 우주방사능 환경은 포획된 양자와 전자, 태양양성자이다. 본 논문에서는 우주방사능 환경에 대해 임무기간동안의 총 피폭량을 계산하였고, 총 피폭량에 대해 HAUSAT-2에서 사용하는 부품들의 부품의 우주방사능 허용레벨 분류과정을 통해 사용가능성을 검증하였다. 또한 단일사건 발생확률을 계산하여 단일사건 발생에 대비하는 시스템을 설계에 반영하였다.

• Tuberculosis and Respiratory Diseases
• /
• 제53권6호
• /
• pp.656-661
• /
• 2002

저자들은 불응성 상심실성 빈맥으로 저용량 amiodarone을 장기간 사용한 환자에서 발생한 폐독성을 경험하고 적절히 치료하였기에 이를 보고하는 바이다.

• BMB Reports
• /
• 제43권9호
• /
• pp.599-603
• /
• 2010

Troglitazone is an anti-diabetic agent that improves hyperglycemia by reducing peripheral insulin resistance in type II diabetic patients. Troglitazone has been shown to cause growth inhibition of various normal and cancerous cells. However, the molecular mechanism by which troglitazone affects the growth of these cancer cells remains unclear. Here, we report that troglitazone treatment of Hep 3B human hepatocellular carcinoma cells resulted in dose-dependent growth inhibition. Analysis of cell cycle distribution by flow cytometry showed that the number of apoptotic cells was increased in a dose-dependent manner in response to troglitazone treatment. cDNA microarray analysis showed a number of differentially expressed genes in response to troglitazone. Among the upregulated genes, hypoxia-inducible factor 1 (HIF-1)-responsive RTP801 was induced in a dose-dependent manner. We also observed HIF-1 accumulation by immnocytochemistry after troglitazone treatment. These results strongly suggest that RTP801 might be involved in troglitazone-induced apoptosis in Hep 3B cells.

• The Korean Journal of Pain
• /
• 제9권1호
• /
• pp.69-74
• /
• 1996

Background: Efficacy of spinal opioids for the treatment of intractable cancer pain has been reported by several authors. The epidural route seems to be a more reliable and effective method of pain control as compared to the intrathecal route which can lead to opioids by portal system. Methods: Medical records were reviewed of 18 patients who had been treated with epidural morphine via an implanted port-A-Cath from Mar. 1991 to Sep. 1994. Results: Patients were treated for a mean of 92 days. There were wide variation of dose requirements. The minimum daily dose ranged from 2 to 10mg, and maximum daily dose from 3 to 30 mg. Verbal rating scale were below moderate until 100th days after posrtal implantation. When 3 patients suffered from aggravated pain associated with vertebral metastasis. Five of 11 patients who were administered medication longer than 50 days reguired increased doses ranging from 3 mg to 25 mg which were higher as compared to initial doses. These patients also experienced pain due to vertebral metastasis. There were no report of epidural scarring, respiratory depression, epidural infections, meningitis, or catheter blockade. Conclusion: Continuous epidural morphine administration via Port-A-Cath is an effective method with minimal complication.

• Radiation Oncology Journal
• /
• 제12권2호
• /
• pp.263-267
• /
• 1994

In clinical radiotherapy, the use of wide and irregular field techniques frequently results in considerable tumor dose inhomogeneity because of, the variation in physical characteristics of irradiated volumes. This report describes an analysis of the dosimetry of the irregular fields such as radiation fields for Hodgkin's disease(mantle field), esophageal cancer, and lung cancer when a 6 MV and a 15 MV linear accelerators are utilized. Doses were measured in a Rando phantom using methods of thermoluminescence dosimetry(TLD), and were calculated by radiotherapy planning computer system with the Clarkson's method for calculation of a irregular field. A dose variation of $5-22\%,\;6-9\%,\;6-14\%$ were found in the mantle field, esophageal cancer field, lung cancer field respectively. Higher doses occurred in the superior portion of the irregular field. The sites of maximum dose variation were the supraclavicular and the upper spinal cord region. To adjust for these substantial differences, a compensator or a shrinking field technique should be adopted.

• Journal of Yeungnam Medical Science
• /
• 제36권2호
• /
• pp.148-151
• /
• 2019

The dose of CD34+ cells is known to influence the outcome of allogeneic peripheral blood stem cell (PBSC) and/or T-cell-depleted transplantation. A previous study proposed that $2{\times}10^6\;CD34+\;cells/kg$ is the ideal minimum dose for allogeneic transplantation, although lower doses did not preclude successful therapy. In the case we present here, CD34+ cells were collected from a matched sibling donor on the day of allogeneic hematopoietic stem cell transplantation; however, the number of cells was not sufficient for transplantation. Consequently, PBSCs were collected three additional times and were infused along with cord blood cells from the donor that were cryopreserved at birth. The cumulative dose of total nuclear cells and CD34+ cells was $15.9{\times}10^8\;cells/kg$ and $0.95{\times}10^6\;cells/kg$, respectively. White blood cells from this patient were engrafted on day 12. In summary, we report successful engraftment after infusion of multiple low doses of CD34+ cells in a patient with severe aplastic anemia.

• Imaging Science in Dentistry
• /
• 제43권2호
• /
• pp.63-69
• /
• 2013

After over one decade development, cone beam computed tomography (CBCT) has been widely accepted for clinical application in almost every field of dentistry. Meanwhile, the radiation dose of CBCT to patient has also caused broad concern. According to the literature, the effective radiation doses of CBCTs in nowadays market fall into a considerably wide range that is from $19{\mu}Sv$ to $1073{\mu}Sv$ and closely related to the imaging detector, field of view, and voxel sizes used for scanning. To deeply understand the potential risk from CBCT, this report also reviewed the effective doses from literatures on intra-oral radiograph, panoramic radiograph, lateral and posteroanterior cephalometric radiograph, multi-slice CT, and so on. The protection effect of thyroid collar and leaded glasses were also reviewed.

• Journal of Yeungnam Medical Science
• /
• 제37권4호
• /
• pp.329-331
• /
• 2020

Negative myoclonus (NM) is a shock-like jerky involuntary movement caused by a sudden, brief interruption of tonic muscle contraction. NM is observed in patients diagnosed with epilepsy, metabolic encephalopathy, and drug toxicity and in patients with brain lesions. A 55-year-old man presented with NM in both his arms and neck. He has taken medications containing tramadol at a dose of 80-140 mg/day for 5 days due to common cold. He had no history of seizures. Acute lesions were not observed during magnetic resonance imaging, and abnormal findings in his laboratory tests were not noted. His NM resolved completely after the discontinuation of tramadol and the oral administration of clonazepam. Our case report suggests that tramadol can cause NM in patients without seizure history or metabolic disorders, even within its therapeutic dose.