• Journal of Pharmaceutical Investigation
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• v.29 no.2
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• pp.127-136
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• 1999

In order to eliminate demerits of conventional dosage forms, dipotassium glycyrrhizate was formulated as a slim mucoadhesive film type dosage form. The mucoadhesive drug layer gel containing dipotassium glycyrrhizate was prepared using $Noveon^{\circledR}$ AA-1, hydroxypropylcellulose-M, ethylcellulose N 100 and citric acid, and the protective layer gel by using ethylcellulose N 100, $Eudragit^{\circledR}$ RS and castor oil. The viscosity of drug layer gel of mucoadhesive film was enhanced as the increased amount of $Noveon^{\circledR}$ AA-1 or hydroxypropyl cellulose-M. The drug content was unifonnly $1160{\pm}14.6\;{\mu}g$, and was varied within 3.5%. The optimum film dosage form showed a good fluidity and malleability of drug layer, with 179 g of thickness, pH 5.7, 411 min of in vitro adhesion time and 172 g in gravity adhesive strength. The release time of drug from the mucoadhesive film was significantly shorter but was delayed when polymers such as ethylcellulose was added. From these results, the new mucoadhesive film may be effective for the treatment of aphthous stomatitis.

• YAKHAK HOEJI
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• v.59 no.2
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• pp.70-76
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• 2015

A Softgel is an oral dosage form for medicine similar to capsules and softgel dosage form offers several advantages over other oral dosage forms, such as delivering a liquid matrix designed to solubilize and improve the oral bioavailability of a poorly soluble compound as a unit dose solid dosage form, delivering low and ultra-low doses of a compound. This study aimed to qualify a proprietary vegetable soft capsule which contains modified starch and carrageenan as capsule shell components compare to the conventional gelatin softgel. Four kinds of samples were prepared with vegetable and gelatin capsule shell, respectively. Morphology of capsule shell, mechanical strength of capsule, and hygroscopic properties were studied for comparing the quality attributes of softgel. Short-term stability against heat and moisture was also investigated in this study. Vegetable capsule shell showed better mechanical strength, physical stability and disintegration time for temperature and humidity than those of conventional gelatin capsule shell with four different filling materials used frequently as soft capsule form. Conclusively, this vegetable capsule shell polymer system can replace easily gelatin-shell systems and additionally allows encapsulation of lipid fills at high temperatures that are semisolid or solid-like at room temperature.

• Journal of The Korean Society of Agricultural Engineers
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• v.46 no.3
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• pp.65-72
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• 2004

Modern underground and tunnel works that the wet type shotcrete is getting widely designed and applied in a large scale project. Further to its applications, the needs of improving the performance of the shotcrete, such as new and developed additives and accelerators fur increasing the performance of shotcrete, become the most important issue in the field. The main objective of this study evaluated to performance of steel fiber reinforced shotcrete using alkali free based accelerator for the durability and high quality of shotcrete. The major test variables are accelerator type and its dosage. One type silicate based accelerator and one type aluminate based accelerator and one type alkali free based accelerator were used. The dosage of accelerators is determined by the manufactures and laboratory test condition. Compressive strength test results showed that the dosage of silicate and aluminate based accelerators caused reduction of mechanical properties of shotcrete. Compressive strength of alkali free based accelerator is more stable than of silicate and aluminate based accelerators. Also, according to the compressive strength and flexural test results, it was found that steel fiber reinforced shotcrete used alkali free based accelerator could attain significant improvement in the mechanical and flexural performance.

• Advances in concrete construction
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• v.6 no.6
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• pp.659-677
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• 2018

The use of some superplasticizers in the production of mortar or concrete influences the hydration kinetic and the amount of total heat. This results in a modification of some properties, namely mortar workability, mechanical strength and durability. Three superplasticizers were used; a polynaphthalenesulfonate (PNS), a melamine resin (PMS) and a polycarboxylate (PC). They have been incorporated into various amount in a standardized mortar based on limestone cement. The aim of this study was to evaluate the rheological, mechanical and Calorimeters properties of this mortar. This will select the most compatible product and more able to be used depending on the climate of the country and the cement used. The PNS is incompatible with this type of cement registering a decrease of strength but the PMS and the PC modify the kinetics of hydration with significant heat generation and improved mechanical strength. The measured heat flow is significantly influenced by the type and dosage of superplasticizer especially for low dosage. Hydration heat and compressive strength of the different mixtures can be evaluated by determining their ultimate values and ages to reach these values where the correlation coefficients are very satisfactory.

• Proceedings of the Korea Concrete Institute Conference
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• 1997.10a
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• pp.203-206
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• 1997

In this paper, the properties of Interlocking block contained blast furnace slag cement are compared with that with O.P.C.(ordinary portland cement) and are analyzed under various mix proportions and the dosage of AE agent. According to the experimental results, compressive strength and flexural strength of interlocking block with blast furnace slag cement are lower than that with OPC. Also the strength and the ratio of absorption decrease with higher dosage of AE agent. although interlocking block with OPC has better performance than that of blast furnace slag in the side of quality, it is worth while to use the blast furnace slag as materials of interlocking block considered the side of recycling of resources and economy.

• Journal of the Korea Institute of Building Construction
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• v.8 no.1
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• pp.91-96
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• 2008

This study is to investigate the influence of the over-added chemical agents, such as water reducing agent(WRA) and AE water reducing agent(AEWRA), on the physical properties of concrete to estimate the degree of damage due to over-added chemical agents. For the fresh concrete, slump and slump flow increased with the increase of WRA and AEWRA as expected. Material segregation phenomenon was observed with the over dosage of lignin based AEWRA about 4 times larger than recommended dosage. The over dosage of AE water reducing agent about 4 times larger than recommended dosage resulted in an increase of air contents remarkably. The set retardation occurred greatly with the increase of AEWRA and WRA. For the properties of the hardened concrete corresponding to the over dosage of AEWRA, it is found that compressive strength of over added AEWRA and WRA concrete are much smaller than those of base and recommended dosage concrete proportionally due to associated increasing air content.

• Journal of the Korea Institute of Building Construction
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• v.4 no.2
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• pp.129-136
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• 2004

High fluidity concrete(HFC) requires high dosage of superplasticizer to acquire sufficient fluidity, and high contents of fine powder and viscosity enhancing admixtures to resist segregation. The use of high amount of admixtures to make HFC at batcher plant in ready mixed concrete company is one of the reasons to raise the manufacturing cost of HFC. For this reason, new type of manufacturing method of HFC are described using both flowing concrete method and segregation reducing superplasticizer(SRS) in order to gain economical profit and offer the convenience for quality control.. As dosage of melamine based superplasticizer increases, it shows that fluidity and bleeding increase, while air contents and ratio of segregation resistance decrease. It also shows that addition of viscosity agent into superplasticizer reduce bleeding and improve segregation resistance of concrete. Dosage of AE agent into superplasticizer containing viscosity agent recovers loss of air contents during flowing procedure. Combination of proper contents of superplasticizer, viscosity agent and AE agent make possible to develope segregation reducing type superplasticizer. Compressive strength of high fluidity concrete applying flowing method with it is higher than that of base concrete. No differences of compressive strength between compacting methods are found. For the estimation of construction cost of high fluidity concreting using segregation reducing type superplasicizer, under same strength levels, although material cost of high fluidity concrete is somewhat higher than that of plain concrete due to segregation reducing type superplasticizer cost, labor cost and equipment cost of high fluidity concrete is cheaper than that of plain concrete. However, based on the strength differences, high fluidity concrete shows lower material cost, labor cost and equipment cost than that of plain concrete due to decreasing in size of member and re-bar caused by high strength development of concrete.

• Journal of Forest and Environmental Science
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• v.22 no.1
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• pp.27-31
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• 2006

Sedimentation characteristics such as SS, COD removal efficiency of wastewater in the toilet paper mill using recycled paper were examined by zeta potential. Optimum dosage of coagulant were determined by turbidity, SS, COD and then equation for treatment efficiency was suggested. Mechanical strength of floc was determined by turbidity.

• Proceedings of the Korea Concrete Institute Conference
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• 1991.04a
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• pp.15-18
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• 1991

This study is designed for analyze the concrete properties according to the over-dosage of AE water-reducing agent; is aimed to analyze the effect of slump, air content, compressive strength of concrete and for presenting the reference data on the practical use.

• Proceedings of the Korea Concrete Institute Conference
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• 2000.04a
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• pp.57-61
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• 2000

This experimental study was carried out to estmate the effects of mixing dosage rate and blain on the compressive strength properties of antiwashout underwater concrete admixed with finely ground granulated blast furnace slag. The experimental parameters are slag contents(0, 20, 30, 40, 50, 60%). As a result the compressive strength have a high correlation with slag blended ratio. Thus, it is possible to calculate the modulus of modified age using compressive strength of antiwashout underwater concrete blended with slag.