• Animal cells and systems
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• 제6권2호
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• pp.159-165
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• 2002

Projections from the prefrontal cortex to subdivisions of the dorsal raphe nucleus were investigated in the rat using retrograde and anterograde tracing methods. A retrograde tracer, gold-conjugated horseradish peroxidase (WGA-apo-HRP-gold), was injected into each subdivision of the dorsal raphe including lateral wing, dorsomedial, and ventromedial areas. The majority of retrogradely labeled cells were located in the prelimbic, infralim-bic, and dorsal peduncular areas of the medial prefrontal cortex. A few cells were also identified in the cingulate, various regions of the orbital, and agranular insular cortices. Secondly, an anterograde tracer, Phaseolus vulgaris leucoagglutinin (PHA-L), was injected into the medial prefrontal cortex involving the prelimbic or infralimbic areas. Axonal fibers with varicosities were identified in all subdivisions of the DR including the lateral wing, dorsomedial, and ventromedial areas. Projections were bilateral, with ipsilateral predominance. Axonal fibers were observed at the lateral border of medial longitudinal fasciculus or in the interfascicular region at the midline. The present findings demonstrate that both the midline and lateral wing regions of the dorsal raphe nucleus receive excitatory input from cognitive and emotional centers of the cerebral cortex.

• Annals of Clinical Neurophysiology
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• 제1권1호
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• pp.19-25
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• 1999

Background & Objectives : In cerebral palsy, spastic paraplegia is one of the most crippling motor manifestations. Reducing the spasticity may improve gait and decrease the incidence of lower-extremity deformities. The spasticity may result from abnormally increased afferent signals via dorsal roots onto interneurons and anterior horn and spreading of reflex activation to other muscle groups. To assess the influence of dorsal rhizotomy to spasticity, the authors analyzed five cerebral palsy patients with spastic paraplegia. Methods : The operation entailed and L1-2 laminectomy, ultrasonographic localization of conus medullaris and identification of lumbosacral dorsal roots. The innervation patterns of each dorsal root were examined by electromyography (EMG) responses to electrical stimulation. Tetanic stimulation was applied to individual rootlets of each root after reflex threshold was determined. the reflex responses were graded and rootlets producing high grade response were selected and cut. Short-term postoperative evaluations were performed. Results : Intraoperative EMG monitoring was satisfactorily performed in all five cases. One month after the operations, all patients showed greatly reduced spasticity which was measured by the instrumental gait analysis. Bilateral knee and ankle jerks were normalized and tip-toe gait with scissoring disappeared in all patients. Conclusion : Intraoperative EMG monitoring seems useful for the selective dorsal rhizotomy to reduce spasticity.

• The Journal of Korean Physical Therapy
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• 제32권5호
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• pp.319-324
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• 2020

Purpose: This study was to investigate the effect of dorsal neck muscle fatigue on the cervical range of motion (CROM) and proprioception in adults with the forward head posture (FHP). Methods: Thirty pain-free subjects were enrolled in this study. All subjects were measured the forward head angle by taking the capture of the sagittal plane of their upper body to determine the FHP. Subjects were distributed into two groups: the FHP group (n=14) and Control group (n=16). All subjects were measured the CROM and the Head repositioning accuracy (HRA) for joint proprioception before and after inducing muscle fatigue of the dorsal neck. The CROM and HRA were measured in neck flexion, extension, right-left lateral flexion, and right-left rotation. Sorenson's test was used to induce muscle fatigue of the dorsal neck. Results: Total CROMs were significantly decreased after dorsal neck muscle fatigue in both groups (p<0.05). Total HRAs were significantly increased after dorsal neck muscle fatigue in the FHP group (p<0.05), but there were no significant differences in the control group (p>0.05). Total CROM changes were not significant differences between groups (p>0.05), but total HRA changes were significant differences between groups (p<0.05) except for right and left lateral flexion (p>0.05). Conclusion: Immediate CROM and proprioception reduction after the dorsal neck muscle fatigue were observed in adults with the FHP. Therefore, FHP can significantly affect the CROM and positioning consistency of cervical proprioception.

• The Korean Journal of Pain
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• 제13권1호
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• pp.19-30
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• 2000

Background: Partial nerve injury to a peripheral nerve may induce the development of neuropathic pain which is characterized by symptoms such as spontaneous burning pain, allodynia and hyperalgesia. Though underlying mechanism has not fully understood, sensitization of dorsal horn neurons may contribute to generate such symptoms. Nitric oxide acts as an inter- and intracellular messenger in the nervous system and is produced from L-arginine by nitric oxide synthase (NOS). Evidence is accumulating which indicate that nitric oxide may mediate nociceptive information transmission. Recently, it has been reported that NOS inhibitor suppresses neuropathic pain behavior in an neuropathic pain animal model. This study was conducted to determine whether nitric oxide could be involved in the sensitization of dorsal horn neurons in neuropathic animal model. Methods: Neuropathic animal model was made by tightly ligating the left L5 and L6 spinal nerves and we examined the effects of iontophoretically applied NOS inhibitor (L-NAME) on the dorsal horn neuron's responses to mechanical stimuli within the receptive fields. Results: In normal animals, NOS inhibitor (L-NAME) specifically suppressed the responses to the noxious mechanical stimuli. In neuropathic animals, the dorsal horn neuron's responses to mechanical stimuli were enhanced and NOS inhibitor suppressed the dorsal horn neuron's enhanced responses to non-noxious stimuli as well as those to noxious ones. Conclusions: These results suggest that nitric oxide may mediate nociceptive transmission in normal animal and also mediate sensitization of dorsal horn neurons in neuropathic pain state.

• Journal of Cerebrovascular and Endovascular Neurosurgery
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• 제25권4호
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• pp.475-484
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• 2023

Objective: This study aimed to develop microsurgical strategies based on the anatomical relationship between dorsal internal carotid artery (ICA) aneurysms, the falciform ligament (FL), and the anterior clinoid process (ACP). Methods: Between 2017 and 2022, 25 patients with unruptured dorsal ICA aneurysms (less than 4 mm in diameter) underwent microsurgical direct clipping. These cases involved the left ICA (n=17) and the right ICA (n=8), with a mean aneurysm size of 3.3 mm (range, 2.5 to 4 mm). We used computed tomography angiography (CTA) and digital subtraction angiography to elucidate the anatomical relationship between dorsal ICA aneurysms and other structures. All procedures involved an ipsilateral pterional approach with securement of the ipsilateral cervical ICA for proximal control. Results: Among the 25 dorsal ICA aneurysms, 8 (32%) were clipped without the FL being incised. Another 5 (20%) were clipped solely after the FL was cut. For the remaining 12 cases, the aneurysms were successfully clipped following FL incision and partial ACP removal. Patients exhibited favorable postoperative recoveries with good outcomes, and postoperative CTA revealed complete aneurysm clipping without any residual remnants. Conclusions: We were able to perform clipping without removing the ACP in 13 patients (52%), and in 8 of these (32%), the clipping was carried out directly without cutting the FL. Microsurgery, coupled with proximal control of the cervical ICA, can serve as a viable alternative for patients with small dorsal ICA aneurysms, especially when endovascular treatment options are limited, and 3D CTA confirms a clear anatomical relationship with the ACP.

• 한국의류학회지
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• 제14권3호
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• pp.183-195
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• 1990

The author has studied the effect of clothes design to mask the dorsal curvature that is one of the commonest changes in elderly women. Body measurements including the body type and the status of dorsal curvature were perfor-med on 153 women of over 60 years of age, and then a body form to fit to the mean measure-ments was made to evaluate the effects of various designs to it. With 31 pattern designs modified by changing in their slash lines and gathers using darts, the diminishing effect of the rounded back were evaluated by means of sensory test. The results of this study can be summarized as follows: I . Results from the body measurements 1) The mean body type in elderly women was that of obesity. 2) With the advancement of age, the angle to indicate the degree of dorsal curvature as well as the angle to indicate the posture are increased. II . Concerning to the clothes design to diminish the shape of dorsal curvature 1) Among the designs by the position of darts, the basic pattern (Fig. 5-1-(1)) showed the best effect to mask the shape of dorsal curvature. 2) Out of the applied designs of princess lines, that in which the slash line is pointing toward the shoulder point (Fig. 5-2-(1)) seemed to be most effective. 3) What has angled princess line (Fig. 5-3-(1)) had the most diminishing effect among the waist darts and armhole princess lines. 4) Among the V-shaped designs, the slashed at the shoulder point (Fig. 5-4-(1)) had the best effect to lessen the shape of the dorsal cuuature. 5) Wider angle yoke had better effect to the narrow angle one among the designs with straight yoke, and that with downward direction (Fig. 5-5-(1)) showed the best effect. 6) Between straight wide angle yoke and curved yoke, that of curved one with downward direction (Fig. 5-6-(1)) had better effect as far as the masking effect of dorsal curvature is concerned. 7) Gathers around the neck showed better effect to those around the shoulder, and the more amount of gathers (Fig. 5-7-(1)), there was better effect. 8) The design with midline gathers at the level of horizontal slash line of armhole (Fig. 5-8-(1)) showed better effect to that with seperated gathers. 9) In case of design with gathers at the horizontal line of armhole, it showed the better effect with less amount of gathers in midline ones, but with more amount in the side ones. 10) Considering all 7 different designs with better effect in covering the shape of dorsal curvature, it was evident that the design with gathers was far better than the design with application of slash lines.

• 한국양식학회지
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• 제16권1호
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• pp.1-7
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• 2003

무지개송어의 대동맥에 삽입관을 부착한 후 스트레스와 관련된 생리화학적 반응을 조사하였고, 실험사료의 위내 강제공급 후 혈장내 유리 아미노산의 농도변화를 비교하였다. 무지개 송어에 있어 아미노산의 요구량 설정 모델 개발을 위한 기초연구로서 사료 영양학적 연구를 위한 새로운 사료공급 및 혈액채취 방법의 개발을 위하여, 강제투여 및 대동맥 삽입방법의 적용 가능성을 조사하였다. 스트레스와 관련된 생리화학적 반응조사에 있어서 혈액내 헤마토크리트(Ht)는 6시간에 최대치를 보였고, 12시간에 최초수준으로 돌아와 48시간까지 유지되었고 혈장내 코티졸과 글루코스는 3시간에 증가하기 시작하여 6시간에 최대치를 보였으며(P<0.05), 48시간에 최초수준으로 돌아왔다. 혈장내 총 단백질 함량, 삼투압, Na농도, K농도, Cl농도, 헤모글로빈(Hb)수와 적혈구수(red blood cell, RBC)는 48시간동안 큰 변화를 보이지 않았다. 실험사료의 위내 강제 공급 후 혈장내 유리 아미노산의 농도 변화는, arginine, histidine, Iysine, methionine, threonine. valine, glutamic acid. isoleucine, leucine, phenylalanine과 tryptophan이 사료공급 후 4시간에 최대치를 보였고, 8~24시간사이에 최초수준 또는 감소하고, 48시간까지 일정하게 유지되었다. glycine은 사료공급 후 4~8사이에 감소하여 12시간에 최대치를 보였고 24시간에 최초수준으로 돌아왔다. alanine과 aspartic acid의 농도는 사료공급 후 4시간에 최대치를 보였고, 48시간에 기본농도로 돌아왔다. 상기 결과를 토대로, 위내 강제 공급 방법과 대동맥 삽입방법을 무지개 송어의 사료 영양학적 연구에 적용 가능하였고, 유리아미노산의 농도 측정으로 필수 아미노산 요구량 추정이 가능함을 보여주었다.

• Animal Systematics, Evolution and Diversity
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• 제29권1호
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• pp.23-30
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• 2013

This study reports the discovery of two oxytrichid ciliates, Cyrtohymena primicirrata (Berger and Foissner, 1987) and Oxytricha granulifera Foissner and Adam, 1983, in Jeju Island, Korea. The morphology of the two species was studied using live observation and protargol impregnation. These species are described as follows: Cyrtohymena primicirrata has a body size in live specimens $90-140{\times}40-60{\mu}m$, length : width ratio 2.3 : 1 on average; elongated and slender obovate in outline of body. Cortical granules are shiny yellow on the ventral and dorsal side. Adoral zone of membranelles (AZM) is covering about 48% of the cell with about 38 adoral membranelles. Arrangement of undulating membranes is ordinary Cyrtohymena pattern. Dorsal kineties is six rows with $5{\mu}m$ long bristles. Oxytricha granulifera has a body size in live specimens $90-115{\times}25-38{\mu}m$, length : width ratio 3.31 on average; elongated ellipsoidal in outline of body. Cortical granules are colorless on the ventral and dorsal side. AZM is covering 28% of the cell length in vivo with about 24 adoral membranelles. Arrangement of undulating membranes is Oxytricha pattern. Dorsal kineties is five rows with about $3{\mu}m$ long dorsal bristles.

• Journal of Acupuncture Research
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• 제37권4호
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• pp.285-289
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• 2020

Background: This study was conducted to evaluate the clinical effect of acupotomy, a newly upcoming acupuncture treatment method for a dorsal wrist ganglion cyst. Methods: A patient with a dorsal wrist ganglion cyst was treated with acupotomy under ultrasonographic guidance. The symptoms caused by the cyst and size of the cyst under ultrasonographic observation were used to evaluate the effect of the acupotomy treatment. Results: The numeric rating scale score reduced from 7 to 1.4 throughout the treatment period. The size and swelling of the cyst decreased following acupotomy treatment. Conclusion: Acupotomy had a positive clinical effect in the treatment of a dorsal wrist ganglion cyst in this case. Further studies are required for its additional retrospective application.

• 대한족부족관절학회지
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• 제9권1호
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• pp.59-63
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• 2005

Purpose: To present the procedure and results of dorsal wedge osteotomy fixated by bioabsorbable polyglycolide pins for the treatment of symptomatic Freiberg's disease. Materials and Methods: From January 1997 to December 2002, six patients with Freiberg's disease underwent dorsal wedge osteotomy of the metatarsal neck to bring the healthy plantar part of the metatarsal head into articulation. Bioabsorbable polyglycolide pins were used for the fixation and short-leg walking cast was applied for 4 weeks. Results: All patients returned to full daily activities without pain in three months after the operation. Radiographically, solid healing of the osteotomy was observed at average ten weeks. The active range of motion of the metatarsophalangeal joint increased by a mean gain of 30 degrees, and no complication such as displacement, osteolysis or sinus formation was observed. Conclusion: Dorsal wedge osteotomy fixated by bioabsorbable pins for patients with symptomatic Freiberg's disease is effective procedure that provides relatively early range of motion exercise and avoids second procedure for implant removal.