• Title/Summary/Keyword: Dormant

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Polyadenylation-Dependent Translational Control of New Protein Synthesis at Activated Synapse

  • Shin Chan-Young;Yang Sung-Il;Kim Kyun-Hwan;Ko Kwang-Ho
    • Biomolecules & Therapeutics
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    • v.14 no.2
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    • pp.75-82
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    • 2006
  • Synaptic plasticity, which is a long lasting change in synaptic efficacy, underlies many neural processes like learning and memory. It has long been acknowledged that new protein synthesis is essential for both the expression of synaptic plasticity and memory formation and storage. Most of the research interests in this field have focused on the events regulating transcriptional activation of gene expression from the cell body and nucleus. Considering extremely differentiated structural feature of a neuron in CNS, a neuron should meet a formidable task to overcome spatial and temporal restraints to deliver newly synthesized proteins to specific activated synapses among thousands of others, which are sometimes several millimeters away from the cell body. Recent advances in synaptic neurobiology has found that almost all the machinery required for the new protein translation are localized inside or at least in the vicinity of postsynaptic compartments. These findings led to the hypothesis that dormant mRNAs are translationally activated locally at the activated synapse, which may enable rapid and delicate control of new protein synthesis at activated synapses. In this review, we will describe the mechanism of local translational control at activated synapses focusing on the role of cytoplasmic polyadenylation of dormant mRNAs.

Wireless Host Agent (WHA)-based IP Multicast Group Management Scheme (무선 호스트 에이전트 기반 IP 멀티캐스트 그룹 관리 기법)

  • Lee, Ji-Hoon;Suh, Jun-Ho;Kwon, Ted Tae-Kyoung;Choi, Yang-Hee
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.34 no.10B
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    • pp.1004-1012
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    • 2009
  • Although it is raising expectation of multimedia multicast services in various wireless networks, it requires an efficient IP multicast group membership management in wireless environment. However, the existing IGMPv3/MLDv2 protocols are too heavy; they are not suitable for wireless environment. Moreover they suffer from a number of problems, such as unreliable signaling, slow state transition, low spectral efficiency, bulk report, and interrupting dormant receivers. In this paper, we propose a wireless host agent (WHA)-based IP multicast group management scheme that requires a reduced number of signaling, which also solves such problems effectively. We develop an analytic model to quantify costs of bandwidth usage and signaling overhead, and perform comparison and analysis of the proposed scheme.

Efficiency of virus elimination in apple calli (cv. Hongro) derived from meristem culture of dormant buds (사과 품종 홍로의 휴면아 분열조직 배양을 통해 형성된 캘러스에서의 바이러스 제거효율)

  • Kim, Mi Young;Chun, Jae An;Cho, Kang Hee;Park, Seo Jun;Kim, Se Hee;Lee, Han Chan
    • Journal of Plant Biotechnology
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    • v.44 no.4
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    • pp.379-387
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    • 2017
  • Various sizes (0.2 ~ 1.2 mm) and developmental stages (referred to as Stage 1 ~ 3) of apical and lateral meristems were excised, together or separately, directly from dormant buds of apple 'Hongro'. They were mixed infected by Apple scar skin viroid (ASSVd), Apple chlorotic leaf spot virus (ACLSV), Apple stem pitting virus (ASPV) and Apple stem grooving virus (ASGV), which are major viruses attacking apples. A total of 31 callus lines (> 10 mm in diameter) were obtained by culturing the explants on Murashige and Skoog (MS) medium supplemented with 3% sucrose, 3.0 mg/L benzyladenine (BA) and 0.1 mg/L indole-3-butyric acid (IBA), and they were subjected to RT-PCR analysis for virus detection. A high rate of virus elimination (expressed as the percentage of calli that did not amplify during RT-PCR, i.e., RT-PCR negative calli per total number of calli obtained) was achieved for ACLSV (100%), ASSVd (93.7%), and ASPV (93.7%), whereas it was only 25.8% for ASGV. ASPV was detected in the presence of 2 ~ 3 bracts. Simultaneous virus elimination of ASSVd, ASPV, ACLSV, and ASGV occurred during the meristem culture, in which the early stages of the dormant buds (Stage 1) were used, because ASGV was mostly eliminated during that stage. The results of the present study will be valuable for the production of virus-free apple trees.

Cost Reduction of Location Registration Using the LiEy UBdate Strategy in Hierarchical Mobile IPv6 (계층적 이동 Ipv6환경에서 지연갱신전략을 이용한 위치등록 비용 감소)

  • Yi Myung-Kyu;Hwang Chong-Sun
    • Journal of KIISE:Information Networking
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    • v.32 no.3
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    • pp.370-381
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    • 2005
  • Mobile IP provides an efficient and scalable mechanism for host mobility within the Internet. Using Mobile If, mobile nodes may change their point of attachment to the Internet without changing their If address. However, it would result in a high signaling cost. To reduce the signaling cost, we factor in the fact that mobile users will not be actively communicating much of the time. In fact, there Is no necessity to send a binding update message to the home agent when an mobile node does not communicates with others while moving. From this point of view, we propose a lazy update strategy for minimizing signaling cost using the forwarding pointer in hierarchical Mobile IPv6. In our proposal, binding updates are sent only when a mobile node is in a busy mode. If an mobile node is in a dormant mode, binding update messages are delayed until busy mode using the forwarding pointer. As a result, our proposal can reduce the total signaling cost by eliminating unnecessary binding update messages when a mobile node Is in a dormant mode. In addition to, our proposal reduces unnecessary location update cost resulting from ping-pong effect under mobile node's dormant mode. Analysis results using the discrete analytic model presented in this paper shows that our proposal can has superior performance than hierarchical Mobile nv6 when the call-to-mobility ratio is low and the length of the forwarding pointer chain K is low.

Effect of stocker management program on beef cattle skeletal muscle growth characteristics, satellite cell activity, and paracrine signaling impact on preadipocyte differentiation

  • Vaughn, Mathew A.;Lancaster, Phillip A.;Roden, Kelly C.;Sharman, Evin D.;Krehbiel, Clinton R.;Horn, Gerald W.;Starkey, Jessica D.
    • Journal of Animal Science and Technology
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    • v.61 no.5
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    • pp.260-271
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    • 2019
  • The objective of this study was to determine the effect of different stocker management programs on skeletal muscle development and growth characteristics, satellite cell (SC) activity in growing-finishing beef cattle as well as the effects of SC-conditioned media on preadipocyte gene expression and differentiation. Fall-weaned Angus steers (n = 76; $258{\pm}28kg$) were randomly assigned to 1 of 4 stocker production systems: 1) grazing dormant native range (NR) supplemented with a 40% CP cottonseed meal-based supplement ($1.02kg{\cdot}steer^{-1}{\cdot}d^{-1}$) followed by long-season summer grazing (CON, 0.46 kg/d); 2) grazing dormant NR supplemented with a ground corn and soybean meal-based supplement fed at 1% of BW followed by short-season summer grazing (CORN, 0.61 kg/d); 3) grazing winter wheat pasture (WP) at high stocking density (3.21 steers/ha) to achieve a moderate rate of gain (LGWP, 0.83 kg/d); and 4) grazing winter WP at low stocking density (0.99 steers/ha) to achieve a high rate of gain (HGWP, 1.29 kg/d). At the end of the stocker (intermediate harvest, IH) and finishing (final harvest, FH) phases, 4 steers / treatment were harvested and longissimus muscles (LM) sampled for cryohistological immunofluorescence analysis and SC culture assays. At IH, WP steers had greater LM fiber cross-sectional area than NR steers; however, at FH, the opposite was observed (p < 0.0001). At IH, CORN steers had the lowest Myf-5+:Pax7+ SC density (p = 0.020), while LGWP steers had the most Pax7+ SC (p = 0.043). At FH, CON steers had the highest LM capillary density (p = 0.003) and their cultured SC differentiated more readily than all other treatments (p = 0.017). At FH, Pax7 mRNA was more abundant in 14 d-old SC cultures from HGWP cattle (p = 0.03). Preadipocytes exposed to culture media from proliferating SC cultures from WP cattle isolated at FH had more $PPAR{\gamma}$ (p = 0.037) and less FABP4 (p = 0.030) mRNA expression compared with NR cattle. These data suggest that different stocker management strategies can impact skeletal muscle growth, SC function, and potentially impact marbling development in growing-finishing beef cattle.

Effects of Different Pruning Time on Bush Growth and Fruit Production of Southern Highbush Blueberry 'Scintilla' Cultivated in a Heated Plastic House (전정시기가 가온재배 남부하이부쉬 블루베리 '신틸라'의 신초 생장과 과실 생산에 미치는 영향)

  • Cheon, Mi Geon;Lee, Seo Hyoun;Park, Kyung Mi;Choi, Seong-Tae;Hwang, Yeon Hyeon;Chang, Young Ho;Kim, Jin Gook
    • Journal of Bio-Environment Control
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    • v.30 no.3
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    • pp.183-187
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    • 2021
  • Appropriate pruning is very important for southern highbush blueberries cultivated in a heated plastic house to control their severe crowding within the bush canopy after harvest. Pruning treatments at different times were evaluated to find out an appropriate pruning time to southern highbush 'Scintilla' cultivation with heating. Seven-year-old (2018) bushes, grown in 180-L containers, were summer-pruned on May 20 (35-39 days after harvest) and June 20, or dormant-pruned on December 20 (5 days before flowering), consecutively in both 2018 and 2019 removing 30% of the total woods. May pruning activated occurrence of shoots the following years, increasing number of shoot by 17 to 49% and total shoot length by 18 to 32% compared with those of the dormant pruning. Fruit characteristic was not significantly affected by different pruning times the previous year. The first year pruning treatment did not influence the yield the following year, but the second year consecutive May pruning significantly increased yield per bush by 7% compared with the dormant pruning. The results indicated that summer pruning in May could be favorable to promote shoot growth and to maintain stable yield.

Why Standard Measures of Human Capital are Misleading

  • HANUSHEK, ERIC A.
    • KDI Journal of Economic Policy
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    • v.37 no.2
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    • pp.22-39
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    • 2015
  • After a long, dormant period, recent attention has turned to a variety of measurement issues surrounding the concept of human capital. The traditional approach of rely entirely on measures of school attainment, while convenient, is almost certainly misleading. The availability of cognitive skills measures greatly improves on these measurements, but there remains also concern about other unmeasured factors, including noncognitive skills. This paper considers alternative approaches to assessing the role of human capital on individual earnings and on economic growth.

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Risk Management and Governmental Investment on New & Renewable Energy (Risk Management 관점에서 신재생에너지 투자)

  • Ahn, Eun-Young
    • 한국신재생에너지학회:학술대회논문집
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    • 2006.06a
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    • pp.360-363
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    • 2006
  • Regester & Larkin(2005) suggest the issue and risk lifecycle analysis method in risk management, made up of the potential, emerging, current, crisis, and dormant stages. Investment on New & Renewable Energy is meaningful in effect ive risk management for diminishing or reducing the shock of a energy current, at the potential stage. In this study, we survey the risk of traditional fossil fuel projects and develop the risk analysis model for new & renewable energy projects specially geothermal energy resources and gas-hydrate resources.

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A Monitoring Observation of Comet 17P/Holmes during 2014 Apparition

  • Kwon, Yuna;Ishiguro, Masateru;Hanayama, Hidekazu;Kuroda, Daisuke;Sarugaku, Yuki;Kim, Yoonyoung;Vaubaillon, Jeremie J.;Takahashi, Jun;Watanabe, Jun-Ichi
    • The Bulletin of The Korean Astronomical Society
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    • v.40 no.1
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    • pp.61.1-61.1
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    • 2015
  • We performed a monitoring campaign of a Jupiter-Family comet 17P/Holmes, which underwent the dramatic outburst on 23.3 October 2007 at $r_h=2.44AU$, to investigate the secular change in activity and subsequent physical properties of the inner dust coma before and after the 2014 perihelion passage. The monitoring observation was carried out over two years: from May to July 2013, from July to November 2014, and January 2015 with ~weekly cadence. We conducted photometry monitoring in Rc band using four ground-based telescopes, which are the Ishigakijima Astronomical Observatory 105cm telescope, the Okayama Astrophysical Observatory 50cm telescope, the Nishi-Harima Astronomical Observatory 2m telescope, and the T30 51cm i-telescope, respectively. In order to examine the dust production rate, we put a constraint upon the physical distance from the center of the nucleus as rho=2500km and conducted aperture photometry. We found that the average absolute Rc magnitude over the period between July to November 2014 was mR(1,1,0)~12.29, which was approximately 1.5 magnitudes fainter than those of 2013 data. Accordingly, comet 17P/Holmes seemed to become dormant, although a minor eruption was detected on January 26, 2015. In this presentation, we will introduce our ongoing project for 17P/Holmes and discuss why the nucleus becomes dormant within one orbital period.

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