• 한국융합학회논문지
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• 제8권7호
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• pp.39-46
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• 2017

중국 경제성장에 핵심적 역할을 해왔던 광동성(廣東省) 동관시는 지리적으로 근접해 있는 홍콩을 이용하여 지속적인 경제발전을 추구해 왔다. 1980년대 초반은 홍콩으로부터 가전산업 관련 중소 다국적 기업이 동관지역에 진출하여 생산 공장을 세우고, 그 후 1990년 중반에는 대만의 PC제조업체의 진출이 잇따르면서 현재 동관에는 정보통신산업과 PC부품 및 전자산업 중심으로 지역 산업클러스터가 발전해 왔다. 동관시 산업클러스터 사례는 개혁개방 이후 중국 제조업 산업의 발전뿐만 아니라, 글로벌 시대에 해외직접투자와 아시아지역에서의 지역경제의 성장 및 산업발전과정의 연구에 대한 이론적 시사점을 줄 수 있는 지역적 사례 중의 하나다. 본 연구는 광동성 동관시 지역산업클러스터의 사례를 중심으로 이론적으로는 지역산업발전의 내생적 성장요인 분석(NMID) 혹은 글로벌 생산네트워크와의 외부적 연계성을 기초로 하는 산업의 지역적 분화(GPN)에 대한 이 두 관점을 상호 비교하고, 글로벌 융합전략을 설명하였다.

• Nuclear Engineering and Technology
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• 제51권8호
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• pp.1998-2004
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• 2019

The Multi-Physics (MP) instrument is one of 20 neutron spectrometers planned in the China Spallation Neutron Source (CSNS). This paper presents a shielding calculation for the MP instrument using Monte Carlo codes MCNPX and FLUKA. First, the neutrons that escape from the CSNS decoupled water moderator and are delivered to the beam line of the MP instrument are calculated to use as the source term of the shielding calculation. Then, to validate the calculation method based on multiple variance reduction techniques, a cross check between MCNPX and FLUKA codes is performed by comparing the calculation results of the dose rate distribution on a simplified beam line model. Finally, a complete geometry model of the MP instrument is set up, and the primary parameters for the shielding design are obtained according to the calculated dose rate map considering different worst-case scenarios.

• Current Optics and Photonics
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• 제4권4호
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• pp.267-272
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• 2020

The propagation of a truncated Airy beam with spatial phase modulation (SPM) is investigated in Kerr nonlinearity with an optical lattice. Before the truncated Airy beam enters the optical lattice, a sinusoidal phase is introduced on the wave-front of the beam. The effect of the spatial phase modulation and optical lattice on propagation behavior is analyzed by direct numerical simulation. It is found that the propagation direction of a truncated Airy beam can be effectively controlled by adjusting the values of phase shift. The effects of optical amplitude, truncation factor, spatial modulation frequency, lattice period and lattice depth on the propagation are discussed in detail. By choosing a high modulation depth, the finite-energy Airy beam can be deflected with a large deflection angle in an optical lattice.

• Journal of Microbiology and Biotechnology
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• 제31권3호
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• pp.429-438
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• 2021

Bacterial cellulose (BC) is widely used in the food industry for products such as nata de coco. The mechanical properties of BC hydrogels, including stiffness and viscoelasticity, are determined by the hydrated fibril network. Generally, Komagataeibacter bacteria produce gluconic acids in a glucose medium, which may affect the pH, structure and mechanical properties of BC. In this work, the effect of pH buffer on the yields of Komagataeibacter hansenii strain ATCC 53582 was studied. The bacterium in a phosphate and phthalate buffer with low ionic strength produced a good BC yield (5.16 and 4.63 g/l respectively), but there was a substantial reduction in pH due to the accumulation of gluconic acid. However, the addition of gluconic acid enhanced the polymer density and mechanical properties of BC hydrogels. The effect was similar to that of the bacteria using glycerol in another carbon metabolism circuit, which provided good pH stability and a higher conversion rate of carbon. This study may broaden the understanding of how carbon sources affect BC biosynthesis.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2021-2026
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• 2014

Aim: Recent research suggests that nucleophosmin (NPM) may be a prognostic marker in colorectal carcinomas (CRC). We here tested its use to predict the survival of CRC patients. Methods: We investigated NPM expression by immunohistochemistry in histologically normal to malignant colorectal tissues and evaluated its association with clinicopathological variables. Overall and disease-free survival after tumor removal were calculated by the Kaplan-Meier method, and differences in survival curves were analyzed by the log-rank test. The Cox proportional hazards model was used for multivariate analysis of prognostic factors. Results: NPM expression was found significantly upregulated in CRC compared to adjacent colorectal tissue, villous adenoma, tubular adenoma and normal colorectal mucosa (p<0.05 for all). NPM expression was statistically linked to cancer embolus, lymph node metastasis, differentiation grade, and recurrence of CRC. Overall and disease-free survival of NPM-negative CRC patients tended to be better than those for patients with NPM-positive lesions (log-rank statistic, p<0.05 for all). Multivariate analysis indicated NPM expression as an independent prognostic indicator for CRC patients (p<0.05 ). Conclusion: Our results suggest that NPM expression can predict the survival of CRC patients. Prognosis of CRC is determined by not only many known prognostic factors but also by NPM expression.

• Journal of Ginseng Research
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• 제47권6호
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• pp.743-754
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• 2023

Background: Myocardial fibrosis post-myocardial infarction (MI) can induce maladaptive cardiac remodeling as well as heart failure. Although 20(S)-ginsenoside Rg3 (Rg3) has been applied to cardiovascular diseases, its efficacy and specific molecular mechanism in myocardial fibrosis are largely unknown. Herein, we aimed to explore whether TGFBR1 signaling was involved in Rg3's anti-fibrotic effect post-MI. Methods: Left anterior descending (LAD) coronary artery ligation-induced MI mice and TGF-β1-stimulated primary cardiac fibroblasts (CFs) were adopted. Echocardiography, hematoxlin-eosin and Masson staining, Western-blot and immunohistochemistry, CCK8 and Edu were used to study the effects of Rg3 on myocardial fibrosis and TGFBR1 signaling. The combination mechanism of Rg3 and TGFBR1 was explored by surface plasmon resonance imaging (SPRi). Moreover, myocardial Tgfbr1-deficient mice and TGFBR1 adenovirus were adopted to confirm the pharmacological mechanism of Rg3. Results: In vivo experiments, Rg3 ameliorated myocardial fibrosis and hypertrophy and enhanced cardiac function. Rg3-TGFBR1 had the 1.78×10^-7 M equilibrium dissociation constant based on SPRi analysis, and Rg3 inhibited the activation of TGFBR1/Smads signaling dose-dependently. Cardiac-specific Tgfbr1 knockdown abolished Rg3's protection against myocardial fibrosis post-MI. In addition, Rg3 downregulated the TGF-β1-mediated CFs growth together with collagen production in vitro through TGFBR1 signaling. Moreover, TGFBR1 adenovirus partially blocked the inhibitory effect of Rg3. Conclusion: Rg3 improves myocardial fibrosis and cardiac function through suppressing CFs proliferation along with collagen deposition by inactivation of TGFBR1 pathway.

• Animal Bioscience
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• 제34권10호
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• pp.1695-1704
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• 2021

Objective: The aim of this work was to assess the effect of ergothioneine (ESH)-enriched mushroom extract on oxidative stability, volatile compounds, and sensory quality of emulsified sausage. Methods: The ESH content was determined by high performance liquid chromatography. The antioxidant activity of Flammulina velutipes (F. velutipes) extract was determined through radical-scavenging activity of 1,1 diphenyl-2-picryl-hydrazyl, 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) and hydroxyl radicals. Four different groups of emulsified sausage were manufactured: control, no antioxidants; BHA, 0.01% butylated hydroxyanisole; EEME, 0.8% ESH-enriched mushroom (F. velutipes) extract; AE, 0.012% authentic ESH, after storage for 14 days (at 4℃), the quality of sausage including oxidative stability (2-thiobarbituric acid reactive substances and protein carbonyls content), volatile compounds and sensory quality were studied. Results: It was demonstrated that adding ESH-enriched F. velutipes extract to sausage could effectively prevent lipid and protein oxidation, and its efficacy was equivalent with 0.01% BHA. During meat processing, the ESH mainly contributed to the antioxidative activity of F. velutipes extract. The flavor and sensory attributes of emulsified sausage were improved through adding ESH-enriched F. velutipes extract. Conclusion: Accordingly, the extract of F. velutipes contained high-level of ESH and could be a good antioxidant candidate for processed meat production.

• Journal of Microbiology and Biotechnology
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• 제34권6호
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• pp.1189-1196
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• 2024

Bacterial resistance to commonly used antibiotics is one of the major challenges to be solved today. Bacteriophage endolysins (Lysins) have become a hot research topic as a new class of antibacterial agents. They have promising applications in bacterial infection prevention and control in multiple fields, such as livestock and poultry farming, food safety, clinical medicine and pathogen detection. However, many phage endolysins display low bactericidal activities, short half-life and narrow lytic spectrums. Therefore, some methods have been used to improve the enzyme properties (bactericidal activity, lysis spectrum, stability and targeting the substrate, etc) of bacteriophage endolysins, including deletion or addition of domains, DNA mutagenesis, chimerization of domains, fusion to the membrane-penetrating peptides, fusion with domains targeting outer membrane transport systems, encapsulation, the usage of outer membrane permeabilizers. In this review, research progress on the strategies for improving their enzyme properties are systematically presented, with a view to provide references for the development of lysins with excellent performances.

• Kyungpook Mathematical Journal
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• 제47권2호
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• pp.191-202
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• 2007

By using the weighted averaging techniques, we establish oscillation criteria for the second order damped quasilinear elliptic differential equation $$\sum_{i,j=1}^{N}D_i(a_{ij}(x){\parallel}Dy{\parallel}^{p-2}D_jy)+{\langle}b(x),\;{\parallel}Dy{\parallel}^{p-2}Dy{\rangle}+c(x)f(y)=0,\;p>1$$. The obtained theorems include and improve some existing ones for the undamped halflinear partial differential equation and the semilinear elliptic equation.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권3호
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• pp.735-748
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• 2014

The fault-tolerance routing problem is one of the most important issues in the application of the Internet of Things, and has been attracting growing research interests. In order to maintain the communication paths from source sensors to the macronodes, we present a hybrid routing scheme and model, in which alternate paths are created once the previous routing is broken. Then, we propose an improved efficient and intelligent fault-tolerance algorithm (IEIFTA) to provide the fast routing recovery and reconstruct the network topology for path failure in the Internet of Things. In the IEIFTA, mutation direction of the particle is determined by multi-swarm evolution equation, and its diversity is improved by the immune mechanism, which can improve the ability of global search and improve the converging rate of the algorithm. The simulation results indicate that the IEIFTA-based fault-tolerance algorithm outperforms the EARQ algorithm and the SPSOA algorithm due to its ability of fast routing recovery mechanism and prolonging the lifetime of the Internet of Things.