• Journal of Ginseng Research
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• v.34 no.3
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• pp.198-204
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• 2010

Korean ginseng (Panax ginseng C.A. Meyer) preserved in syrup, known as ginseng Jung Kwa (GJK), is a popular traditional snack in Korea. We investigated the effects of heat processing time on total phenolic content and antioxidant capacity of GJK. Water extract was prepared from GJK with different heat processing times, 3 hours (GJK-3), 6 hours (GJK-6), or 12 hours (GJK-12), with sonication for 2 hours. The GJK extract contained total phenolic content in the following order: GJK-12 (2.28%)>GJK-6 (1.57%)>GJK-3 (1.29%). Both the peroxy and hydroxyl radical-scavenging activity and cellular antioxidant capacity of GJK extract was significantly enhanced with increasing heat processing time. The hydroxyl radical-scavenging activity of GJK-12 extract was greater than that of the GJK-3 and GJK-6 extracts, consistent with metal chelating capacity and reducing capacity. In a cellular model, the GJK extract effectively reduced 2,2'-azobis(2-amidinopropane) dihydrochloride, $Cu^{2+}$-, and $H_2O_2$-induced oxidative stress, with GJK-12 and GJK-6 extracts demonstrating greater cellular antioxidant capacity than the GJK-3 extract. These results suggest that heat processing time can contribute to the antioxidant capacity of GJK and that GJK extract may have the potential to be used as an effective dietary antioxidant to prevent oxidative stress-related diseases.

• Journal of Ginseng Research
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• v.38 no.3
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• pp.203-207
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• 2014

Background: There is limited understanding of the effect of dietary components on the absorption of ginsenosides and their metabolites into the blood. Methods: This study investigated the pharmacokinetics of the ginseng extract and its main constituent ginsenoside Rb1 in rats with or without pretreatment with a prebiotic fiber, NUTRIOSE, by liquid chromatography tandem mass spectrometry. When ginsenoside Rb1 was incubated with rat feces, its main metabolite was ginsenoside Rd. Results: When the intestinal microbiota of rat feces were cultured in vitro, their ginsenoside Rd-forming activities were significantly induced by NUTRIOSE. When ginsenoside Rb1 was orally administered to rats, the maximum plasma concentration (Cmax) and area under the plasma drug concentratione-time curve (AUC) for the main metabolite, ginsenoside Rd, were $72.4{\pm}31.6ng/mL$ and $663.9{\pm}285.3{\mu}g{\cdot}h/mL$, respectively. When the ginseng extract (2,000 mg/kg) was orally administered, Cmax and AUC for ginsenoside Rd were $906.5{\pm}330.2ng/mL$ and $11,377.3{\pm}4,470.2{\mu}g{\cdot}h/mL$, respectively. When ginseng extract was orally administered to rats fed NUTRIOSE containing diets (2.5%, 5%, or 10%), Cmax and AUC were increased in the NUTRIOSE receiving groups in a dose-dependent manner. Conclusion: These findings reveal that intestinal microflora promote metabolic conversion of ginsenoside Rb1 and ginseng extract to ginsenoside Rd and promote its absorption into the blood in rats. Its conversion may be induced by prebiotic diets such as NUTRIOSE.

• YAKHAK HOEJI
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• v.42 no.5
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• pp.527-533
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• 1998

6-(3,4-Dichlorophenyl)amino-7-chloro-5,8-quinolinedione (RCK50) was tested for antifungal activities in mice systemically infected with Candida albicans. The therapeutic potential of RCK50 was also assessed in comparison with ketoconazole. CK50 had $ED_{50}$ 0.22${\pm}$0.01mg/kg. Ketoconazole as a positive control had $ED_{50}$ 6.00${\pm}$1.70mg/kg. Intraperitoneally administered RCK50 at the $ED_{50}$ for 7 days and 14 days reduced Candida albicans colony count in the kidneys and liver. And administered RCK50 at the $ED_{50}$ for 14 days improved survival rates. The genotoxicities of RCK50 had been evaluated. RCK50 was negative in Ames test with Salmonella typhimurium and chromosomal aberration test in CHL cells. RCK50 did not show any clastogenic effect in mouse peripheral blood and was negative in mouse micronucleus assay. These results indicate that RCK50 has no genotoxic potential under these experimental conditions. Acute oral toxicity studies of RCK50 were carried out in ICR mice of both sexes. RCK50 did not show acute oral toxicities and $LD_{50}$ values were over 2,850mg/kg in ICR mice.

• Advances in Traditional Medicine
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• v.10 no.3
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• pp.214-221
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• 2010

Clematis chinensis is the root of Clematis chinensis OSBECK and is classified in Ranunculaceae. Clematis chinensis is a traditional medicinal herb possesses analgesic, diuretic, anti-tumorigenic, and anti-inflammatory effects. In this study, the effect of aqueous extract of Clematis chinensis against lipopolysaccharide-induced inflammation was investigated in mouse BV2 microglial cells. The aqueous extract of Clematis chinensis at the respective concentration was treated one hour before the lipopolysaccharide treatment in mouse BV2 microglial cells. From the present results, pre-treatment with the aqueous extract of Clematis chinensis suppressed prostaglandin E2 synthesis and nitric oxide production by inhibiting on the lipopolysaccharide-stimulated cyclooxygenase-2 and inducible nitric oxide synthase expressions in mouse BV2 microglial cells. The present study suggests that Clematis chinensis may offer a valuable mean of therapy for brain inflammatory diseases.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.44 no.1
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• pp.1-9
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• 2007

Digital Multimedia Broadcasting is the next generation broadcasting service which enables various digital multimedia contents, i.e., audio and video, and data access for mobile users. However, due to the bandwidth limitation, the spatial resolution is limited to CIF(Common Interleaved Frame). The Advanced Terrestrial DMB (AT-DMB) secures additional bandwidth by adopting hierarchical modulation transmission technology and provides high data rate and quality for mobile multimedia broadcasting services with scalable video coding(SVC). This paper proposes scalable video coding technology for AT-DMB which enables high quality mobile multimedia broadcasting services that exceeds current DMB service's quality and contents capability.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.44 no.7 s.361
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• pp.1-6
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• 2007

In this paper, the spiral zeroth-order resonance (ZOR) antenna using composite right- and left-handed (CRLH) transmission line is proposed. The zeroth-order resonant characteristics of the antenna are described by dispersion relation of a periodic structure. The size of the $2{\times}2$ spiral ZOR antenna is $0.155{\lambda}_{0}{\times}0.155{\lambda}_{0}$. By increasing shunt inductance of CRLH transmission line, the size of this antenna is reduced by 65% compared with that of a mushroom ZOR antenna. The radiation pattern of this antenna have omnidirectional pattern which is similar to that of mushroom ZOR antenna.

• Composites Research
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• v.33 no.3
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• pp.147-152
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• 2020

In this study, void behavior of composite laminate by local internal pressure gradient due to structural geometry and surface film application condition was experimentally evaluated through fabrication of spar/skin integrated structure specimens. Viscosity comparison and thermal analysis for both carbon fiber prepreg and surface film were conducted and cure characteristic and rate difference were analyzed. 2 types of spar/skin integrated structural specimens were prepared based on different application condition of surface film. Subsequently, those specimens were evaluated through visual surface inspection, non-destructive and destructive inspection. In a specimen #1 with full application of surface film, low pressurized area of composite laminate created by pressure gradient of structural geometry had voids. It exhibited that voids could not be evacuated and were locked in cured laminate by the influence of pre-cured surface film with relatively faster cure rate. In a specimen #2 without surface film, it revealed that all internal voids disappeared in the cured laminate. Therefore, it is verified that surface film acts as barrier film preventing void movement and evacuation during autoclave cure.

• 한국지구과학회:학술대회논문집
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• 2010.04a
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• pp.80-80
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• 2010

본 연구에서는 식물의 개화시기가 기온에 민감하게 반응한다는 것에 근거하여 54개의 기상관측지점을 선택하고 1988년부터 2008년까지 21년간 벚꽃 개화일의 시계열적 변화를 분석하였고 이들과 3월 평균기온과의 상관관계를 조사하였다. 그리고 엘니뇨와 라니냐 시기에 기온과 벚꽃개화일의 변화 경향과 도시화에 의한 기온변화가 벚꽃 개화일에 미치는 영향을 대도시와 교외도시와의 비교를 통해 알아보았다. 또한 경험직교함수(EOF) 분석을 통하여 벚꽃개화일의 시 공간 분포를 알아보았다. 그 결과는 다음과 같다. 첫 번째, 3월 평균기온 분석을 통해 1988-2008년 사이에 한반도의 기온은 평균적으로 $0.13^{\circ}C$ 증가하였음을 확인할 수 있다. 그리고 평균적으로 남해안이 동해안과 서해안보다 평균기온이 높게 나타났으며, 서해안이 가장 낮은 평균기온을 보였다. 그리고 내륙지역의 경우 위도에 따라 평균기온이 달랐으며, 위도가 낮아질수록 평균기온이 크게 나타났다. 하지만 모든 지점에서 유의하지는 않았다. 두 번째, 벚꽃개화일의 변화를 보면, 개화일은 시간이 지날수록 빨라지는 경향을 보였다. 그리고 벚꽃개화일의 분포를 보면 위도가 낮은 지역이 개화일이 빨랐으며, 해안지역 중에서는 남해안, 동해안, 서해안 순이었다. 세 번째, 2월, 3월, 4월의 평균기온과 벚꽃 개화일의 상관관계 분석결과 3월 평균기온이 벚꽃개화일과 상관관계가 가장 높았다. 네 번째, 엘니뇨가 발생한 해에는 한반도의 기온이 상승하는 경향을 보였으며, 동시에 벚꽃개화일도 빨라졌다. 다섯 번째, 대도시가 교외도시에 비해서 기온상승이 높았으며, 벚꽃개화일도 빠르게 나타났다. 마지막으로, 경험직교함수(EOF) 분석 결과 3월 평균기온과 벚꽃 개화일의 1mode 시계열 패턴이 비슷하다는 것을 확인하였다. 또한, 1996년을 기준으로 이전에는 개화일이 느려지고, 이후에는 빨라지는 패턴을 보였다.

• Child Health Nursing Research
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• v.8 no.4
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• pp.422-434
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• 2002

This study was conducted with 512 students in 4 primary schools located at the inner and the outskirt of K city, Northern Kyungsang Province from November 6, 2001 to November 27, 2001(during 3 weeks). This study was a research about the difference of a bullying degree and tendency of both teasing and teased students. The purpose of the study was to help nursing teachers in charge of student consultation and treatment. The findings are as follows: First, for to whom students confess their worries, students in lower grade talked to their parents while students in higher grade talked to their close friends. The higher grader, the higher rate in solving their problems by themselves. For how many students are teased by their peers in groups, 52.0％ students answered 1 or 2 students in a class. For the reasons of bully, 37.0％ higher graders answered, very selfish and putting on airs after 29.6％ lower graders answered, ugly and bad at speaking. Second, for perception of peer relation, 81.3％ students participating in the study answered, very important. For a question whether students satisfy present relation with their friends by gender, 53.7％ boys were satisfied while 34.6％ girls were satisfied. Third, for difference in bullying by gender, boys mainly teased others by using words and physical power(p<0.000) while girls estranged others. When it goes to teased students, it was the case: boys were bullied physically(p<0.000) and linguistically while girls were hurt by estrangement. Having nothing direct to do with school achievement, nursing teacher should make good use of such an advantage that students tend to easily confess their worries to them and take care of psychological aspects of students in treatment. Furthermore, it needs to include contents of bully in the regular heath care education.

• Journal of the Korean Ceramic Society
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• v.43 no.12 s.295
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• pp.781-787
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• 2006

NiO-coated YSZ powder was prepared using heterogeneous precipitation of Ni hydroxides on YSZ particle surface and high energy milling. The powders were characterized by TG/DTA, XRD, XPS, and SEM. Amorphous Ni precipitate completely decomposed into NiO at $500^{\circ}C$ and the growth of NiO crystallites was constrained by the core particles. Nanocrystalline NiO-coated YSZ core-shell structure powder could be obtained after calcination at $800^{\circ}C$ for 2 h. A core-shell powder compact, due to high sinterability, showed a near theoretical density at $1350^{\circ}C$. After reduction at $900^{\circ}C$, interpenetrating Ni-YSZ microstructure with very uniformly distributed fine Ni and YSZ grains and pores was observed. In contrast, the mechanically mixed oxide sample showed less uniform distribution of pores and larger discontinuous We particles as compared with the core-shell samples.