• Title/Summary/Keyword: Dong

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An Analysis on the Residents' Perceptions of the Ecotourism Village (서귀포시 생태관광마을조성에 대한 주민인식에 관한 연구)

  • Lee, Jin-Hee
    • Journal of Korean Society of Rural Planning
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    • v.12 no.2 s.31
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    • pp.17-25
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    • 2006

  • The purpose of this research is to survey resident's perceptions on the development of ecotourism village and to provide basic data far ecotourism vitalization. This research has been carried out four villages at Seogwipo city in Jeju province. A survey was implemented to investigate the resident's perceptions toward ecotourism development. To speak the results of resident's cognition, First, the existing condition on the development of ecotourism village are ranked in the order of Bomok Dong, Beobhwan Dong, Topyong Dong, Kangjung Dong. Second, the necessity of development for ecotourism village are ranked in the order of Bomok Dong, Topyong Dong, Kangjung Dong and Beobhwan Dong. Third, ecological residential style are most needed Bomok Dong, and equilibrium of ecosystem are most needed Bomok Dong.

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The effects of the novel IDPc inhibitor, DA-11004, on NADPH generation, insulin secretion, and glucose level in zucker rats

  • Shin, Chang-Yell;Jeong, Mi-Young;Sohn, Jin-Bup;Lee, In-Ki;Son, Mi-Won;Bae, Cheol-Jun;Byun, Jong-Soo;Kim, Dong-Sung;Kim, Soon-Hae
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.130.3-131
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    • 2003

  • The biological effects of NADPH-dependent isocitrate dehydrogenase (IDPc) inhibitor. DA-11004, was examined in obese zucker rats or streptozotocin-induced diabetic SD rats. Diabetes was induced by injection of streptozotocin (50mg/kg) dissolved in citrate buffer (pH 4.8) into the tail vein and induction of diabetes was confirmed by the measurement of the tail blood glucose level at 48h. DA-11004 (30mg/kg, po) was injected for successive 7days and significantly reduced the plasma glucose in streptozotocin-induced diabetic rats (P<0.05). (omitted)

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The effects of the novel IDPc inhibitor, DA-11004, on NADPH generation, insulin secretion, and glucose level in obese diabetic (ob/ ob) mice

  • Lee, In-Ki;Yell, Shin-Chang;Bup, Sohn-Jin;Young, Jeong-Mi;Son-Miwon;Jun, Bae-Cheol;Soo, Byun-Jong;Kim, Dong-Sung;Kim, Soon-Hae
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.132.2-133
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    • 2003

  • The biological effects of NADPH-dependent isocitrate dehydrogenase (IDPc) inhibitor, DA-11004, was investigated in obese diabetic (ob/ ob) mice. DA-11004, metformin, and oxalomalate were daily injected (ip) for 8 weeks and after completing an 8-week period of experiment, mice were sacrificed at 1 hr after the last drugs treatment to collect their blood, liver, and adipose tissues(epididymal and retroperitoneal fat). (omitted)

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DA 11004, a synthetic IDPc inhibitor, inhibits the high fat high sucrose diet-induced obesity in C57BL/6 mice.

  • Jeong, Mi-Young;Shin, Chang-Yell;Sohn, Jin-Bup;Lee, In-Ki;Son, Mi-Won;Bae, Cheol-Jun;Byun, Jong-Soo;Kim, Dong-Sung;Kim, Soon-Hae
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.129.2-130
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    • 2003

  • Recently. it has been known that NADPH-dependent isocitrate dehydrogenase (IDPc) involves in the obesity through production of NADPH, an important cofactor. DA-11004 is a synthetic potent IDPc inhibitor that $IC_{50}$ for IDPc is 1.49$\mu\textrm{M}$ (0.9$\mu$g/ml). The purpose of this study was to evaluate the effects of DA-11004 on the high fat high sucrose (HF)-induced obesity in C57BL/6 mice. (omitted)

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