• Title/Summary/Keyword: Domain Action

Search Result 198, Processing Time 0.025 seconds

Urban Redevelopment, Displacement and Anti-Gentrification Movements (재개발, 이주, 젠트리피케이션 반대운동)

  • Lee, Seon Young
    • Journal of the Korean Geographical Society
    • /
    • v.49 no.2
    • /
    • pp.299-309
    • /
    • 2014
  • The displacement of business tenants is of growing concern in urban redevelopment. This research focuses on why business tenants have not collectively taken action against urban redevelopment and explores how their rights can be improved. It met the research aim through a case study on one urban redevelopment area in Yongsan. Although urban redevelopment plans create many problems for business tenants, there is no effective mechanism in place to enable them to get involved in the decision-making procedures of urban planning. They are collectively and individually powerless in urban politics, so they do not have enough opportunities to change the Korean urban redevelopment system. The findings from this research suggest that many tenants have been apathetic to anti-gentrification movements due to their powerlessness in the urban redevelopment domain. In order to overcome structural injustice, it is important to improve business tenants' awareness of 'the right to the city' and enforce strong legislation to safeguard tenants.

  • PDF

The fucose containing polymer (FCP) rich fraction of Ascophyllum nodosum (L.) Le Jol. protects Caenorhabditis elegans against Pseudomonas aeruginosa by triggering innate immune signaling pathways and suppression of pathogen virulence factors

  • Kandasamy, Saveetha;Khan, Wajahatullah;Kulshreshtha, Garima;Evans, Franklin;Critchley, Alan T.;Fitton, J.H.;Stringer, Damien N.;Gardiner, Vicki-Anne;Prithiviraj, Balakrishnan
    • ALGAE
    • /
    • v.30 no.2
    • /
    • pp.147-161
    • /
    • 2015
  • Brown algal extracts have long been used as feed supplements to promote health of farm animals. Here, we show new molecular insights in to the mechanism of action of a fucose containing polymer (FCP) rich fraction from the brown seaweed Ascophyllum nodosum using the Caenorhabditis elegans-Pseudomonas aeruginosa PA14 infection model. FCP enhanced survival of C. elegans against pathogen stress, correlated with up-regulation of key immune response genes such as: lipases, lysozyme (lys-1), saponin-like protein (spp-1), thaumatin-like protein (tlp-1), matridin SK domain protein (msk-1), antibacterial protein (abf-1), and lectin family protein (lfp). Further, FCP caused down regulation of P. aeruginosa quorum sensing genes: (lasI, lasR, rhlI, and rhlR), secreted virulence factors (lipase, proteases, and elastases) and toxic metabolites (pyocyanin, hydrogen cyanide, and siderophore). Biofilm formation and motility of pathogenic bacteria were also greatly attenuated when the culture media were treated with FCP. Interestingly, FCP failed to mitigate the pathogen stress in skn-1, daf-2, and pmk-1 mutants of C. elegans. This indicated that, FCP treatment acted on the regulation of fundamental innate immune pathways, which are conserved across the majority of organisms including humans. This study suggests the possible use of FCP, a seaweed component, as a functional food source for healthy living.

SCYL1BP1 has Tumor-suppressive Functions in Human Lung Squamous Carcinoma Cells by Regulating Degradation of MDM2

  • Yang, Zhi-Ping;Xie, Yong-Hong;Ling, Dan-Yan;Li, Jin-Rui;Jiang, Jin;Fan, Yao-Hua;Zheng, Jia-Lian;Wu, Wan-Xin
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.15 no.17
    • /
    • pp.7467-7471
    • /
    • 2014
  • SCY1-like 1-binding protein 1 (SCYL1BP1) is a newly identified transcriptional activator domain containing protein with many unknown biological functions. Recently emerging evidence has revealed that it is a novel regulator of the p53 pathway, which is very important for the development of human cancer. However, the effects of SCYL1BP1 on human lung squamous carcinoma cell biological behavior remain poorly understood. In this study, we present evidence that SCYL1BP1 can promote the degradation of MDM2 protein and further inhibit the G1/S transition of lung squamous carcinoma cell lines. Functional assays found that reintroduction of SCYL1BP1 into lung squamous carcinoma cell lines significantly inhibited cell proliferation, migration, invasion and tumor formation in nude mice, suggesting strong tumor suppressive function of SCYL1BP1 in lung squamous carcinoma. Taken together, our data suggest that the interaction of SCYL1BP1/MDM2 could accelerate MDM2 degradation, and may function as an important tumor suppressor in lung squamous carcinomas.

In-depth Analysis of Soccer Game via Webcast and Text Mining (웹 캐스트와 텍스트 마이닝을 이용한 축구 경기의 심층 분석)

  • Jung, Ho-Seok;Lee, Jong-Uk;Yu, Jae-Hak;Lee, Han-Sung;Park, Dai-Hee
    • The Journal of the Korea Contents Association
    • /
    • v.11 no.10
    • /
    • pp.59-68
    • /
    • 2011
  • As the role of soccer game analyst who analyzes soccer games and creates soccer wining strategies is emphasized, it is required to have high-level analysis beyond the procedural ones such as main event detection in the context of IT based broadcasting soccer game research community. In this paper, we propose a novel approach to generate the high-level in-depth analysis results via real-time text based soccer Webcast and text mining. Proposed method creates a metadata such as attribute, action and event, build index, and then generate available knowledges via text mining techniques such as association rule mining, event growth index, and pathfinder network analysis using Webcast and domain knowledges. We carried out a feasibility experiment on the proposed technique with the Webcast text about Spain team's 2010 World Cup games.

Mechanism of Inhibition of HepG2 Cell Proliferation by a Glycoprotein from Hizikia fusiformis (톳(Hizikia fusiformis) 당단백질에 의한 HepG2 세포 증식 억제기전)

  • Ryu, Jina;Hwang, Hye-Jung;Kim, In-Hye;Nam, Taek-Jeong
    • Korean Journal of Fisheries and Aquatic Sciences
    • /
    • v.45 no.6
    • /
    • pp.553-560
    • /
    • 2012
  • Hizikia fusiformis, a brown alga that is widely consumed in Korea, Japan, and China, possesses a number of potentially beneficial compounds, including antioxidants and anticoagulants. However, the molecular mechanisms of H. fusiformis in hepatoma cells have not been elucidated. This study investigated the antiproliferative effect and mechanism of action of a glycoprotein from H. fusiformis (HFGP) in HepG2 human hepatoma cells. In an MTS assay, 25 ${\mu}g/mL$ HFGP inhibited the proliferation of HepG2 cells by $52.36{\pm}2.37%$. HFGP caused the dose-dependent growth inhibition of HepG2 cells by inducing apoptosis and a sub-G1 phase arrest. The antiproliferative activity of HFGP was confirmed based on the expression of several apoptosis-related proteins, which was assessed by Western blot analysis. The expressions of Fas, Fas-associated death domain protein, Bax, and Bad was significantly up-regulated in HFGP-treated cells, and HFGP induced the translocation of Bax to mitochondria and the release of cytochrome c into the cytosol. Therefore, HFGP might be useful in the treatment of liver cancer.

Analysis of Flow and Bed Change on Hydraulic Structure using CCHE2D : Focusing on Changnyong-Haman (CCHE2D를 이용한 수리구조물에 의한 흐름 및 하상변동 연구 -창녕함안보를 중심으로-)

  • Ahn, Jung Min;Lyu, Siwan
    • Journal of Korea Water Resources Association
    • /
    • v.46 no.7
    • /
    • pp.707-717
    • /
    • 2013
  • Channel-bed of erosion and sedimentation, where eroded bed and bank materials re-deposit through the action of flow, is a natural phenomenon in alluvial systems. Analysis using a numerical model is important to understand the sediment transport mechanism associated with erosion and sedimentation near weirs and other hydraulic structures within riverine systems. The local riverbed change near a hydraulic structure (Changnyong-Haman multi-function weir in Nakdong river) has been analyzed in order to examine the effect of hydraulic structure on local bed change. A 2D numerical model (CCHE-2D) has been implemented to simulate the sedimentation and erosion over a reach (10 km) including the weir. For the calibration and verification of the model, the rainfall data from a real event (Typoon 'Maemi' in 2003) has been used for flow and stage simulation. And the simulated results show a good agreement with the observed data for whole domain. From the result, it was found that the installation and operation of weir can aggravate the local bed change caused from the flow field change and resulting redistribution of sediment.

An Autonomous Navigation System for Unmanned Underwater Vehicle (무인수중로봇을 위한 지능형 자율운항시스템)

  • Lee, Young-Il;Jung, Hee;Kim, Yong-Gi
    • Journal of KIISE:Software and Applications
    • /
    • v.34 no.3
    • /
    • pp.235-245
    • /
    • 2007
  • UUV(Unmanned Underwater Vehicle) should possess an intelligent control software performing intellectual faculties such as cognition, decision and action which are parts of domain expert's ability, because unmanned underwater robot navigates in the hazardous environment where human being can not access directly. In this paper, we suggest a RVC intelligent system architecture which is generally available for unmanned vehicle and develope an autonomous navigation system for UUV, which consists of collision avoidance system, path planning system, and collision-risk computation system. We present an obstacle avoidance algorithm using fuzzy relational products for the collision avoidance system, which guarantees the safety and optimality in view of traversing path. Also, we present a new path-planning algorithm using poly-line for the path planning system. In order to verify the performance of suggested autonomous navigation system, we develop a simulation system, which consists of environment manager, object, and 3-D viewer.

Environmental Education in the Moral Education (도덕과 교육에서의 환경 교육)

  • 윤현진
    • Hwankyungkyoyuk
    • /
    • v.12 no.1
    • /
    • pp.64-75
    • /
    • 1999
  • The goals of moral education according to the 7th educational curriculum are (1) to learn the basic life custom and ethical norms necessary to desirable life, (2) to develop the judgment to solve desirably and practically the ethical matters in daily life, (3) to develop the sound citizenship, national identity and consciousness, and the consciousness of world peace and mankind's mutual prosperity, and (4) to develop the ethical propensity to practice the ideal and principle of life systematically Based on the goals in the above, the following can be established as goals of environmental education possible: (1) to learn judgment to solve practically the environmental problems in the society with their ethical understanding, and (2) to recognize that environmental consciousness is the basic necessity of sound citizenship and national identity and consciousness, and mankind's mutual prosperity, and to have attitudes to practice environmental preservation in daily life. Like these, the intellectual aspect, the affective aspect, and the active aspect can be established in the environmental education in the ethics education keeping their balance. In order to achieve its goals, the contents of ethics subject are organized largely with 4 domains: (1) individual life, (2) home life, life with neighbors, and school life, (3) social life, and (4) national life. Among these, environmental education is mainly included in the domain of social life. These contents concerning environmental education take 22 (32.4%) out of the whole 68 teaching factors which are taught in the ethics subject from the 3rd grade to 10th grade. These 22 environmental teaching factors are mainly related to environmental ethics, environmental preservation and measures, and sound consumption life. Classified according to each goal, the environmental contents in the 7th curriculum for ethics subject put emphasis on environmental value and attitudes, action and participation, and information and knowledge. Therefore, the recommendable teaching and learning method for the environmental education in ethics subject is to motivate students' practice or to make them practice in person. For example, role-play model, value-conflict model, group study model can be applied according to the topics of environmental education.

  • PDF

Flood risk estimation with scenario-based, coupled river-overland hydrodynamic modeling (시나리오 기반 하천-제내지 연계 통합수리해석에 의한 홍수위험도 산정)

  • Lee, Jae Young;Nam, Myeong Jun;Kwon, Hyun Han;Kim, Ki Young
    • Journal of Korea Water Resources Association
    • /
    • v.49 no.9
    • /
    • pp.773-787
    • /
    • 2016
  • A coupled river-overland hydrodynamic model was applied to estimate flood risk by a scenario-based approach. The study area is Seongseo Industrial Complex in Daegu which is located near Nakdong river and Geumho river. Inundation depth and velocity at each time were calculated by applying a coupled 1D/2D hydrodynamic model to the target area of interest. The 2D inundation analysis for river and overland domain was performed with the scenario-based approach that there are levee overflow against 100/200 year high quantile (97.5%) design flood and levee break against 100/200 year normal quantile (50%) design flood. The level of flood risk was displayed for resident/industrial area using information about maximum depth and velocity of each node computed from the 2D inundation map. The research outcome would be very useful in establishing specified emergency action plans (EAP) in case of levee break and overflowing resulting from a flood.

A Review of Research on Self Efficacy Theory Applied to Health Related Behavior (자기효능 이론이 적용된 건강행위 관련 연구의 분석)

  • 구미옥;유재순;권인각;김혜원;이은옥
    • Journal of Korean Academy of Nursing
    • /
    • v.24 no.2
    • /
    • pp.278-302
    • /
    • 1994
  • This article reviewed and analyzed 39 studies on self efficacy theory applied to health related behavior. The following analysis was done : 1) study subjects 2) measurement tools 3) analysis according to the type of research design(intervention re-search, explanatory research). Some findings are summarized as follows : The study subjects were both healthy people in various developmental stages and patients with various illnesses. The health related behaviors examined in the studies were also various including exercise, smoking cessation, self care behaviors, etc. The measurement of self efficacy was done with specific tools in most studies. In the tools, activities that measured the health behavior domain were listed according to increasing difficulty or contexual arrangement or in combination of both of them The analysis of 17 intervention research studies showed that generally the intervention program increased the self efficacy level of subjects and then the increased strongly self efficacy influenced behavioral changes. Most studies used more than one intervention method for increasing the self efficacy level. these were derived from sources of self efficacy suggested by Bandura. The analysis of 21 explanatory research studies showed that self efficacy strongly influenced behavior change and persistence. The major independent variable to affect the self efficacy was performance accomplishment in the past. Self efficacy explained more of the variance in health related behavior when it was applied with the variables in the health belief model, health promotion model, and reasoned action theory. On the basis of the above findings, the following suggestions are made : 1. For a desirable research design, self efficacy should be the intervening variable. That is, desirable designs would include intervention-self efficacy-behavior in intervention research studies and antecedent-self efficacy-behavior in explanatory research studies. 2. More prospective, longitudinal studies are needed to test the effect of self efficacy on persistence in health related behavior. 3. Studies comparing the effects of intervention methods are needed for each health related behavior, subject group, and context. 4. It is necessary to develop a reliable, valid measurement tool for self efficacy for each health related behavior. 5. Studies to differenciate the effect of self efficacy from that of outcome expectation on the health related behavior are necessary. 6. The antecedents of self efficacy should be investigated further.

  • PDF