• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.137.3-138
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• 2003

The major active components of EGb 761, extract of Ginkgo biloba leaves, include flavonoid glycosides and unique diterpenes known as ginkgolides. Ginkgolides are potent inhibitors of platelet activating factor. In this study, we investigated antiinflammatory activity of ginkgolides on the Complete Freund"s Adjuvant (CFA)-induced mice. The ginkgolides were extracted from commercially available EGb 761. This extracting procedure was done by sequential treatments of the EGb 761 with chloroform, methanol, and water. (omitted)tted)

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.373.3-374
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• 2002

Alismatis Rhizoma is originated from the rhizome of Alisma plantago-aquatica L. var. orientale Samuelson or A. canaliculatum A. Br. et Bouche (Alismataceae). Prostane-type triterpenes, guaiane-type sesquiterpenes, and kaurane-type diterpenes have been reported as the main canstituents from these plants. Four prostane-type triterpenes. alisol B 23-acetate (1). alisol C 23-acetate (2), alisol B (3). and alisol A 24-actate (4). were isolated from the EtOAc-soluble fraction of this dried rhizome. (omitted)

• Natural Product Sciences
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• 제26권2호
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• pp.132-135
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• 2020

Volatile constituents obtained by water distillation from the aerial parts and root of Onosma dichroanthum Boiss (Boraginaceae) native to the north of Iran were investigated by GC and GC/MS for the first time. Palmitic acid (39.61%) and decane (31.39%) were the major components in the root while decane (26.26%) and phytol (25.52%) were the predominant constituents in the aerial parts. Ketones, aldehydes, alkanes, fatty acids, oxygenated diterpenes and sesquiterpenes were characterized as the most phytochemicals in the aerial parts. Alkanes and fatty acids were identified as the main groups in the root volatile substances. There were two ketone derivatives, belong to apocarotenoids, in the aerial parts; β-ionone and hexahydrofarnesyl acetone.

• 생약학회지
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• 제4권4호
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• pp.205-207
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• 1973

A component $F,\;C_{20}H_{30}O_4,\;M^+\;(m/e)\;334,\;mp\;258{\sim}260^{\circ},\;[{\alpha}]D=-133.25^{\circ}\;(C=0.2,\;EtOH)$, was isolated from Siegesbeckia pubescens $M_{AKINO}$. This compound was identified as $16{\beta}-(-)-kauran-17$, 19-dioic acid, using spectroscopies and synthesizing various derivatives of the compound F.

• 한국연초학회지
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• 제22권1호
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• pp.19-24
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• 2000

To obtain the genetic information about DVT( $\alpha$- and $\beta$-4,8,13- duvatriene-1,3-diols) and cis-abienol contents, two burley(Burley 21, KB 108), three sun-cured cultivars(N. tabacum L. cv. Yonbyun 3, Jahengyon and Jaraehong), TI 1068, and thirty F$_1$ hybrids derived from them were sampled and the diterpenes were analysed using thin layer chromatography (TLC) procedures. DVT exudation from the leaf scerface could Ie detected in all coltivars and F$_1$ hybrids tested. TI 1068 and Yonbyun 3 had cis-abienol exdudates. Burley 21, KB 108, Jaheungyon, and Jaraehong had no spot of cis-abienol. It is considered that cis-abienol exdudation might be controlled by dominant gene(s). The cytoplasmic effect on the cis-abienol exdudation was not detected.

• 한국해양바이오학회지
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• 제1권4호
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• pp.225-231
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• 2006

The secondary metabolites from Taiwanese marine soft corals and sponges have attracted much attention because they possess considerable potential biological activities. To explore the origin of bioactivity, many cytotoxic natural products were isolated and characterized in the past few years. For examples, The lipophilic extracts from marine sponges Petrosia elastica and Ircinia formosana were found active against several human tumor cells. The investigation of the gorgonian Junceela has also resulted in the discovery of a series of new juncenolides. Bioassay-directed fractionation of Clavularia viridis yielded seven new prostanoids. These compounds have been tested and evaluated as potential antitumor agents. The soft corals of the genus Cespitularia produced novel secondary metabolites with diverse chemical structures and interesting biological activities. Four new norditerpenoids, designated cespitulactones and cespihypotins were isolated from Cespitularia hypotentaculata. Cespitulactones are novel structures having a bond cleavage between C-10 and C-11. In addition, three novel diterpenes were isolated from C. taeniata and designated cespitulactams A, B and C having a phenylethyl amino side chain.

• Toxicological Research
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• 제30권4호
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• pp.291-296
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• 2014

Saururus chinensis has been reported to contain compounds such as lignans, alkaloids, diterpenes, flavonoids, tannins, steroids, and lipids. Fermentation is commonly used to break down certain undesirable compounds, to induce effective microbial conversion, and to improve the potential nutraceutical values. Previous studies have reported that the fermentation process could modify naturally occurring constituents, including isoflavons, saponins, phytosterols, and phenols, and could enhance biological activities, specifically antioxidant and antimicrobial properties. The probiotic strains used for fermentation exert beneficial effects and are safe. In this study, the antioxidative effects of the Bacillus subtilis fermentation of Saururus chinensis were investigated in a rat model with Triton WR-1339-induced hyperlipidemia by comparing the measured antioxidative biological parameters of fermented Saururus chinensis extract to those of nonfermented Saururus chinensis extract. Fermentation played a more excellent role than nonfermentation in ultimately protecting the body from oxidative stress in the liver of the experimental rats with Triton WR-1339-induced hyperlipidemia.

• Biomolecules & Therapeutics
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• 제25권2호
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• pp.91-104
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• 2017

Acute bronchitis and chronic obstructive pulmonary diseases (COPD) are essentially lung inflammatory disorders. Various plant extracts and their constituents showed therapeutic effects on several animal models of lung inflammation. These include coumarins, flavonoids, phenolics, iridoids, monoterpenes, diterpenes and triterpenoids. Some of them exerted inhibitory action mainly by inhibiting the mitogen-activated protein kinase pathway and nuclear transcription $factor-{\kappa}B$ activation. Especially, many flavonoid derivatives distinctly showed effectiveness on lung inflammation. In this review, the experimental data for plant extracts and their constituents showing therapeutic effectiveness on animal models of lung inflammation are summarized.

• Journal of Microbiology and Biotechnology
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• 제34권8호
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• pp.1563-1579
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• 2024

More and more diterpenoids have attracted extensive attention due to the diverse chemical structures and excellent biological activities, and have been developed into clinical drugs or consumer products. The vast majority of diterpenoids are derived from plants. With the long-term development of plant medicinal materials, the natural resources of many plant diterpenoids are decreasing, and the biosynthetic mechanism of key active components has increasingly become a research hotspot. Using synthetic biology to engineer microorganisms into "cell factories" to produce the desired compounds is an essential means to solve these problems. In this review, we depict the plant-derived diterpenoids from chemical structure, biological activities, and biosynthetic pathways. We use representative plant diterpenes as examples to expound the research progress on their biosynthesis, and summarize the heterologous production of plant diterpenoids in microorganisms in recent years, hoping to lay the foundation for the development and application of plant diterpenoids in the future.

• Applied Biological Chemistry
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• 제45권2호
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• pp.101-107
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• 2002

순비기나무의 잎, 꽃, 줄기 및 열매로부터 수증기 증류법으로 정유를 분리한 다음 GC-MS 및 GC를 이용한 표준품과 머무름 시간의 비교에 의해 76종의 성분을 동정하였다. 동정된 성분은 monoterpene hydrocarbons 16종, oxygenated monoterpenes 30종, sesquiterpene hydrocarbons 10종, oxygenated sesquiterpenes 8종, diterpenes 3종, 기타 성분 9종으로서, 특히 ${\alpha}-pinene$, ${\beta}-pinene$, sabinene, 1,8-cineole, terpinen-4-ol, ${\alpha}-terpineol$등의 monoterpene류가 주요 구성성분들이었다. 부위별 주요 구성성분으로서 잎에서는 ${\alpha}-pinene$ (30.25%) > 1,8-cineole (19.89%) > sabinene (9.56%) > ${\alpha}-ternineol$ (7.94%) > ${\beta}-pinene$ (5.69%) > terpinen-4-ol (2.37%), 꽃에서는 ${\alpha}-pinene$ (25.47%) > 1,8-cineole (7.69%) > manoyl oxide(6.21%) > ${\beta}-pinene$ (4.20%) > ${\alpha}-terpineol$ (3.76%) >sabinene (2.78%), 줄기에서는 ${\alpha}-pinene$ (13.24%)>${\alpha}-terpineol$ (10.64%)>1,8-cineole (4.40%)>manoyl oxide (4.02%) > ${\beta}-pinene$ (2.39%) > terninen-4-ol (2.21%), 그리고 열매에서는 ${\alpha}-pinene$ (20.24%) > 1,8-cineole (11.47%) > ${\beta}-pinene$ (9.79%) > u-terpineol (7.08%) > sabinene (3.68%) limonene (2.77%)의 순서로 조성비율이 높았다. 전반적으로 순비기나무의 잎과 열매에서 분리한 정유에서는 monoterpene류의 조성비율이 높았으나 꽃과 줄기에서는 잎이나 열매에 비해 sesquitepene류, diterpene류 이외에도 구조를 동정하지 못하였으나 diterpene류 일 것으로 예상되는 분자량이 비교적 큰 성분들의 조성비율이 높았다.