• Title/Summary/Keyword: Diterpene alkaloids

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Studies on Korean Aconitum Species ( IV ). -Alkaloids of Aconitum pseudolaeve var. erectum- (한국산(韓國産) 부자류(附子類) 생약(生藥)에 관한 연구( IV. ) -진범(Aconitum pseudolaeve var. erectum)의 diterpene alkaloid에 대하여-)

  • Chung, Bo-Sup;Lee, Hyun-Sun
    • Korean Journal of Pharmacognosy
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    • v.19 no.3
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    • pp.181-187
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    • 1988
  • $Two\;C_{19}-diterpene\;alkaloids$ were isolated from the root of Aconitum psedolaeve var. erectum Nakai, and identified as lycoctonine and septentriodine by UV, IR, MS and NMR data.

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Diterpene Alkaloids from Kyong-Po Buja (Processed Aconitium carmichaeli) (경포부자의 다이테르펜 알칼로이드 성분)

  • Choi, Sang-Zin;Kwon, Hak-Cheol;Min, Yong-Deak;Lee, Sung-Ok;Kim, Kyung-Ran;Choi, Sang-Un;Son, Kun-Ho;Kang, Sam-Sik;Lee, Kang-Ro
    • Korean Journal of Pharmacognosy
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    • v.33 no.3 s.130
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    • pp.187-190
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    • 2002
  • Three diterpene alkaloids, songorine (1), neoline (2), N-deethylneoline (3), were isolated from Kyong-Po Buja (Processed Aconitium carmichaeli, Ranunculaceae) which was used as Chinese traditional medicine with analgesic, anti-inflammatory and cardiotonic activity. Their structures were established by chemical and spectroscopic methods.

Studies on Korean Aconitum Species ( III ). -Alkaloids of Aconitum uchiyamai- (한국산(韓國産) 부자류(附子類) 생약(生藥)에 관한 연구( III ). -그늘돌쩌귀(Aconitum uchiyamai)의 diterpene alkaloid에 대하여-)

  • Chung, Bo-Sup;Lee, Hyeong-Kyu;Lee, Hyun-Sun
    • Korean Journal of Pharmacognosy
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    • v.19 no.3
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    • pp.177-180
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    • 1988
  • A diterpene alkaloid and a disaccharide were isolated from root of Aconitum uchiyamai, and identified as mesaconitine and sucrose respectively by UV, IR, MS, and NMR data.

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Primary Pharmacological and Other Important Findings on the Medicinal Plant "Aconitum Heterophyllum" (Aruna)

  • Paramanick, Debashish;Panday, Ravindra;Shukla, Shiv Shankar;Sharma, Vikash
    • Journal of Pharmacopuncture
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    • v.20 no.2
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    • pp.89-92
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    • 2017
  • Aconitum Heterophyllum (A. Heterophyllum) is an indigenous medicinal plant of India and belongs to the family Ranunculaceae. A. Heterophyllum is known to possess a number of therapeutic effects. For very ancient times, this plant has been used in some formulations in the traditional healing system of India, i.e., Ayurveda. It is reported to have use in treating patients with urinary infections, diarrhea, and inflammation. It also has been used as an expectorant and for the promotion of hepatoprotective activity. The chemical studies of the plant have revealed that various parts of the plant contain alkaloids, carbohydrates, proteins and amino acids, saponins, glycosides, quinones, flavonoids, terpenoids, etc. In the present study, a comprehensive phytochemistry and pharmacognosy, as well as the medicinal properties, of A. Heterophyllum are discussed. Scientific information on the plant was collected from various sources, such as electronic sources (Google scholar, Pubmed) and some old classical text books of Ayurveda and Ethnopharmacology. The study also presents a review of the literature on A. Heterophyllum, as well as the primary pharmacological and other important findings on this medicine. This review article should provide useful information to and be a valuable tool for new researchers who are initiating studies on the plant A. Heterophyllum.

Alkaloids from the Tuber of Aconitum chiisanense (지리바꽃 괴경의 알카로이드)

  • Lee, Moo-Taek;Sung, Hwan-Kil;Whang, Wan-Kyunn;Kim, Il-Hyuk
    • YAKHAK HOEJI
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    • v.41 no.2
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    • pp.161-173
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    • 1997
  • Tuber of Aconitum chiisanense(Ranunculaceae) a specific medicinal plant in Korea, which is known to have the activity to recover reduced metabolism of feeble patients and has been used to symptoms such as pain, paralysis, atonia and coldness of extremities, etc. were studied. The powdered tubers of the plant were extracted with 10% EtOH 3 times and the combined extract was dissolved in 1N HCl solution and washed with ethyl acetate. The aqueous layer was basified with solid $Na_2CO_3$ and extracted with $CHCl_3$ to obtain an alkaloidal fraction. The alkaloidal fraction was subjected to column chromatography using silica gel, alumina and Sephdex LH 20, etc. From the alkaloidal fraction, five diterpene alkaloids, mesaconitine, aconitine, hypaconitine, 8-O-ethyl 14-benzoylmesaconine and talatizamine, were isolated and identified on the basis of their physico-chemical properties and spectroscopic evidences($^1H$-, $^{13}C$-NMR, EI-MS, IR, 2D-NMR) respectively. Especially the Compound IV, 8-O-ethyl 14-benzoylmesaconine, was assumed to be an artifact resulting from mesaconitine during extraction procedures. The contents of mesaconitine, aconitine and hypaconitine in the mother tuber of this plant were 0.300%, 0.024%, and 0.068%. And that of the attached tuber(new one) of this plant were 0.336%, 0.034% and 0.240% respectively.

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