• Title/Summary/Keyword: Distribution strategies

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Role of PET in Gene Therapy (유전자 치료에서 PET의 역할)

  • Lee, Kyung-Han
    • The Korean Journal of Nuclear Medicine
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    • v.36 no.1
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    • pp.74-79
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    • 2002
  • In addition to the well-established use of positron emission tomography (PET) in clinical oncology, novel roles for PET are rapidly emerging in the field of gene therapy. Methods for controlled gene delivery to living bodies, made available through advances in molecular biology, are currently being employed in animals for research purposes and in humans to treat diseases such as cancer. Although gene therapy is still in its early developmental stage, it is perceived that many serious illnesses could be treated successfully by the use of therapeutic gene delivery. A major challenge for the widespread use of human gene therapy is to achieve a controlled and effective delivery of foreign genes to target cells and subsequently, adequate levels of expression. As such, the availability of noninvasive imaging methods to accurately assess the location, duration, and level of transgene expression is critical for optimizing gene therapy strategies. Current endeavors to achieve this goal include methods that utilize magnetic resonance imaging, optical imaging, and nuclear imaging techniques. As for PET, reporter systems that utilize genes encoding enzymes that accumulate positron labeled substrates and those transcribing surface receptors that bind specific positron labeled ligands have been successfully developed. More recent advances in this area include improved reporter gene constructs and radiotracers, introduction of potential strategies to monitor endogenous gene expression, and human pilot studies evaluating the distribution and safety of reporter PET tracers. The remarkably rapid progress occurring in gene imaging technology indicates its importance and wide range of application. As such, gene imaging is likely to become a major and exciting new area for future application of PET technology.

Impact of applying sex sorted semen on the selection proportion of the sire of dams selection pathway in a nucleus program

  • Joezy-Shekalgorabi, Sahereh;De Vries, Albert
    • Asian-Australasian Journal of Animal Sciences
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    • v.31 no.9
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    • pp.1387-1392
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    • 2018
  • Objective: In a nucleus breeding scheme, the sire of dam's pathway plays an important role in producing genetic improvement. Selection proportion is the key parameter for predicting selection intensity, through truncating the normal distribution. Semen sexing using flow cytometry reduces the number of vials of sperm that can be obtained from a proved bull. In addition, a lower fertility of this kind of sperm is expected because of the lower sperm dosage in sex sorted semen. Both of these factors could affect the selection proportion in the sire of dam's pathway ($p_{SD}$). Methods: In the current study, through a deterministic simulation, effect of utilizing sex sorted semen on selection ($p_{SD}$) was investigated in three different strategies including 1: continuous use of sex sorted semen in heifers (CS), 2: the use of sex sorted semen for the first two (S2) and 3: the first (S1) inseminations followed by conventional semen. Results: Results indicated that the use of sex sorted semen has a negative impact on the sire of dams (SD) pathway due to increase in selection proportion. Consequently selection intensity was decreased by 10.24 to 20.57, 6.38 to 8.87 and 3.76 to 6.25 percent in the CS, S2, and S1 strategies, respectively. Conclusion: Considering the low effect of sexed semen on genetic improvement in dam pathways, it is necessary to consider the joint effect of using sex sorted semen on the sire and dams pathway to estimate about the real effect of sexed semen on genetic improvement in a nucleus breeding scheme.

A Case Study on Collaborations in 3D Printing Fashion (3D 프린팅 패션에 나타난 콜라보레이션(Collaboration) 사례연구)

  • Park, Suyeon;Yoo, Youngsun
    • Journal of the Korean Society of Costume
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    • v.66 no.7
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    • pp.124-138
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    • 2016
  • The present study observes collaboration methods in which 3D printing was a part of the fashion manufacturing process, expression methods of such cases, and their ripple effects. As a result, the three types of collaborations between fashion designers and other industry fields, fashion brands and 3D printing companies, and fashion designers and artists. Case analysis results and ripple effects found according to each collaboration method were as follows. First, in collaborations found were between fashion designers and other industry fields, 3D printed fashion works with futuristic images were seen through the fusion of future industries, which claim to support cutting edge digital technology, and creative fashion design. As they were mainly collaborations between automobile industries with cutting edge images or digital related industries and fashion designers, they were expressed as a new form of experimental clothing, and were used as strategies to improve future corporate images of the high tech industry. Second, in collaborations between fashion brands and 3D printing technology businesses, the sporting good brands and the shoe industry attempted to let their products be known through the promotion of functional material or ergonomic technology. While they emphasize practicality by mainly using flexible material, they were mainly proposed as functional sporting goods for famous players or as shoe accessories, so methods are still used for public distribution as brand promoting marketing strategies. Third, with collaborations between fashion designers and artists, creative pieces were shown through the grafting of 3D printing technology, the artistry of artists, and the experimentation of fashion designers. In particular, the innovative value of fashion as art was created through the union of the artistic 3D modeling technology support of artists and the creativity of designers. Like this, 3D printing fashion can graft the cutting edge nature of fashion to other industry fields through collaborations, enhancing pacesetting images, and in the fashion field, it can improve possibilities for innovations in the fashion industry through the support of 3D printing technology businesses and artists, raising expectations towards future human living.

The Critical Role of ICT and Core Strategies: The Case of Korean Travel Agencies (ICT가 여행사 경영환경에 미친 영향과 대응방안: 한국 여행사를 중심으로)

  • Kim, Nan-young
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.22 no.9
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    • pp.1179-1184
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    • 2018
  • Korean travel agencies that have been utilizing the Internet passively feel threatened as global online travel agencies are quickly permeating the Korean travel market. Under these circumstances, this study conducted a focused analysis on how ICT affects the business environment of travel agencies. Based on the analyzed data, it also presents coping strategies for the Korean travel agencies. First, it is imperative to accelerate platform development to counteract the distribution structure of global tourism products. Second, it is essential that travel agencies actively utilize big data, the new paradigm of technology where data are generated at high speed, high volume, and for numerous purposes. Third, it is necessary to actively utilize a travel blog marketing strategy. As a communication tool for travel agencies, the continuing development of the Internet highlights the usefulness of marketing activities using blogs. Finally, it is essential to provide each customer more specialized travel consultancy.

Does Big Data Analytics Enhance Sustainability and Financial Performance? The Case of ASEAN Banks

  • ALI, Qaisar;SALMAN, Asma;YAACOB, Hakimah;ZAINI, Zaki;ABDULLAH, Rose
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.7
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    • pp.1-13
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    • 2020
  • This study analyzes the key drivers (commitment, integration of big data, green supply chain management, and green human resource practices) of sustainable capabilities and the influence to which these sustainable capabilities impact the banks' environmental and financial performance. Additionally, this study analyzes the impact of green management practices on the integration of big data technology with operations. The theory of dynamic capability was deployed to propose and empirically test the conceptual model. Data was collected through a self-administrated survey questionnaire from 319 participants employed at 35 banks located in six ASEAN countries. The findings indicate that big data analytics strategies have an impact on internal processes and banks' sustainable and financial performance. This study indicates that banks committed towards proper data monitoring of its clients achieve operational efficiency and sustainability goals. Moreover, our results confirm that banks practising green innovation strategies experience better environmental and economic performance as the employees of these banks have received advance green human resource training. Finally, our study found that internal and external green supply chain management practices have a positive impact on banks' environmental and financial performance, which confirms that ASEAN banks contributing in reduction of environmental impact through its operations will ultimately experience increased financial performance.

Omni-Channel Strategies in Response to the Showrooming Phenomenon in Department Stores -A Case Study of Macy's- (백화점 쇼루밍 현상에 따른 옴니채널(Omni-Channel) 전략 -메이시스 백화점(Macy's Department Store) 사례연구-)

  • Oh, Jeongsook;Lee, Seunghee
    • Journal of the Korean Society of Clothing and Textiles
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    • v.41 no.3
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    • pp.393-406
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    • 2017
  • A "Showrooming" phenomenon has emerged due to the rapid growth of the on-line shopping market and is associated with consumer shopping patterns. This phenomenon is resulted in new strategies such as the Omni-Channel strategy that are now being employed by the off-line retail industry to meet the needs of consumers who seek information on-line. In particular, human services provided in department stores (which still occupy an important place in the off-line retail industry) are reaching limitations in the ability to maintain consumers. This study provides basic data for the Omni-Channel strategy of domestic department stores by researching and analyzing Omni-Channel strategy cases in Manhattan. This study dissects and analyzes the "Showrooming" phenomenon and the development of the Omni-Channel strategy through a literature review as well as analyzes the Omni-Channel success case of Macy's department store. The findings indicate that the use of the Omni-Channel strategy by Macy's department store has solved the problem of "Showrooming," by integrating on-line and off-line shopping to provide an efficient and convenient shopping experience for consumers. The Omni-Channel strategy offers a means for off-line stores to connect to the online shopping behavior of consumers. The results suggest the need for an organic combination of on-line and off-line distribution channels to adapt to changes in consumer shopping patterns due to a recession in the domestic market.

A Policy Study on the Diffusion of the Engineering Technical Culture (공학기술문화 확산에 관한 정책적 연구)

  • Lee, Tai-Sik;Jun, Young-Joon;Lee, Dong-Wook;Park, Eun-Soo
    • Journal of Engineering Education Research
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    • v.11 no.1
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    • pp.48-63
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    • 2008
  • The engineering technical culture needs to be fostered since it has been an important factor that decides the results of engineering and affects the establishment of social culture to a great extent. However, it is considered that awareness about invisible environments required for the distribution, education, promotion, and development of the engineering culture are not sufficient enough even though physical environments such as investments in engineering and research facilities have reached a substantial level through a recent series of efforts. Thus, distributing cultural activities by improving social awareness is desperately required to solve these problems, To take realistic measures and establish social atmosphere are particularly important. In order to design strategies for the diffusion of the engineering technical culture in the position of users, this research suggests short-term and mid-term plans and operating strategies that could produce substantial results.

Multi-core-based Parallel Query of 3D Point Cloud Indexed in Octree (옥트리로 색인한 3차원 포인트 클라우드의 다중코어 기반 병렬 탐색)

  • Han, Soohee
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.31 no.4
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    • pp.301-310
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    • 2013
  • The aim of the present study is to enhance query speed of large 3D point cloud indexed in octree by parallel query using multi-cores. Especially, it is focused on developing methods of accessing multiple leaf nodes in octree concurrently to query points residing within a radius from a given coordinates. To the end, two parallel query methods are suggested using different strategies to distribute query overheads to each core: one using automatic division of 'for routines' in codes controlled by OpenMP and the other considering spatial division. Approximately 18 million 3D points gathered by a terrestrial laser scanner are indexed in octree and tested in a system with a 8-core CPU to evaluate the performances of a non-parallel and the two parallel methods. In results, the performances of the two parallel methods exceeded non-parallel one by several times and the two parallel rivals showed competing aspects confronting various query radii. Parallel query is expected to be accelerated by anticipated improvements of distribution strategies of query overhead to each core.

Domestic co-branded operating status and activation strategies (국내 공동브랜드 운영현황과 활성화 전략)

  • Kim, Koosung;Yu, Seung Yeob
    • Journal of Digital Convergence
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    • v.11 no.3
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    • pp.189-197
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    • 2013
  • Weak competitive Small Business are getting attention for their ability to enhance the brand power and marketing co-brand. Under these circumstances, in this study examined the operational status of the domestic co-branded. Also enable co-branding strategy was proposed. First, learn the various aspects of the concept of co-branding, and looked at the advantages and disadvantages of co-branding. Second, the type of co-branded partner combined, joint venture between companies Union type, a leading company driven and private companies and state agencies co-branded. Looked at the type of advantages and disadvantages of each. Thirdly, we presented the current status of the important co-branded domestic. Fourth, we examined the status of the Small and Medium Business Administration supports a co-branded Examined in detail by year look at the status of support for this type of co-branded Industry Distribution and co-branded interrupted. Finally, the short-term aspects and long-term perspective on the domestic co-brand activation strategy based on these materials are presented. The results of this study is expected to be the foundation of domestic co-branded business in the future to explore the ways to improve the system of government support will help to raise.

EST-SSR Based Genetic Diversity and Population Structure among Korean Landraces of Foxtail Millet (Setaria italica L.)

  • Ali, Asjad;Choi, Yu-Mi;Do, Yoon-Hyun;Lee, Sukyeung;Oh, Sejong;Park, Hong-Jae;Cho, Yang-Hee;Lee, Myung Chul
    • Korean Journal of Plant Resources
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    • v.29 no.3
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    • pp.322-330
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    • 2016
  • Understanding the genetic variation among landrace collections is important for crop improvement and utilization of valuable genetic resources. The present study was carried out to analyse the genetic diversity and associated population structure of 621 foxtail millet accessions of Korean landraces using 22 EST-SSR markers. A total of 121 alleles were detected from all accessions with an average of 5.5 alleles per microsatellite locus. The average values of gene diversity, polymorphism information content, and expected heterozygosity were 0.518, 0.594, and 0.034, respectively. Following the unweighted neighbor-joining method with arithmetic mean based clustering using binary data of polymorphic markers, the genotypes were grouped into 3 clusters, and population structure analysis also separated into 3 populations. Principal coordinate analysis (PCoA) explained a variation of 13.88% and 10.99% by first and second coordinates, respectively. However, in PCoA analysis, clear population-level clusters could not be found. This pattern of distribution might be the result of gene flow via germplasm exchanges in nearby regions. The results indicate that these Korean landraces of foxtail millet exhibit a moderate level of diversity. This study demonstrated that molecular marker strategies could contribute to a better understanding of the genetic structure in foxtail millet germplasm, and provides potentially useful information for developing conservation and breeding strategies.