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The Analysis of the Value of the Thyroid Autoantibody Measured by Radioimmunoassay (방사면역측정법에 의한 갑상선 자가항체 측정의 기본적 및 임상적 검토)

  • Chung, Jae-Hoon;Lee, Myung-Shik;Cho, Bo-Youn;Lee, Hong-Kyu;Koh, Chang-Soon;Mim, Hun-Ki;Lee, Mun-Ho
    • The Korean Journal of Nuclear Medicine
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    • v.21 no.2
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    • pp.133-141
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    • 1987
  • To evaluate the values of the thyroid autoantibody measured by radioimmunoassay (RIA) and compare it with hemagglutination method (HA) in the normal and the thyroid disease, data were obtained from total 618 persons; 236 healthy persons, 217 patients with Graves' disease (including 113 patients with undertreated Graves' disease), 100 Hashimoto's disease, 31 thyroid nodule, and 34 simple goiter. RSR kit made in England was used and could be detected to at least 3 U/ml. The positive rates of normal group were antimicrosomal antibody (AMA) 31.8%, antithyroglobulin antibody (ATA) 44.5% by RIA and there was no considerable change in sex and age distribution. In Graves' disease, the positive rates of AMA and ATA were 90.4, 76.9% by RIA, 85, 39% by HA. In Hashimoto's disease, 94,91 % by RIA, and 87,48% by HA, respectively. The autoantibody titer by RIA in thyroid autoimmune disease as well as in normal group was more senisitive than that by HA, especially in ATA. There were linear relationships between the titer of RIA and that of HA in AMA of Graves' disease and AMA and ATA of Hashimoto's disease. There was no relationship among thyroid autoantibody, free $T_4$ index, TBII, and TSH. The titers of AMA and ATA were found to decrease in patients with Graves' disease during the course of antithyroid drug therapy. Of the 236 normal subjects, thirty-seven (15.7%) had concentrations of above 7.5 U/ml in AMA, forty. four (18.6%) above 9 U/ml in ATA. These values were considered as the upper limit for the normal range. In Graves' disease, 82.7, 53.8% were above 7.5, 9 U/ml, respectively; In Hashimoto's disease, 82, 79% were positive. We conclude that RIA was more sensitve than HA in measuring the thyoird autoantibody, but we will study further more for determining the normal range and its interpretation.

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The Developmental History and Recent Trends of TOPIK: from the 1st TOPIK in 1997 through the 52nd TOPIK in 2016 (한국어능력시험 20년 발전사와 최근 동향 -1997년 제1회 시험부터 2016년 제52회 시험까지-)

  • Kim, Chungsook
    • Journal of Korean language education
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    • v.28 no.3
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    • pp.1-24
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    • 2017
  • This article explores the developmental history of TOPIK over the last 20 years and its recent trends. Over the last two decades, TOPIK underwent two major systematic reforms, achieving both quantitative and qualitative growth over the course of its 52 testing sessions. TOPIK has utilized a six-level evaluation system from its inception to the present. The evaluation system was amended from the earlier six-test set - whereby each level corresponded with a separate test (1997~2005: the $1^{st}{\sim}9^{th}$) - to the three-test set (2006~2014: the $10^{th}{\sim}34^{th}$), and finally to the two-test set (2014~present: the $35^{th}{\sim}42^{nd}$). In the earlier exams, abilities in Vocabulary Grammar, Writing, Listening, and Reading were assessed. However, beginning with the $35^{th}$ TOPIK, abilities in Listening, Reading, and Writing (only in TOPIK II) were assessed and the evaluation of the writing section was changed to a task-based process, improving TOPIK into a more qualified analysis of proficiency. Over the last 20 years, the number of countries TOPIK is administered in has greatly increased from 4 to 73 countries, and the annual number of test-takers has also significantly increased from 2,692 to 250,141. The distribution of proficiency levels of the test-takers has shifted over time - initially "Beginner>Intermediate>Advanced" in the earlier exams, to "Intermediate>Advanced>Beginner" after the mid 2000s - as the number of those studying the Korean language for specific purposes and continuing education increased. Test-takers have indicated a shift in their purpose for taking the exam, initially citing "to assess proficiency" and more recently selecting "to study abroad," and this could also correlate with changes in the proportion of test-takers' proficiency level. In general, 85~95% of beginner, 50~65% of intermediate, and 45~60% of advanced test applicants passed the respective proficiency level. To date, no practices have yet been implemented to standardize the difficulty level longitudinally across test sets.

Lithological Characteristics and Provenance Consideration on the Jade Investiture Books of Joseon Dynasty in National Palace Museum of Korea (국립고궁박물관 소장 조선왕조 옥책의 암석학적 특징과 산지검토)

  • Lee, Chan Hee;Park, Jun Hyoung
    • Economic and Environmental Geology
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    • v.52 no.5
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    • pp.485-497
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    • 2019
  • The Jade Investiture Books in Joseon Dynasty shows diverse facies with various petrographic characteristics to green and white based on color. In lithologically, the green rocks are jade composed of calcite and serpentine, and the white ones are marbles consisting mainly in crystalline calcite. As a result of X-ray diffraction of jade rocks, the more green in color, the more increased intensity of serpentine appears. Therefore, the grade of jade is correlated with contents of serpentine. The Jade Investiture Books owned by the National Palace Museum of Korea are subdivided with 104 (41.3%) books made by only jade rocks, 98 (38.9%) books made by only marbles, and 50 (19.8%) books mixed with jade rocks and marbles. Among the mixed ones, 47 (18.6%) books consisted mainly of the marbles. This result shows the superior marble books occupy more than half of the total books. The Jade Investiture Books made in early Joseon Dynasty are composed of high grade jade. However, the grade of jade had decreased as the kings changed in process of time, and the composition of marble had increased in reverse proportion of jade. The quality of letter pigments, metal accessories and fabrics also had decreased with jade. These trends are reflected in the aspect of society such as weakening royal authority, national power and finance with the course of time. The jade of the books has different mineralogical characteristics from some modern jade produced in Chuncheon nephrite and Buyeo precious serpentine in Korea. Meanwhile, there is ancient literature that described quarries from Namyang in Hwaseong of Gyeonggi province. This area has a wide distribution of gneiss, limestone and limesilicate rocks are interbedded between muscovite schist. The limesilicate rocks contain diopside, which produced serpentine through alteration. It has possibility to make the Jade Investiture Books using these small amounts of jade through mining activity.

A Study on the Application of Modularization Technique to Standard Security Policy to Protect Information Assets and the Securement of Confidentiality and Integrity (정보자산 보호를 위한 표준 보안정책 모듈화 기법 적용과 기밀성 및 무결성 확보를 위한 연구)

  • Seo, Woo-Seok
    • The Journal of the Korea institute of electronic communication sciences
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    • v.14 no.1
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    • pp.111-118
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    • 2019
  • For the security of a vast amount of information, it has been started to diagnose the site as a way of operating and managing the information owned by a company holding assets, to establish indexes to check the actual status and all kinds of standards to obtain security, and also to classify the information assets based on that. This has been extended to many different areas including policies to operate and manage information assets, services, the management of owned devices as physical assets, and also the management of logical assets for application software and platforms. Some of these information assets are already being operated in reality as new technology in new areas, for example, Internet of Things. Of course, a variety of electronic devices like Smart Home are being used in ordinary families, and unlike in the past, these devices generate a series of information life cycles such as accumulating and processing information. Moreover, as even distribution is now being realized, we are facing a task to secure the stability of information assets and also information that assets are holding. The purpose of this study is to suggest and apply standard security policy by moduling methods for information assets owned by companies and even families and obtain the enhancement of confidentiality as well as integrity.

The Analysis on interest of the physical education teachers about the revised physical education curriculum in 2015 (2015 개정 체육과 교육과정에 대한 체육교사의 관심도 분석)

  • Lee, Jong won;Park, Changun
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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    • v.7 no.5
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    • pp.165-173
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    • 2017
  • In this research, based on the CBAM model, there is a research purpose to measure the degree of interest of the physical education teacher ahead of execution of the revised educational curriculum 2015 and to analyze the difference in degree of interest by teacher's background variation. For this reason, we conducted an an- nental survey of 200 physical education teachers in K-area middle school, high schools and analyzed the results. The conclusion of this research is as follows. Firstly, as a whole, the attention to the revised education curriculum has been very high in view, as a result, the physical education teacher at the middle / high school, 2015 about the influence and the result that the revised curriculum gives to the student in the physical education class Although the interest is very high, a systematic approach will be necessary for training and utilization schemes so that 2015 the revised educational curriculum can be executed appropriately. Secondly, since the interest in the revised educational curriculum by the whole number of classes 2015 is different, we need to develop and give a training program for revised curriculum 2015 customization by class number 2015. Training that departs from the one-way set form of transmission training and distribution method of materials depending on the class number may be different. Thirdly, in order to stabilize the revised educational curriculum 2015, it is necessary to develop a course example program corresponding to the level of interest of the physical education teacher.

Effects of Velocity Structures on Tracer Mixing in a Meandering Channel (사행수로에서 유속구조가 추적물질의 혼합에 미치는 영향)

  • Seo, Il Won;Park, Sung Won
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.29 no.1B
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    • pp.35-45
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    • 2009
  • In this study, a laboratory experiment has been performed on a S-curved channel with two curved sections. In the experiments, effects of 3-D velocity structures on mixing characteristics of tracer material were investigated. As a result, it was clearly noticed that the primary flow travels taking the shortest course of the meandering channel and has a very ununiform distribution at the bends. The secondary cell which was developing at the first bend disappears at the crossover, and then, at the next bend, secondary cell is re-developing in the opposite direction. The experimental results show that mixing of tracer is significantly affected by the combined action of ununiform primary flow and secondary cell. The ununiform primary flow separates the tracer cloud in the longitudinal direction, and the secondary cell further separates the retarding tracer cloud mainly in the transverse direction. As a result, these complex flow structures cause separation and spreading of tracer cloud both in the longitudinal and in the transverse directions. The measured dimensionless transverse dispersion coefficients calculated using 2-D routing procedure ranges 0.012-0.875, and is generally proportional to width to depth ratio (W/h). The predicted values calculated by the theoretical equation overestimate slightly the measured transverse dispersion coefficients.

Generative Adversarial Network Model for Generating Yard Stowage Situation in Container Terminal (컨테이너 터미널의 야드 장치 상태 생성을 위한 생성적 적대 신경망 모형)

  • Jae-Young Shin;Yeong-Il Kim;Hyun-Jun Cho
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2022.06a
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    • pp.383-384
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    • 2022
  • Following the development of technologies such as digital twin, IoT, and AI after the 4th industrial revolution, decision-making problems are being solved based on high-dimensional data analysis. This has recently been applied to the port logistics sector, and a number of studies on big data analysis, deep learning predictions, and simulations have been conducted on container terminals to improve port productivity. These high-dimensional data analysis techniques generally require a large number of data. However, the global port environment has changed due to the COVID-19 pandemic in 2020. It is not appropriate to apply data before the COVID-19 outbreak to the current port environment, and the data after the outbreak was not sufficiently collected to apply it to data analysis such as deep learning. Therefore, this study intends to present a port data augmentation method for data analysis as one of these problem-solving methods. To this end, we generate the container stowage situation of the yard through a generative adversarial neural network model in terms of container terminal operation, and verify similarity through statistical distribution verification between real and augmented data.

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Long-Term Trend of Picophytoplankton Contribution to the Phytoplankton Community in the East Sea (동해 식물플랑크톤 군집에 대한 초미소 식물플랑크톤(< 2 ㎛) 기여도 장기 경향성 연구)

  • Hyo Keun Jang;Dabin Lee;Sang Heon Lee
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.29 no.6
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    • pp.525-535
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    • 2023
  • In thi study, we unveil the intricate interplay among picophytoplankton (0.2-2 ㎛) communities, warming surface water temperatures, and major inorganic nutrients within the southwestern East Sea from 2003-2022. The observed surface temperature rise, reflecting global climate trends, defies conventional seasonal patterns in temperate seas, with highest temperatures in summer and lowest in spring. Concurrently, concentrations of major dissolved inorganic nutrient display distinct seasonality, with peaks in winter and gradually declining thereafter during spring. The time course of chlorophyll-a concentrations, a proxy for phytoplankton biomass, reveals a typical bimodal pattern for temperate seas. Notably, contributions from picophytoplankton exhibited a steady annual increase of approximately 0.5% over the study period, although the total chlorophyll-a concentrations declined slightly. The strong correlations between picophytoplankton contributions and inorganic nutrient concentrations is noteworthy, highlighting their competitively advantageous responsiveness to the shifting nutrient regime. These findings reflect significant ecological implications for the scientific insights into the marine ecosystem responses to changing climate conditions.

A Study on Satisfaction of Practicing Dentists about Prosthesis in Pusan Part I : About Fixed Prosthetic appliances (부산지역(釜山地域) 개업치과(開業齒科)의 치과보철물(齒科補綴物)에 관(關)한 만족도(滿足度) 조사(調査)(I) - 일부정식 치과 보철물에 관하여 -)

  • Lee, Myung-Kon
    • Journal of Technologic Dentistry
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    • v.10 no.1
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    • pp.159-169
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    • 1988
  • Fixed prosthetic appliance is the restorations of damaged teeth with cast metal or porcelain, and of replacing missing teeth with fixed, or cemented prosthesis. Successfully treating a patient by means of fixed prosthodontics requires the thoughtful combination of dentist and dental laboratory technician. In order to know the satisfaction of dentisits about fixed prosthetic appliances-porcelain, precious and non precious metal-, this study was conducted for 69 practicing dentisis in Pusan during Fed. to Mar. 1988 using a questionnaire method and was analyzed by the use of percentage, $X^2$-test The results are obtained as follow: 1. General characteristics of the respondents, The rate of age distribution of practcing dentists responded was as follow : 31$\sim$35 age group is 29.0%, 51$\sim$55age group 18.8%, 41$\sim$45 age group and 46$\sim$50 group each 11.6%, 36$\sim$40 age group and 56$\sim$60 age group 8.7%, over 60 age group 7.3%, below 30 age group 4.3% respectively. The tate of term of practice experience distribution of dentists responded was as follow : 6$\sim$10 year group 26.1%, 25$\sim$25year group 18.8%, 11$\sim$15 years group and 16~20 years group each 13.0%, below 5 years group and over 30 years group each 10.2%, 26$\sim$30 years group 8.7% in order. The rate of respondents’ degree was follow : bachelor group 81.2%, doctor group 13.0%, master group 5.8% in order. The rate of respondents’completed medical specialist course was as follow : non-complete group 75.4%, complete group 24.6%. The rate of having own laboratory in respondents’clinic was as follow : no having own laboratory group 58.0%, having own labiratory group 42.0% The rate of being lab. technician in respondent;s clinic was as follow: non-being lab. technician group 91.3%, being lab. technician group 8.7%. The rate of transactional commercial dental lab. numbers was as follow : I dental lab. group 40.6%, 2 dental lab. group 30.4%, 3 dental lab. group 20.3%, production at own lab. group 8.7% 2. Cognitions about the respondent's job, About cognition of patient numvers, there were neither many nor few group 62.3%, few group 17.4%, many group 15.9%, too many group 4.4% in order.(P<.01) As compared with the ratio of dentists to patient prothetic treatment, there were moderate level group 46.4%, high level group 33.6%, low level group 18.8% in order.(P<.01) By job satisfaction of respondents, the highest percentage group was satisfied group 44.9%, neither astisfied nor disstified group 33.3%, dissatisfied group 14.5%, much satisfied group 7.3%(P<.01). As compared with the level of prosthetics price, the were moderate level group 71.0%, low level group 23.2%, high level group 5.8%(P<.01) 3. Satisfaction and assessment of dissatisfied factor of the fixed prosthetic appliance, As compared with the satisfaction of al prosthetic appliance, there were neither satisfied nor dissatisfied group 59.4%, satisfied group 20.3% dissatisfied group 18.8%, much satisfied group 1.5% in order.(P<.01). About precious and non precious metal crown and bridge, there were neither satisfied nor dissatisfied group 60.9%, satisfied group 24.6%, dissatisfied group 11.6%, much satisfied group 2.9% in order.(P<.01) The reat of respondent;s satisfaction about porcelain crown and bridge was as follow : neither satisfied nor dissatisfied group 43.5%, dissatisfied group 33.3%, satisfied group 21.7%, much satisfied group 1.5%(P<.01). The rate of respondent's dissatisfied factor item of precious and non precious metal crown and bridge was as follow : inadequate margin fit item 39.1% respondent, inadequate occlusion item 24.6%, inadequate adaptation item 23.2%, poor anat omic form item 15.9%, inadequate contact item 31.9%, improper polishing item 4.4%, the rest item 11.6% respectively. The rate of respondent's dissatisfied factor item of porcelain crown and bridge was as follow : inadequate margin fit item 52.2%, inadequate occlusion item 2.9%, inadequate adaptation item 10.1%, poor anatomic form item 11.6%, improper polishing item 1.5%, shade mismatching item 71%, the rest item 7.2% respectively. The rate of cognition of respondents’ about cause of dissatisfied factor on fixed prosthetic appliance by item was as follow : deficiency of sincerity item 55.1%, deficiency of knowledge about work item 47.8%, deficiency of experience item 15.9%, poor quality of using material item 5.8%, the rest item 2.9% respectively.

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A Study for The Prognostic Indicators of Korean Alcoholics in Psychological, Social and Biological Aspects (한국인 알코올중독 환자의 예후인자에 관한 연구 : 심리적, 사회적, 생물학적 요인을 중심으로)

  • Sung, Sang-Kyung;Chang, Hwan-Il
    • Korean Journal of Biological Psychiatry
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    • v.2 no.2
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    • pp.218-236
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    • 1995
  • The author studied prognostic indicators of sixty Korean male alcoholics in psychological, social and biological aspects who were divided into abstinent and drinking groups. Thirty patients were assigned to each group. They were controlled in age and sex. Both groups were compared in terms of the demographic characteristics, past drinking history, treatment history, famaily history, ego strength and personality factors differences and distribution of dopamine $D_2$ receptor gene Al allele. Also the author studied relation of clinical course, alcoholic family history and dopamine $D_2$ receptor gene Al allele in both groups. The results were as follows; 1) The abstinent group had higher rate of married state, higher economic status, longer education years and maintained more stable job than the drinking group. But made no differences in occupation and religion. 2) The abstinent group showed higher rate of living with family members than the drinking group, and wives and fellows of the alcoholics anonymous were important factors for maintenance of abstinence. Family loading and parent's characters were not different. 3) The abstinent group had longer maximal length of abstinence but mean amount of alcohol consumption per day were larger than the drinking group. But there were no differences in duration of past drinking, drinking pattern, main drinking time, first drinking age and preference of the kind of alcoholic beverage in the past drinking history. 4) The abstinent group showed stronger treatment motivation, absolute abstinence in treatment goal, more voluntary adimission and maintained longer therapeutic relationship otter discharge than the drinking group. But both groups showed negative attitude toward antabuse therapy. 5) The abstinent group had higher mean score in ego strength scale than the drinking group. 6) In the personality factor questionnaire, the abstinent group showed strong laugh poise and the trait of praxernia, conservatism personality but the drinking group showed tough poise, the trait of weak ego strength(unstableness) and tough mindedness personality. 7) In comparision of dopamine $D_2$ receptor gene A1 allele, the prevalence of A1 allele was seventy percent and the frequency was 0.38 in the abstinent group. The prevalence of A1 allele was sixty percent and the frequency was 0.42 in the drinking group. Both groups were not significantly different in A1 allele prevalence and frequency. 8) In comparision of dopamine $D_2$ receptor gene A1 allele according to alcoholic family history, the prevalence of A1 allele was seventy percent and the frequency was 0.43 in the family history positive group. The prevalence of A1 allele was sixty-one percent and the frequency was 0.38 in the family history negative group. Both groups were not significantly different in A1 allele prevalence and frequency. In comparision of past drinking history according to alcoholic family history, the family history positive group showed earlier first drinking and problem drinking, but the family history negative group hod longer duration of past drinking. The mean amount of alcohol consumption per day, the longest duration of abstinence and Alcoholism Screening Test of Seoul Natoinal Mental Hospital(NAST) results were not significant. In conclusion, the results suggest that successful prognostic indicators of Korean alcoholics are married state, higher economic status, longer education years, stable job, living with family members, longer abstinence during past drinking history, strong treatment motivation, absolute abstinence in treatment goal, voluntary adimission, maintained therapeufic relationship, strong ego strength and the trait of praxernia, conservatism personality. But occupation, religion, alcoholic family history, parent's characters, duration of past drinking, drinking pattern, main drinking time, first drinking age, preference of the kind of alcoholic beverage, attitude to antabuse therapy and distribution of dopamine $D_2$ receptor A1 allele were not significantly related to the prognostic indicators of Korean alcoholics.

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