• Strategy21
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• 통권44호
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• pp.79-102
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• 2018

2015년 미 해군에서 발간한 미 수상함대전략(Surface Force Strategy)에 따르면, 미 해군은 반접근-지역거부(Anti-Acess and Anti-Denial, A2/AD) 전략에 대한 대응책으로 '분산된 치명성(Distributed Lethality, DL)'이라는 신 작전개념을 개발 중에 있다. 이 개념은 각 유닛(unit)의 공격력(offensive power)을 향상시키고 지리적으로 분산 시킴으로써(geographical dispersion) 생존성을 향상시키는데 목적을 두고 있다. 하지만 동맹국(한국/일본 등)이 '분산된 치명성(DL)' 개념에 기여할 수 있는 영역이 다양함에도 불구하고, 지금까지 미 해군 내에서는 동맹국과 어떻게 공조해야 할 것인가에 대한 논의가 부족한 것이 사실이다. 따라서, 미 해군은 향후 '분산된 치명성(DL)' 이라는 작전개념에 동맹국이 줄 수 있는 이점을 추가적으로 적용하는 '동맹국을 활용한 분산된 치명성(Distributed Lethality with Allies, DL+A)' 개념을 발전시켜야 할 것이다. '동맹국을 활용한 분산된 치명성(DL+A)' 개념이란 동맹국이 가지고 있는 전력, 시설, 플랫폼 등 가용자산을 최대한 활용하여 기존의 '분산된 치명성(DL)' 개념을 강화시키는 신 작전개념이다. 미 해군은 본 논문에서 제시하는 신 작전개념(DL+A)을 적용함으로써 다양한 영역(정찰, 군수, 지리적 요충지, 플랫폼)에서 동맹국으로부터 지원을 받을 수 있을 것이다. 또한, 동맹국은 미 해군의 신 작전개념을 적용함으로써 A2/AD 전략에 대비한 안보능력을 향상시킬 수 있을 것이다.

• Strategy21
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• 통권44호
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• pp.28-53
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• 2018

The U.S. has recently developed Free and Open Indo-Pacific strategy and Distributed Lethality strategy based on a common perception that they are responding to China's threats. In the future, it is anticipated the following. Strengthen cooperation of the U.S.-India-Vietnam navy, Maximizing the combined combat power between the U.S. and regional navies, Improving its ability to restore damage control, Economic cooperation between the Pacific and Indian countries. The meanings given to the Korean navy are as follows. First, South Korea should pursue cooperation with the Indian Navy, which will grow into a regional balance on China's growth. The growth of the Indian navy is expected to increase cooperation with other Pacific countries. The government should seek ways to promote cooperation with india navy in various fields. Secondly, it is a joint drill between the U.S. Navy and the Korean Navy. Recently, the Korea-U.S. joint drill has not been conducted and many changes are expected to be made regarding the implementation of the joint drill in the future. Therefore, it is necessary to respond to possible changes in the naval relationship between Korea navy and the U.S. navy Also, due to distributed lethality strategy, preparations for operations and training with U.S.navy will be necessary. Lastly, it should contribute to cooperation among regional countries in preparation for maritime territorial disputes. The growth of the Chinese navy and the territorial disputes in the East and South China sea has raised the possibility of accidental military clashes at sea. Therefore, the government should make efforts to create multilateral security cooperation systems that can continue to promote the prevention of armed conflict.

• Strategy21
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• 통권41호
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• pp.52-84
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• 2017

After finishing Cold War, the U.S. Navy's ability to Sea control has been gradually eroded last 15-20 years. The global security environment demands that the surface Navy rededicate itself to sea control, as a new group of potential adversaries is working to deny U.S. navy command of the sea. China has been increasing their sea denial capability, such as extended anti-surface cruise missile and anti-surface ballistic missile. To cope with this situation, the U.S. Naval Surface Forces Command has announced Surface Forces Strategy: Return to Sea Control. It is a new operating and organizing concept for the U.S. surface fleet called 'distributed lethality'. Under distributed lethality, offensive weapons such as new ASCMs are to be distributed more widely across all types of Navy surface ships, and new operational concept for Navy surface fleet's capability for attacking enemy ships and make it less possible for an enemy to cripple the U.S. fleet by concentrating its attack on a few very high-value Navy surface ships. By increasing the lethality of the surface ships and distributing them across wide areas, the Navy forces potential adversaries to not only consider the threat from our carrier-based aircraft and submarines, but they now consider the threat form all of those surface ships. This idea of using the distributed lethality template to generate surface action groups and adaptive force package and to start thinking about to increase the lethal efficacy of these ships. The U.S. Navy believes distributed lethality increases the Navy's sea control capability and expands U.S. conventional deterrence. Funding new weapons and renovated operating concept to field a more lethal and distributed force will enable us to establish sea control, even in contested area. The U.S. Navy's Surface Forces Strategy provides some useful implications for The ROK Navy. First the ROK Navy need to reconsider sea control mission. securing sea control and exploiting sea control are in a close connection. However, recently the ROK Navy only focuses on exploiting sea control, for instance land attack mission. the ROK Navy is required to reinvigorate sea control mission, such as anti-surface warfare and anti-air warfare. Second, the ROK Navy must seek the way to improve its warfighting capability. It can be achieved by developing high-edge weapons and designing renewed operating concept and embraced new weapon's extended capabilities.

• Journal of Plant Biology
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• 제12권3호
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• pp.1-7
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• 1969

The lethal actions in Arabidopsis thaliana and Lemna polyrhiza brought about by certain inorganic form of Mn, Ba, Hg, Cu salts, and organic form of Na salts, were studied with aseptic artificial media. These metal ions at certain concentrations caused lethality of either Arabidopsis or Lemna when the media were without Ca ion. On the contrary, addition of Ca to the media protected the organisms from such lethality. It was postulated for the present from the proceeding evidence that Ca adsorbed and distributed along the sites between the plasma and cell membrane acts for suppressing permeation of toxic level of metal ions causing the lethality of these plants.

• Advances in Traditional Medicine
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• 제7권4호
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• pp.336-340
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• 2007

Plants from the genus Centaurea (C.) (Family: Asteraceae alt. Compositae), widely distributed in Asia, Europe and North America, have traditionally been used in the treatment of various ailments. As a part of our on-going studies on the plants from the genus C. for their phytochemistry and biological activities, extracts of the seeds of Turkish endemic C. species, C. bornmuelleri and C. huber-morathii, were tested for their cytotoxicity towards the CaCo2 colon cancer cell line as well as for the toxicity towards the brine shrimps, using the MTT and the brine shrimp lethality assays, respectively. Among the extracts, the MeOH extract of these plants showed significant toxicity towards the brine shrimps ($LD_{50}=55.2{\times}10^{-2}\;and\;42.4{\times}10^{-2}mg/ml$, respectively). The MeOH extract of both C. species also inhibited the growth of CaCo2 colon cancer cells in the MTT assay ($IC_{50}$=29.9 and 33.0 g/ml, respectively). As the most prominent activities in both assays were observed with the MeOH extracts, it can be assumed that the compound(s) responsible for these activities are polar in nature.

• 한국가스학회지
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• 제21권5호
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• pp.77-82
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• 2017

노후화 된 공정설비와 공장의 규모 확대 등 유해화학물질 사용량이 증가하고 있으며, 2013년부터 지속적으로 누출에 의한 사고가 발생하는 것을 확인할 수 있다. 장외영향평가에서 누출에 대한 끝점 농도는 ERPG 2로 나타내며, 안전보건공단의 가이드에서 시간에 따라 7분 미만에서 10분의 AEGL 2, 7분 이상 25분 미만일 때는 30분의 AEGL 2값을 사용한다. 기준이 되는 끝점 농도가 시간에 따라 모호하게 사용되고 있어, 사고 발생 시 문제를 야기할 것으로 생각이 된다. 이에 본 연구에서 회귀곡선을 통해 1~10분 사이의 AEGL 값을 도출하고, 동 시간의 Probit function의 0% Lethality 데이터와 비교하였으며, AEGL 결과 값을 사용하여 보다 명확한 시간에 따른 독성누출 평가에 활용될 것으로 생각된다.

• Reproductive and Developmental Biology
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• 제33권2호
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• pp.93-98
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• 2009

In this study, bovine Dnmt1 cDNA was sequenced and detected Dnmt1 mRNA level in bovine tissues by northern blot, methylation pattern of genome by southern blot, specific localization of Dnmt1 in mouse and bovine preimplantation embryos by immunocytostaining and Dnmt1 protein level in ovary and testis by western blot. Bovine Dnmt1 cDNA sequence showed more homology with that of human than mouse and rat. The RNA level of Dnmt1 was 10 times higher expression in placenta than other tissues. This indicates that placenta was hypermethylated compared to others organs. The genomic DNA could not be cut by a specific restriction enzyme (HpaII) in placenta, lung and liver of bovine. It suggests that Dnmt1 in some somatic cells was already methylated. Dnmt1, which has the antibody epitope 1316~1616, was distributed in nucleus and cytoplasm including the stage of pronuclear stage and maturation of oocyte and gradually weaken to blastocyst stage compare to negative. In addition, Dnmt1 was strongly expressed in tetraploid embryo and cloned 8-cell than IVF 8-cell. An aberrant pattern of DNA methylation in cloned embryo may be abnormal development of fetus, embryonic lethality and placenta dysfunction. The somatic specific band (190kDa) was appeared in ovary and testis, but oocyte specific band (175kDa) was not. Further investigations are necessary to understand the complex links between the methyltransferases and the transcriptional activity of genes in the cloned bovine tissues.

• 지능정보연구
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• 제24권4호
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• pp.137-154
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• 2018

조류인플루엔자와 구제역 같은 동물감염병은 거의 매년 발생하며 국가에 막대한 경제적 사회적 손실을 일으키고 있다. 이를 예방하기 위해서 그간 방역당국은 다양한 인적, 물적 노력을 기울였지만 감염병은 지속적으로 발생해 왔다. 최근 빅데이터와 딥러닝 기술을 활용하여 감염병의 예측모델을 개발하고자 하는 시도가 시작되고 있지만, 실제로 활용가능한 모델구축 연구와 사례보고는 활발히 진행되고 있지 않은 실정이다. KT와 과학기술정보통신부는 2014년부터 국가 R&D사업의 일환으로 축산관련 차량의 이동경로를 분석하여 예측하는 빅데이터 사업을 수행하고 있다. 동물감염병 예방을 위하여 연구진은 최초에는 차량이동 데이터를 활용한 회귀분석모델을 기반으로 한 예측모델을 개발하였다. 이후에는 기계학습을 활용하여 좀 더 정확한 예측 모델을 구성하였다. 특히, 2017년 예측모델에서는 시설물에 대한 확산 위험도를 추가하였고 모델링의 하이퍼 파라미터를 다양하게 고려하여 모델의 성능을 높였다. 정오분류표와 ROC 커브를 확인한 결과, 기계 학습 모델보다 2017년 구성된 모형이 우수함을 확인 할 수 있었다. 또한 2017에는 결과에 대한 설명을 추가하여 방역당국의 의사결정을 돕고 이해관계자를 설득할 수 있는 근거를 확보하였다. 본 연구는 빅데이터를 활용하여 동물감염병예방시스템을 구축한 사례연구로 모델주요변수값, 이에따른 실제예측성능결과, 그리고 상세하게 기술된 시스템구축 프로세스는 향후 감염병예방 영역의 지속적인 빅데이터활용 및 분석 모델 개발에 기여할 수 있을 것이다. 또한 본 연구에서 구축한 시스템을 통해 보다 사전적이고 효과적인 방역을 할 수 있을 것으로 기대한다.