• Journal of Pharmaceutical Investigation
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• 제24권3호
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• pp.155-165
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• 1994

Some mucoadhesive polymers such as hydroxypropylcelluose (HPC) and carbopol-934 (CP) have been employed for the preparation of mucoadhesive polymeric systems, and their physical properties including mucoadhesion, swelling, and drug release were evaluated. A new simple experimental technique that can quantitatively measure the bioadhesive properties of various polymeric systems has been developed by the methods of detachment force test. As the polymeric systems, the discs of freeze-dried HPC/CP solid dispersions were prepared. The mucosa used in these tests were upper, middle, and lower parts of small intestine of male rats weighing $300{\sim}350\;g$. Detachment forces were increased as the mole fraction of CP increased in discs of HPC/CP solid dispersions. In the points of intestinal site dependence of mucoadhesion, the solid dispersions revealed non-specific mucoadhesion to the intestine. Swelling and drug release characteristics of mucoadhesive polymeric systems were studied extensively to find out the feasibility for the oral controlled delivery systems. Swelling ratio, expressed as the final height/initial height, has been determined in various pH buffer solutions. Hydrochlorothiazide (HCT) was employed as a model drug for release study. Apparent swelling and drug release rate constants, $K_s$ and $K_r$ respectively, were obtained from the square-root time plot of either swelling ratio or released amount of drug, particularly for the time periods before reaching the equilibrium. As a result, the swelling ratio of HPC/CP solid dispersions was increased as the weight percentage of CP increased. Similarly, the release of HCT from the solid dispersions was dependent on pH changes and CP contents, resulted in the slower release of HCT with the increases of pH and CP contents.

• 천문학회보
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• 제36권2호
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• pp.86.1-86.1
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• 2011

We are developing a new universal spectropolarimeter on the Domeless Solar Telescope (DST) at the Hida Observatory to realize precise spectropolarimetric observations in a wide range of wavelength in visible and near infrared. The system aims to open a new window of plasma diagnostics by using Zeeman effect, Hanle effect, Stark effect, impact polarization, and atomic polarization for measuring the external magnetic field, electric field, or an anisotropy in the excitation of the atoms. The polarimeter is a successor of formerly developed polarimeter on DST, which make possible to observe a polarization in a photospheric spectral line with polarimetric accuracy of 10-2 (Kiyohara et al. 2004). The new system consists of a 60cm aperture vacuum telescope, a high dispersion vacuum spectrograph, polarization modulator / analyzer composed of a rotating waveplate whose retardation is constant for a wide range of wavelength and Wallaston prism, and a fast and large format CCD camera or IR camera. Spectral images in both orthogonal polarizations are taken simultaneously with a frame rate of ~20Hz while the waveplate rotates continuously in a rate of 1rev./sec. Thus It takes 5 ~ 60 sec to observe polarization with accuracy of 10-3 in a wide wavelength range (400 - 1100nm). We also examined a polarimetric model of the telescope with accuracy of 10-3 to calibrate instrumental polarization on some wavelengths. In this talk, I will focus on the performance of the instrument.

• Macromolecular Research
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• 제17권9호
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• pp.688-696
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• 2009

In this study, a new class of polyurethane (PU) nanofibers containing silver (Ag) nanoparticles (NPs) was synthesized by electrospinning. A simple method that did not depending on additional foreign chemicals was used to self synthesize the silver NPs in/on PU nanofibers. The synthesis of silver NPs was carried out by exploiting the reduction ability of N,N-dimethylformamide (DMF), which is used mainly to decompose silver nitrate to silver NPs. Typically, a sol-gel consisting of $AgNO_3$/PU was electrospun and aged for one week. Silver NPs were created in/on PU nanofibers. SEM confirmed the well oriented nanofibers and good dispersion of pure silver NPs. TEM indicated that the Ag NPs were 5 to 20 nm in diameter. XRD demonstrated the good crystalline features of silver metal. The mechanical properties of the nanofiber mats showed improvement with increasing silver NPs content. The fixedness of the silver NPs obtained on PU nanofibers was examined by harsh successive washing of the as-prepared mats using a large amount of water. The results confirmed the good stability of the synthesized nanofiber mats. Two model organisms, E. coli and S. typhimurium, were used to check the antimicrobial influence of these nanofiber mats. Subsequently, antimicrobial tests indicated that the prepared nanofibers have a high bactericidal effect. Accordingly, these results highlight the potential use of these nanofiber mats as antimicrobial agents.

• 한국수산과학회지
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• 제36권6호
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• pp.749-756
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• 2003

Hydroacoustic and open-closing zooplankton net survey were conducted to understand the characteristics of the sound scattering layer (SSL) and to estimate the density of an euphausiid (Euphausia pacifica) in the SSL, in the northwestern part of the East China Sea. The survey was carried out during July 6-9 2002 at 8 sampling stations for zooplankton. The virtual echogram technique was used to identify E. pacifica from all acoustic scatters. Mean volume backscattering strength difference $(MVBS_{120kHz-38kHz})$ and target strength equation for E. pacifica were derived from the Distorted-wave Born Approximation (DWBA) model. Although vertical migration of the SSL is similar to the general pattern, dispersion at night shows some differences. Estimated mean density using acoustic data ranged from $20.4-221.4\;mg/m^3$ over the whole depth, and $87.1-553.5\;mg/m^3$ in the SSL. The density using the zooplankton net ranged from $0.2-362.4\;mg/m^3$ and was not related to net deploying method. The results from the acoustic and net survey suggest that E. pacifica might be an important zooplankton community in the northwestern part of the East China Sea.

• 한국지반환경공학회 논문집
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• 제16권5호
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• pp.5-11
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• 2015

지하수 내에 영양염류와 중금속 등의 오염물질이 동시에 존재하는 경우 두 가지 이상의 반응성 매질을 적용한 연속식 반응벽체공법이 적용될 수 있다. 본 연구에서는 영양염류 오염물질인 암모늄과 인산염, 그리고 중금속인 카드뮴의 복합오염물질의 제거를 위해 제올라이트와 제강슬래그를 반응성 매질로 구성한 연속식 반응벽체공법의 적용성을 평가하였다. 흐름 조건을 모사한 주상실험을 수행하여 제올라이트와 제강슬래그와의 연속반응에 의한 오염물질의 제거효과를 평가하였다. 주상실험결과는 비평형 이류확산 모델을 적용하여 주상실험에서의 비평형 반응을 해석하였다. 주상실험을 통해 제올라이트는 암모늄 제거에 효과적이며 제강슬래그는 인산염과 카드뮴 제거에 효과적임을 확인하였으며, 연속식 반응벽체 구성 시 제올라이트와 제강슬래그 순서로 반응시키는 조건이 효과적인 것으로 나타났다.

• Journal of Radiation Protection and Research
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• 제41권4호
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• pp.368-372
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• 2016

Background: Methodologies for a series of radiological consequence assessments show a distinctive difference according to the design principles of the original nuclear suppliers and their technical standards to be imposed. This is due to the uncertainties of the accidental source term, radionuclide behavior in the environment, and subsequent radiological dose. Both types of PWR and PHWR are operated in Korea. However, technical standards for evaluating atmospheric dispersion have been enacted based on the U.S. NRC's positions regardless of the reactor types. For this reason, it might cause a controversy between the licensor and licensee of a nuclear power plant. Materials and Methods: It was modelled under the framework of the NRC Regulatory Guide 1.145 for light-water reactors, reflecting the features of heavy-water reactors as specified in the Canadian National Standard and the modelling features in MACCS2, such as atmospheric diffusion coefficient, ground deposition, surface roughness, radioactive plume depletion, and exposure from ground deposition. Results and Discussion: An integrated accident consequence assessment code, ACCESS (Accident Consequence Assessment Code for Evaluating Site Suitability), was developed by taking into account the unique regulatory positions for reactor types under the framework of the current Korean technical standards. Field tracer experiments and hand calculations have been carried out for validation and verification of the models. Conclusion: The modelling approaches of ACCESS and its features are introduced, and its applicative results for a hypothetical accidental scenario are comprehensively discussed. In an applicative study, the predicted results by the light-water reactor assessment model were higher than those by other models in terms of total doses.

• 한국정보처리학회논문지
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• 제2권5호
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• pp.667-676
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• 1995

ATM 트래픽의 다중화시 셀 지연 변경(cell delay variance)에 의한 트래픽의 특성 변화로 인하여 셀밉집 현상과 셀 분산 현상이 발생된다. 이러한 현상들은 셀 스트림 의 버스티니스를 증가시키고 네트워크의 폭주 상태를 유발하게 된다. 따라서 입력 스 트림을 일정한 간격으로 네트워크나 트래픽 제어 기능으로 전송하는 트래픽 쉐이핑 기능이 필요하다. 기존 방법들의 대부분이 입력 트래픽을 동일한 특성을 갖는 트래픽 으로 간주하여 연구를 수행하였지만, 본 연구에서는 입력 트래픽을 손실과 지연의 관 점으로 트래픽 특성을 고려한 트래픽 쉐이핑 기법을 제안한다. 입력 트래픽의 특성을 고려한 쉐이핑 모델과 알고리즘을 제시하고 셀 지연 변경의 크기에 따른 트래픽 영향 을 연구한다. 제안된 기법을 가상 스케쥴링 기법(virtual scheduling algorithm)과 비교하여 쉐이핑 기법의 효율성을 평가한다. 실험 결과 제안된 기법이 지연에 민감한 트래픽인 경우 약 12%의 평균 지연의 감소와 손실에 민감한 트래픽인 경우 11%의 버 스티니스의 감소를 보였다.

• 청정기술
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• 제2권2호
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• pp.100-125
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• 1996

After recycle of spent materials has been optimised, there remains a proportion of waste which must be dealt with in the most environmentally friendly manner available. For materials such as municipal waste, clinical waste, toxic waste and special wastes such as tyres, incineration is often the most appropriate technology. The study of incineration must take a process system approach covering the following aspects: ${\bullet}$ Collection and blending of waste, ${\bullet}$ The two stage combustion process, ${\bullet}$ Quenching, scrubbing and polishing of the flue gases, ${\bullet}$ Dispersion of the flue gases and disposal of any solid or liquid effluent. The design of furnaces for the burning of a bed of material is being hampered by lack of an accurate mathematical model of the process and some semi-empirical correlations have to be used at present. The prediction of the incinerator gas phase flow is in a more advanced stage of development using computational fluid dynamics (CFD) analysis, although further validation data is still required. Unfortunately, it is not possible to scale down many aspects of waste incineration and tests on full scale incinerators are essencial. Thanks to a close relationship between SUWIC and Sheffield Heat&Power Ltd., an extended research programme has been carried out ar the Bernard Road Incinerator plant in Sheffield. This plant consists of two Municipal(35 MW) and two Clinical (5MW) Waste Incinerators which provide district heating for a large part of city. The heat is distributed as hot water to commercial, domestic ( >5000 dwelling) and industrial buildings through 30km of 14" pipes plus a smaller pipe distribution system. To improve the economics, a 6 MW generator is now being added to the system.

• 한국전산구조공학회논문집
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• 제21권1호
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• pp.13-20
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• 2008

기능경사 소재(FGM)에는 서로 다른 두 가지 구성입자들이 혼합되어 있는 경사층(graded layer)이 삽입되어, 소재 전 영역에 걸쳐 구성입자의 체적분율이 연속적이고 기능적으로 변화하도록 되어있다. 이러한 이상(dual-phase) 입자복합재의 열 기계적 거동을 해석함에 있어 필수적인 경사층의 물성치는 전통적으로 균질화 기법을 이용하여 예측되었다. 하지만, 이러한 균질화 기법은 구성입자의 형태, 분산구조 등과 같은 상세 형상을 반영하지 못하지 때문에 복합재의 총체적인 등가 물성치 예측에만 국한 되어왔다. 이러한 맥락에서 본 연구에서는 경사층을 미시역학적으로 이산화 모델링하고, 다양한 체적분율과 외부 하중조건에 대해 유한요소해석을 실시하여 이러한 균질화 기법들의 특성을 분석하였다.

• Archives of Pharmacal Research
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• 제18권3호
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• pp.183-188
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• 1995

Polymeric reinforcement and coatings of alginate beads were carried out to control the release rate of drug from alginate beads. A poorly water-soluble ibuprofen (IPF) was selected as a model drug. A commercially available $Eudragit^{\circledR}$ RS100 was also used as a polymer. Effects of polymeric contents, the presence of plasticizers and amount of drug loading on the release rate of drug were investigated. The release rate of drug from alginate beads in the simulated gastric fluid did not occur within 2 h but released immediately when dissolution media were switched to the simulated intestinal fluid. No significant difference of release rate from polymer-reinforced alginate bead without plasticizers was observed when compared to plain (simple) beads. However, the release rate of drug from polymer-reinforced alginate beads was further sustained and retarded when aluminium tristearate (AT) as a plasticizer was added to polymer. However, polyethylene glycol 400 (PEG400) did not change the release rate of drug from alginate beads although PEG400 was used to improve dispersion of polymer and sodium alginate, and plasticize $Eudragit^{\circledR}$ RS100 polymer. The presence of plasticizer was crucial to reinforce alginate gel matrices using a polymer. As the amount of drug loading increased, the release rate of drug increased as a result of decreasing effects of polymer contents in matrices. The significantly sustained release of drug from polymer-coated alginate beads occurred as the amount of polymer increased because the thickness of coated membrane increased so that cracks and pores of the outer surface of alginate beads could be reduced. The sustained and retarded action of polymer-reinforced and coated beads may result from the disturbance of swelling and erosion (disintegration) of alginate beads. From these findings, polymeric-reinforcement and coatings of alginate gel beads can provide an advanced delivery system by retarding the release rate of various drugs.