• The Korean Journal of Urological Oncology
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• 제15권3호
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• pp.178-186
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• 2017

Purpose: Poloxamer 407 (P407) thermo-sensitive hydrogel formulations were developed to enhance the retention time in the urinary bladder after intravesical instillation. Materials and Methods: P407 hydrogels (P407Gels) containing 0.2 w/w% fluorescein isothiocyanate dextran (FD, MW 4 kDa) as a fluorescent probe were prepared by the cold method with different concentrations of the polymer (20, 25, and 30 w/w%). The gel-forming capacities were characterized in terms of gelation temperature (G-Temp), gelation time (G-Time), and gel duration (G-Dur). Homogenous dispersion of the probe throughout the hydrogel was observed by using fluorescence microscopy. The in vitro bladder simulation model was established to evaluate the retention and drug release properties. P407Gels in the solution state were administered to nude mice via urinary instillation, and the in vivo retention behavior of P407Gels was visualized by using an in vivo imaging system (IVIS). Results: P407Gels showed a thermo-reversible phase transition at $4^{\circ}C$ (refrigerated; sol) and $37^{\circ}C$ (body temperature; gel). The G-Temp, G-Time, and G-Dur of FD-free P407Gels were approximately $10^{\circ}C-20^{\circ}C$, 12-30 seconds, and 12-35 hours, respectively, and were not altered by the addition of FD. Fluorescence imaging showed that FD was spread homogenously in the gelled P407 solution. In a bladder simulation model, even after repeated periodic filling-emptying cycles, the hydrogel formulation displayed excellent retention with continuous release of the probe over 8 hours. The FD release from P407Gels and the erosion of the gel, both of which followed zero-order kinetics, had a linear relationship ($r^2=0.988$). IVIS demonstrated that the intravesical retention time of P407Gels was over 4 hours, which was longer than that of the FD solution (<1 hour), even though periodic urination occurred in the mice. Conclusions: FD release from P407Gels was erosion-controlled. P407Gels represent a promising system to enhance intravesical retention with extended drug delivery.

• Economic and Environmental Geology
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• v.52 no.3
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• pp.231-241
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• 2019

Kinematic analysis determines the stability of rock slope by analyzing the relationship between the slope face orientation and the discontinuity orientation. In this study, terrestrial LiDAR was used to obtain a large amount of discontinuity orientation data and then, the probabilistic characteristics of the orientation data obtained using terrestrial LiDAR were analyzed. Subsequently, the probabilistic kinematic analysis was carried out using the discontinuity orientations generated randomly from Fisher function in Monte Carlo simulation. In addition, the probabilistic kinematic analysis was also performed using the actual orientation data obtained from the terrestrial LiDAR to compare their results. Consequently, the results of both probabilistic analyses showed similar results. Therefore, if sufficient orientation data are provided by other means such as terrestrial LiDAR, the probabilistic analysis will show reasonable results using the actual field data without randomly generating orientation data. In addition, the deterministic kinematic analysis was also carried out using representative orientation of discontinuity sets. The analysis result of the probabilistic analysis showed similar results with the deterministic analysis because the dispersion of the discontinuity orientations in a joint set is not large.

• Journal of the Korea Institute of Building Construction
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• v.19 no.2
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• pp.113-121
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• 2019

Single walled carbon nanotube (SWCNT) has been used as a material for reinforcing various advanced materials because it has superior mechanical properties. However, pure SWCNT that does not have any functional group has a hydrophobic character, and exists as bundles due to the strong Van der Waals attraction between each SWCNT. Due to these reasons, it is very difficult to disperse SWCNTs in the water. In this work, in order to use SWCNT for production of cementitious composites, SWCNT was first dispersed in water to make an aqueous solution. Sodium deoxycholate (DOC) and Sodium dodecyl sulfate (SDS) were chosen as surfactants, and the dosage of DOC and SDS were 2wt% and 1wt%, respectively. Sonication and ultracentrifugation were applied to separate each SWCNT and impurities. Using such processed SWCNT solutions, cement paste was prepared and its shear stress vs. strain rate relationship was studied. The yield stress and plastic viscosity of cement paste were obtained using Bingham model. According to the results in this work, cement pastes made with DOC and SDS showed similar rheological behavior to that of air entrained cement paste. While cement paste made with DOC 2 wt.% SWCNT solution showed similar rheological behavior to that of plain cement paste, cement paste made with SDS 1 wt.% SWCNT solution showed different rheological behavior showing much less yield stress than plain cement paste.

• The Journal of the Korea Contents Association
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• v.19 no.5
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• pp.280-286
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• 2019

This study first examines whether the matching principle reduces information asymmetry and verifies the effect on earnings sustainability and information asymmetry. In the presence of information asymmetry between managers and information users, managers can reduce information asymmetry by increasing the quality of earnings. Information asymmetry is measured by the financial analysts' earnings forecast variance. When we look at the results of previous studies, verify whether information asymmetry decreases as the response to the revenue cost increases and whether negative relationship between profit persistence and information asymmetry appears when the response to the revenue cost is high. As a result, firms with high revenue cost response showed a decrease in information asymmetry. The persistence of the earningss from the high earnings-cost response shows that the analysts' earnings forecast dispersion decreases. This means that the better the response to the revenue cost, the better the quality of the earnings and the less the information risk about the uncertainty of the enterprise. This study is different from the previous studies in that it analyzed whether the persistence of the earnings that responded to the high revenue cost reduces the information asymmetry. The results of this study suggest that managers can reduce the information asymmetry by carrying out appropriate revenue - cost responses, which provides important implications for stakeholders who use accounting earnings information.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.4C
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• pp.231-238
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• 2008

A column testing device capable of measuring the electrical resistivity of soil at 3 different locations was developed to verify applicability of bulk electrical conductivity (BEC) breakthrough curves in monitoring contaminant transport. Tracer injection tests were conducted with three different types of saturated sands to obtain average linear velocities and longitudinal hydrodynamic dispersion coefficients based on BEC breakthrough curves and effluent solute breakthrough curves. Comparative analysis of transport parameters obtained from curve fitting the results into the analytical solutions confirmed the validity of resistance measurements in estimating time-continuous resident solute concentration. Under the assumption that a linear relationship exists between ${\sigma}_{sat}-{\sigma}_w-C$, the BEC breakthrough curves are able to effectively reduce the laborious and time-consuming processes involved in the conventional method of sampling and analysis. In order to reduce possible uncertainties in analyzing the BEC breakthrough curves, it was recommended that resistance measurements take place nearby the effluent boundary. In addition, a sufficient electrical contrast or difference in the electrical conductivity of the influent and the saturating solution is required to conduct reliable analysis.

• Journal of Intelligence and Information Systems
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• v.22 no.1
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• pp.43-61
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• 2016

Customer reviews help potential customers make purchasing decisions. However, the prevalence of reviews on websites push the customer to sift through them and change the focus from a mere search to identifying which of the available reviews are valuable and useful for the purchasing decision at hand. To identify useful reviews, websites have developed different mechanisms to give customers options when evaluating existing reviews. Websites allow users to rate the usefulness of a customer review as helpful or not. Amazon.com uses a ratio-type helpfulness, while Yelp.com uses a count-type usefulness index. This usefulness index provides helpful reviews to future potential purchasers. This study investigated the effects of sentiment and readability on useful votes for customer reviews. Similar studies on the relationship between sentiment and readability have focused on the ratio-type usefulness index utilized by websites such as Amazon.com. In this study, Yelp.com's count-type usefulness index for restaurant reviews was used to investigate the relationship between sentiment/readability and usefulness votes. Yelp.com's online customer reviews for stores in the beverage and food categories were used for the analysis. In total, 170,294 reviews containing information on a store's reputation and popularity were used. The control variables were the review length, store reputation, and popularity; the independent variables were the sentiment and readability, while the dependent variable was the number of helpful votes. The review rating is the moderating variable for the review sentiment and readability. The length is the number of characters in a review. The popularity is the number of reviews for a store, and the reputation is the general average rating of all reviews for a store. The readability of a review was calculated with the Coleman-Liau index. The sentiment is a positivity score for the review as calculated by SentiWordNet. The review rating is a preference score selected from 1 to 5 (stars) by the review author. The dependent variable (i.e., usefulness votes) used in this study is a count variable. Therefore, the Poisson regression model, which is commonly used to account for the discrete and nonnegative nature of count data, was applied in the analyses. The increase in helpful votes was assumed to follow a Poisson distribution. Because the Poisson model assumes an equal mean and variance and the data were over-dispersed, a negative binomial distribution model that allows for over-dispersion of the count variable was used for the estimation. Zero-inflated negative binomial regression was used to model count variables with excessive zeros and over-dispersed count outcome variables. With this model, the excess zeros were assumed to be generated through a separate process from the count values and therefore should be modeled as independently as possible. The results showed that positive sentiment had a negative effect on gaining useful votes for positive reviews but no significant effect on negative reviews. Poor readability had a negative effect on gaining useful votes and was not moderated by the review star ratings. These findings yield considerable managerial implications. The results are helpful for online websites when analyzing their review guidelines and identifying useful reviews for their business. Based on this study, positive reviews are not necessarily helpful; therefore, restaurants should consider which type of positive review is helpful for their business. Second, this study is beneficial for businesses and website designers in creating review mechanisms to know which type of reviews to highlight on their websites and which type of reviews can be beneficial to the business. Moreover, this study highlights the review systems employed by websites to allow their customers to post rating reviews.

• Economic and Environmental Geology
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• v.47 no.4
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• pp.405-420
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• 2014

To investigate geochemical characteristics of soil and atmospheric environments by anthropogenic source, we have analyzed and determined heavy metal concentrations of the surface soils beneath roadside trees and leaves of Platanus occidentalis from 52 points in Seoul during autumn 2001. For comparison of the contents of heavy metal for the soil and leaf, we have analyzed heavy metal contents of the surface soils beneath roadside trees and leaves from 2 points in rural area of Yesan during the same time period. The composition of heavy metals of soils are relatively high for Cd, Co, Cr and Ni in industrial area (IA, Industrial Area) and high for Cu, Pb and Zn in heavy traffic area (HTA, Heavy Traffic Area). The heavy metal contents of rural area in Seoul are higher than those in Yesan. The differences of chemical compositions between the washed and unwashed leaves are high for Cd, Cu, Pb and Zn in the HTA. The element couples of Cd-Co, Cr-Ni and Pb-Zn for the soils had shown a good correlation and their contamination sources could be similar. The relationship for Pb-Cu and Cu-Zn showed good correlation in Platanus leaves. The relationship between soils and unwashed leaves show a good correlation for Cr, Cu, Pb and Zn but low correlation for Cd, Co, Fe, Mn and Ni. It is thought that the Cr, Cu, Pb and Zn were derived from contaminants of soils, whereas Cd, Co, Fe, Mn and Ni were originated from atmospheric source. From the spatial variations of elements for soils and leaves, Ni and Cr were dominant in the soils of IA and Cd, Cu and Zn were dominant in those of HTA. The Contamination by Cd-Pb and Cu-Zn in unwashed leaves were analyzed to show similar patterns. Using the enrichment factors (EF) of heavy metals in unwashed leaves, the EF sequences were to be Cu, Zn, Pb, Mn, Co, Ni, Cd and Cr. We identified that Cu, Zn, Pb and Mn were most problematic of environmental hazard in Seoul.

• Archives of design research
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• v.18 no.4 s.62
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• pp.257-266
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• 2005

The purpose of this study is to investigate the psychological reaction to the image of the worship space in the church buildings and to quantify its contribution of the stimulation elements causing such reaction, and finally to suggest basic data for realizing emotional worship space of the church architecture. For this, 143 christians were surveyed to analyze the relationship between 23 emotional expressions extracted from the worship space and 32 images of the worship space. The combined data was described with the two dimensional dispersion using the quantification theory III. The analysis found out that 'simplicity-complexity' of the image consisted of the horizontal axis (the x-axis) and 'creativity' of the image the vertical axis(the y-axis). In addition, to extract the causal relationship between the value of emotional reaction and its stimulation elements quantitatively, the author indicated 4 emotional word groups such as simple, sublime for x-axis and typical creative for y-axis based on its similarity by the cluster analysis, The quantification theory I was also used with total value of equivalent emotional words as the standard variance and the emotional stimulation elements of the worship space as the independent variance. 9 specific examples of the emotional stimulation elements were selected including colors and shapes of the wall and the ceiling, shapes and finish of the floor materials, window shapes, and the use of the symbolic elements. Furthermore, 31 subcategories were also chosen to analyse their contribution on the emotional reaction. As a result, the color and finish of the wall found to be the most effective element on the subjects' emotional reaction, while the symbolic elements and the color of the wall found to be the least effective. It is estimated that the present study would be helpful to increase the emotional satisfaction of the users and to approach a spatial design through satisfying the types and purposes of the space.

• Journal of the Korean earth science society
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• v.25 no.8
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• pp.774-783
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• 2004

The S wave velocity and Q$s^{-1}$ structure of the uppermost part of the soil in Nakdong Delta area have been obtained to determine the characteristics of the forementioned soil. The phase and attenuation coefficients of multichannel seismic records were inverted to obtain the S wave velocity and Q$s^{-1}$ structure of the soil. The inversion results have been compared with the borehole measurements of the area. The seismic signal of the nearest geophone from a seismic source was used as the source signal to obtain the attenuation coefficients. Amplitude ratios of the signal at each geophone to the source signal wave plotted as a function of distance for the frequency range between 10 Hz and 45 Hz. The slope of a linear regression line which fits amplitude ratio-distance relationship best for a given frequency was used as the attenuation coefficients for the frequency. The dispersion curve of Rayleigh waves and the attenuation coefficients were inverted to obtain the S-wave velocity and Q$s^{-1}$, respectively, in the uppermost 8 meter of soil layer. The borehole measurements of the area show that are two distinct layers; the upper 4 meter of silty-sand and the lower 4 meter of silty-clay. The inversion results indicate that the shear wave velocity of the upper layer is 80 m/sec and 40m/sec in the lower silty-clay layer. The spacial resolution of the shear wave velocity structure is very good down to a depth of 8 meter. The Q$s^{-1}$ in the upper silty-sand layer is 0.02 and increase to 0.03 in the lower silty-sand layer. The spacial resolution of quality factor is relatively good down to a depth of 5 meter, but very poor below the depth. In this study, the S-wave velocity is higher in the silty-clay and the Q$s^{-1}$ is smaller silty-sand than in the silty-clay. However, much more data should be analyzed and accumulated before making any generalization on the shear wave velocity and Q$s^{-1}$ of the sediments.

• Economic and Environmental Geology
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• v.17 no.2
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• pp.115-139
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• 1984

The Cu-Pb-Zn-Ag hydrothermal vein-type deposits which comprise the Sambong mine occur within calc-alkaline volcanics of the Cretaceous Gyeongsang Basin. The ore mineralization took place through three distinct stages of quartz (I and II stages) and calcite veins (III stage) which fill the pre-existing fault breccia zones. These stages were separated in time by tectonic fracturing and brecciation events. The reflection variations of one mineral depending on mineralization sequence are considered to be resulted from variation in its chemical composition due to different physico-chemical conditions in the hydrothermal system. The reflection power of sphalerite increases with the content of Fe substituted for Zn. Reflectances of the sphalerite grain are lower on (111) than on (100) surface. The spectral profiles depend on the internal reflection color. Sphalerite, showing green, yellow and reddish brown internal reflection, have the highest reflection power at $544m{\mu}$ (green), $593m{\mu}$ (yellow) and $615m{\mu}$ (red) wavelength, respectively. Chalcopyrite is recognized as biaxial negative from the reflectivity data of randomly oriented grains measured at the most sensitivity at $544m{\mu}$. The microindentation hardness against the Fe content (wt. %) for the sphalerite increases to 8.05% Fe and then decreases toward 9.5% Fe content. Vickers hardness of the sphalerite is considerably higher on surface of (100) than on (111). The relationship between Vickers hardness and crystal orientation of the galena was determined to be $VHN_{(111)}$ > $VHN_{(210)}$ > $VHN_{(100)}$. The softer sulfides have the wider variation of the diagonal length in the indentation. Diagonal length in the indentation is pyrite