• Genomics & Informatics
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• v.14 no.4
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• pp.187-195
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• 2016

In genetic association studies with high-dimensional genomic data, multiple group testing procedures are often required in order to identify disease/trait-related genes or genetic regions, where multiple genetic sites or variants are located within the same gene or genetic region. However, statistical testing procedures based on an individual test suffer from multiple testing issues such as the control of family-wise error rate and dependent tests. Moreover, detecting only a few of genes associated with a phenotype outcome among tens of thousands of genes is of main interest in genetic association studies. In this reason regularization procedures, where a phenotype outcome regresses on all genomic markers and then regression coefficients are estimated based on a penalized likelihood, have been considered as a good alternative approach to analysis of high-dimensional genomic data. But, selection performance of regularization procedures has been rarely compared with that of statistical group testing procedures. In this article, we performed extensive simulation studies where commonly used group testing procedures such as principal component analysis, Hotelling's $T^2$ test, and permutation test are compared with group lasso (least absolute selection and shrinkage operator) in terms of true positive selection. Also, we applied all methods considered in simulation studies to identify genes associated with ovarian cancer from over 20,000 genetic sites generated from Illumina Infinium HumanMethylation27K Beadchip. We found a big discrepancy of selected genes between multiple group testing procedures and group lasso.

• Transactions of the Korean Society of Automotive Engineers
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• v.19 no.4
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• pp.72-77
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• 2011

This study is to investigate the effect of the distillation temperature in ultra low sulfur diesel fuel on exhaust emissions in the low-temperature diesel combustion with 1.9L common rail direct injection diesel engine. Low temperature diesel combustion was achieved by adopting an external high EGR rate with a strategic injection control. The engine was operated at 1500 rpm 2.6 bar BMEP. The 90% distillation recovery temperature (T90) was $270^{\circ}C$ and $340^{\circ}C$ for the respective cetane number (CN) 30 and 55. It was found that there exists no distinctive discrepancy on exhaust emissions with regards to the different T90s. The high CN (CN55) fuels follow the similar trend of exhaust emissions as observed in CN30 fuels' except that high T90 fuel (CN55-T340) produced higher PM compared to low T90 fuel (CN55-T270). This may come from that high T90 plays an active role in aggravating the degree of fuel-air mixture preparedness before ignition.

• Special Issue of the Society of Naval Architects of Korea
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• 2009.09a
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• pp.47-51
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• 2009

It is well known that a rudder is influential devices to help ship maintain its stable performances, such as a course-keeping and maneuverability. In the procedures of a commercial ship design proper rudder dimensions (area and shape) ensuring better ship maneuverability have been settled in an initial concept design stage performed by a preceding department, without little structural consideration. It is true that there are time discrepancy between an initial design and a structural analysis stage. Therefore structural analysis results would sometimes cause a rudder to modify its dimensions. Most of these cases, however, ship design and performance tests had been finished. In this matter, only limited modifications of redder could be carried out. Besides, these could also cause bad effects on productivity. Finally, it is necessary to develop a new program considering co-relationship between an initial rudder design and a following work, a structural strength analysis, in order to enhance productivity and minimize a rate of redesign procedures.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.23 no.9
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• pp.627-632
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• 2011

As an innovative effort to secure economically viable heat recovery system, various fin shapes for industrial fin-tube heat exchangers have been studied for better performance. In this study, the waste gas heat recovery from four different fin shapes was experimentally performed for heat transfer rate and pressure drop. According to the tested results, the twist and wavy shape fins of rectangular type show the superior performance in terms of Goodness factor and jH/f factor ratio, whereas the circular spiral fin shows the inferior values. Experimental results shows good comparison with the numerical results with a slight discrepancy of 5%, which is quite resonable.

• Journal of Chest Surgery
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• v.49 no.6
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• pp.485-488
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• 2016

Different suture techniques have been used for anastomosis in coronary artery bypass graft surgery. Bypass surgery may be difficult for patients who have small coronary arteries or marked size discrepancies between target coronary arteries and grafts. For proximal and distal anastomoses, three continuous stitches are first placed in the heel and toe of the small coronary arteries; for sequential anastomosis, an interrupted eight-stitch technique is used. We applied these anastomotic suture techniques in patients requiring coronary artery bypass graft surgery, achieving an early angiographic patency rate of 100%.

• Journal of the Korean Society of Combustion
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• v.3 no.1
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• pp.11-19
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• 1998

The influence of oxidant addition on soot formation is investigated experimentally with ethylene, propane and mixture fuel co-flow diffusion flames. Oxidant addition into fuel shows the increase of integrated soot volume fractions for ethylene, ethylene/ethane and ethylene/methane mixture flames. However, the increase of integrated soot volume fraction with oxidant addition was not significant for propane and ethylene/propane mixture flames. This discrepancy is explained with $C_2\;and\;C_3$ chemistry at the early stage of soot formation process. The oxidant addition increases the concentration of $C_3H_3$ in the soot formation region, and therefore, enhances soot formation process. A new soot formation rate model that includes both dilution effect and chemical effect of oxygen is suggested to interpret the increase of integrated soot volume fractions with oxidant addition into ethylene. Also, the role of adiabatic flame temperature for the chemical effect of oxygen addition into fuel was reviewed. The influence of oxidant or diluent addition into fuel on soot formation process are the fuel dilution effect, the adiabatic flame temperature altering effect and/or the chemical effect of oxygen. Their relative importance could change with fuel structure and adiabatic flame temperature.

• Progress in Superconductivity and Cryogenics
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• v.19 no.2
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• pp.48-52
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• 2017

Discrepancy between a power supply current and an actual "spiral" coil current makes the conventional 4-probe measurement of a critical current ($I_c$) of a no-insulation (NI) high temperature superconductor (HTS) coil inaccurate and time-consuming. This paper presents a fast and accurate approach for $I_c$ measurement of NI HTS coils. With an NI HTS coil energized at a constant ramping rate, a complete analytic expression for the spiral coil current was obtained from a first-order partial differential equation that derived from an equivalent circuit model of the NI coil. From the analytic solution, both spiral coil current and radial leak current can be obtained simultaneously, which enables fast and accurate measurement of the NI coil $I_c$. To verify the proposed approach, an NI double-pancake (DP) coil, wound with GdBCO tapes of $6mm{\times}0.1mm$, was constructed and its $I_c$ was repeatedly measured with various ramping rates in a bath of liquid nitrogen at 77 K. The measured results agreed well with the calculated ones, which validates the proposed approach to measure $I_c$ of an NI HTS coil.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.1
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• pp.39.2-39.2
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• 2012

We present our study on a comparison of dark matter halo merger history from the runs using different numerical simulation codes. To analyze the uncertainty caused by the use of different N-body calculation methods, we compare the results from two cosmological hydrodynamic simulation codes GADGET-2 and RAMSES, which use a TreePM algorithm and the Adaptive Mesh Refinement(AMR) technique respectively. We perform cosmological dark matter-only simulations with the same parameter set and initial condition for both. The dark matter halo mass functions from two simulation runs correspond well with each other, except for lower mass haloes. The discrepancy on the low-mass haloes in turn causes a notable difference in halo merger rate, especially for the case of extremely minor merger. The result from GADGET-2 predicts that most haloes undergo more number of mergers with small haloes than that from RAMSES, independent of halo mass and environment. However, in the context of the study on galaxy evolution, such extreme minor mergers generally do not have strong effects on galaxy properties such as morphology or star formation history. Hence, we suggest that this uncertainty could be quantitatively negligible, and the results from two simulations are reliable even with only minor difference in merger history.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.28 no.2
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• pp.207-214
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• 2004

The burning velocities of conventional and oxygen-enriched methane flame in various equivalence ratio were determined by experiments. The validity of existing reaction mechanisms was examined in oxygen-enriched flame on the basis of the experiment results. Modified reaction mechanism is suggested, which was able to predict burning velocity of oxygen enriched flame as well as methane-air flame. Complementary study on reaction mechanisms shows the following results : Present experiment data were found to be more reliable in comparison with existing ones in a oxygen-enrichment condition. It was found that some modification in existing reaction mechanisms is necessary, since discrepancy between measurements and predictions is increasing with oxygen enrichment ratio. The sensitivity analysis was performed to discriminate the dominantly affecting reactions on the burning velocity in various oxygen enrichment and equivalence ratio. A modified GRI 3.0 reaction mechanism based on our experiment results was suggested, in which reaction rate coefficients of (R38) H+O$_2$<=>O+OH in GRI 3.0 reaction mechanisms were corrected based on sensitivity analysis results. This mechanism showed a good agreement in predicting the burning velocity and number density of NO in oxygen-enriched flame and would provide proper reaction information of oxygen-enriched flame at this stage.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.7
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• pp.877-884
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• 2004

In this paper, structural analysis is performed to investigate the deformation of porous media in a proton exchange membrane fuel cell (PEMFC). Structural deformation of air plate of the fuel cell causes the change in configuration and cross sectional area of the channel. The distributions of mass flow rate and pressure are major factors to decide the performance of a PEMFC. These factors are affected by channel configuration of air plate. Two kinds of numerical air plate models are suggested for flow analyses. Deformed porous media and undeformed porous media are considered for the two models. The Numerical flow analysis results between deformed porous media and undeformed porous media have some discrepancy in pressure distribution. The pressure and velocity distribution under a working condition are numerically calculated to predict the performance of the air plates. Pressure and velocity distributions are compared for two models. It is shown that structural deformation makes difference in flow analysis results.