• Journal of Ginseng Research
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• 제41권3호
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• pp.373-378
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• 2017

Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported. The biological activities of ocotillol-type saponins include neuroprotective effect, antimyocardial ischemia, antiinflammatory, antibacterial, and antitumor activities. Owing to their chemical structure, pharmacological actions, and the stereoselective activity on antimyocardial ischemia, ocotillol-type saponins are subjected to extensive consideration. In this review, we sum up the discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.

• 한국기술혁신학회:학술대회논문집
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• 한국기술혁신학회 2011년도 추계 학술대회 논문집
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• pp.274-289
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• 2011

• 벤처창업연구
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• 제11권3호
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• pp.121-130
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• 2016

치열한 경쟁상황에서 기업의 성공과 혁신은 경영자에서 비롯되는 신사업 발견능력을 통한 경쟁전략의 수립이 매우 중요하다. 본 연구는 경영자의 신사업기회 발견능력과 기업성과 사이에 경쟁전략의 매개효과를 실증분석을 통해 규명하는데 목적을 두고 있다. 이를 위해서 전국의 대기업 사업장과 중소기업 286개의 기업 자료를 대상으로 자료를 수집하고 구조모델에 의한 분석을 실시하였다. 실증분석 결과 발견능력 중 실험하기와 연관시키기가 경쟁전략을 강화시키는 것으로 나타났다. 또한 발견능력 맥락에서는 원가우위 전략 보다 차별화 전략이 기업성과에 미치는 영향이 큰 것으로 나타났으며, 경쟁 전략의 매개효과는 실험하기와 기업성과 사이에 강하게 나타났다.

• The Journal of Asian Finance, Economics and Business
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• 제9권6호
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• pp.139-149
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• 2022

The article investigates the impact mechanism of absorption capacity (potential absorptive capacity - PAC and realized absorptive capacity - RAC) on the innovation efficiency of enterprises through the intermediate variable of dual innovation (exploratory innovation- INOR and exploitative innovation- INOI), based on the actual situation of Vietnam's small and medium enterprises (SMEs). A survey of Vietnam's SMEs was conducted from August 2020 to April 2021. The data was collected through interviews and questionnaires, and 146 valid questionnaires were received. The following results were acquired using SPSS 20.0 software to do correlation and regression analysis of data results.: The results show that the absorptive capacity of enterprises has a positive impact on innovation performance and dual innovation acts as a mediator in how absorptive capacity affects innovation performance. This study deepens the understanding of how absorptive capacity affects innovation performance and provides important new evidence for developing absorptive capacity and dual innovation in both theories and practice in Vietnam's SMEs. The study also proposes several solutions and recommendations to help Vietnam's small and medium enterprises improve their innovation capacity, competitiveness, and performance.

• 벤처창업연구
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• 제9권6호
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• pp.199-212
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• 2014

최근 글로벌 기업들의 성공 혁신사례들에 대한 관심이 혁신의 원천인 DNA관점에서 접근이 진행되고 있다. 본 연구는 이러한 글로벌 대기업의 사례가 중소기업의 경영자 측면에서 적용되는가를 규명하고자 한다. 특히 중소기업의 혁신전략 관점에서 혁신DNA에 어떻게 작용하는가를 실증적으로 밝히는데 목적을 두었다. 실증연구는 대구경북 110개 기업으로부터 수집된 전반에 더 강하게 작용하는 것을 확인하였다. 실행DNA 또한 시장차별화 전략에 긍정적인 영향을 미치지만, 발견DNA와 동시에 고려할 때 제품차별화에 부정적인 영향을 미치는 것으로 나타났다. 하위 구성요소 측면에서는 발견DNA의 질문하기와 연자료를 통해서 실시하였다. 본 연구의 결과 혁신DNA는 혁신전략에 영향을 미치며, 특히 발견DNA가 실행DNA보다 혁신전략결하기가 혁신전략 전반에, 실행DNA의 분석하기는 시장차별화 전략에 긍정적인 영향을 미치나, 세부 업무 추진하기는 제품차별화에 부정적으로 작용하였다. 본 연구의 결과는 글로벌 성공기업 사례에서와 같이 중소기업 경영자의 혁신DNA의 논리가 전반적으로 적용될 수 있음을 확인하였으며, 중소기업의 혁신전략에 있어서 발견DNA의 중요성과 더불어 이를 제고하기 위한 학습노력이 중요하다는 것을 시사한다.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2022년도 추계학술대회
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• pp.34-34
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• 2022

Capacity building for bioinformatics could be achieved with the systematic training of research staff and higher degree students in the current best practices for analysis of data from 'omic-type experiments. It is anticipated that the KOICA-University of the Philippines Los Baños - International Rice Research Insitute Agricultural Genomics Research Center activities will focus on the use of next generation sequencing technology for genome sequencing and annotation, genome variant discovery for use in GWAS and QTL mapping, and transcriptome analysis of organisms important to agriculture and food security. Such activities require that researchers have high levels of knowledge and skills in bioinformatics in order to gain insights from the results of the experiments performed. In this talk the bioinformatic tools/solutions and online training materials already available will be presented, as well the upcoming resources under development in support of the project.

• Journal of Information Technology Applications and Management
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• 제27권5호
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• pp.35-47
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• 2020

Global waste has become a global issue and we can see the new trend of discovery businesses established to focus on solving the waste problem using new renewable energy technology and the circular economy business model. This paper aims to study factors that impact green entrepreneurship in Thailand, such as environmental concern, organizational environment, founder demographics, education background, entrepreneurship awareness, as well as external factors of a business. The study analyzes the data from three qualitative in-depth interviews with green entrepreneur founders who started the businesses in polymer up-cycling, waste management, and renewable energy. The study finds overseas educational background to be one of the key main drivers for the entrepreneurial courage to decide to pursue a new business venture. By having the exposure toward the different culture, three entrepreneurs hands-on experiential learning through three key drivers who are composed of the can-do attitude, the willingness to be self-employed, and the way of seeking for the freedom to express their passions.

• 대한의용생체공학회:의공학회지
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• 제42권3호
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• pp.125-142
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• 2021

The POCT (point-of-care test) sensing that has been a fast-developing field is expected to be a next generation technology in health care. The POCT sensors for the detection of proteins, small molecules and especially nucleic acids have lately attracted considerable attention. According to the World Health Organization (WHO), the POCT methods are required to follow the ASSURED guidelines (Affordable, Sensitive, Specific, User- friendly, Robust and rapid, Equipment-free, Deliverable to all people who need the test). Recently, several CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) based diagnostic techniques using the sensitive gene recognition function of CRISPR have been reported. CRISPR/Cas (Cas, CRISPR associated protein) systems based detection technology is the most innovative gene analysis technology that is following the ASSURED guidelines. It is being re-emerged as a powerful diagnostic tool that can detect nucleic acids due to its characteristics that enable rapid, sensitive and specific analyses of nucleic acid. The first CRISPR-based diagnosis begins with the discovery of the additional function of Cas13a. The enzymatic cleavage occurs when the conjugate of Cas protein and CRISPR RNA (crRNA) detect a specific complementary sequence of the target sequence. Enzymatic cleavage occurs on not only the target sequence, but also all surrounding non-target single-stranded RNAs. This discovery was immediately utilized as a biosensor, and numerous sensor studies using CRISPR have been reported since then. In this review, the concept of CRISPR, the characteristics of the Cas protein required for CRISPR diagnosis, the current research trends of CRISPR diagnostic technology, and some aspects to be improved in the future are covered.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
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• 제10권12호
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• pp.329-342
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• 2021

오랜 기간과 막대한 비용에도 성공 확률이 낮은 제약·바이오 산업의 생산성 위기를 해결하기 위한 전략으로 전 세계적으로 인공지능과 빅데이터를 활용하려는 사례가 증가하고 있고 가시적인 성과가 나오고 있지만 국내에서는 신약연구에 인공지능 플랫폼 도입에는 관망하는 상황이다. 본 연구는 신약개발을 지원하는 인공지능 플랫폼의 사용과 확산을 촉진하기 위해 도입 및 수용을 견인하는 지각된 가치와 변화에 대한 저항, 수용의도 관계를 검증할 가치기반수용모형과 혁신저항모형 결합 연구모형을 제시하였다. 인공지능 신약개발 플랫폼 사용의도의 연구모형은 지각된 편익으로 유용성, 지식풍부성을, 지각된 희생으로 복잡성, 알고리즘 불투명성을 채택하였고 지각된 가치, 혁신저항의 매개변수로 구성되었다. 실증 결과, 유용성, 지식풍부성, 복잡성, 인공지능 알고리즘의 불투명성이 지각된 가치에 유의미한 영향을 미치고, 유용성, 지식풍부성, 알고리즘의 불투명성, 시험가능성, 인공지능 기술지원환경이 플랫폼 도입에 따른 혁신저항에 유의미한 영향을 미치는 것으로 나타났다.

• 대한산업공학회지
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• 제40권5호
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• pp.442-450
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• 2014

Technology opportunity discovery (TOD) based on technological capability is a process which identifies new product and technology items that can be developed by utilizing or improving a firm's existing products or technologies. By taking into consideration the investment risk of R&D and its practicality, developing technological capability-based TOD methodology is considered to be important for both business and research. To this end, we propose a technological capability-based TOD method and its system using TOD knowledge base. The method can support four types of TOD cases, which are based on a firm's existing technologies and products, and TOD knowledge base is developed by using function information extracted from patent documents. In this paper, we introduce the overall framework of the method and provide application examples on the four TOD cases using the prototype system.