• 제목/요약/키워드: Discovery

검색결과 3,566건 처리시간 0.033초

Diaralkylthiourea Derivatives as a Novel Vanilloid Receptor Antagonist

  • Joo, Yung-Hyup;Kim, Jin-Kwan;Kim, Sun-Young;Choi, Jin-Kyu;Koh, Hyun-Ju;Jeong, Yeon-Su;Park, Young-Ho;Chung, Shin;Suh, Young-Ger;Oh, Uh-Taek;Park, Hyeung-Geun;Kim, Hee-Doo
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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    • pp.350.1-350.1
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    • 2002
  • A series of diaralkylthiourea derivatives was prepared and tested for its antagonistic activity against vanilloid receptor. In this study we explored the possibility of selected compound type (Ⅰ) with tetrahydronaphthyl group as rigid pendant moiety. Our premise for antagonistic activity of molecules was modeled on the capsazepine. the first antagonist for vanilloid receptor. These compounds (Ⅰ) showed less potent antagonistic activity than that of capsazepine. but they were devoid of agonistic activity. (omitted)

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Retrieval of Legal Information Through Discovery Layers: A Case Study Related to Indian Law Libraries

  • Kushwah, Shivpal Singh;Singh, Ritu
    • Journal of Information Science Theory and Practice
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    • 제4권3호
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    • pp.71-83
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    • 2016
  • Purpose. The purpose of this paper is to analyze and evaluate discovery layer search tools for retrieval of legal information in Indian law libraries. This paper covers current practices in legal information retrieval with special reference to Indian academic law libraries, and analyses its importance in the domain of law.Design/Methodology/Approach. A web survey and observational study method are used to collect the data. Data related to the discovery tools were collected using email and further discussion held with the discovery layer/ tool /product developers and their representatives.Findings. Results show that most of the Indian law libraries are subscribing to bundles of legal information resources such as Hein Online, JSTOR, LexisNexis Academic, Manupatra, Westlaw India, SCC web, AIR Online (CDROM), and so on. International legal and academic resources are compatible with discovery tools because they support various standards related to online publishing and dissemination such as OAI/PMH, Open URL, MARC21, and Z39.50, but Indian legal resources such as Manupatra, Air, and SCC are not compatible with the discovery layers. The central index is one of the important components in a discovery search interface, and discovery layer services/tools could be useful for Indian law libraries also if they can include multiple legal and academic resources in their central index. But present practices and observations reveal that discovery layers are not providing facility to cover legal information resources. Therefore, in the present form, discovery tools are not very useful; they are an incomplete and half solution for Indian libraries because all available Indian legal resources available in the law libraries are not covered.Originality/Value. Very limited research or published literature is available in the area of discovery layers and their compatibility with legal information resources.

시공간 지식탐사를 위한 3계층 프레임워크 (A 3-Layered Framework for Spatiotemporal Knowledge Discovery)

  • 이준욱;남광우;류근호
    • 한국정보과학회논문지:데이타베이스
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    • 제31권3호
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    • pp.205-218
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    • 2004
  • 시공간 데이타관리를 위한 데이타베이스 기술이 발전함에 따라 방대한 시공간 데이타 집합으로부터 의미 있는 시공간 지식 탐사를 필요로 하는 시공간 응용 서비스가 증대되고 있다. 이 논문에서는 시공간 지식 탐사 기법 개발을 지원하기 위하여 시공간 3계층 지식탐사 프레임워크를 제안하였다. 프레임 워크에서는 시공간 지식 탐사 문제 정의를 위한 기반 모델을 제시하여 시공간 지식에 대한 정의 및 관계를 표현할 수 있도록 하였다. 또한 시공간 지식 탐사 시스템의 구성요소 및 구현 모델을 제시하였다. 이 논문에서 제안한 시공간 지식 탐사를 위한 프레임워크는 앞으로 새로운 유형의 시공간 지식 탐사 기법 개발에 적용될 수 있는 특징을 포함하고 있다. 제안한 프레임워크는 시공간 이동 패턴과 같은 새로운 유형의 지식 탐사 기법 개발 지원에 있어 시공간 데이타 집합, 정보 및 지식에 대한 관계 규정과 각 요소에 대한 표현 모델을 제공함으로써 지식 탐사 문제를 형식화하고 단순화할 수 있다.

LTE-Advanced 네트워크에서 D2D 통신을 위한 특정 디바이스 탐색 기법 (Specific Device Discovery Method for D2D Communication as an Underlay to LTE-Advanced Networks)

  • 김향미;이한나;김상경
    • 한국IT서비스학회지
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    • 제13권1호
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    • pp.125-134
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    • 2014
  • Device discovery for D2D (device-to-device) communication enables a device to discover other devices in order to initiate communication with them. Devices should perform the discovery phase using a small quantity of radio resource in a short time and be able to reduce the load of the base station. Legacy device discovery schemes have focused on discovering as many target devices as possible. However, it is not appropriate for peer-to-peer D2D communication scenario. Further, synchronization problems are an important issue for discovery signal transmission. This paper proposes a discovery method that one requesting device discovers a specific target for communication. Multiple antenna beamforming is employed for the synchronization between the base station and a target device. The proposal can reduce the load of the base station using the information that it already maintains and improve the reliability of the device discovery because two times of synchronizations using beamforming among the base station and devices can make the exact discovery of a target device with mobility possible.

지능형 협업환경에서 서비스 발견을 위한 다중 에이전트 시스템 적용 방법 (Multi-agent-based approach for service discovery in smart meeting spaces)

  • 배창혁;한상우;김종원
    • 한국HCI학회:학술대회논문집
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    • 한국HCI학회 2008년도 학술대회 1부
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    • pp.669-673
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    • 2008
  • 지능형 협업환경에서 사용자가 원하는 서비스를 제공받기 위해 선행되어야 할 기술은 사용자가 원하는 협업기능 요구사항에 따라 협업환경 내 서비스들을 적절히 발견하는 서비스 발견(service discovery) 기술이다. 일반적인 서비스 발견과 관련하여, UPnP(universal plug & play) 의 SSDP(simple service discovery protocol)을 비롯한 여러 종류의 서비스 발견 기술이 존재하나, 지능형 협업환경이 요구하는 서비스 발견 특정을 만족시키기에는 일부 제약 사항이 존재한다. 이에 본 논문에서는 지능형 협업환경에서 제공되어야 하는 서비스 발견 기술의 요구사항을 살펴보고, 이를 만족하기 위한 방법으로써 다중 에이전트 시스템 (multi-agent system,, MAS)을 적용한 실용적인 서비스 발견 방법을 제시한다. 또한 지능형 협업환경의 일부 서비스에 제안된 방법을 적용하여, 본 접근방법의 타당성을 구현 결과를 통해 확인하고자 한다.

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A Framework for Developing interoperable Knowledge Discovery System

  • Li, Sheng-Tun;Shue, Li-Yen
    • 한국지능정보시스템학회:학술대회논문집
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    • 한국지능정보시스템학회 2001년도 The Pacific Aisan Confrence On Intelligent Systems 2001
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    • pp.435-440
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    • 2001
  • The development of web-aware knowledge discovery system has received a great deal of attention in recent years. It plays a key-enabling role for competitive businesses in the E-commerce era. One of the challenges in developing web-aware knowledge discovery systems is to integrate and coordinate and coordinate existing standalone or legacy knowledge discovery applications in a seamless manner, so that cost-effective systems can be developed without the need of costly proprietary products. In this paper, we present an approach for developing a framework of web-aware interoperable knowledge discovery system to achieve this purpose. This approach applies RMI and high-level code wrapper of Java distributed object computing to address the issues of interoperability in heterogeneous environments, which includes programming language, platform, and visual object model. The effectiveness of the proposed framework is demonstrated through the integration and extension of the two well-known standalone knowledge discovery tools, SOM_PAK and Nenet. It confirms that a variety of interoperable knowledge discovery systems can be constructed efficiently on the basis of the framework to meet various requirements of knowledge discovery tasks.

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Discovery Layer in Library Retrieval: VuFind as an Open Source Service for Academic Libraries in Developing Countries

  • Roy, Bijan Kumar;Mukhopadhyay, Parthasarathi;Biswas, Anirban
    • Journal of Information Science Theory and Practice
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    • 제10권4호
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    • pp.3-22
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    • 2022
  • This paper provides an overview of the emergence of resource discovery systems and services, along with their advantages, best practices, and current landscapes. It outlines some of the key services and functionalities of a comprehensive discovery model suitable for academic libraries in developing countries. The proposed model (VuFind as a discovery tool) performs like other existing web-scale resource discovery systems, both commercial and open-source, and is capable of providing information resources from different sources in a single-window search interface. The objective of the paper is to provide seamless access to globally distributed subscribed as well as open access resources through its discovery interface, based on a unified index. This model uses Koha, DSpace, and Greenstone as back-ends and VuFind as a discovery layer in the front-end and has also integrated many enhanced search features like Bento-box search, Geodetic search, and full-text search (using Apache Tika). The goal of this paper is to provide the academic community with a one-stop shop for better utilising and integrating heterogeneous bibliographic data sources with VuFind (https://vufind.org/vufind).

The Predictive QSAR Model for hERG Inhibitors Using Bayesian and Random Forest Classification Method

  • Kim, Jun-Hyoung;Chae, Chong-Hak;Kang, Shin-Myung;Lee, Joo-Yon;Lee, Gil-Nam;Hwang, Soon-Hee;Kang, Nam-Sook
    • Bulletin of the Korean Chemical Society
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    • 제32권4호
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    • pp.1237-1240
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    • 2011
  • In this study, we have developed a ligand-based in-silico prediction model to classify chemical structures into hERG blockers using Bayesian and random forest modeling methods. These models were built based on patch clamp experimental results. The findings presented in this work indicate that Laplacian-modified naive Bayesian classification with diverse selection is useful for predicting hERG inhibitors when a large data set is not obtained.