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Effects of Soaansintang(SOAT) on the hemodynamics and electrocardiogram of isolated rat hearts induced by electrical stimulation (소아안신탕(小兒安神湯)이 STRESS를 유발한 흰쥐의 적출심장(摘出心臟)에 미치는 영향)

  • Lee Seung-Jun;Lee Jin-Yong;Kim Deok-Gon
    • The Journal of Pediatrics of Korean Medicine
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    • v.14 no.2
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    • pp.1-32
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    • 2000
  • It has long been known that SOAT is effective for sudden palpitation occurring unexpectedly in Oriental Medicine. However, effect of SOAT on the isolated heart has not been studied yet. The purpose of this study is to investigate the effect of SOAT on hemodynamics and ECG of isolated rat hearts induced by electrical stimulation using Langendorff perfusion apparatus for nonworking heart. SOAT extract was manufactured by water-alcohol precipitated method. Sprague-Dawley rats weighting $120{\sim}150g$ were used for the experiments, Subject animals were divided into four groups, which are consisted of 1) control(Group orally administered by normal saline 1ml for 14days), 2) sample A(Group orally administered by SOAT extract 1ml for 14days), 3) sample C(Group injected by SOAT extract 0.5ml after stimulation, 4) sample C(Group injected by SOAT extract 1ml after stimulation. To evluate the effects of SOAT on hemodynamics and ECG of isolated rat heart induced by stimulation, heart rate, left ventricular pressure, systolic power, diastolic power, coronary artery perfusion volume and ECG were measured using Langendorff apparatus in both stimulation mode(5 volts, 450 beats/min) and arrythmic mode(5 volts, 420 beats/min including 60 beats/min) The results obtained are as follows : 1. After receiving stressful electrical stimuli, isolated heart showed the heart rate, left ventricular pressure, systolic power, diastolic power, coronary artery perfusion volume were all decreased temporarily, but perfusion continued longer recovery to the control state appeared. However, the coronary artery perfusion volume diminished continuously. 2. The heart rates did not change significantly with both stimulation mode and arrhythmic mode, among experimental groups. 3. The left ventricular pressure showed with both stimulation mode and arrhythmic mode, the significant changes(p<0.05) especially in the injection sample group. In case of stimulation mode, low concentration injection group(0.5ml) was more significantly increased rather than high concentration group(1ml) and in case of arrhythmic mode, high density group(1ml) was so increased than the other(0.5ml). 4. For the systolic power and diastolic power, no significant changes were noticed in the stimulation mode, but in the arrhythmic mode of injection sample groups, significant change(p<0.05) was noticed in both systolic power and diastolic power. Specially the high concentration group(1ml) showed more significant increase than the low concentration group. 5. For the coronary artery perfusion volume, no significant change difference among sample groups was observed in both the stimulation mode and the arrhythmic mode. 6. For the ECG recordings, arrhythmia was induced by electrical stimulus of arrythmia mode and after the stimulus was removed, irregular wave appeared temporarily, but as perpusion continued, recovery to the control state was abtained like the stimulation mode. According to the above results, SOAT significantly changed the hemodynamic data from the electrically stressed, isolated hearts of connected Langendorff perfusion apparatus and we propose SOAT has the direct effects on the muscular function of heart.

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The Study on Wound Healing in Rabbit Skins by Low-intensity Laser Irradiation (저강도 레이저 조사에 의한 가토 피부의 상처 치유에 관한 연구)

  • 김식현;전진석
    • Biomedical Science Letters
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    • v.6 no.2
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    • pp.119-129
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    • 2000
  • The skin is an organ that has many important roles, including protection against infection, regulation of temperature and fluid loss, and sensory function. Injury to the skin, wound repair normally involves: (1) balanced activity of inflammation, (2) the re-epithelial phase and (3) the matrix formation of remodeling phase. Thus, skin wound healing is a finely controlled biological process involving a series of complex cellular interactions. Laser therapy is being implemented with increasing frequency in medicine. Low intensity laser is one that is capable of producing an energy density so low that any biologic alterations are the result of direct irradiation effect, not thermal events. This study was designed to evaluate the efficacy of low intensity laser therapy on skin wound healing in rabbits. A total of 10 male rabbits (New Zealand White Rabbit), age 8 weeks were used. Skin wound were surgically created dorso-lateral on the flank of 10 rabbits (2$\times$2 cm/damage areas). The experimental animals were treated with 5Hz (830 nm wave length) low-intensity laser (MILTA-01 Model) daily for 10 min (1.6 J/$cm^2$) for 12 days. Control animals were sham treated with the laser head. Laser irradiation animals showed a complete remodeling of the epithelial layer, a positive repair of connective tissues, and enhanced the wound closure rate over time as compared to the control animals. Especially, laser irradiation groups improved fibroblast activity, cellular content, granulation tissue formation, and collagen deposition which is resulted in improving the tensile strength of the wound. These findings suggest that laser photostimulation could accelerate healing of open wound in rabbits, and may be benefit in the treatment of open wound, including decubitis ulcers.

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Optimal Design of Generalized Process-storage Network Applicable To Polymer Processes (고분자 공정에 적용할 수 있는 일반화된 공정-저장조 망구조 최적설계)

  • Yi, Gyeongbeom;Lee, Euy-Soo
    • Korean Chemical Engineering Research
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    • v.45 no.3
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    • pp.249-257
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    • 2007
  • The periodic square wave (PSW) model was successfully applied to the optimal design of a batch-storage network. The network structure can cover any type of batch production, distribution and inventory system, including recycle streams. Here we extend the coverage of the PSW model to multitasking semi-continuous processes as well as pure continuous and batch processes. In previous solutions obtained using the PSW model, the feedstock composition and product yield were treated as known constants. This constraint is relaxed in the present work, which treats the feedstock composition and product yield as free variables to be optimized. This modification makes it possible to deal with the pooling problem commonly encountered in oil refinery processes. Despite the greater complexity that arises when the feedstock composition and product yield are free variables, the PSW model still gives analytic lot sizing equations. The ability of the proposed method to determine the optimal plant design is demonstrated through the example of a high density polyethylene (HDPE) plant. Based on the analytical optimality results, we propose a practical process optimality measure that can be used for any kind of process. This measure facilitates direct comparison of the performance of multiple processes, and hence is a useful tool for diagnosing the status of process systems. The result that the cost of a process is proportional to the square root of average flow rate is similar to the well-known six-tenths factor rule in plant design.

Downtime Analysis for Pohang New Harbor through Long-term Investigation of Waves and Winds (장기간 파.바람 조사를 통한 포항신항의 하역중단 원인 분석)

  • Jeong, Weon-Mu;Ryu, Kyong-Ho;Baek, Won-Dae;Choi, Hyuk-Jin
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.23 no.3
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    • pp.226-235
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    • 2011
  • Field measurements of the winds and waves were carried out for one year at multiple locations inside and outside of the Pohang New Harbor in order to clarify the reason of downtimes frequently occurring at most of the harbor quays and to establish an efficient countermeasure. In addition, the downtime records of the quays and precipitation data provided by Korea Meteorological Agency were acquired for mutual comparison and comprehensive analysis of the cause of downtimes. Except the influence of precipitation, it was found that the downtimes occurred when the height of waves entering into the harbor incurred by either one of swell, wind seas, or mixture of both, exceeded a threshold. The seiche whose period ranges from 5 to 80 minutes, which was suspected as a possible cause of the downtimes, is shown to have no direct relation with the downtimes. Meanwhile, the height of far-infra-gravity waves whose period ranges between 0.5 and 3 minutes, propagating to the harbor mouth forced by short period waves, showed almost proportional relationship with the height of short period waves. Based on the result of this study, it is concluded that the downtime problems of Pohang New Harbor can be greatly improved by effectively preventing the entrance of short period waves such as swell or wind seas.

Classification by Erosion Shapes and Estimation of Sea-cliff Erosion Rates through Field Survey in Dundu-ri, Anmyeondo in Korea's Western Coast (현장 조사를 통한 안면도 둔두리 해식애의 침식율 산정 및 침식형태 분류)

  • KIM, Jang-soo;JANG, Dong-Ho
    • Journal of The Geomorphological Association of Korea
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    • v.20 no.3
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    • pp.41-53
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    • 2013
  • This research was carried out to classify erosion shapes and sea-cliff erosion rates were estimated through periodic field survey in Dundu-ri, Anmyeondo. Based on the results of field measurements using the datum-point, the annual sea-cliff erosion rate was estimated about 25~102cm/yr by point. The erosion rate gradually increases from spring to summer, but tends to decrease slightly in autumn. Specifically, the erosion rate between June and July indicated a rather decreasing trend, but showed a sharp increase between July and September. This was attributed to erosion that proceeds more rapidly than during other periods due to severe rainstorms in summer that had a direct impact on the study area as well as storm surges caused by hurricanes. Afterwards, the sea-cliff erosion rate gradually decreased in autumn, but reflected an increasing trend again from December to January. This was attributed to the mechanical weathering that actively progresses as bed rocks on the sea-cliff undergo repeated freezing and thawing in winter. The seacliff in Dundu-ri is divided into three types according to the erosion shape. First, Type A is observed in the sea-cliff composed of the same bed rocks and hard rock stratum. Second, Type B is found in the sea-cliff with a relatively gentler slope compared to Type A, since weathering material including soil is formed on the surface of the sea-cliff consisting of the same bed rocks and hard rock stratum. Lastly, Type C is observed in the sea-cliff where hard rock stratum is mixed with soft rock stratum. In this case, the soft rock stratum slumps and erodes first by precipitation and wave energy, followed by additional slumping of the exposed hard rock stratum.

Lifestyles of Korean Older Adults - Focusing on the consumption pattern and its determinants - (한국노인의 생활양식 분석 : 소비패턴과 그 결정요인을 중심으로)

  • Lee, So-Chung
    • Korean Journal of Social Welfare Studies
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    • v.40 no.3
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    • pp.327-348
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    • 2009
  • The purpose of this study is to understand the diverse lifestyles of Korean older adults by analyzing the consumption pattern of older households and its determinants. The 9th wave of the Korea Labor and Income Panel Study(KLIPS) data was used for analysis. The twenty consumption items provided by the dataset was reduced to thirteen according to the consumption purpose inherent in the item. K-means cluster analysis and multinomial logistic regression was employed to categorize the consumption pattern of older households and to analyze the determinants. The results are as follows. The consumption pattern of Korean older adults was clustered into six distinctive groups named Breadwinner, Leisure-time pursuer, Friendly outgoes, Daily-life survivor, Illness sufferer and Shelter seeker. Breadwinner, Leisure-time pursuer and Friendly outgoes were lifestyles that earn and spend more compared to the other three. Nevertheless, they differed according to the family size, indicating that the parenting burden might have direct influence on the lifestyle of Korean older adults. Older adults without parenting burden and with high level of education and economic capacity were likely to show Friendly outgoes lifestyle. On the other hand, Daily-life survivor, Illness sufferer and Shelter seeker showed lower level of spending, indicating that for those lacking in economic capacity, urgent needs such as medical need or housing need dominates the lifestyle. The results call for adequate custom policies that best fit the needs of older adults.

The effect of parental rearing behavior on self-esteem and gender role Stereotypes in Adolescents: Mediating effect of self-esteem -The use of Latent Growth Model-

  • Ju, Sunyoung
    • Journal of the Korea Society of Computer and Information
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    • v.24 no.6
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    • pp.189-197
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    • 2019
  • The purpose of this study was to investigate about the effects of parental rearing behavior on self-esteem and gender role stereotype during adolescence and to reveal the mediating effect of self-esteem on adolescents' gender role strerotype. Also investigated the relationship among these variables and condition variables. For this purpose, used the Second Grade longitudianl Panel data of Middle School from the Korea Youth Panel Survay(KYPS). And the latent growth model was analyzed 3,449 men and women adolescents' cases of the first, the fourth and the sixth wave of the Korea Youth Panel Survey(KYPS) administered by Korea Institute for Youth development. And the structural equation model was used to investigate whether self-esteem mediates parental rearing behavior and male and female gender role Strerotype. The results of this study, the direct effect between variable factors showed that the more positive the parenting behavior of the second grader of middle school is, the more positive the self-esteem of male adolescents and the initial value of stereotypes of male gender role. It also affects the self-esteem of female adolescents and stereotypes of female gender roles but not statistically significant. The male gender role stereotypes were decreased in influence by the rate of change of parental rearing behaviors, and the initial value and the rate of change of self-esteem were statistically influenced to the male gender role stereotypes and the higher the self-esteem, the higher the self-esteem. However, there was no significant effect on stereotypes of female gender roles. As a result of analyzing the mediating effect of self-esteem, partially mediated between the initial value of parental rearing behavior and initial stereotype of male gender role, but there was no longitudinal mediation effect. There was no mediating effect of self-esteem between parental rearing behaviors and stereotypes of female gender roles and there was no longitudinal mediation effect. The effect of condition variable gender was found that female adolescents are more affected by paretal rearing behavior than male adolescents and also affected by the growth process. The monthly income of households influenced the initial value of parental rearing behaviors and showed a difference in parental rearing behavior according to household income. And the higher the mother 's educational level, the more the self-esteem of male adolescents was affected.

Exploring the Latent Classes in Students' Executive Function Difficulty by Mother and Teacher: Multivariate Analysis across School Adaption and Academic Performance (초등학생의 집행기능곤란에 대한 어머니와 담임교사 평정에 따른 잠재집단 탐색 및 학교적응, 학업수행 차이 검증)

  • Yeon, Eun Mo;Choi, Hyo-Sik
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.6
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    • pp.38-47
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    • 2019
  • The purpose of this study was to identify latent classes in executive function difficulty of first graders depends on evaluations from their mother and teacher and to investigate how its related with their school adaption and academic performance in second grade. Based on the model of the latent profile analysis, the 8th and 9th wave data from Korean Children and Youth Panel Survey were analyzed. The results of this study were as following. First, results showed that there were three types of latent classes in the executive function difficulty depend on evaluations from their mother and teacher: 'low executive function,' 'students who were highly evaluated by mother,' and 'students who were highly evaluated by teacher.' Second, students' executive function difficulty had a direct effect on the students' school adaption and academic performance in their second year of school. Especially students who were evaluated as having the lowest executive function difficulty showed significant higher means than students who were evaluated higher by mother and teacher. This study emphasized the importance of multiple evaluation in students' executive function difficulty to provide an educational intervention.

The Effect of the Transmission of Coronavirus Disease-2019 on the Mentality of Parents and Children After the First Wave of Infections (1차 확산기 이후 코로나바이러스감염증-2019의 전파가 부모와 아동의 심리에 미치는 영향)

  • Kim, Jeongyeon;Lee, Koeun;Nam, Okhyung;Lee, Hyo-seol;Choi, Sungchul;Kim, Kwangchul;Kim, Misun
    • Journal of the korean academy of Pediatric Dentistry
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    • v.48 no.3
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    • pp.269-279
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    • 2021
  • The purpose of this study is to evaluate the effect of the spread of a new type of coronavirus infection (COVID-19) on the mental state in school-age children and parents focusing on the aspects of sleep disorders and depression. A questionnaire survey was conducted for 123 parents and 108 school-age children who visited Department of Pediatric Dentistry, Kyung Hee University Dental Hospital at Gangdong from April 2, 2020 through April 25, 2020, via the direct writing method. Participants were assessed with Pittsburgh Sleep Quality Index, Generalized Anxiety Disorder (GAD)-7, Center for Epidemiology Scale for Depression. Logistic regressions were used with a level of significance of 5%. The prevalence of GAD, depression, and poor sleep in parents were 34.1%, 17.1% and 44.7%, respectively. The prevalence of GAD in children was 20.4%. Logistic regression showed that stress from Emergency Alert Messages about COVID-19 was associated with GAD and depression in parents. In children, the degree of emotional change after COVID-19 was associated with GAD. This study confirmed that there was a change in the psychological status of children and guardians due to the epidemic of coronavirus disease-2019, and it would be necessary to consider their psychological status during dental treatment.

Precariousness and Happiness of South Korean Young Adults: The Mediating Effects of Uncertainty and Disempowerment (한국 청년의 삶의 불안정성(precariousness)과 행복: 불확실성과 통제권한 부재의 매개효과)

  • Han, Seungheon;Yim, Dahye;Kang, Minah
    • 한국사회정책
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    • v.24 no.2
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    • pp.87-126
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    • 2017
  • This study aims to examine the level of precariousness among young adults in South Korea and analyze the factors affecting their subjective well-being by adopting the three forms of precariousness suggested by Rodgers(1989) such as lack of resource, uncertainty and disempowerment as its analytical framework. Structural Equation Model was used for analyzing the path model of self-rated health, income level and social support(three forms of resource) affecting subjective wellbeing through uncertainty and disempowerment. Study population include young adults aged between 19 to 34 with a sample size of 415 using data of the 8th wave of the Korean General Social Survey(KGSS), 2010. Study population is divided into lower-age group (aged between 19-26) and upper-age group (aged between 27-34) in order to examine the differences between age groups by using Multiple Group Analysis. Study results show that three forms of resources, uncertainty and disempowerment had direct effect on the subjective well-being of South Korean young adults and disempowerment had the most significant effect among the factors. In addition, self-rated health and income level had indirect effect on subjective well-being through both uncertainty and disempowerment while social support had indirect effect on subjective well-being only through disempowerment. Results from the Multiple Group Analysis indicate that among the two age groups, income level only has a significant effect on subjective well-being in the upper-age group. In addition, disempowerment had greater effect on subjective wellbeing among upper-age group than the lower-age group. Based on the study results, this paper suggested policy implications and discussion for further research.