• The Journal of Korean Society for Radiation Therapy
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• v.23 no.1
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• pp.59-66
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• 2011

Purpose: Investigation of the clinical use of tangential fields technique using TOMO direct in comparison to conventional LINAC based radiation therapy after breast partial mastectomy. Materials and Methods: Treatment plans were created for 3 left-sided breast cancer patients who had radiation therapy after breast partial mastectomy by using wedged tangential fields technique, field in field technique (FIF), TOMO Direct, TOMO Direct intensity modulated radiation therapy (IMRT) under the normalized prescription condition ($D_{90%}$: 50.4 Gy/28 fx within CTV). Dose volume histogram (DVH) and isodose curve were used to evaluate the dose to the clinical target volume (CTV), organ at risk (OAR). We compared and analyzed dosimetric parameters of CTV and OAR. Dosimetric parameters of CTV are $D_{99}$, $D_{95}$, Dose homogeneity index (DHI: $D_{10}/D_{90}$) and $V_{105}$, $V_{110}$. And dosimetric parameters of OAR are $V_{10}$, $V_{20}$, $V_{30}$, $V_{40}$ of the heart and $V_{10}$, $V_{20}$, $V_{30}$ of left lung. Results: Dosimetric results of CTV, the average value of $D_{99}$, $D_{95}$ were $47.7{\pm}1.1Gy$, $49.4{\pm}0.1Gy$ from wedged tangential fields technique (W) and FIF (F) were $47.1{\pm}0.6Gy$, $49.2{\pm}0.4Gy$. And it was $49.2{\pm}0.4$ vs. $48.6{\pm}0.8Gy$, $49.9{\pm}0.4$ vs. $49.5{\pm}0.3Gy$ Gy for the TOMO Direct (D) and TOMO Direct IMRT (I). The average value of dose homogeneity index was W: $1.1{\pm}0.02$, F: $1.07{\pm}0.02$, D: $1.03{\pm}0.001$, I: $1.05{\pm}0.02$. When we compared the average value of $V_{105}$, $V_{110}$ using each technique, it was the highest as $34.6{\pm}9.3%$, $7.5{\pm}7.9%$ for wedged tangential fields technique and the value dropped for FIF as $16.5{\pm}14.8%$, $2.1{\pm}3.5%$, TOMO direct IMRT as $7.5{\pm}8.3%$, $0.1{\pm}0.1%$ and the TOMO direct showed the lowest values for both as 0%. Dosimetric results of OAR was no significant difference among each technique. Conclusion: TOMO direct provides improved target dose homogeneity over wedged tangential field technique. It is no increase the amount of normal tissue volumes receiving low doses, as oppose to IMRT or Helical TOMO IMRT. Also, it simply performs treatment plan procedure than FIF. TOMO Direct is a clinical useful technique for breast cancer patients after partial mastectomy.

• Journal of Radiation Protection and Research
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• v.41 no.4
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• pp.384-388
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• 2016

Background: For a verification of newly-developed neutron absorbers, one of guidelines on the qualification and acceptance of neutron absorbers is the neutron attenuation test. However, this approach can cause a problem for the qualifications that it cannot distinguish how the neutron attenuates from materials. Materials and Methods: In this study, an estimation method of neutron absorption performances for materials is proposed to detect both direct penetration and back-scattering neutrons. For the verification of the proposed method, MCNP simulations with the experimental system designed in this study were pursued using the polyethylene, iron, normal glass and the vitrified form. Results and Discussion: The results show that it can easily test neutron absorption ability using single absorber model. Also, from simulation results of single absorber and double absorbers model, it is verified that the proposed method can evaluate not only the direct thermal neutrons passing through materials, but also the scattered neutrons reflected to the materials. Therefore, the neutron absorption performances can be accurately estimated using the proposed method comparing with the conventional neutron attenuation test. Conclusion: It is expected that the proposed method can contribute to increase the reliability of the performance of neutron absorbers.

• Journal of the Korean Solar Energy Society
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• v.21 no.1
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• pp.43-49
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• 2001

Informations of the solar radiation component are essential for modeling various solar energy systems. These Informations are particularly used for middle and high temperature applications, those need concentrating direct normal insolation. In order to estimate the performance of concentrating systems, it is necessary to know the intensity of the beam radiation, as only this component can be concentrated. The Korea Institute of Energy Research(KIER) has began collecting solar radiation component data since August, 1996. KIER's component data will be extensively used by concentrating system users or designers as well as by research institutes.

• Journal of Radiation Industry
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• v.17 no.4
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• pp.509-518
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• 2023

The Kori Unit 1 nuclear power plant, which is planned to be dismantled after permanent shutdown, is expected to generate a large amount of various types of radioactive waste during the dismantling process. For the disposal of Very-low-level waste, which is expected to account for the largest amount of generation, the Korea Radioactive waste Agency (KORAD) is in the process of detailed design to build a 3-phase landfill disposal facility in Gyeongju. In addition, a large container is being developed to efficiently dispose of metal and concrete waste, which are mainly generated as Very low-level waste of decommissioning. In this study, based on the design characteristics of the 3-phase landfill disposal facility and the large container under development, radiation exposure dose evaluation was performed considering the normal and accident scenarios of radiation workers during operation. The direct exposure dose evaluation of workers during normal operation was performed using the MCNP computer program, and the internal and external exposure dose evaluation due to damage to the decommissioning waste package during a drop accident was performed based on the evaluation method of ICRP. For the assumed scenario, the exposure dose of worker was calculated to determine whether the exposure dose standards in the domestic nuclear safety act were satisfied. As a result of the evaluation, it was confirmed that the result was quite low, and the result that satisfied the standard limit was confirmed, and the radiational disposal suitability for the 3-phase landfill disposal facility of the large container for dismantled radioactive waste, which is currently under development, was confirmed.

• Molecules and Cells
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• v.38 no.4
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• pp.327-335
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• 2015

Piperlongumine, a natural alkaloid isolated from the long pepper, selectively increases reactive oxygen species production and apoptotic cell death in cancer cells but not in normal cells. However, the molecular mechanism underlying piperlongumine-induced selective killing of cancer cells remains unclear. In the present study, we observed that human breast cancer MCF-7 cells are sensitive to piperlongumine-induced apoptosis relative to human MCF-10A breast epithelial cells. Interestingly, this opposing effect of piperlongumine appears to be mediated by heme oxygenase-1 (HO-1). Piperlongumine upregulated HO-1 expression through the activation of nuclear factor-erythroid-2-related factor-2 (Nrf2) signaling in both MCF-7 and MCF-10A cells. However, knockdown of HO-1 expression and pharmacological inhibition of its activity abolished the ability of piperlongumine to induce apoptosis in MCF-7 cells, whereas those promoted apoptosis in MCF-10A cells, indicating that HO-1 has anti-tumor functions in cancer cells but cytoprotective functions in normal cells. Moreover, it was found that piperlongumine-induced Nrf2 activation, HO-1 expression and cancer cell apoptosis are not dependent on the generation of reactive oxygen species. Instead, piperlongumine, which bears electrophilic ${\alpha},{\beta}$-unsaturated carbonyl groups, appears to inactivate Kelch-like ECH-associated protein-1 (Keap1) through thiol modification, thereby activating the Nrf2/HO-1 pathway and subsequently upregulating HO-1 expression, which accounts for piperlongumine-induced apoptosis in cancer cells. Taken together, these findings suggest that direct interaction of piperlongumine with Keap1 leads to the upregulation of Nrf2-mediated HO-1 expression, and HO-1 determines the differential response of breast normal cells and cancer cells to piperlongumine.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1997.04a
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• pp.701-708
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• 1997

A direct boundary element method(DBEM) is developed for thin bodies whose surfaces are rigid or compliant. Th eHelmholtz integral equation and its normal derivative integral equation are adopted simultaneously to calculate the pressure on both sides of the thin body, instead of the jump values across it, to account for the different surface conditions of each side. Unlike the usual assumption, the normal velocity is assumed to be discontinuous across the thin body. In this approach, only the neutral surface of the thin body has to be discontinuous across the thin body. In this approach, only the neural surface of the thin body has to be discretized. The method is validated by comparison with analytic and/or numerical results for acoustic scattering and radiation from several surface conditions of the thin body; the surfaces are rigid when stationary or vibrating, and part of the interior surface is lined with a sound-absorbing material.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.20 no.4
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• pp.511-521
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• 2022

Decommissioning of nuclear power plants generates a large amount of radioactive waste in a short period. Moreover, Radioactive waste has various forms including a large volumes of metal, concrete, and solid waste. The disposal of decommissioning waste using 200 L drums is inefficient in terms of economics, work efficiency, and radiation safety. Therefore, The Korea Radioactive Waste Agency is developing large containers for the packaging, transportation, and disposal of decommissioning waste. Assessing disposability considering the characteristics of the radioactive waste and facility, convenience of operation, and safety of workers is necessary. In this study, the exposure dose rate of workers during the disposal of new containers was evaluated using Monte Carlo N-Particle Transport code. Six normal and four abnormal scenarios were derived for the assessment of the dose rate in a near surface disposal facility operation. The results showed that the calculated dose rates in all normal scenarios were lower than the direct exposure dose limitation of workers in the safety analysis report. In abnormal scenarios, the work hours with dose rates below 20 mSv·y^-1 were calculated. The results of this study will be useful in establishing the optimal radiation work conditions.

• 한국태양에너지학회:학술대회논문집
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• 2008.11a
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• pp.161-166
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• 2008

The major purpose of this paper is to develop an uncertainty estimate for the calibration of thermopile instruments used to measure solar radiation parameters. We briefly describe the solar radiation parameters most often measured, instrumentation, reference standards, and calibration techniques. The bulk of the paper describes elemental sources of error and their magnitude. We then apply a standard error analysis methodology to combine these elemental error estimates into a statement of total uncertainty for the instrument calibration factor. Our results allow one to evaluate the accuracy of a radiometric measurement using thermopile instrumentation in the light of the application, such as engineering test evaluation or for validation of theoretical models.

• Journal of the Korean Solar Energy Society
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• v.30 no.2
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• pp.81-86
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• 2010

Since the solar energy resource is the main input for sizing any solar photovoltaic system and solar thermal power system, it is essential to utilize the solar radiation data as a application and development of solar energy system increase. It will be necessary to understand and evaluate the insolation data. The Korea Institute of Energy Research(KIER) has begun collecting horizontal global insolation data since May, 1982 and direct normal insolation data since December 1992 at 16 different locations in Korea. Because of a poor reliability of existing data, KIER's new data will be extensively used by solar energy system users as well as by research institutes. From the results, the yearly averaged horizontal global insolation was turned out 3.60kWh/$m^2$/day and a significant difference of horizontal global insolation is observed between 1982~1990 and 1991~1999, 2000~2008 through 16 different cities in Korea.

• Radiation Oncology Journal
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• v.1 no.1
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• pp.103-109
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• 1983

47 out of 56 cases of intact uterine cervix cancer treated by radiation at the Hanyang University Hospital were followed 18 months or more after treatment. (7 patients died before 18 months, 2 cases lost to follow-up). Age distribution reveal 5 cases in 30's, 18 cases in 40's, 17 cases in 50's, 7 cases in 60's. Histologically, all cases were squamous cell type except one case of adenocarcinoma. 1. 45 cases were treated by combined external Co-60 irradiation and intracavitary irradiation by Cs-137 small sources. 1 case was treated by external irradiation only, and 1 case by intracavitary only. 2. Rectal injuries were observed in 13 cased (27.6%), 4 cases in Grade 1, 8 cased in Grade 2 and 1 cases in Grade 3 which needed surgical management. 3. Average intervals of rectal injury following treatment was 9.2 months varying from 5 to 15 months. 4. Relation between rectal injury and point A dose reveal 6 cases between 7000-7999 rad and 6 cases between 8000-8999 rad and 1 case above 9000 rad. Even though there is no direct relation between point A dose and rectal injury, it is expected that rectal injury increases as point A dose increase. 5. In the normal condition, rectal injury can't be attributed to one major cause. Radiation dose, small source distribution, general condition of patients, local anatomy of the individual patient, history of PID and previous surgery, all play complex roles.