• The Journal of Internal Korean Medicine
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• v.42 no.5
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• pp.923-930
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• 2021

Objectives: The purpose of this study was to examine the effect of combined Korean medical treatment on chronic headache with digestive symptoms. Methods: We collected data from October to December 2020 and evaluated the efficacy of combined Korean medical treatment using the Korean Headache Impact Test-g (KHIT-6), European Quality of Life Five Dimensions (EQ5D) Scale, and Numerical Rating Scale (NRS) at admission, after two weeks of hospitalization, and on discharge. Results: At the end of treatment, the patient had increased EQ5D and reduced KHIT-6 and NRS scores. Conclusions: After the combined Korean medical treatment, the patient showed improvement, suggesting the efficacy of treatment.

• 대한상한금궤의학회지
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• v.14 no.1
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• pp.51-68
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• 2022

Objectives : Osuyu-tang of Shanghanlun have historically been proved for clinical validity and stability in the Korean Medicine. It is necessary to review the clinical fields of application, and to review the conformity with the old texts. Methods : As of October 20, 2022, clinical research papers on Osuyu-tang were searched in RISS, Naver, KISS, PUBMED, and Science Direct. The searched articles were classified by clinical subject, and the contents were reviewed by year. Results : As of Oct 20, 2022, the present study looked up thirteen papers. The 13 clinical research papers could be classified into 6 chronic headaches which includes migraine, 2 digestive diseases, 5 skin diseases and 1 restless leg syndrome by subject. Conclusion : As a result of analyzing 13 papers, clinical research achievements on the nervous system and digestive system diseases implied by the provisions in Shanghanlun were accumulating. However, case-level reports on skin diseases require more advanced research in the future.

• The Journal of Pediatrics of Korean Medicine
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• v.30 no.1
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• pp.45-58
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• 2016

Objectives The purpose of this study is to investigate about chief complaints of Korean pediatrics and adolescent outpatients in the ${\bigcirc}{\bigcirc}$ university hospital for their recent trend. Methods The study was composed of 4,677 new patients aged between 1 month and 20 years who had been visited pediatrics in ${\bigcirc}{\bigcirc}$ university hospital from 2012 January to 2015 December. Results 1. Among those patients, majority was early childhood as 51.4%, followed by early childhood, late childhood, infancy, and adolescence. 2. Chief complaints in this population have been recorded in the fall the most as 29.6%, but the distribution was inconsistent. 3. To categorize, digestive-related chief complaints were the highest as 30.6%, followed by respiratory, supplemental use, growth, psychiatrics. Respiratory-related chief complaints increased dramatically in the fall. 4. In infancy and early childhood, digestive/respiratory complaints were common, whereas, growth complaints were common in late childhood and adolescence. 5. Digestive/respiratory complaints have been over 50% out of all chief complaints annually. Psychiatric and growth-related complaints have been trending up, whereas, supplemental/skin complaints have decreased every year. 6. Specifically, anorexia were the most common in digestive complaints, and rhinitis/sinusitis were top among respiratory complaints. Precocious puberty and developmental disability increased every year. Conclusions The most common chief complaints were digestive and respiratory-related, and precocious puberty and growth issues have been trending up lately. Based on this result, more studies that targets precocious puberty and growth problems are needed.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.1
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• pp.140-151
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• 2014

Objectives: Cold hypersensitivity has been regarded to be associated with digestive function. This study is aims to evaluate the correlation between digestive function and coldness of hands. Methods: We made a research of 80 women who is in ${\bigcirc}{\bigcirc}$ University. The patients were subjected to thermometer, and those with thermal difference between upper arm and palm were diagnosed with cold hypersensitivity. The patients were divided into two group by cold hypersensitivity group (n=20), and non-cold hypersensitivity group (n=19), and 39 women are mesured by Nepean dyspepsia index-Korean version (NDI-K) to evaluate the severity of functional dyspepsia. Results: There was no difference between two groups on age, height, weight. In functional dyspepsia symptom score, 6 symptoms (Pain in upper abdomen, Burning in upper abdomen, Cramps in upper abdomen, Pressure in upper abdomen, Vomiting, Bad breath) out of 15 were significantly increased in cold hypersensitivity group compared with non-cold hypersensitivity group. And in quality of life score, 3 domains (Tension/sleep, Interference with daily activities, Knowledge/control) out of 5, and total quality of life score were significantly decreased in cold hypersensitivity group compared with non-cold hypersensitivity group. Conclusions: This study shows the correlation between cold hypersensitivity and digestive function.

• Clinical Endoscopy
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• v.56 no.1
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• pp.38-49
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• 2023

Background/Aims: Patients with Barrett's esophagus are at increased risk of developing esophageal adenocarcinoma. Endoscopic therapies aim to eradicate dysplastic and metaplastic tissues. Hybrid argon plasma coagulation (hybrid-APC) utilizes submucosal fluid injection to create a protective cushion prior to ablation that shields the submucosa from injury. We performed a pooled meta-analysis to evaluate the safety and efficacy of hybrid-APC. Methods: We conducted a systematic search of major electronic databases in April 2022. Studies that included patients with dysplastic and non-dysplastic Barrett's esophagus undergoing treatment with hybrid-APC were eligible for inclusion. Outcome measures included complete remission of intestinal metaplasia (CR-IM), stricture formation, serious adverse events, and number of sessions necessary to achieve CR-IM. Results: Overall pooled CR-IM rate for patients undergoing hybrid-APC was 90.8% (95% confidence interval [CI], 0.872-0.939; I²=0%). Pooled stricture rate was 2.0% (95% CI, 0.005-0.042; I²=0%). Overall serious adverse event rate was 2.7% (95% CI, 0.007-0.055; I²=0%). Conclusions: Results of the current meta-analysis suggest that hybrid-APC is associated with high rates of CR-IM and a favorable safety profile. Interpretation of these results is limited by the inclusion of retrospective cohort and case series data. Randomized controlled trials that standardize treatment and outcome evaluation protocols are necessary to understand how this treatment option is comparable to the current standards of care.

• The Journal of Korean Medicine
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• v.19 no.1
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• pp.234-250
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• 1998

Bujeonghangamtang(扶正抗癌湯) has been used for cure of tumor as a traditional medicine without any experimental evidence to support the rational basis for its clinical use. This study was carroed out to evaluate the possible therapeutic or antitumoral effects of Bujeonghangamtang extract against tumor, and to carry out some mechanisms responsible for its effect. Some kinds of tumor were induced by .the typical application of 3-methylcholanthrene (MCA) or by the implantation(s.c) of malignant tumor cells such as leukemia cells(3LL cells) or sarcoma cells(Sl80 cells). Treatment of the Bujeonghangamtang water-extract (dailly 1mg/mouse, i. p.) was continued for 7 days prior to tumor induction and after that the treatment was lasted for 20 days. Against squamous cell carcinoma induced by MCA, Bujeonghangamtang decreased not only the frequency of tumor production but also the number and the weight of tumors per tumor bearing mice (TBM). Bujeongmngamtang also significantly suppressed the development of 3LL cell and S180 cell-implanted tumors in occurence-frequency and their size, and some developed tumors were regressed by the continuous treatment of Bujeonghangamtang extract into TBM. In vitro, treatment of Bujeonghangamtang extract had no effect on the growth of some kinds of cell line such as FsaII, A431 strain but significantly inhibited the proliferation of 3LL, S180 cells and augmented the DNA synthesis of mitogen-activated lymphocytes. Bujeonghangamtang also stimulated the migrative ability of leukocyte, the MIF and IL-2 production of T lymphocytes, but not IL 6 production of B cells. Bujeonghangamtang-administration to mice enhanced NK cells attivities. These results demonstrated that Bujeonghangamtang extract exhibited a significant prophylactic benefits against tumors and its antitumor activity was manifested depending on the type of tumor cells. And these results also suggested that effect of Bujeonghangamtang might be chiefly due to nonspecific enhancement of NK cell activities and cell-mediated immune responses.

• Journal of Sasang Constitutional Medicine
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• v.33 no.3
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• pp.54-71
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• 2021

Objectives The purpose of this study was to revise Sasang Digestive Function Inventory (SDFI) and improve its validity and reliability using clinical data. Methods The Sasang type and Cold-Heat pattern differentiation by certified clinical specialist and responses to SDFI items were acquired from 419 hospital patients. The revision of SDFI was performed using item analysis and Explorative Factor Analysis (EFA). Furthermore, the validity and reliability of the revised SDFI (rSDFI) were investigated using Confirmatory Factor Analysis (CFA), Internal Consistency and Item Response Theory (IRT). And, clinical significance of the rSDFI was examined for the differentiation of Sasang types and Cold-Heat patterns. Results The number of the SDFI items were modified from 21 to 15. And, the validity and reliability of the rSDFI subscale structure were found to be acceptable. The scores of rSDFI-total and rSDFI-E significantly decreased in the order of Tae-Eum (TE), So-Yang (SY), So-Eum (SE) types, and the rSDFI score of SE type was significantly lower than that of TE and SY types. The rSDFI-total score could differentiate Cold-Heat pattern in both SY and SE types. And the difference of digestive function between Cold and Heat pattern of SE type could be explained with the rSDFI-D score. The rSDFI-total score in Cold pattern significantly decreased in the order of TE, SY, and SE types, and the rSDFI-total score of TE type is significantly higher than that of SE type in Heat pattern. Conclusions Current results demonstrated the reliability, validity and clinical usefulness of the rSDFI in clinical patients. Therefore, rSDFI can be utilized as an objective clinical measure supporting the differential diagnosis of Sasang typology.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.6
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• pp.1388-1391
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• 2006

Jangwi(腸胃) was recorded to Young Chu(靈樞)'s volume 33. Also, This Was recorded in Tae So(太素)‘s volume 10 Sindo Jangdo(身度 腸道), Gap Eul(甲乙)’s volume 2 Goldojangdojangwisosujechil(骨度腸道腸胃所受第七) and You Gyung(類經)‘s volume 4 Jangsnagyou jangwidaesojisu(臟象類 腸胃大小之數). Reason which call that it is Jangwi(腸胃) is that is describing length, width, diameter, weight, capacity, bends state of digestive organ from mouth to rectum. This chapter can not be understood in view of yin and yang five elements with Makedo(맥도), Goldo(骨度). This chapter can approach from specially viewpoint that is anatomy. Name of This chapter's terminology and position and types are very realistic. I feel pity that study does not exist about this. Therefore, I compared with comments of several doctors and modern anatomy. I believe that will be beaconed to understand This chapter.

• Journal of Digestive Cancer Research
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• v.9 no.1
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• pp.33-36
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• 2021

• Journal of Veterinary Clinics
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• v.20 no.2
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• pp.185-197
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• 2003

This survey was performed to investigate frequency of clinical disease in Holstein dairy cattle and Korean native cattle in Chungbuk region of Korea. This study was conducted with the veterinary clinical charts recorded by veterinarians in an animal hospital for 387 Holstein herds(14,701$\pm$1,766 head) and 180 Korean native cattle herds(1,440$\pm$786 head) from October 1998 to September 2001. The prevalent disease classes in Holstein dairy cattle were digestive systems(26.84%), reproductive system(22.48%), locomotor system(21.43%) and metabolic disorders(10.08%). The locomotor diseases were increased with 1st year, 16.27%, 2nd year, 20.93% and 3rd year, 27.08%. The dieases of digestive and reproductive system occurred frequently in winter season(30.01%, 26.03% respectively) and the disease frequency of locomotor system were very high in fall(28.44%). The predominant diseases of Holstein dairy cattle were : claw overgrowth(13.58%), indigestion(11.23%), functional infertility(8.77%), metritis(8.28%), foot diseases(7.35%), LDA (6.57%) and ketosis(5.76%). The prevalent disease classes in Korean native cattle were digestive system(43.80%), respiratory system(28.11%) and reproductive system(10.69%). Seasonally, digestive diseases occurred frequently in spring (51.55%), whereas respiratory diseases occurred frequently in winter (39.60%). The predominant diseases in Korean native cattle were calf diarrhea(32.03%), calf pneumonia(21.79%), indigestion(8.26%), dystocia(7.65%) and pneumonia(5.90%).