The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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The Effects of Bujeong hangamtang on antitumor Immune Response

부정항암탕(扶正抗癌湯)이 항종양(抗腫瘍) 면역반응(免疫反應)에 미치는 영향(影響)

  • Im, Mi-Yang (Dept. of Digestive Interanl Medicine, Col. of Oriental Medicine, Wonkwang Univ.) ;
  • Moon, Sook-Jea (Dept. of Digestive Interanl Medicine, Col. of Oriental Medicine, Wonkwang Univ.) ;
  • Moon, Gu (Dept. of Digestive Interanl Medicine, Col. of Oriental Medicine, Wonkwang Univ.) ;
  • Won, Jin-Hee (Dept. of Digestive Interanl Medicine, Col. of Oriental Medicine, Wonkwang Univ.) ;
  • Jeon, Byung-Hoon (Medicinal Regional Research Center supported by Korea Science and Engineering Foundation)
  • 임미량 (원광대학교 한의과대학 비계내과학교실) ;
  • 문석재 (원광대학교 한의과대학 비계내과학교실) ;
  • 문구 (원광대학교 한의과대학 비계내과학교실) ;
  • 원진희 (원광대학교 한의과대학 비계내과학교실) ;
  • 전병훈 (원광대학교 한의과대학 병리과학교실,과학재단지정 의약자원연구센터)
  • Published : 1998.04.30
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Abstract

Bujeonghangamtang(扶正抗癌湯) has been used for cure of tumor as a traditional medicine without any experimental evidence to support the rational basis for its clinical use. This study was carroed out to evaluate the possible therapeutic or antitumoral effects of Bujeonghangamtang extract against tumor, and to carry out some mechanisms responsible for its effect. Some kinds of tumor were induced by .the typical application of 3-methylcholanthrene (MCA) or by the implantation(s.c) of malignant tumor cells such as leukemia cells(3LL cells) or sarcoma cells(Sl80 cells). Treatment of the Bujeonghangamtang water-extract (dailly 1mg/mouse, i. p.) was continued for 7 days prior to tumor induction and after that the treatment was lasted for 20 days. Against squamous cell carcinoma induced by MCA, Bujeonghangamtang decreased not only the frequency of tumor production but also the number and the weight of tumors per tumor bearing mice (TBM). Bujeongmngamtang also significantly suppressed the development of 3LL cell and S180 cell-implanted tumors in occurence-frequency and their size, and some developed tumors were regressed by the continuous treatment of Bujeonghangamtang extract into TBM. In vitro, treatment of Bujeonghangamtang extract had no effect on the growth of some kinds of cell line such as FsaII, A431 strain but significantly inhibited the proliferation of 3LL, S180 cells and augmented the DNA synthesis of mitogen-activated lymphocytes. Bujeonghangamtang also stimulated the migrative ability of leukocyte, the MIF and IL-2 production of T lymphocytes, but not IL 6 production of B cells. Bujeonghangamtang-administration to mice enhanced NK cells attivities. These results demonstrated that Bujeonghangamtang extract exhibited a significant prophylactic benefits against tumors and its antitumor activity was manifested depending on the type of tumor cells. And these results also suggested that effect of Bujeonghangamtang might be chiefly due to nonspecific enhancement of NK cell activities and cell-mediated immune responses.

Keywords

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