• Journal of Periodontal and Implant Science
• /
• 제25권3호
• /
• pp.478-486
• /
• 1995

Periodontal therapy for treatment of periodontitis involves the elimination of bacterial plaque and elimination of the anatomic defects by regenerative procedure. The purpose of this study was to evaluate on the biological effect of magnolia and Ginkgo biloba extract to the antimicrobial, antiinflammatory and cellular activity. Antimicrobial assay was performed with the diffusion method of the extract by measuring of growth inhibitory zone of B. cereus from blood agar plate. Effect of the extract to cellular activity of gingival fibroblast were examined using MTT method and measured the result with optical density on 570nm by ELISA reader. Inhibitory effects of $PGE_2$ production from gingival fibroblast was performed with the addition of $IL-l{\beta}$ and the extract to the well and examined to the product of $PGE_2$ from cell by ELISA reader. In vivo anti-inflammatory effect was performed with injection examined with clinically and histologically for their extent of mecrosis and inflammation. Antimicrobial activity of Magnolia extract showed significantly higher activity than that of control. However, GBE did not showed significant activity to compare with control, and mixture of Magnolia and GBE extract showed significantly higher activity than that of control. The effect of cellular activity to gingival fibroblast showed no significant differences of between control and Magnolia extract. However, GBE showed significantly higher rate of cellular activity to compare with control and even to PDGF-BB, and also showed same degree of cellular activity even though mixed with Magnolia extract. The inhibitory effect of $PGE_2$ production showed significantly reduction of $PGE_2$ production to compare with control, but its inhibitory effect was not much strong to compare with Indomethacin. In vivo, antiinflammatory effect of Magnolia extract to P. gingivalis injection of Hamster buccal check showed significantly reduction of inflammatory cell infiltration and tissue necrosis, but GBE showed no effect on the inhibition of inflammatory process. These results suggested that Magnolia and GBE extract possessed different kind of biological activity and also can be compensated on their activity with each other for elimination of bacterial plaque and anatonical defect.

• 디지털융복합연구
• /
• 제15권8호
• /
• pp.391-400
• /
• 2017

본 논문의 목적은 영상자극이 신체 안정성에 미치는 영향을 개념 모델(Conceptual Model)로 제시하고, 시청자에게 제공되는 영상의 종류(2D, VR)에 따라 신체 안정성(손 안정성)에 미치는 영항을 실험을 통해 알아보는 것이다. 최근에 VR과 같은 입체 영상이 스마트폰이나 운동기구 등과의 결합이 활발해지고 있고, 영상자극이 제거된 후 일시적으로 신체 균형 및 손 안정성에 영향을 미침에 따라 안전사고나 인적오류의 가능성도 높아지고 있다. 개념모델은 기존 연구결과들을 바탕으로 제시되었고, 실험결과를 기반으로 뇌에서 일어나는 인간정보처리과정 및 인지적 자원모델과 결합되어 설명되었다. 20명의 피실험자는 2D, VR 자극에 노출 된 후 영상피로가 Cybersickness 질문지를 통해, 손 안정성은 Hand Steadiness Tester를 이용해 측정되었다. 실험결과 2D보다 VR 영상이 높은 영상피로, 낮은 손 안정성을 유발하였다. 본 연구는 아직 시도되지 않은 영상 종류 및 영상피로 수준에 따른 손 안정성을 개념모델과 실험을 통해 밝혔다는데 의의가 있다.

• 생태와환경
• /
• 제34권4호통권96호
• /
• pp.261-266
• /
• 2001

이산화탄소 농도가 증가할 때에 북구 이탄 습지에서 나타나는 생지화학적 변화과정을 살펴보았다. 표면 식생을 포함한 온전한 코어를 북웨일스의 이탄습지로부터 채취하여, 높은 이산화탄소농도(700ppm)와 자연상태 (350ppm)환경에서 4개월간 배양하였다. 배양 후, 화학적인 저해제를 이용하여 습지 토양에서 미량기체의 생성과 소비를 측정하였다. 메탄의 경우, 불화메탄($CH_3F$)를 이용하여 메탄 산화율을 결정하였고, 질산화와 탈질작용을 측정하기위해 아세틸렌($C_2H_2$)저해 방법을 적용하였다. 이를 위해, 먼저 각 측정 방법을 습지 시료에 적합하도록 최적화 시켰고, 둘째로 두 수준의 이산화탄소에서 배양한 시료에 이 방법들을 적용하였다. 높은 이산화탄소 농도는 메탄의 생성량을 증가 시켰으나(210대 $100\;ng\;CH_4 g^{-1}\;hr^{-1}$), 메탄 산화의 양도 증가시켜서 (128대 $15\;ng\;CH_4 g^{-1}\;hr^{-1}$) 결국에는 순메탄 방출량에는 변화가 없었다. 아산화질소의 경우에는 증가된 발생량이 탈질 보다는 질산화 과정에서 생성된 것으로 사료된다. 이러한 변화들은 높은 이산화탄소 하에서 조류의 성장이 증가되어 야기된 것으로 추측된다.

• 감성과학
• /
• 제10권1호
• /
• pp.13-21
• /
• 2007

모바일 컨버전스가 확산되면서 많은 기업들은 다양한 기능을 통합한 컨버전스 제품을 출시하고 있다. 이러한 모바일 컨버전스는 휴대의 편의성과 디지털 기기의 특성상 기기들 간의 공통된 요소를 함께 사용할 수 있는 경제적인 측면과 사용상의 편리성 증가 등 여러 가지 장점을 가지고 있다. 그러나 컨버전스 경향에 힘입어 많은 제품이 시장에 출시되었으나 기대와는 달리 실패하는 사례가 발생하고 있다. 이것은 제품개발에 있어서 컨버전스 제품에 대한 소비자의 평가를 반영하는데 미흡한 결과로 볼 수 있다. 컨버전스 제품이 시장에서 살아남기 위해서는 제품의 우수성과 인프라 구축도 중요하지만 무엇보다도 소비자가 컨버전스 제품을 어떻게 평가하고 어떠한 요인의 영향을 받는지에 대한 이해가 필수적이라 할 수 있다. 그럼에도 불구하고 현재까지 모바일기기를 중심으로 제품 평가에 대한 연구가 미비했다. 따라서 본 연구는 모바일 컨버전스 제품에 대한 소비자 평가와 영향 요인을 알아보고자 한다. 본 연구는 설문조사 방법에 의해 이루어졌으며, 158명으로부터 수집한 자료는 분산분석과 다중회귀분석을 통해 분석하였다. 연구결과 상대적 이점, 복잡성, 관찰가능성(MP3, 게임), 지각된 편리성 등의 요인들이 유의적인 영향을 미치는 것으로 나타났다.

• 한국정밀공학회지
• /
• 제3권1호
• /
• pp.40-49
• /
• 1986

Crack, craze and void are common defects which may be found in the bulk of polymeric materials such as either themoplastics or thermosets. The healing phenomena, autohesion, of these defects are known to be a intrinsic material property of various polymeric materials. However, only a few experimental and theoretical investigations on crack, void and craze healing phenomena for various polymeric materials have been reported up to date [1, 2, 3]. This may be partly due to the complications of healing processes and lacking of appropriate theoretical developments. Recently, some investigators have been urged to study the healing phenomena of various polymenic materials since the significance of the use of polymer based alloys or composites has been raised in terms of specific strength and energy saving. In the earlier published reports [1, 2, 3, 4], the crack and void healing velocity, healing toughness and some other healing mechanical and physical properties were measured experimentally and compared with predicted values by utilizing a simple model such as the reptation model under some resonable assumptions. It seems, however, that the general acceptance of the proposed modeling analyses is yet open question. The crack healing processes seem to be complicate and highly dependent on the state of virgin material in terms of mechanical and physical properties. Furthermore, it is also strongly dependent on the histories of crack, craze and void development including fracture suface morphology, the shape of void and the degree of disentanglement of fibril in the craze. The rate of crack healing may be a function of environmental factors such as healing temperature, time and pressure which gives different contact configurations between two separated surfaces. It seems to be reasonable to assume that the crack healing processes may be divided in several distinguished steps like stress relaxation with molecular chain arrangement, surface contact (wetting), inter- diffusion process and com;oete healing (to obtain the original strength). In this context, it is likely that we no longer have to accept the limitation of cumulative damage theories and fatigue life if it is probable to remove the defects such as crack, craze and void and to restore the original strength of polymers or polymer based compowites by suitable choice of healing histories and methods. In this paper, we wish to present a very simple and intuitive theoretical model for the prediction of healed fracture toughness of cracked or defective polymeric components. The central idea of this investigation, thus, may be the modeling of behavior of chain molecules under healing conditions including the effects of chain scission on the healing processes. The validity of this proposed model will be studied by making comparisons between theoretically predicted values and experimentally determined results in near future and will be reported elsewhere.

• 환경위생공학
• /
• 제24권1호
• /
• pp.1-12
• /
• 2009

The various environmental problems that we face on today are basically about environmental quality. Since early 1960s affluent material was produced because of remarkable economic growth by many cooperations. However, for the lack of environmental policy, environmental pollutions has been serious. The central government should transfer the producing and consuming structure to environmental affinity through the regulations for developing Korea as a model of environmental nation which takes an active part in global environmental programme and in which the environment and economy are well harmonized. Moreover, the central government should take the lead in prevention of environmental pollution through the direct policies such as strengthening the discharge limit or setting up environmental basic institutions by securing budget for conserving environment. This thesis emphasize on the public institution among many environmental basic institutions for environmental anti-pollution project. It will find the problems with running those institutions, and will suggest the preview of improvement. Also, it is necessary to investigate of variation trend for inflow and pollutant loading to environmental infrastructure as increased of the diffusion rate as established and maintenance of sewer system. The purpose of this study is to investigate for inflow and pollutant loading to environmental infrastructure, and also to provide the method of efficiently maintenance and management. The results obtained were summarized as follows; 1. Survey of actual condition on operation and management of environmental infrastructure was evaluated the propriety of treatment process and problem of plant management. 2. Analysis of pollutant loading contribution for river system of environmental infrastructure with data analysis of water quality measuring network. 3. To investigate on case study for efficiently maintenance and management of environmental infrastructure. The result on this study was provide the method of efficiently maintenance and management with survey for establish and repair of sewer system and survey of actual condition on operation and management of environmental infrastructure in the water area of discharge to Geum River System. Application as guideline for establish and management of environmental infrastructure, and management of Geum River System. Also, application for preliminary data for fulfill-assess of total effluent regulation of water pollution.

• 한국콘텐츠학회논문지
• /
• 제16권3호
• /
• pp.269-287
• /
• 2016

이 연구는 유병언 사망 사건과 관련된 언론 보도를 네트워크 분석하고, 이 사건이 소셜네트워크사이트를 통해 어떻게 확산되는지 이슈의 확산 과정을 네트워크 분석했다. 지상파 언론과 종편을 분석 대상으로 언론보도의 이슈 현저성, 단어의 가시성과 연결성을 분석했다. 네트워크 분석 결과 종편은 사건과 관련된 핵심 정보보다는 유병언 유류품, 브랜드, 시신에 대한 루머를 강조했고, 지상파 방송은 국과수의 DNA 검사 결과를 중심으로 보도했다. 시기별로 보면 1기 지상파는 '유병언 시신 발견 프레임'을, 종편은 '수사 비난 프레임', '명품 강조 프레임'으로 사건을 틀지었다. 2기 지상파는 '유병언 사인 분석 프레임'을, 종편은 '의혹 제기 프레임'을 강조했다. 3기 지상파는 몇 건 밖에 보도하지 않아 분석의 의미가 없고 종편은 '주변 정보 강조 프레임'이 부각되었다. 언론의 보도는 유투브와 SNS를 통해 확산되었는데, 네트워크 분석 결과 유병언 사망과 관련된 루머가 주목을 받은 것으로 나타났다. 인터넷과 SNS의 발달로 독자들이 적극적으로 의견을 표출하면서 루머를 확산시킨 것으로 생각된다. 음모론의 확산 과정에서 주류 언론은 종편의 선정적이고 자극적인 보도에 밀려 영향을 발휘하지 못했음이 밝혀졌다.

• 한국식품영양과학회지
• /
• 제14권4호
• /
• pp.359-364
• /
• 1985

본(本) 연구(硏究)에서는 3종(種)의 잎담배 추출액(抽出液)을 시료(試料)로 하여 동결농축(凍結濃縮)에 관(關)한 기초적(基礎的) 실험(實驗)과 검토(檢討)를 행(行)하였으며, 자작(自作)한 과냉각액(過冷却液) 공급형(供給形) 연속(連續) 교반조(攪拌槽)을 써서 빙결정(氷結晶) 성장속도(成長速度)와 과냉각도(過冷却度) 및 빙결정(氷結晶)의 입경분포(粒徑分布)를 측정(測定)한 결과(結果) 다음과 같은 결론(結論)을 얻었다. 1. 공급(供給) 과냉각액(過冷却液)의 과냉각도(過冷却度) $0.2{\sim}0.6^{\circ}C$에서 빙결정(氷結晶)의 평균입경(平均粒徑)은 $0.04{\sim}0.1cm$였다. 2. 순수(純水) 및 시료용액(試料溶液)에서 생성(生成)된 빙결정(氷結晶)의 α축방향성장속도(軸方向成長速度) v는 과냉각도(過冷却度) $0.1^{\circ}C$ 이하에서 과냉각도(過冷却度)에 비례했다. 즉, v=0.058 ${\Delta}t_b$였다. 또한 농도(濃度) 20%까지의 비례상수는 농도(濃度)에 의존(依存)하지 않았다. 3. 빙결정(氷結晶) 성장속도(成長速度)는 입경(粒徑)에 의존(依存)하지 않았다. 4. 빙결정(氷結晶)의 성장속도(成長速度)는 확산(擴散)과 전열(傳熱)의 율속과정(律速過程)뿐만 아니라 결정화(結晶化) 과정(過程)도 고려하지 않으면 안된다. 5. 핵발생속도(核發生速度)는 Huige et al의 결과(結果)에 비해 현저하게 작았다. 그 원인은 조내(槽內)의 빙결정농도(氷結晶濃度)와 교반속도(攪拌速度)가 Huige et al의 실험(實驗)에 비해 매우 작았기 때문이다.

• Interdisciplinary Bio Central
• /
• 제3권3호
• /
• pp.10.1-10.8
• /
• 2011

Introduction: Hash functions are computer algorithms that protect information and secure transactions. In response to the NIST's "International Call for Hash Function", we developed a biological hash function using the computing capabilities of bacteria. We designed a DNA-based XOR logic gate that allows bacterial colonies arranged in a series on an agar plate to perform hash function calculations. Results and Discussion: In order to provide each colony with adequate time to process inputs and perform XOR logic, we designed and successfully demonstrated a system for time-delayed bacterial growth. Our system is based on the diffusion of ${\ss}$-lactamase, resulting in destruction of ampicillin. Our DNA-based XOR logic gate design is based on the op-position of two promoters. Our results showed that $P_{lux}$ and $P_{OmpC}$ functioned as expected individually, but $P_{lux}$ did not behave as expected in the XOR construct. Our data showed that, contrary to literature reports, the $P_{lux}$ promoter is bidirectional. In the absence of the 3OC6 inducer, the LuxR activator can bind to the $P_{lux}$ promoter and induce backwards transcription. Conclusion and Prospects: Our system of time delayed bacterial growth allows for the successive processing of a bacterial hash function, and is expected to have utility in other synthetic biology applications. While testing our DNA-based XOR logic gate, we uncovered a novel function of $P_{lux}$. In the absence of autoinducer 3OC6, LuxR binds to $P_{lux}$ and activates backwards transcription. This result advances basic research and has important implications for the widespread use of the $P_{lux}$ promoter.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2014년도 제46회 동계 정기학술대회 초록집
• /
• pp.150.1-150.1
• /
• 2014

Showerhead is used as a main part in the semiconductor equipment. The face plate flatness should remain constant and the cleaning performance must be gained to keep the uniformity level of etching or deposition in chemical vapor deposition process. High operating temperature or long period of thermal loading could lead the showerhead to be deformed thermally. In some case, the thermal deformation appears very sensitive to showerhead performance. This paper describes the methods for robust design using computational fluid dynamics. To reveal the influence of the post distribution on flow pattern in the showerhead cavity, numerical simulation was performed for several post distributions. The flow structure appears similar to an impinging flow near a centered baffle in showerhead cavity. We took the structure as an index to estimate diffusion path. A robust design to reduce the thermal deformation of showerhead can be achieved using post number increase without ill effect on flow. To prevent the showerhead deformation by heat loading, its face plate thickness was determined additionally using numerical simulation. The face plate has thousands of impinging holes. The design key is to keep pressure drop distribution on the showerhead face plate with the holes. This study reads the methodology to apply to a showerhead hole design. A Hagen-Poiseuille equation gives the pressure drop in a fluid flowing through such hole. The assumptions of the equation are the fluid is viscous-incompressible and the flow is laminar fully developed in a through hole. An equation can be expressed with radius R and length L related to the volume flow rate Q from the Hagen-Poiseuille equation, $Q={\pi}R4{\Delta}p/8{\mu}L$, where ${\mu}$ is the viscosity and ${\Delta}p$ is the pressure drop. In present case, each hole has steps at both the inlet and the outlet, and the fluid appears compressible. So we simplify the equation as $Q=C(R,L){\Delta}p$. A series of performance curves for a through hole with geometric parameters were obtained using two-dimensional numerical simulation. We obtained a relation between the hole diameter and hole length from the test cases to determine hole diameter at fixed hole length. A numerical simulation has been performed as a tool for enhancing showerhead robust design from flow structure. Geometric parameters for the design were post distribution and face plate thickness. The reinforced showerhead has been installed and its effective deposition profile is being shown in factory.