• 전자공학회논문지 IE
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• 제47권2호
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• pp.60-65
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• 2010

본 논문은 저대역과 고대역 신호를 번갈아 전송하는 DBO-CSS 시스템에 최적화된 이중 대역 필터링 방법을 제안한다. 전체 신호 대역을 통과시키는 기존의 채널 필터링은 이웃하는 부대역 (sub-band)의 초과 잡음이 수신되는 다른 부대역의 신호에 더해지는 문제를 발생시킨다. 본 논문에서 제안하는 이중 대역 필터링 방법은 하드웨어 복잡도의 증가 없이 기존 채널 필터링 방법에서의 성능 저하를 극복할 수 있다. 제안된 방법은 저대역과 고대역 신호가 번갈아 수신되는 DBO-CSS 신호에 대응되는 두 개의 필터에 기반하므로 이웃하는 부 대역에서의 잡음 신호를 배제할 수 있다. 시뮬레이션 결과, 제안된 방법은 기존 필터링 방법보다 약 2.5 dB의 성능 향상을 가질 수 있음을 볼 수 있었다.

• 대한전자공학회논문지SP
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• 제39권6호
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• pp.672-686
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• 2002

현재 단대단(End-to-End) 비디오 서비스의 질을 높이기 위해 많은 연구가 각 계층별로 진행되고 있다. 전송계층에서의 오류 제어(Error Control), 네트워크계층에서의 QoS (Quality of Service)모델, 표현 및 응용계층에서의 오류 강인성(Error resilience)/오류 은닉(Error concealment) 등이 연구 개발되고 있다. 그러나 계층 간의 연관성이 높은 부분에서의 통합을 통한 성능향상에 관한 연구는 그 필요성과 효율에 비해 아직도 미흡하다. 본 논문은 QoS 서비스 모델하에서의 적응적 FEC(Forward Error Correction) 적용 및 우선순위에 따른 비디오패킷(VP ,VideoPacket)을 통하여 효율적인 계층화 비디오 스트리밍을 단대단 QoS성능의 향상에 관점을 맞추어 제안한다. 제안하는 방식은 최소 화질 보장과 같은 효율에서 보다 적은 가격에서의 서비스를 제공할 수 있다. 이를 위하여 통합형 서비스(IntServ, IS, Integrated Service) 의 자원예약을 사용하는 방법과 높은 가격의 자원 예약을 사용하지 않는 차별화 서비스(DiffServ, DS, Differentiated Service)를 적용했으며 이에 보장형 서비스의 특징을 공통을 가지기 위해 계층화 FEC를 적용하였으며 적절한 가격의 조절을 위하여 비디오패킷을 통한 데이터 분할을 적용하였다. 본 논문은 또한 최종 사용자의 만족도를 PSNR(Picture Signal to Noise Ration)과 PSNR에서 표현하지 못하는 부분의 평가를 위해 손상프레임율(DFR, Damaged Frame Ratio)과 오류프레임율(EFR,Error Frame Ratio)을 제안 이를 통해 평가하고자 한다. 제안하는 방식의 실험 결과는 비디오 코딩계층과 전송 계층, 네트워크 계층의 결합된 성능이며 이는 또한 화질의 개선뿐만 아니라 사용자의 가격문제에 대하여서도 비교 분석하였다.

• 전자공학회논문지C
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• 제36C권7호
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• pp.10-16
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• 1999

본 논문은 FCSR(Freedback Control Swing voltage Reduction) 방식을 이용하여 bus 구동전압을 수백 mV이내로 줄일 수 있는 구동기에 대한 내용을 다루고 있다. 이는 MDL 구조와 같이 대용량, 대단위 bus에서의 전력소모를 줄이기 위한 연구로 FCSR은 dual-line bus와 bus precharging을 기본구조로 채택하고 있다. Bus 환경이 변화함에 따라 일정한 구동전압을 유지하기 위하여 구동기의 크기를 자동적으로 조절할 수 있도록 구동기와 bus를 모델링 하였고 또한 odd mode로 동작하는 이웃하는 선간의 커플링 영향을 평행 전류원으로 모델링하여 선간간섭(crosstalk) 영향을 분석하였다. 현대 0.8um 공정으로 제작된 chip은 bus를 600mV로 구동하도록 설계되었으며 테스트결과 3.3V에서 70Mhz로 동작 가능하다. Hspice 시뮬레이션으로 FCSR은 3.3V에서 250Mhz의 동작이 가능하다.

• 한국식물병리학회:학술대회논문집
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• 한국식물병리학회 2003년도 정기총회 및 추계학술발표회
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• pp.78.2-79
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• 2003

Pepper defensin ( CADEFl) clone was isolated from cDNA library constructed from pepper leaves infected with avirulent strain Bv5-4a of Xanthomonu campestris pv. vesicatoria. The deduced amino acid sequence of CADEFl is 82-64％ identical to that of other plant defensins. Putative protein encoded by CADEFl gene consists of 78 amino acids and 8 conserved cysteine residues to form four structure-stabilizing disulfide bridges. Transcription of the CADEF1 gene was earlier and stronger induced by X campestris pv. vesicatoria infection in the incompatible than in the compatible interaction. CADEF1 mRNA was constitutively expressed in stem, root and green fruit of pepper. Transcripts of CADEFl gene drastically accumulated in pepper leaf tissues treated With Salicylic acid (SA), methyl jasmonate (MeJA), abscisic acid (ABA), hydrogen Peroxide (H$_2$O$_2$), benzothiadiazole (BTH) and DL-${\beta}$-amino-n-butyric acid (BABA). In situ hybridization results revealed that CADEF1 mRNA was localized in the phloem areas of vascular bundles in leaf tissues treated with exogenous SA, MeJA and ABA. Strong accumulation of CADEF1 mRNA occurred in pepper leaves in response to wounding, high salinity and drought stress. These results suggest that bacterial pathogen infection, abiotic elicitors and some environmental stresses may play a significant role in signal transduction pathway for CADEF1 gene expression.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제32권5호
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• pp.473-477
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• 2010

Organized hematoma of the maxillary sinus is a rare, nonneoplastic benign lesion with locally destructive behavior that may mimic a malignancy. Clinically, symptoms do not usually occur while the lesion remains localized to the maxillary sinus. Because there is gradual enlargement of the lesion causing erosion and displacement of the adjacent bony structures, symptoms such as epistaxis, cheek swelling, nasal obstruc-tion, headache, and exophthalmos become manifest. Radiologically, unilateral cases are much more fre-quent than bilateral, and Waters' view shows complete opacity of the expanded maxillary sinus and some masses. CT scan shows a large heterogeneous enhancing mass causing considerable expansion of the max-illary sinus with bony erosion. On MR imaging, the mass usually has a variable signal intensity on T1- and T2- weighted images, ranging from low to high. After contrast administration, discrete areas of enhance-ment are present within the mass. Although the disease is essentially benign and nonneoplastic, differen-tial diagnosis from neoplastic disease including malignancy both clinically and radiologically has been always problematic. Accurate preoperative diagnosis of organized hematoma of the maxillary sinus is important to avoid unnecessary extensive surgery, because this condition is curative with a simple, conservative surgical approach and rarely recur. Organized hematoma of the maxillary sinus should be included in the differential diagnosis when patients have recurrent epistaxis, slow-growing mass of the cheek, nasal obstruction, and expansile mass in the maxillary sinus. A 33-year-old man was referred to the department of oral and maxillofacial surgery with a three-month history of slowly growing painful swelling of the left cheek. The mass of the maxillary sinus was resected by a Caldwell-Luc approach. Histopahtoly showed only a fibous encapsulated organized hematoma. To our knowledge, organized hematoma of the maxillary sinus has not been previously described in the Korean literature of the oral and maxillofacial surgery. We report a case of organized hematoma of the maxillary sinus presenting with an enlarging maxillary sinus mass.

• BMB Reports
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• 제40권4호
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• pp.562-570
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• 2007

Soluble or cell-bound IL-1 receptor accessory protein (IL-1RAcP) does not bind IL-1 but rather forms a complex with IL-1 and IL-1 receptor type I (IL-1RI) resulting in signal transduction. Synthetic peptides to various regions in the Ig-like domains of IL-1RAcP were used to produce antibodies and these antibodies were affinity-purified using the respective antigens. An anti-peptide-4 antibody which targets domain III inhibited 70% of IL-$1\beta$-induced productions of IL-6 and PGE2 from 3T3-L1 cells. Anti-peptide-2 or 3 also inhibited IL-1-induced IL-6 production by 30%. However, antipeptide-1 which is directed against domain I had no effect. The antibody was more effective against IL-$1\beta$ compared to IL-$1\alpha$. IL-1-induced IL-6 production was augmented by coincubation with PGE2. The COX inhibitor ibuprofen blocked IL-1-induced IL-6 and PGE2 production. These results confirm that IL-1RAcP is essential for IL-1 signaling and that increased production of IL-6 by IL-1 needs the co-induction of PGE2. However, the effect of PGE2 is independent of expressions of IL-1RI and IL-1RAcP. Our data suggest that domain III of IL-1RAcP may be involved in the formation or stabilization of the IL-1RI/IL-1 complex by binding to epitopes on domain III of the IL-1RI created following IL-1 binding to the IL-1RI.

• 생물정신의학
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• 제6권1호
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• pp.67-73
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• 1999

The cAMP-dependent protein kinase(PKA) is an intracellular enzyme with serine-threonine kinase activity that plays a key role in cell growth, differentiation, and apoptosis in eukaryotes. In order to understand the PKA signal transduction pathway regulating cell life cycle and identify its role, we focused on the characterization of up-/down-regulated genes by PKA using the differential display polymerase chain reaction. Seven differentially expressed sequence tags(DEST) have been obtained. Among these DESTs, 2 DESTs were homologous to the sequence of genes from BLAST search result. KC1-5 DEST that was up-regulated in A123.7 cells was highly corresponded to mouse apoptosis-related gene(MA-3) or mouse mRNA for topoisomerase inhibitor suppressed(TIS). MA-3 was induced in various types of apoptosis, specially in NGF-deprived apoptotic PC12 cells. TIS was down-regulated in the RVC lymphoma cells incubated with topoisomerase inhibitor that induces DNA strand breakages. PG1-1 DEST that was highly expressed in PC12 cells was corresponded to transposon Tn10 3'-end. Tnansposon Tn10 was up-regulated in differentiated myeloblastic ML-1 cells by 12-O-tetradecanoylphorbol-13-acetate. This study illuminates that MA-3/TIS was down-regulated by PKA activity, and transposon Tn10 was up-regulated by it.

• 대한교통학회지
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• 제28권3호
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• pp.39-49
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• 2010

본 연구에서는 감성공학적 분석방법론을 이용하여 운전자가 감성적인 측면에서 효과적으로 반응할 수 있는 교통안전 경고정보 제공방식 도출을 위한 연구를 수행하였다. 교통안전 경고정보는 운전자에게 전방의 위험요소를 미리 알려주어 사고회피를 위한 적절한 반응을 유도하는 역할을 하며 네비게이션과 같은 차내단말기를 통해 제공될 수 있다. 경고정보는 정보 제공방식들의 조합으로 구성되며 9개 시나리오를 설정하고 두 번의 설문조사를 시행하였다. 의미미분법, 상관분석, 수량화I류 이론을 이용한 감성공학I류 분석방법을 통해 연구를 진행하였으며, 성별차이에 따른 운전자 감성특성을 분석하였다. 분석결과 성별차이에 따라 각 정보의 제공방식에 대해 운전자가 느끼는 감성정도가 전체적으로 차이가 나는 것으로 분석되었다. 제공방식의 조합은 '청각적 요소: Beep음+음성안내', '메시지창: Text+픽토그램', '배경점멸: 빨간색 점멸'이 운전자의 감성정도와 선호도가 높게 나타났다. 본 연구의 결과는 운전자의 감성특성을 고려한 효과적인 교통안전 경고정보 설계 및 제공을 위한 유용한 자료로 활용될 것으로 기대된다.

• Nutrition Research and Practice
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• 제4권4호
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• pp.276-282
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• 2010

The principal objective of this study was to evaluate the chemopreventive and therapeutic effects of a combination of all-trans-retinoic acid (RA) and knockdown of delta-like 1 homologue (Drosophila) (DLK1) on neuroblastoma, the most common malignant disease in children. As unfavorable neuroblastoma is poorly differentiated, neuroblastoma cell was induced differentiation by RA or DLK1 knockdown. Neuroblastoma cells showed elongated neurite growth, a hallmark of neuronal differentiation at various doses of RA, as well as by DLK1 knockdown. In order to determine whether or not a combination of RA and DLK1 knockdown exerts a greater chemotherapeutic effect on neuroblastoma, cells were incubated at 10 nM RA after being transfected with SiRNA-DLK1. Neuronal differentiation was increased more by a combination of RA and DLK1 knockdown than by single treatment. Additionally, in order to assess the signal pathway of neuroblastoma differentiation induced by RA and DLK1 knockdown, treatment with the specific MEK/ERK inhibitors, U0126 and PD 98059, was applied to differentiated neuroblastoma cells. Differentiation induced by RA and DLK1 knockdown increased ERK phosphorylation. The MEK/ERK inhibitor U0126 completely inhibited neuronal differentiation induced by both RA and DLK1 knockdown, whereas PD98059 partially blocked neuronal differentiation. After the withdrawal of inhibitors, cellular differentiation was fully recovered. This study is, to the best of our knowledge, the first to demonstrate that the specific inhibitors of the MEK/ERK pathway, U0126 and PD98059, exert differential effects on the ERK phosphorylation induced by RA or DLK1 knockdown. Based on the observations of this study, it can be concluded that a combination of RA and DLK1 knockdown increases neuronal differentiation for the control of the malignant growth of human neuroblastomas, and also that both MEK1 and MEK2 are required for the differentiation induced by RA and DLK1 knockdown.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 춘계학술대회
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• pp.208-208
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• 1996

In this work we investigated coupling of the m2 and m4 subtypes of muscarinic acetylcholine receptors expressed in chinese hamster ovary (CHO) cells to activation of neuronal nitric oxide synthase (nNOS). Stimulation of guanylate cyclase activity in detector neuroblastoma cells was used as an index of generation of nitric oxide (NO) in CHO cells. The agonist carbachol induced marked time and concentration-dependent enhancement of the activity of nNOS at m2 receptors. In sharp contrast, the response in CHO cells transfected with the m4 receptor gene was similar in magnitude to that observed in non-transfected cells, suggesting lack of significant coupling of m4 muscarinic receptors to NO signaling. This novel observation of functional divergence of the two muscarinic receptor subtypes at the level of activation of nNOS is quite intriguing, in light of the currently accepted dogma that they belong to the same functional class. This functional selectivity was not due to differential effects on intracellular Ca$\^$2+/ concentration, since activation of both subtypes of muscarinic receptors produced a comparable, albeit quite small, Ca$\^$2+/ signal. Taken together, our present data strongly suggest that the generally assumed functional equivalence of m2 and m4 muscarinic receptors should be carefully reexamined. These data also suggest the presence of alternate mechanisms of activation of nNOS, which might be operative in the absence of large changes in the concentration of cellular Ca$\^$2+/. The latter mechanisms are expected to be activated by m2, but not m4 muscarinic receptors. Both sets of findings are quits important in regards to refining the functional classification of muscarinic receptor subtypes and the cellular mechanisms of activation of NOS.