• Clinical Nutrition Research
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• v.12 no.1
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• pp.40-53
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• 2023

Differential bitterness perception associated with genetic polymorphism in the bitter taste receptor gene taste 2 receptor member 38 (TAS2R38) may influence an individual's food preferences, nutrition consumption, and eventually chronic nutrition-related disorders including cardiovascular disease. Therefore, the effect of genetic variations on nutritional intake and clinical markers needs to be elaborated for health and disease prevention. In this study, we conducted sex-stratified analysis to examine the association between genetic variant TAS2R38 rs10246939 A > G with daily nutritional intake, blood pressure, and lipid parameters in Korean adults (males = 1,311 and females = 2,191). We used the data from the Multi Rural Communities Cohort, Korean Genome and Epidemiology Study. Findings suggested that the genetic variant TAS2R38 rs10246939 was associated with dietary intake of micronutrients including calcium (adjusted p = 0.007), phosphorous (adjusted p = 0.016), potassium (adjusted p = 0.022), vitamin C (adjusted p = 0.009), and vitamin E (adjusted p = 0.005) in females. However, this genetic variant did not influence blood glucose, lipid profile parameters, and other blood pressure markers. These may suggest that this genetic variation is associated with nutritional intake, but its clinical effect was not found. More studies are needed to explore whether TAS2R38 genotype may be a potential predictive marker for the risk of metabolic diseases via modulation of dietary intake.

• The Proceeding of the Korean Institute of Electromagnetic Engineering and Science
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• v.3 no.2
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• pp.30-38
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• 1992

In this paper, in order to apply the $\pi$/4 shift QPSK to TCM, we propose the $\pi$/8 shift 8PSK modulation technique and the trellis-coded $\pi$/8 shift 8PSK performing signal set expansion and set partition by phase difference. In addition, the Viterbi decoder with branch metrics of the squared Euclidean distance of the first phase difference as well as the Lth phase difference is introduced in order to improve the bit error rate(BER) performance in differential detection of the trellis-coded $\pi$/8 shift 8 PSK. The proposed Viterbi decoder is conceptually the same as the sliding multiple de- tection by using the branch metric with first and Lth order phase difference. We investigate the performance of the uncoded .pi. /4 shift QPSK and the trellis-coded $\pi$/8 shift 8PSK with or without the Lth phase difference metric in an additive white Gaussian noise (AWGN) and Rayleigh fading channel using the Monte Carlo simulation. The study shows that the $\pi$/4 shift QPSK with the Trellis-code i. e. the trellis-coded $\pi$/8 shift 8PSK is an attractive scheme for power and bandlimited systems and especially, the Viterbi decoder with first and Lth phase difference metrics improves BER performance. Also, the next proposed algorithm can be used in the TC $\pi$/8 shift 8PSK as well as TC MDPSK.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.4A
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• pp.440-449
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• 2008

In this paper, we propose a 16-QAM carrier recovery loop which is suitable for the implementation of Inmarsat M4 system receiver. Because the frequency offset of ${\pm}924\;Hz$ on signal bandwidth 33.6 kHz is recommended in Inmarsat M4 system specification, carrier recovery loop having stable operation in the channel environment with large relative frequency offset is required. the carrier recovery loop which adopts only PLL can't be stable in relatively large frequency offset environment. Therefore, we propose a carrier recovery loop which has stable operation in large relative frequency offset environment for Inmarsat M4 system. The proposed carrier recovery loop employed differential filter-based noncoherent UW detector which is robust to frequency offset, CP-AFC for initial frequency offset acquisition using UW signal, and 16-QAM DD-PLL for phase tracking using data signal to overcome large relative frequency offset and achieve stable carrier recovery performance. Simulation results show that the proposed carrier recovery loop has stable operation and satisfactory performance in large relative frequency offset environment for Inmarsat M4 system.

• Journal of Acupuncture Research
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• v.17 no.4
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• pp.41-50
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• 2000

Objectives : Acupuncture is expected to have somewhat like the efficacy parallel increasing activity of immune system in Western modem medicine. There, already, are many animal researches on activating effect of acupuncture for the immune system in peripheral organs. So, we carried out this experiment to see whether acupuncture has controlling effect on interleukin-6(IL-6) activity in rat's brain. Methods and Results : We had topical application of IL-6(1U=lpg, $10{\mu}l$) on brain of rat. It reduced afferent sensory transmission to the primary somatosensory(SI) cortex from periphery. Whereas, electrical stimulation(ES, 2Hz, 1.5V, 15min) of ST36(足三里) with application of IL-6 prominently activated afferent sensory transmission. ES of non-acupoint(proximal tail) with IL-6 showed suppression of afferent transmission. ES of ST36 without IL-6 application also exerted facilitation of afferent transmission to the SI cortex. Conclusions : Electoacupuncture(EA) on ST36 has noticeable influences on modulating activation of IL-6 in central nervous system, which do major role in immune system.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.18 no.6
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• pp.815-823
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• 1993

In this paper, the structure of modified multiplication-free adaptive filter(M-MADF) and convergence analysis are presented. To evaluate the performance of proposed M-MADF algorithm, fractionally spaced equalizer (FSE) is used. The input signals are quantized using DPCM and the reference signals is processed using a first-order linear prediction filter, and the outputs are processed by a conventional adaptive filter. The filter coefficients are updated using the Sign algorithm. Under the assumption that the primary and reference signals are zero mean, wide-sense stationary and Gaussian, theoretical results for the coefficient misalignment vector and its autocorrelation matrix of the filter are driven. The convergence properties of Sign. MADF and M-MADF algorithm for updating of the coefficients of a digital filter of the fractionally spaced equalizer (FSE) are investigated and compared with one another. The convergence properties are characterized by the steady state error and the convergence speed. It is shown that the convergence speed of M-MADF is almost same as Sign algorithm and is faster that MADF in the condition of same steady error. Especially it is very useful for high correlated signals.

• Development and Reproduction
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• v.19 no.1
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• pp.43-51
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• 2015

Connexin (Cx) is a complex which allows direct communication between neighboring cells via exchange of signaling molecules and eventually leads to functional harmony of cells in a tissue. The initial segment (IS) is an excurrent duct of male reproductive tract and expression of numerous genes in the IS are controlled by androgens and estrogens. The effects of these steroid hormones on gene expression in the IS during postnatal development have not extensively examined. The present research investigated expressional modulation of Cx isoforms in the IS by exogenous exposure to estrogen agonist, estradiol benzoate (EB), or androgen antagonist, flutamide (Flu), at weaning age. Two different doses of EB or Flu were subcutaneously administrated in 21-day old of male rats, and expressional changes of Cx isoforms in the adult IS were analyzed by quantitative real-time PCR. Treatment of a low-dose EB ($0.015{\mu}g/kg$ body weight) resulted in an increased expression of Cx31 gene and a decreased expression of Cx37 gene. A high-dose EB ($1.5{\mu}g/kg$ body weight) treatment caused an increase of Cx31 gene expression. Increased levels of Cx30.3 and Cx40 transcripts were observed with a low-dose Flu ($500{\mu}g/kg$ body weight) treatment. Treatment of high-dose Flu (50 mg/kg body weight) led to expressional increases of Cx30.3, 40, and 43 genes. Our previous and present findings suggest differential responsiveness on gene expression of Cx isoforms in the IS by androgens and estrogens at different postnatal ages.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.206-206
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• 1996

The C-terminus ends of the second putative transmembrane domains of both m1 and m2 muscarinic receptors contain a triplet of amino acid residues consisting of leucine (L), tyrosine (Y) and threonine (T), This triplet is repeated as LYT-LYT in m2 receptors at the interface between the second transmembrane domain and the first extracellular loop. Interestingly, however, it is repeated in a transposed fashion (LYT-TYL) in the sequence of m1 receptors. In this work we employed site-directed mutagenesis to investigate the possible significance of this unique sequence diversity for determining the distinct differential drug-receptor interaction and cellular function at m1 muscarinic receptor. Mutation of the LYTTYL sequence of m1 receptors to the corresponding m2 receptor LYTLYT sequence, however, did not result in a significant change in the binding affinity of the agonist carbachol or in the affinity of the majority of a series of receptor antagonists which are able to discriminate between wild-type m1 and m2 receptors. Surprisingly, the LYTLYT ml receptor mutant demonstrated markedly enhanced coupling to activation of phospholipase C without a change in its coupling to increased cyclic AMP formation. There was also an enhanced receptor sensitivity in transducing elevation of intracellular Ca$\^$2+/. These changes were not due to alterations in the rate of receptor. desensitization or sequestration, On the other hand, the reverse LYTLYT-LYTTYL mutation in the m2 receptor did not alter its coupling to inhibition of adenylate cyclase, but slightly enhanced its coupling to stimulation of PI hydrolysis, Our data suggest that the LYTTYL/LYTLYT sequence difference between ml and n12 muscarinic receptors is not involved in determining receptor pharmacology. On the other hand, while these differences might play a role in the modulation of muscarinic receptor coupling to PI hydrolysis, they are not important for specifying coupling of various subtypes of muscarinic receptors to different cellular signaling pathways.

• Journal of Satellite, Information and Communications
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• v.10 no.2
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• pp.109-114
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• 2015

Frame synchronization is achieved by correlation between received symbols and a preamble pattern which is periodically appended at a frame header. In this paper, we deal with a frame detection method complaint with satellite-based DVB-S2 system. In DVB-S2, frame synchronization is performed under the low signal-to-noise ratio(SNR), a large frequency offset which can be up to 20% of a symbol transmission rate and unknown modulation schemes ranging from QPSK to 32-APSK. In this environment, we propose a method combining differential correlation based on SOF and PLSC with an accumulated correlation method for the detection of frame structures. In addition, detection performances about mean acquisition time(MAT) and detection error probability are evaluated via computer simulations.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2017.11a
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• pp.193-195
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• 2017

This paper focuses on development status of eLoran system which is an representative backup PNT system in order to overcome the vulnerability of GNSS signals by radio frequency interference such as jamming. eLoran testbed system consists of new transmitting system for amplifying the signal through signal generation and modulation, differential Loran (dLoran) reference stations for calculating the signal errors received from transmitters, an integrated operation and control system (IOCS) for eLoran service. Therefore we present the configuration of testbed architecture for trial operation of eLoran service and the development status, and discuss about the next step toward backup PNT service using eLoran system.

• Journal of the Korean Institute of Telematics and Electronics C
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• v.36C no.6
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• pp.18-26
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• 1999

This paper presents the architecture and design of a DSSS MODEM ASIC chip for wireless local area networks (WLAN). The implemented MODEM chip supports the DSSS physical layer specifications of the IEEE 802.11. The chip consits of a transmitter and a receiver which contain a CRC encoder/decoder, a differential encoder/decoder, a frequency offset compensator and a timing recovery circuit. The chip supports various data rates, i.e., 4,2 and 1Mbps and provides both DBPSK and DQPSK for data modulation. We have performed logic synthesis using the $SAMSUNG^{TM}$ $0.6{\mu}m$ gate array library and the implemented chip consists of 53,355 gates. The MODEM chip operates at 44MHz, the package type is 100-pin QFP and the power consumption is 1.2watt at 44MHz. The implemented MODEM architecture shows lower BER compared with the Harris HSP3824.