• Advances in nano research
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• 제5권4호
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• pp.281-301
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• 2017

In this disquisition, an exact solution method is developed for analyzing the vibration characteristics of magneto-electro-elastic functionally graded (MEE-FG) beams by considering porosity distribution and various boundary conditions via a four-variable shear deformation refined beam theory for the first time. Magneto-electroelastic properties of porous FG beam are supposed to vary through the thickness direction and are modeled via modified power-law rule which is formulated using the concept of even and uneven porosity distributions. Porosities possibly occurring inside functionally graded materials (FGMs) during fabrication because of technical problem that lead to creation micro-voids in FG materials. So, it is necessary to consider the effect of porosities on the vibration behavior of MEE-FG beam in the present study. The governing differential equations and related boundary conditions of porous MEE-FG beam subjected to physical field are derived by Hamilton's principle based on a four-variable tangential-exponential refined theory which avoids the use of shear correction factor. An analytical solution procedure is used to achieve the natural frequencies of porous-FG beam supposed to magneto-electrical field which satisfies various boundary conditions. A parametric study is led to carry out the effects of material graduation exponent, porosity parameter, external magnetic potential, external electric voltage, slenderness ratio and various boundary conditions on dimensionless frequencies of porous MEE-FG beam. It is concluded that these parameters play noticeable roles on the vibration behavior of MEE-FG beam with porosities. Presented numerical results can be applied as benchmarks for future design of MEE-FG structures with porosity phases.

• Translational and Clinical Pharmacology
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• 제26권4호
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• pp.166-171
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• 2018

Although there are many commercially available training software programs for pharmacokinetics, they lack flexibility and convenience. In this study, we develop simulation software to facilitate pharmacokinetics education. General formulas for time courses of drug concentrations after single and multiple dosing were used to build source code that allows users to simulate situations tailored to their learning objectives. A mathematical relationship for a 1-compartment model was implemented in the form of differential equations. The concept of population pharmacokinetics was also taken into consideration for further applications. The source code was written using R. For the convenience of users, two types of software were developed: a web-based simulator and a standalone-type application. The application was built in the JAVA language. We used the JAVA/R Interface library and the 'eval()' method from JAVA for the R/JAVA interface. The final product has an input window that includes fields for parameter values, dosing regimen, and population pharmacokinetics options. When a simulation is performed, the resulting drug concentration time course is shown in the output window. The simulation results are obtained within 1 minute even if the population pharmacokinetics option is selected and many parameters are considered, and the user can therefore quickly learn a variety of situations. Such software is an excellent candidate for development as an open tool intended for wide use in Korea. Pharmacokinetics experts will be able to use this tool to teach various audiences, including undergraduates.

• Structural Engineering and Mechanics
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• 제71권6호
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• pp.627-641
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• 2019

The paper focuses on bending analysis of the functionally graded (FG) plates with arbitrary shapes and boundary conditions. The material property of FG plates is modelled by using the power law distribution. Based on the first order shear deformation plate theory (FSDT), the governing equations as well as boundary conditions are formulated and obtained by using the principle of virtual work. The coupled Boundary Element-Radial Basis Function (BE-RBF) method is established to solve the complex FG plates. The proposed methodology is developed by applying the concept of the analog equation method (AEM). According to the AEM, the original governing differential equations are replaced by three Poisson equations with fictitious sources under the same boundary conditions. Then, the fictitious sources are established by the application of a technique based on the boundary element method and approximated by using the radial basis functions. The solution of the actual problem is attained from the known integral representations of the potential problem. Therefore, the kernels of the boundary integral equations are conveniently evaluated and readily determined, so that the complex FG plates can be easily computed. The reliability of the proposed method is evaluated by comparing the present results with those from analytical solutions. The effects of the power index, the length to thickness ratio and the modulus ratio on the bending responses are investigated. Finally, many interesting features and results obtained from the analysis of the FG plates with arbitrary shapes and boundary conditions are demonstrated.

• 디지털융복합연구
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• 제19권8호
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• pp.205-217
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• 2021

탈중앙형 SSI(Self Sovereign Identity)가 새로운 디지털 신원 식별 기술의 대안으로 등장하였으나 이는 데이터 거래의 고유 알고리즘 특성으로 인해 효율적인 비식별화 기법이 제안되지 않았다. 본 논문에서는 SSI의 탈중앙형 동작을 보장하기 위해 ZKP(Zero Knowledge Proof)의 검증 결과를 검증인 측에서 외부에 제공 가능한 형태로 재구성함으로써 식별자를 제거하지 않는 비식별 기술을 제안한다. 또한, 이는 검증 참여 각 개체에 대한 차등 주권 관리 개념을 제안하는 것으로 재구성된 비식별 데이터를 정보주체의 동의 없이 제공할 수 있다. 결과적으로 제안 모델은 탈중앙형 SSI 환경에서 국내 개인정보보호법을 만족하고, 안전하며 효율적인 비식별 처리 및 주권 관리를 제공한다.

• 해양환경안전학회지
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• 제27권2호
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• pp.402-408
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• 2021

위성신호 반사계측(GNSS-Reflectometry) 기술은 위성으로부터 전송되는 신호의 지표면 혹은 해수면에 반사되는 신호를 측정하여 분석하는 기법으로서, 해수면 높이측정, 태풍 및 기상이변, 그리고 토양의 수분 및 적설량 측정 등에 활용되고 있다. 본 논문에서는 GNSS-R 기술의 해양 활용확대와 그 가능성을 살펴보기 위하여, 위성신호의 신호대잡음비를 이용하는 GNSS-R 기술의 개념과 측정원리에 대해 설명하고, 국제적인 활용 사례를 조사하여 제시하였다. 특히 GNSS-R 기술을 기존 DGNSS 기준국 및 상시관측소 인프라를 이용하여 해양안전 및 환경 모니터링에 활용 가능할 뿐만 아니라, 지상 및 해양기준국, 위성기반, 해상선박 탑재 측면에서의 해양 응용 가능분야를 조사하여 제안하였다.

• Mycobiology
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• 제50권2호
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• pp.121-131
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• 2022

The rare edible and medicinal fungus Antrodia cinnamomea has a substantial potential for development. In this study, Illumina HiSeq 2000 was used to sequence its transcriptome. The results were assembled de novo, and 66,589 unigenes with an N50 of 4413 bp were obtained. Compared with public databases, 6,061, 3,257, and 2,807 unigenes were annotated to the Non-Redundant, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes databases, respectively. The genes related to terpene biosynthesis in the mycelia of A. cinnamomea were analyzed, and acetyl CoA synthase (ACS2 and ACS4), hydroxymethylglutaryl CoA reductase (HMGR), farnesyl transferase (FTase), and squalene synthase (SQS) were found to be upregulated in XZJ (twig of C. camphora) and NZJ (twig of C. kanehirae). Moreover, ACS5 and 2,3-oxidized squalene cyclase (OCS) were highly expressed in NZJ, while heme IX farnesyl transferase (IX-FIT) and ACS3 were significantly expressed in XZJ. The differential expression of ACS1, ACS2, HMGR, IX-FIT, SQS, and OCS was confirmed by real-time quantitative reverse transcription PCR. This study provides a new concept for the additional exploration of the molecular regulatory mechanism of terpenoid biosynthesis and data for the biotechnology of terpenoid production.

• Journal of the Korean Wood Science and Technology
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• 제31권1호
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• pp.61-70
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• 2003

원심법을 이용하여 침엽수 생재 심재부의 조재와 만재에 대한 수분이동경로의 크기를 평가하였다. 또한, 원심처리 후의 포수율 분포와 수분포텐셜의 관계로부터 액체투과성을 측정하였다. 삼나무의 경우, 조재는 0.70 ㎛, 만재는 0.50 ㎛의 반경에서 뚜렷한 피크가 관찰되었다. 솔송나무는 조재와 만재 모두 0.50 ㎛의 반경에서 피크를 나타냈다. 일본전나무와 일본잎갈나무는 조재 0.70 ㎛, 만재 0.30 ㎛의 반경범위에서 피크 값이 관찰되었다. 반면에, 미송과 시트카스푸르수는 뚜렷한 피크 값을 보이지 않았다. 액체투과성은 미송을 제외한 모든 수종에서 조재가 만재보다 좋게 평가되었다.

• Journal of Yeungnam Medical Science
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• 제40권2호
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• pp.136-145
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• 2023

Hepatic encephalopathy (HE) is a severe neuropsychiatric abnormality in patients with either acute or chronic liver failure. Typical brain magnetic resonance imaging findings of HE are bilateral basal ganglia high signal intensities due to manganese deposition in chronic liver disease and hyperintensity in T2, fluid-attenuated inversion recovery, or diffusion-weighted imaging (DWI) with hemispheric white matter changes including the corticospinal tract. Low values on apparent diffusion coefficient mapping of the affected area on DWI, indicating cytotoxic edema, can be observed in acute HE. However, neuropsychological impairment in HE ranges from mild deficits in psychomotor abilities affecting quality of life to stupor or coma with higher grades of hepatic dysfunction. In particular, the long-lasting compensatory mechanisms for the altered metabolism in chronic liver disease make HE imaging results variable. Therefore, the clinical relevance of imaging findings is uncertain and differentiating HE from other metabolic diseases can be difficult. The recent introduction of concepts such as "acute-on-chronic liver failure (ACLF)," a new clinical entity, has led to a change in the clinical view of HE. Accordingly, there is a need to establish a corresponding concept in the field of neuroimaging diagnosis. Herein, we review HE from a historical and etiological perspective to increase understanding of brain imaging and help establish an imaging approach for advanced new concepts such as ACLF. The purpose of this manuscript is to provide an understanding of HE by reviewing neuroimaging findings based on pathological and clinical concepts of HE, thereby assisting in neuroimaging interpretation.

• 디자인학연구
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• 제19권1호
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• pp.225-234
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• 2006

디자인과정 후반에서 제품 디자이너는 전경 형태(디테일 디자인)에 대한 다양한 아이디어를 스케치하고 배경형태(기본 조형)와의 수많은 조합을 테스트하게 된다. 이 때 디자이너들은 실제 제품과 거의 동일한 하이피델리티(high fidelity)의 디자인 모형을 제작해 세밀한 부분까지 점검하게 된다. 하지만 디자인 모형 제작에는 적지 않은 시간과 경비가 소요되기 때문에 배경형태와 전경 형태에 대한 다양한 조합을 모두 평가해 보는 것은 사실상 불가능하다고 할 수 있다. 또한 물리적으로 구현된 아이디어는 화면 속의 디지털 모형과는 달리 편집가능성이 부족하기 때문에 '디자인과 평가'라는 순환적 작업과정이 제한적으로 이루어질 수밖에 없다. 이런 문제를 해결하기 위해 본 연구는 증강현실기술을 응용하여 물리적 오브젝트에 디지털적으로 조형적 편집가능성을 증강시킬 수 있는 증가가소성의 개념을 제안하고 이를 디지털스킨으로 구체화하였다. 디지털스킨은 ARToolKit의 비주얼 마커를 이용해 오브젝트 표면의 위치와 방향을 트래 킹하고 차분렌더링기법을 활용하여 변형된 표면을 이음매 없이 덧붙일 수 있다. 본 연구는 구현된 디지털스킨을 제품 디테일과 부분수정 디자인 그리고 디자인 소재탐색 작업에 대한 적용해 보았다. 그 결과 디자인과정 후반에서 효과적으로 디자인 아이디어를 구현하고 테스트하는데 상당한 도움을 줄 수 있을 것으로 평가되었다.

• 전기화학회지
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• 제5권1호
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• pp.21-26
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• 2002

비정질 루테늄 산화물을 사용한 수퍼캐패시터를 개발하였다. 삼염화루테늄 수화물$(RuCl_3{\cdot}xH_2O)$로부터 제조한 비정질의 이산화루테늄 수화물$(RuO_2{\cdot}nH_2O)$을 사용하여 수퍼캐패시터 전극을 제조하였다. 집전체로는 티타늄 및 STS 304박막에 비해 보다 넓은 전위창을 가지는 탄탈륨 박막을 사용하였다. 제조한 전극과 4.8M 황산 전해액을 사용하여 수퍼캐패시터를 제조하였다. 전극의 비정전용량은 순환전위전류분석에서 미분 최대 값으로 산화 및 환원 과정 각각 710 및 $645\;F/g-RuO_2{\cdot}nH_2O$이었으며, 평균값은 $521\;F/g-RuO_2{\cdot}nH_2O$으로 나타났다. 수퍼캐패시터를 포화카로멜기준전극에 대하여 0.5 V로 protonation level을 조정하고, 충방전 시험한 바, $151\;F/g-RuO_2{\cdot}nH_2O$의 비정전용량을 나타내었다.