• Parasites, Hosts and Diseases
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• 제41권1호
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• pp.35-39
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• 2003

Although stool examination is the standard diagnostic method of clonorchiasis, serodiagnosis by ELISA using crude antigen is now widely used because of its convenience. However, ELISA diagnosis still suffers from cross-reactions, and therefore there is a need to improve the present conventional ELISA. The present study was undertaken to evaluate the diagnostic value of ELISA using excretory-secretory antigen (ESA) instead of crude antigen (CA) of Clonorchis sinensis. The diagnostic sensitivity of ELISA using excretory-secretory antigen was 92.5%, which was higher than that of ELISA using crude Clonorchis sinensis antigen (88.2%). In addition, the specificity of excretory-secretory antigen was found 93.1% while that of crude antigen was 87.8%. In summary, Clonorchis sinensis ESA was found to be a better serodiagnostic antigen than CA for ELISA.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5123-5126
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• 2014

Background: To evaluate the diagnostic performance of IOTA simple rules in differentiating between benign and malignant ovarian tumors. Materials and Methods: A study of diagnostic performance was conducted on women scheduled for elective surgery due to ovarian masses between March 2007 and March 2012. All patients underwent ultrasound examination for IOTA simple rules within 24 hours of surgery. All examinations were performed by the authors, who had no any clinical information of the patients, to differentiate between benign and malignant adnexal masses using IOTA simple rules. Gold standard diagnosis was based on pathological or operative findings. Results: A total of 398 adnexal masses, in 376 women, were available for analysis. Of them, the IOTA simple rules could be applied in 319 (80.1%) including 212 (66.5%) benign tumors and 107 (33.6%) malignant tumors. The simple rules yielded inconclusive results in 79 (19.9%) masses. In the 319 masses for which the IOTA simple rules could be applied, sensitivity was 82.9% and specificity 95.3%. Conclusions: The IOTA simple rules have high diagnostic performance in differentiating between benign and malignant adnexal masses. Nevertheless, inconclusive results are relatively common.

• 치과방사선
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• 제25권1호
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• pp.99-107
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• 1995

The aim of this study was to evaluate clinician's detectability in the diagnosis of bone loss in the bifurcation of mandibular molars on periapical radiographs and Digital images. Periapical radiographs were obtained of the first molars in 2 dry mandibles after preparation of bony defects corresponding to degree I, degree II and degree III buccal furcation involvements. The radiographs were randomly presented to 39 clinicians(1 oral radiologist, 4 periodontist, 34 general dentists) who were asked to determine the presence or absence of bone loss. Periapical films were digitized with a TV camera. Digital images were assessed by 15 clinicians(1 oral radiologist, 4 periodontist, 10 general dentists). I. the overall diagnostic accuracy of Digital images for detection of bone loss in the bifurcation of mandibular molars was higher than that of the periapical radiographs. 2. the largest increase in diagnostic accuracy was found between lesion grade II and III on both radiographs and Digital images(P<0.05). 3. there was no significant difference between the standard state and the controlled contrast state on Digital images. 4. the overall diagnostic accuracy of I radiologist and 4 periodontists was better than that of the general dentists for detecting bifurcation involvements.

• 대한의용생체공학회:의공학회지
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• 제36권4호
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• pp.86-94
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• 2015

In order for medical devices to be used outside hospital, they have to be not only of small size but also power consumption has to be kept at low level. This study investigates the feasibility of application of ADS1298 ECG single-chip solution developed by Texas Instruments Inc. for use in development of a new platform for diagnostic resting ECG. To prove the feasibility of commercial products based on the ADS1298 chip, the performance of the ADS1298 chip was measured in terms of input impedance, common mode rejection, frequency response, and input dynamic range using the testing method under the suitability criteria of the IEC 60601-2-25 standard. Result of the this study shows that commercialization of the ECG products based on the ADS1298 ECG single-chip solution that satisfies the international standards would be possible, if the manufactures take the filter characteristics into account in building a new platform for diagnostic resting ECG.

• 대한한방내과학회지
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• 제36권2호
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• pp.85-92
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• 2015

Objectives: The liver fibroscan has been developed as a noninvasive and convenient method to assess hepatic fibrosis. This study aimed to review this device in terms of its technological concept and clinical application in traditional Korean medicine (TKM). Methods: The technological background, diagnostic evaluation, and clinical usefulness of fibroscan were reviewed using various literature and clinical studies. One clinical example-a patient with hepatofibrosis who had been treated with TKM-is presented. Results: The liver fibroscan was approved as a medical device for noninvasive measurement of the hepatic fibrosis level by the Korean Food and Drug Administration (KFDA). Numerous clinical studies have confirmed that its sensitivity and specificity allow it to serve as a substitute for liver biopsy, the present gold standard diagnostic method. The accuracy and reproducibility and lack of technical risks are strong points of the fibroscan; however, it has some limitations for application, especially in patients with obesity or severe hepatitis. One clinical example showed the applicability of the liver fibroscan in herbal medicine-based treatments. Conclusions: The requirement for diagnostic medical devices is an important issue in TKM; therefore, this study provides valuable information for practitioners of TKM.

• 대한산업공학회지
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• 제30권1호
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• pp.44-49
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• 2004

The aim of this study is to compare the methods in analyzing bio-signals representing measure driver's psychophysiological staus. This study has considered three approaches: first, the deterministic approach calculating the mean and standard deviation of bio-signal, second, probabilistic approach converting driver's bio-signal values to probability density function and identifying individual state relative to overall distribution, and third, diagnostic approach identifying the pattern change of signal over certain period of time. For evaluation of analysis methods, driver's bio-signal was collected under various road conditions, and three analysis approaches were applied respectively. In result, the deterministic approach was found to be simple to use, but generated a large variability of bio-signal. The probabilistic approach provide a relative status of individual driver among overall population, but too much affected by temporal variability of individual driver. The diagnostic approach seemed to reasonably find driver's psychophysiological change over certain period of time, but still needs to develop quantification method of the bio-signal.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제29권4호
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• pp.172-177
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• 2018

Objectives: We examined the agreement between the Autism Diagnostic Observation Schedule (ADOS) and the Childhood Autism Rating Scale (CARS) in the diagnosis of autism spectrum disorder. Methods: The ADOS and CARS scores of 78 children were retrospectively collected from a chart review. A correlation analysis was performed to examine the concurrent validity between the two measures. Using the receiver operating characteristic (ROC) curve, we determined the optimal cut-off score of the CARS for identifying autism spectrum disorder. Results: The CARS score was significantly correlated with the ADOS score (r=0.808, p<0.001). Taking ADOS as the ideal standard, the optimal cut-off scores of CARS for identifying autism and autism spectrum were 30 and 24.5, respectively. Conclusion: We determined the optimal cut-off scores of CARS for screening and diagnosing autism spectrum disorder.

• 한국지능시스템학회논문지
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• 제16권6호
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• pp.742-746
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• 2006

학습자에 대한 학습능력의 평가는 진단평가, 형성평가와 총괄평가 단계로 구분할 수 있다. 이러한 단계적 평가는 학습자의 사전 학습 준비상태부터 학습 과정의 충실성 및 학습 결과까지를 종합적으로 판단할 수 있는 기준이 된다. 본 논문에서는 퍼지추론을 이용하여 각 단계의 평가를 모두 고려한 종합학습평가 방법을 제안하였다. 학습 수행능력에 대한 객관적인 평가를 위하여 각 평가 단계별로 가중치를 부여하였고, 진단, 형성 및 총괄 평가에 대한 퍼지추론에서 획득한 비퍼지화 값을 최종평가의 소속함수 구간으로 적용하였다. 그 결과 객관성을 보장할 수 있는 명확한 추론을 수행할 수 있었으며, 종합적인 학습평가 방법의 타당성을 보였다.

• 대한의생명과학회지
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• 제29권4호
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• pp.220-230
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• 2023

Identification of the pathogens causing infection is important in terms of patient's health management and infection control. Synovial fluids could be used as clinical samples to detect causative pathogens of prosthetic joint infections (PJIs) using molecular diagnostic assays, therefore, normalization and validation of clinical samples are necessary. Microbial culture is considered the gold standard for all infections, including PJIs. Recently, molecular diagnostic methods have been developed to overcome the limitation of microbial culture. Therefore, guideline for validating clinical samples to provide reliable results of molecular diagnostic assays for infectious diseases is required in clinical field. The present study aimed to develop an accurate validating method of synovial fluid clinical samples using GAPDH gene as an internal control to perform the quantitative PCR TaqMan probe assay to detect pathogens causing PJIs.

• Journal of Trauma and Injury
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• 제36권3호
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• pp.165-171
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• 2023

Trauma remains a significant healthcare burden, causing over five million yearly fatalities. Notably, the liver is a frequently injured solid organ in abdominal trauma, especially in patients under 40 years. It becomes even more critical given that uncontrolled hemorrhage linked to liver trauma can have mortality rates ranging from 10% to 50%. Liver injuries, mainly resulting from blunt trauma such as motor vehicle accidents, are traditionally classified using the American Association for the Surgery of Trauma grading scale. However, recent developments have introduced the World Society of Emergency Surgery classification, which considers the patient's physiological status. The diagnostic approach often involves multiphase computed tomography (CT). Still, newer methods like split-bolus single-pass CT and contrast-enhanced ultrasound (CEUS) aim to reduce radiation exposure. Concerning management, nonoperative strategies have emerged as the gold standard, especially for hemodynamically stable patients. Incorporating angiography with embolization has also been beneficial, with success rates reported between 80% and 97%. However, it is essential to identify the specific source of bleeding for effective embolization. Given the severity of liver trauma and its potential complications, innovations in diagnostic and therapeutic approaches have been pivotal. While CT remains a primary diagnostic tool, methods like CEUS offer safer alternatives. Moreover, nonoperative management, especially when combined with angiography and embolization, has demonstrated notable success. Still, the healthcare community must remain vigilant to complications and continuously seek improvements in trauma care.