• Tuberculosis and Respiratory Diseases
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• 제44권3호
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• pp.611-620
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• 1997

연구배경 : 결핵성 흉막염의 감별 진단 목적으로 널리 이용되고 있는 검사는 adenosine deaminase와 INF-$\gamma$를 세포성 면역에 또다른 중요한 매개체로 알려진 TNF-$\alpha$의 진단적 의의를 조사하고, 현재 임상에서 유용한 지표로 사용되고 있는 adenosine deaminase와의 감별력을 비교하고자 본 연구를 시행하였다. 방 법 : 삼출성 흉막염 80예(결핵성 : 39예, 암성 : 31예, 부폐렴흉막염 : 10예)를 대상으로 흉수의 기본적인 세포조성, 화학 검사와 더불어 ADA와 TNF-$\alpha$(Medgenix IRMA kit)를 측정하였다. 결 과 : 흉수내 ADA농도는 결핵성 흉막염에서 $48.7{\pm}32.7U/L$로 비결핵성 흉막염 $26.0{\pm}41.3U/L$에 비해 유의한 차이로 높았고(p < 0.05), TNF-$\alpha$치 또한 결핵성 흉막염에서 $184.1{\pm}214.2pg/mL$로 비결핵성 흉막삼출액 $44.1{\pm}114.2pg/mL$에 비해 유의하게 높았다(p < 0.01). ROC 곡선을 이용하여 ADA와 TNF-$\alpha$의 감별력을 가장 높일 수 있는 기준치를 정하였을 때, ADA는 30U/ml, TNF-$\alpha$는 15pg/ml로 측정되었고, 각각의 기준치를 이용하여 감수성과 특이도를 구하였을때, ADA는 감수성 66.7%, 특이도 85.0%, TNF-$\alpha$는 감수성 69.2% 특이도 87.1%를 보였다. 두 검사의 민감도와 특이도를 비교하기 위한 ROC 곡선에서, ROC 곡선아래의 면적(area under curve)은 ADA와 TNF-$\alpha$사이에 유의한 차이가 없었다(ADA 0.83, TNF-$\alpha$ 0.82). 다중회귀분석(multiple stepwise regression)에서 ADA가 가장 유용한 지표로 계산되었으나 TNF-$\alpha$의 추가가 분별력에 더 이상의 기여함은 없었다. 결 론 : 결핵성 흉막염과 비결핵성 흉막염을 감별 진단하는데 ADA와 함께 TNF-$\alpha$도 유용한 지표로 이용될 수 있으나 두가지 검사를 함께 시행함에 따른 진단에 있어서의 잇점은 없었다.

• 과학교육연구지
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• 제37권1호
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• pp.52-67
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• 2013

이 연구는 과학교육마술 프로그램을 개발하고 실제 교수-학습 과정에 적용함으로써 과학교육마술 프로그램 활용 수업이 초등학생의 창의적 문제해결력, 과학탐구능력, 과학적 태도에 미치는 영향과 과학교육마술 프로그램 활용 수업에 대한 학생들의 인식을 알아보는 데 목적이 있다. 이 연구를 위해 경기도 수원시에 위치한 J초등학교 3학년 2개 학급 60명을 대상으로 비교반(30명)과 실험반(30명)을 선정하였고, 비교반은 교과서 중심의 수업 방법을 적용하였으며 실험반은 과학교육마술 프로그램을 활용하여 수업을 진행하였다. 실험처치 후, 실험반과 비교반을 대상으로 각 영역에 대한 검사를 실시하여 과학교육마술 프로그램이 창의적 문제해결력, 과학탐구능력, 과학적 태도에 미치는 영향과 과학교육마술 프로그램 활용 수업에 대한 학생들의 인식을 알아보았다. 이 연구의 결과는 다음과 같다. 첫째, 과학교육마술 프로그램을 적용한 실험반 학생들의 창의적 문제해결력의 변화에 있어서 비교반 학생들에 비해 통계적으로 유의한 향상을 보였다(p<.05). 둘째, 과학교육마술 프로그램을 적용한 실험반 학생들의 과학탐구능력 점수는 비교반 학생들에 비해 향상되었으나 통계적으로 유의한 수준은 아니었다. 그러나 기초탐구과정의 하위 영역 중 '측정'에서 유의한 차이를 나타냈으며, 과학교육마술 프로그램 활용 수업은 측정 능력에 긍정적인 영향을 미친다고 할 수 있다. 셋째, 실험반 학생들의 과학적 태도 점수는 비교반 학생들에 비해 향상되었으나 통계적으로 유의한 수준은 아니었다. 그러나 과학적 태도의 하위 영역 중 '끈기성'에서 유의한 차이를 나타냈으며, 과학교육마술 프로그램 활용 수업은 끈기성에 긍정적인 영향을 미친다고 할 수 있다. 넷째, 설문 분석 결과 '과학교육마술 수업으로 과학 수업이 즐거웠다'(100%), '과학교육마술 수업을 할 때 수업에 더 열심히 참여하였다'(87%), '과학교육마술 프로그램이 수업 내용을 이해하는 데 도움이 되었다'(93%), '과학교육마술 수업을 하면서 과학에 대한 흥미와 관심이 많아졌다'(90%), '앞으로도 과학교육마술 수업을 계속 했으면 좋겠다'(100%)라는 의견은 과학교육마술 프로그램이 학생들의 과학에 대한 관심 및 흥미 증가, 수업 참여도 향상, 학습 내용의 이해, 과학 수업에서의 즐거움 증가 등 인지적, 정의적 영역에 골고루 긍정적인 영향을 주는 것으로 나타났다. 따라서 이 연구에서 적용한 과학교육마술 프로그램은 창의적 문제해결력 및 과학에 대한 흥미와 관심, 학습 내용의 이해도, 과학수업에서의 즐거움, 수업 참여도 등을 향상시킬 수 있다는 측면에서 초등 과학 현장에 활용할 가치가 있음을 알 수 있다.

• 대한의생명과학회지
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• 제19권2호
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• pp.90-97
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• 2013

The tuberculin skin test (TST) and interferon gamma (IFN-${\gamma}$) release assay (IGRA) have been widely used for diagnosis of latent tuberculosis infection (LTBI). In order to overcome limitations of current LTBI diagnostic methods, the development of a novel molecular assay which is able to measure the IFN-${\gamma}$ messenger RNA (mRNA) expression level after stimulation with Mycobacterium tuberculosis (MTB) specific antigen was recently developed. The ability of a molecular assay to detect MTB infection was similar to commercial IGRA however, the optimal incubation time for stimulating IFN-${\gamma}$ was not yet established. Therefore, in this study the direct comparisons of MTB Ag stimulation times (4 and 24 hrs) were performed for diagnosis of MTB infection. Data showed that the coincident rate between QFT-GIT IFN-${\gamma}$ ELISA and IFN-${\gamma}$ RT-PCR (4 hrs) was 88.35% and that of QFT-GIT and IFN-${\gamma}$ RT-PCR (24 hrs) was 70.85%. Based on a receiver operating characteristic (ROC) curve, the 4 hrs-MTB specific Ag stimulation time for IFN-${\gamma}$ RT-PCR had the significant P value, 95% CI value, and AUC (P < 0.0001, 95% CI=0.82 to 1.02, and AUC=0.9214) in comparison with 24 hrs-MTB specific Ag stimulation time (P = 0.009, 95% CI=0.06 to 0.94, and AUC=0.7711). These results show that 4-hr was the most optimal MTB Ag stimulation time for performing IFN-${\gamma}$ RT-PCR. Although semi-quantitative RT-PCR had a few analytical limitations, it might be useful as an alternative molecular diagnostic method for detecting MTB infection.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제8권1호
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• pp.101-112
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• 1997

본 연구의 목적은 학습 장애를 진단하는데 있어 성취도 검사인 기초학습기능검사의 유용성을 살펴보는 것이다. 학습 장애 집단은 두 유형으로 나누어 언어적 학습 장애 집단(VLD：Verbal Learning Disorder) 34명, 비언어적 학습 장애 집단(NVLD：Nonverbal Learning Disorder) 14명으로 총 48명으로 구성되었으며, 비교 집단으로는 Dysthymia 집단 11명, 정상아 20명을 대상으로 지능 검사 및 기초학습 기능검사의 수행을 비교하였다. 지능 검사에서 VLD집단은 어휘력 및 언어를 통한 학습 과제, 언어-청각적인 주의과제에서 의미있는 저하를 나타내었고, NVLD 집단은 시-지각의 정확도, 정신-운동성 기능의 협응 속도, 시각-공각적인 조직력 등 동작성 기능 전반에 걸쳐 비효율성을 나타내었다. 기초학습기능검사에서는 VLD 집단은 음운 부호화과제, 셈하기 능력, 단어 재인 과제에서 의미있는 저하를 나타내었다. 또한 지능 검사의 소검사들에 기초학습기능검사의 소검사들을 포함하여 판별 분석을 한 결과, 기초학습기능검사를 포함시키지 않은 경우보다 판별율이 높아졌을 뿐 아니라, VLD집단을 유의미하게 판별해 주는 판별 함수를 도출하였다. 각 소검사들의 속성을 분석하기 위하여 요인 분석을 실시하였으며 이를 통하여 소검사들을 유목화하였으며 마지막으로 현 논문의 제한점 및 기초학습기능검사의 제한점을 논의하였다.

• 대한핵의학회지
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• 제3권1호
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• pp.73-82
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• 1969

The newly developed diagnostic method with application of $^{113}Sn-^{113m}In$ cow system ($^{113}Sn:\;T\frac{1}{2}$ 118 days, $^{113m}In:\;T\frac{1}{2}$ 1.7 hrs, 390 Kev, Single ${\gamma}$) has the remarkable advantages such as increased diagnostic ability by single large dose administration of $^{113m}In$ with no subsequent radiation hazard and shortened examining time. We reformed the research of following scope with the use of developed $^{113}Sn-^{113m}In$ cow (25 mCi) generator: The sizes of particles produced under various conditions were investigated, and possibility for application to the scannings of various organs such as brain, liver, lung, bone marrow and blood pool etc. were studied. Results: $^{113m}InCl_3$ solution eluted from diluted HCl solution (pH 1.5) passed through $^{113}Sn-^{113m}In$ generator, and there can be produced various sized particles of colloidal indium. And there observed the state of distribution of $^{113m}In$ in each organ which showed many differences according to the particle sizes of colloidal indium. The results are stated as follows: 1. The adjustment of pH is the most important factor in making the desirable particle size of colloidal indium. The colloid for blood pool showed the highest level as 7.1%/gm blood, at pH 1.7, the colloid of pH 3.5 for liver scanning showed the highest level, 88.4%, in the liver, the colloid pH 6 showed the highest level, 3.1%, in the spleen, and the colloid of pH 11.0 showed the highest level, 85.3%/gm, in the lung. 2. The colloid for liver scanning made with NaCl-NaOH system showed the highest liver uptake at pH 7.2, and at either higher or lower pH than 7.2 showed decrease of liver uptake more or less. 3. The activity of $^{113m}In$ eluted through $^{113}Sn-^{113m}In$ generator indicated over 90% in the initial 4 ml, and particularly 88.1%-86.0% in the initial 2 ml. 4. The incubation time, tempertaure and mechanical irritation related to colloid formation and coating of colloid were not the definite condition of influence.

• 한국치위생학회지
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• 제10권6호
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• pp.1037-1048
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• 2010

Objectives : The awareness of health care need increasing attention from the public along with changing professional human-resources activity. As there are increasing social demand for the roles and professionalism of dental hygienists, the purpose of this study was to examine the job performance, creativity and organizational climate of dental hygienists by their own self-diagnostic evaluation in an attempt to help enhance their work ability. Methods : According to the data released as August 2008 by the Dental Association and public health centers in Gwangju, 735 dental hygienists worked at 425 dental clinics. The subjects in this study were 156 dental hygienists at 85 dental clinics who were selected by proportionate sampling method from among the dental hygienists. After an interview survey was conducted in person, the answer sheets from 132 respondents were analyzed except 24 incomplete ones. The questionnaire used in this study consisted of 49 items. A five-point Likert scale was used and SPSS 12.0 program was analyzed the data. Results : 1. As a result of checking the types of works, treatment cooperation(54%), and oral health education often(45%), They weren't responsible for preventive treatment(42%). 2. When they made a self-diagnostic evaluation of creativity and organizational climate, they put the highest value on their autonomy(2.21), followed by positive attitude(2.10). Out of seven organizational climate, challenging spirits(2.81) ranked highest, followed by reliability(2.66). 3. Major management eopmubyeol individual creativity compared with three business relationships and a positive attitude in the case of the high group received oral health education and care management services in a group doing the most was General office work and office assistance work in the medical assistance group that was doing business primarily. 4. In the relationship between self-assesment score and three performance duties, Positive difference was noted in the group with positive attitude and elevated autonomy in terms of performing oral health education. Conclusions : As a result, individual creativity and organization of the atmosphere, each detail, through analysis of the self-assessment model, developed guide on the investigation by doing a dental hygienist, a unique business promotion and Enlargement of the study suggested the need to be considered is.

• 생물정신의학
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• 제14권2호
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• pp.129-141
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• 2007

Objectives : Empathy has been conceptualized as the ability of emotional resonance and perspective-taking. Emotional awareness has been proposed as the basis of empathy. In this study we examined the relationship between empathy and mood awareness and their neural correlates in resting-state activity in normal controls and patients with schizophrenia. Methods : Empathy and mood awareness scale scores were compared between 29 patients with schizophrenia and 21 normal controls by voxel-based t-tests and voxel-based correlation analyses of resting-state $^{18}F$-FDG PET images. Results : Empathy and mood labeling scale scores were significantly decreased in schizophrenic patients. Mood monitoring was positively correlated with empathy score in normal controls, but not in schizophrenic patients. In normal controls, empathy was positively correlated with resting-state activities in the intraparietal sulcus and mood monitoring was positively correlated with the temporal pole, frontopolar cortex, inferior temporal gyrus, entorhinal cortex and the subgenual prefrontal cortex resting activities. The orbitofrontal cortex resting activity was positively correlated with mood monitoring-related subgenual prefrontal cortex activity in the normal controls. Patients with schizophrenia showed decreased orbitofrontal resting activity and loss of its correlations with mood monitoring-related regional activities. Conclusion : This study showed that alteration in the resting-state activity in schizophrenia may reflect dysfunctional empathy and distorted characteristic of emotional awareness. However, the resting-state activity may not reflect the relationship between emotional awareness and empathy.

• Korean Journal of Radiology
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• 제19권6호
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• pp.1110-1118
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• 2018

Objective: To perform a meta-analysis to quantitatively assess functional magnetic resonance imaging (MRI) in the diagnosis of locally recurrent prostate cancer. Materials and Methods: A comprehensive search of the PubMed, Embase, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews was conducted from January 1, 1995 to December 31, 2016. Diagnostic accuracy was quantitatively pooled for all studies by using hierarchical logistic regression modeling, including bivariate modeling and hierarchical summary receiver operating characteristic (HSROC) curves (AUCs). The Z test was used to determine whether adding functional MRI to T2-weighted imaging (T2WI) results in significantly increased diagnostic sensitivity and specificity. Results: Meta-analysis of 13 studies involving 826 patients who underwent radical prostatectomy showed a pooled sensitivity and specificity of 91%, and the AUC was 0.96. Meta-analysis of 7 studies involving 329 patients who underwent radiotherapy showed a pooled sensitivity of 80% and specificity of 81%, and the AUC was 0.88. Meta-analysis of 11 studies reporting 1669 sextant biopsies from patients who underwent radiotherapy showed a pooled sensitivity of 54% and specificity of 91%, and the AUC was 0.85. Sensitivity after radiotherapy was significantly higher when diffusion-weighted MRI data were combined with T2WI than when only T2WI results were used. This was true when meta-analysis was performed on a per-patient basis (p = 0.027) or per sextant biopsy (p = 0.046). A similar result was found when $^1H$-magnetic resonance spectroscopy ($^1H$-MRS) data were combined with T2WI and sextant biopsy was the unit of analysis (p = 0.036). Conclusion: Functional MRI data may not strengthen the ability of T2WI to detect locally recurrent prostate cancer in patients who have undergone radical prostatectomy. By contrast, diffusion-weight MRI and $^1H$-MRS data may improve the sensitivity of T2WI for patients who have undergone radiotherapy.

• Korean Journal of Radiology
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• 제1권1호
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• pp.25-32
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• 2000

Objective: The purpose of our study was to determine the ability of H-1 MR spectroscopy (MRS) to lateralize the lesion in patients with hippocampal sclerosis. Materials and Methods: Twenty healthy volunteers and 25 patients with intractable temporal lobe epilepsy whose MR imaging diagnosis was unilateral hippocampal sclerosis were included. This diagnosis was based on the presence of unilateral atrophy and/or high T2 signal intensity of the hippocampus. Single-voxel H-1 MRS was carried out on a 1.5-T unit using PRESS sequence (TE, 136 msec). Spectra were obtained from hippocampal areas bilaterally with volumes of interest (VOIs) of 6.0 cm³ and 2.25 cm³ in healthy volunteers, and of either 6.0 cm³ (n = 14) or 2.25 cm³ (n = 11) in patients. Metabolite ratios of NAA/Cho and NAA/Cr were calculated from relative peak height measurements. The capability of MRS to lateralize the lesion and to detect bilateral abnormalities was compared with MR imaging diagnosis as a standard of reference. Results: In healthy volunteers, NAA/Cho and NAA/Cr ratios were greater than 0.8 and 1.0, respectively. In patients, the mean values of these ratios were significantly lower on the lesion side than on the contralateral side, and lower than those of healthy volunteers (p < .05). The overall correct lateralization rate of MRS was 72% (18/25); this rate was lower with a VOI of 6.0 cm³ than of 2.25 cm³ (64% versus 82%, p < .05). Bilateral abnormalities on MRS were found in 24% (6/25) of cases. Conclusion: Although its rate of correct lateralization is low, single-voxel H-1 MRS is a useful and promising diagnostic tool in the evaluation of hippocampal sclerosis, particularly for the detection of bilateral abnormalities. To improve the diagnostic accuracy of H-1 MRS, further investigation, including the use of a smaller VOI and measurement of the absolute amount of metabolites, are needed.

• 컴퓨터교육학회논문지
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• 제17권2호
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• pp.11-19
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• 2014

현재 인터넷윤리교육은 통합적 도덕성을 바탕으로 한 윤리교육 모델에 기반하여 이루어지고 있다. 즉 인지적인 영역과 행동적인 영역이 상관관계를 가지고 윤리적 인지가 도덕적 행동으로 실행될 것으로 기대한 학습모델이다. 그러나 인터넷윤리교육이 범국민적으로 추진되고 있지만, 정보화의 역기능으로 인한 문제는 증가하고 있다. 본 연구에서는 효과적인 인터넷윤리교육에 대한 시사점을 도출하고자 윤리적 인지와 도덕적 행동이 관련이 있는지 분석하였다. 현실에서의 도덕적 행동에 관한 측정 도구는 '도덕 판단력', 인터넷 상에서의 도덕적 행동은 '정보윤리 판단력', 인터넷에서의 윤리적 인지는 '인터넷윤리의식' 자가진단 도구를 사용하여 수준을 측정하고 이들 간의 관계를 분석하였다. 연구결과 대학생들의 도덕 판단력과 정보윤리 판단력, 인터넷윤리의식 수준은 전반적으로 현저히 낮았다. 도덕 판단력과 정보윤리 판단력은 약한 상관관계를 가지고 있어 현실에서의 행동과 인터넷 상에서의 행동은 거의 상관관계가 없는 것으로 나타났다. 정보윤리 판단력, 인터넷윤리의식 간에도 유의미한 상관관계가 없었다. 즉 인터넷 상에서의 인지와 행동은 상관관계가 없으므로, 인터넷윤리교육은 윤리적인지가 윤리적 행동으로 이어진다는 이론에 근거한 윤리교육학습 모델과는 다른 교육모델을 기반으로 수행되어야 한다. 인터넷윤리교육은 윤리적 인식과 도덕적 행동을 각각 중요한 교수영역으로 다루어야 한다.