• Journal of Life Science
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• v.20 no.4
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• pp.602-606
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• 2010

Type 2 diabetes is a typical polygenic disease complex, for which several common risk alleles have been identified. Proteins in the matrix metalloproteinase-3 (MMP3) family are involved in the breakdown of the extracellular matrix in normal physiological processes such as embryonic development, reproduction and tissue remodeling, as well as in disease processes. Therefore, we investigated the genotype for the A(-267)G, A658G and T813C polymorphisms in the MMP3 gene in the Korean population and compared genotypes of patients with those of the control group. 200 patients (male 108, female 92), who had previously been diagnosed with type 2 diabetes (T2DM) and 100 control subjects (male 36, female 64) participated in this study. There was a strong association between A(-267)G and A658G polymorphism in the MMP3 gene and T2DM. The present study shows that MMP3 polymorphisms (A(-267)G and A658G) may be associated with the pathogenesis of T2DM. Further studies with a larger population may be needed for the development of diagnostic methods at a genetic level, such as DNA chip.

• Smart Structures and Systems
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• v.10 no.3
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• pp.229-251
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• 2012

Guided waves have shown a great potential for structural health monitoring (SHM) applications. In contrast to traditional non-destructive testing (NDT) methodologies, a key element of SHM approaches is the high process of automation. The monitoring system should decide autonomously whether the host structure is intact or not. A basic requirement for the realization of such a system is that the sensors are permanently installed on the host structure. Thus, baseline measurements become available that can be used for diagnostic purposes, i.e., damage detection, localization, etc. This paper contributes to guided wave-based inspection in anisotropic materials for SHM purposes. Therefore, computational strategies are described for both, the solution of the complex equations for wave propagation analysis in composite materials based on exact elasticity theory and the popular global matrix method, as well as the underlying equations of two active damage localization algorithms for anisotropic structures. The result of the global matrix method is an angular and frequency dependent wave velocity characteristic that is used subsequently in the localization procedures. Numerical simulations and experimental investigations through time-delay measurements are carried out in order to validate the proposed theoretical model. An exemplary case study including the calculation of dispersion curves and damage localization is conducted on an exemplary unidirectional composite structure where the ultrasonic signals processed in the localization step are simulated with the spectral element method. The proposed study demonstrates the capabilities of the proposed algorithms for accurate damage localization in anisotropic structures.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2175-2178
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• 2012

Purpose: Definite diagnosis of follicular thyroid carcinoma (FTC) is based on the presence of capsular or vascular invasion. To date, no reliable and practical method has been introduced to discriminate this malignant neoplasm from follicular thyroid adenoma (FTA) in fine needle aspiration biopsy material. Matrix metalloproteinase-2 (MMP-2), by degrading extracellular matrix, and caspase-3, by induction of apoptosis, have been shown to play important roles in carcinogenesis and aggressive behavior in many tumor types. The aim of this study was to examine expression of MMP-2 and caspase-3 in thyroid follicular neoplasms and to determine their usefulness for differential diagnosis. Method: Sixty FTAs and 41 FTCs were analysed immunohistochemically for MMP-2 and caspase-3. Result: MMP-2 was positive in 4 FTCs (9.8%), but in none of FTAs, with statistical significance (p= 0.025). Caspase-3 was positive in 30 (50%) of FTAs and in 27 (65.9%) of FTCs. Conclusion: Our results show MMP-2 expression only in FTCs and suggest that this protein may be a useful marker to confirm diagnosis of FTC versus FTA with 100% specificity and 100% predictive value of a positive test. We failed to show any differential diagnostic value for caspase-3 in thyroid follicular neoplasms.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2887-2889
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• 2012

Malignant tumors have a capacity to degrade the extracellular matrix by controlled proteolysis. One system involved in these processes is the urokinase-type plasminogen activator (uPA) system. uPAR levels are elevated in tumors from several types of cancer. Our study was planned to investigate serum and urine levels of uPAR in breast cancer patients (n=180) and healthy controls (n=60) by ELISA. Serum (p<0.001) and urine (p<0.001) uPAR values in the patients were both significantly elevated. High serum and urine levels of uPAR can be used as diagnostic tools in lymph node positive patients.

• Proceedings of the KSME Conference
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• 2001.11a
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• pp.562-567
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• 2001

The number of required modes to provide accurate force information in a truncated model of a flexible structure is investigated. In the case of modal truncation of a distributed parameter system, the difference in convergence rates between displacements and forces is discussed. The residual flexibility, a term from past literature, is used to recapture some of the lost force information in a truncated model. This paper presents numerical and experimental results of a study where the residual flexibility is used in conjunction with a Kalman filter so that accurate force information may be obtained from a small set of displacement measurements with a reduced-order model. The motivation for this paper is to be able to obtain accurate information about unmeasurable dynamic reaction forces in a rotating machine for diagnostic and control purposes.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1997.10a
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• pp.224-228
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• 1997

Computer vision system become more important as the researches on inspection systems, intelligent robots , diagnostic medical systems is performed actively. In this paper, 3D measuring system is developed by using stereo vision. The relation between left image and right image is obtained by using 8 point algorithm, and fundamental matrix, epipole and 3D reconstruction algorithm are used to measure 3D dimensions. 3D measuring system was developed by Visual Basic, in which 3D coordinates would be obtained by simple mouse clicks. This software would be applied to construction area, home interior system, rapid measuring system.

• Journal of the Korean Society for Precision Engineering
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• v.19 no.1
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• pp.150-157
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• 2002

The number of required modes to provide accurate force information in a truncated model of a flexible structure is investigated. In the case of modal truncation of a distributed parameter system, the difference in convergence rates between displacements and forces is discussed. The residual flexibility. a term from past literature, is used to recapture some of the lost force information in a truncated model. This paper presents numerical and experimental results of a study where the residual flexibility is used in conjunction with a Kalman filter so that accurate force information may be obtained from a small set of displacement measurements wish a reduced-order model. The motivation for this paper is to be able to obtain accurate information about unmeasurable dynamic reaction forces in a rotating machine for diagnostic and control purposes.

• The Korean Journal of Cytopathology
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• v.5 no.1
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• pp.61-64
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• 1994

Chondroblastoma is a benign bone tumor accounting for less than 1 % of bone tumor. It infrequently involves the flat bones, among which ribs are particularly rare. On fine needle aspiration cytology, the diagnostic smear consists of chondroblasts, osteoclast-like giant cells, and chondroid matrix. The cytologic hallmark to differentiate from other giant cell-containing lesions is chondroblasts. We experienced a case of chondroblastoma in a 13-year-old female. Fine needle aspiration cytology from the 5 th rib revealed dispersed chondroblasts and osteoclast-like giant cells on hemorrhagic background. Chondroblasts had round to oval nuclei with fine, evenly distributed chromatin and distinctive grooves or indentation. Their cytoplasm was well-defined.

• Proceedings of the KSMRM Conference
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• 2002.11a
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• pp.135-135
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• 2002

Purpose： To assess diagnostic accuracy of dynamic contrast enhanced MR mammography in differentiating between benign and malignant lesions. Materials and methods： Ninety-three patients with suspicious mammographic, sonographic or palpable findings underwent pre- or postoperative contrast-enhanced MR imaging of breast using three dimensional fast low-angle shot (3D FLASH) sequence (16/4 msec［repetition time / echo time］, 20 flip angle, 3mm slice thickness with no slice gap, 256 by 256 in-plane matrix) covering whole breasts. T1 weighted images were obtained before and after bolus administration of gadopentetate dimeglumine (0.15 mmol/kg). Subtraction images and time-signal intensity curves of region of interest were obtained sequentially and correlated with pathologic diagnoses of lesions.

• Progress in Medical Physics
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• v.12 no.1
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• pp.9-17
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• 2001

The prior purpose of this study is to introduce a optical biopsy and evaluate whether the optical biopsy, real-time, non-invasive technique, is a reliable tool to assess response to radiotherapy Four healthy volunteers, and four patients with inflammatory conditions of the oral cavity participated on the study. was obtained from each person enrolled in the study. Using FastEEM(Ercited Emission Matrix) as a optical biopsy tool, normal and tumor spectra are taken from the normal and the tumor regions. And then second optical biopsy are taken from the tumor regions in 4 patients with time delay at 7days.. Using a diagnostic algorithm, made by Gillenwater based on spectra excited at 337nm The Optical Biopsy turned out to be more suited for tumor diagnostic resulting in significant difference fluorescence spectra. The fluorescence intensity of cancerous tissue showed a higher position. The second fluorescence intensity of optical biopsy of cancerous oral tissue has more smaller than the first result. I conclude that optical biopsy, which technique don't need to remove tissue sample from body, and is a real time , and non-invasive measurement is a reliable tool to access to radiotherapy because FastEEM can do measure the variation of the tissue composition chemical, biological, and morphological after radiotherapy. Based on the fluorescence spectrum are taken from the optical biopsy in normal and tumor spectra as well as tumor spectra after 7days.