• Title/Summary/Keyword: Diagnostic Indicators

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Exploratory Study to Evaluate Changes in Serum Lipid Levels as Early Diagnostic and/or Prognostic Indicators for Oral Submucous Fibrosis and Cancer among Gutkha Consumers in India

  • Agarwal, Ankit;Saxena, Anshul;Rubens, Muni;Ahuja, Rinky;Tijare, Manisha
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.15
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    • pp.6439-6444
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    • 2015
  • Background: In India smokeless tobacco users account for 25.9% of total tobacco use, Gutkha being the most common form. This study evaluated the association between serum lipid profile and Gutkha use as an early diagnostic and/or prognostic indicator for oral submucous fibrosis (OSMF) and oral cancer (Oral Ca) in non-smokers and non-alcohol consumers. Materials and Methods: A total of 163 participants were recruited from two sites in India. Participants were divided into four groups: individuals without any Gutkha chewing habit and without any oral lesions (control group), individuals with Gutkha chewing habit but without any oral lesions (GWL), patients with a confirmed clinical diagnosis of OSMF, and patients with a confirmed diagnosis of Oral Ca. Mixed linear modelling (MLM) was conducted to detect the change in mean serum lipid levels among four groups. Results: The sample consisted of 69% males and 31% females. Results of MLM show an inverse relationship between serum lipid levels in OSMF, and Oral Ca groups when compared to the control group. Conclusions: The results of our study demonstrated that GWL, OSMF and Oral Ca patients had lower serum lipid levels. Low serum lipid levels could be an indicator of initial neoplastic changes in oral cancer.

Image analysis of the eruptive positions of third molars and adjacent second molars as indicators of age evaluation in Thai patients

  • Mahasantipiya, Phattaranant May;Pramojanee, Sakarat;Thaiupathump, Trasapong
    • Imaging Science in Dentistry
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    • v.43 no.4
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    • pp.289-293
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    • 2013
  • Purpose: This study was performed to determine the relationship between the stage of tooth eruption (both vertical and mesio-angular) and chronological age. Materials and Methods: Indirect digital panoramic radiographs were used to measure the distances from the dentinoenamel junction (DEJ) of the second molars to the occlusal plane of the second molar teeth and of the adjacent third molars in 264 Thai males and 437 Thai females using ImageJ software. The ratio of those distances was calculated by patient age, and the correlation coefficient of the ratio of the third molar length to the second molar length was calculated. Results: The correlation between the height of the vertically erupted upper third molar teeth and age was at the intermediate level. The age range of ${\geq}15$ to <16 years was noted to be the range in which the correlation between the chronological age determined from the eruptional height and actual chronological age was statistically significant. The mean age of the female subjects, in which the position of the right upper third molar teeth was at or above the DEJ of the adjacent second molar but below one half of its coronal height was $19.9{\pm}2.6$ years. That for the left side was $20.2{\pm}2.7$ years. The mean ages of the male subjects were $20.1{\pm}3.3$ years and $19.8{\pm}2.7$ years for the right and left sides, respectively. Conclusion: It might be possible to predict chronological age from the eruption height of the wisdom teeth.

Building Living Lab for Acquiring Behavioral Data for Early Screening of Developmental Disorders

  • Kim, Jung-Jun;Kwon, Yong-Seop;Kim, Min-Gyu;Kim, Eun-Soo;Kim, Kyung-Ho;Sohn, Dong-Seop
    • Journal of the Korea Society of Computer and Information
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    • v.25 no.8
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    • pp.47-54
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    • 2020
  • Developmental disorders are impairments of brain and/or central nervous system and refer to a disorder of brain function that affects languages, communication skills, perception, sociality and so on. In diagnosis of developmental disorders, behavioral response such as expressing emotions in proper situation is one of observable indicators that tells whether or not individual has the disorders. However, diagnosis by observation can allow subjective evaluation that leads erroneous conclusion. This research presents the technological environment and data acquisition system for AI based screening of autism disorder. The environment was built considering activities for two screening protocols, namely Autism Diagnostic Observation Schedule (ADOS) and Behavior Development Screening for Toddler (BeDevel). The activities between therapist and baby during the screening are fully recorded. The proposed software in this research was designed to support recording, monitoring and data tagging for learning AI algorithms.

Personalized Diabetes Risk Assessment Through Multifaceted Analysis (PD- RAMA): A Novel Machine Learning Approach to Early Detection and Management of Type 2 Diabetes

  • Gharbi Alshammari
    • International Journal of Computer Science & Network Security
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    • v.23 no.8
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    • pp.17-25
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    • 2023
  • The alarming global prevalence of Type 2 Diabetes Mellitus (T2DM) has catalyzed an urgent need for robust, early diagnostic methodologies. This study unveils a pioneering approach to predicting T2DM, employing the Extreme Gradient Boosting (XGBoost) algorithm, renowned for its predictive accuracy and computational efficiency. The investigation harnesses a meticulously curated dataset of 4303 samples, extracted from a comprehensive Chinese research study, scrupulously aligned with the World Health Organization's indicators and standards. The dataset encapsulates a multifaceted spectrum of clinical, demographic, and lifestyle attributes. Through an intricate process of hyperparameter optimization, the XGBoost model exhibited an unparalleled best score, elucidating a distinctive combination of parameters such as a learning rate of 0.1, max depth of 3, 150 estimators, and specific colsample strategies. The model's validation accuracy of 0.957, coupled with a sensitivity of 0.9898 and specificity of 0.8897, underlines its robustness in classifying T2DM. A detailed analysis of the confusion matrix further substantiated the model's diagnostic prowess, with an F1-score of 0.9308, illustrating its balanced performance in true positive and negative classifications. The precision and recall metrics provided nuanced insights into the model's ability to minimize false predictions, thereby enhancing its clinical applicability. The research findings not only underline the remarkable efficacy of XGBoost in T2DM prediction but also contribute to the burgeoning field of machine learning applications in personalized healthcare. By elucidating a novel paradigm that accentuates the synergistic integration of multifaceted clinical parameters, this study fosters a promising avenue for precise early detection, risk stratification, and patient-centric intervention in diabetes care. The research serves as a beacon, inspiring further exploration and innovation in leveraging advanced analytical techniques for transformative impacts on predictive diagnostics and chronic disease management.

A Study on the Selection of Indicators and the Utilization of Public Data for the Diagnosis of Rural Areas - Focusing on Social, Environmental and Cultural Data - (농촌지역 진단을 위한 지표 선정과 공공데이터 활용 방안 - 사회·환경·문화를 중심으로 -)

  • Do, Jee yoon;Kim, Sang-Bum;Kim, Suyeon
    • Journal of Korean Society of Rural Planning
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    • v.29 no.4
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    • pp.153-163
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    • 2023
  • This study was conducted to review data utilization plans and suggest solutions based on the need for tools that can objectively diagnose problems in rural areas. The study extracted items through prior research and was carried out as a process of reviewing data capable of constructing spatial data. The results performed in the above manner are as follows. First, prior research and expert surveys were conducted to select diagnostic items to derive details of a total of three items that should be considered for rural space plans such as regional revitalization and regeneration using regional characteristics such as environment, society, and culture. Second, as a result of listing data available for regional diagnosis, 6 types of environment, 15 types of society, and 18 types of culture were selected out of a total of 529. Finally, it was suggested to establish a national standard spatial unit by grasping the limitations of public data such as omission of spatial data and accuracy. This study is significant in that it presented implications for data utilization as well as selection of items for rural diagnosis and reviewed data utilization based on rural specialized districts of "The Act on Support for Restructuring and Regeneration of Rural Spaces" to be implemented in 2024. This is considered to be valuable as a study for sustainable rural diagnosis if processes such as spatial data construction and weight setting are carried out in the future.

Systematic Review and Meta-Analysis on Herbal Medicine for Generalized Anxiety Disorder: Focusing on Clinical Studies over the Past 5 Years (범불안장애의 한약 치료에 관한 체계적 문헌고찰 및 메타분석: 최근 5년 임상연구를 중심으로)

  • Min-Jae Kim;Hyun-Seob Park;Chan-Young Kwon
    • Journal of Oriental Neuropsychiatry
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    • v.34 no.4
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    • pp.403-420
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    • 2023
  • Objectives: This study investigated the effectiveness of herbal medicine for generalized anxiety disorder (GAD) based on recent clinical studies. Methods: Studies were searched through four databases. Clinical research studies on herbal medicine treatment for GAD patients were included. The studies were analyzed according to study design, diagnostic criteria, population, and intervention. A risk of bias assessment was performed to assess the quality of the included randomized controlled trials (RCT). If the intervention applied to the treatment and control groups was the same and two or more studies were reporting the same items as outcome indicators, a meta-analysis was performed. Results: A total of 19 studies, including 12 RCTs were selected. The most common pattern identification was 'Phlegm fire disturbing upward' (痰熱上擾), and the most used herb for therapeutic purposes was 'Rhizome of Poria cocos' (茯苓). Meta-analysis results of three studies showed that there were no significant differences in effectiveness between the herbal medicine intervention and the Western medicine intervention. Meta-analysis results of five studies showed that the Hamilton Anxiety Rating Scale was significantly reduced in the case of herbal medicine intervention compared to Western medicine intervention. Conclusions: The results of our study demonstrated that herbal medicine treatment for GAD is effective in alleviating anxiety symptoms and chief symptoms of GAD. However, this study has several limitations; there was a lack of placebo-controlled RCT and an absence of objective diagnostic criteria in case reports. Therefore, further well-designed clinical studies, conducted based on the results of this study, are recommended.

Development of Impact Evaluation and Diagnostic Indicators for Sinkholes

  • Lee, KyungSu;Kim, TaeHyeong
    • International Journal of Contents
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    • v.14 no.3
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    • pp.53-60
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    • 2018
  • Based on the previous studies on sinkholes and ground subsidence conducted until date, the factors affecting the occurrence of sinkholes can be divided into natural environmental factors and human environmental factors in accordance with the purpose of the study. Furthermore, to be more specific, the human environment can be classified into the artificial type and the social type. In this study, the assessment indices for assessing risks of sinkholes and ground subsidence were developed by performing AHP analysis based on the results of the study by Lee et al. (2016), who selected the risk factors for the occurrence of sinkholes by performing Delphi analysis targeting relevant experts. Analysis showed that the artificial environmental factors were of significance in affecting the occurrence of sinkholes. Explicitly, the underground factors were found to be of importance in the natural environment, and among them, the level of underground water turned out to be an imperative influencing factor. In the artificial environment, the underground and subterranean structures exhibited similar importance, and in the underground structures, the excessive use of the underground space was found to be an important influencing factor. In the subterranean ones, the level of water leakage and the erosion of the water supply and sewage piping system were the influential factors, and in the surface, compaction failure was observed as an imperative factor. In the social environment, the regional development, and above all, the groundwater overuse were found to be important factors. In the managemental and institutional environment, the improper construction management proved to be the most important influencing factor.

Comparative Study of Pre and Postoperative Voice and Image Analysis in Unilateral Vocal Cord Paralysis and Vocal Polyp (편측 성대마비와 성대폴립 환자의 수술 전후 음성검사와 이미지 화상분석의 상관관계에 대한 객관적 비교연구)

  • 김시찬;정유삼;홍정표;오정석;최홍식
    • Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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    • v.11 no.1
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    • pp.20-27
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    • 2000
  • To determine what is the change of pre and postoperative voice and image analysis parameters and correlations between them, videostroboscopy was analyzed in each 18 patients with unilateral vocal cord paralyses or vocal polyps before and after the surgery from November, 1996 to April, 1999. The correlation between acoustic and aerodynamic parameters was investigated. The software-Videolink and $\pi$-View(Mediface Co, Seoul, Korea)-was used in a quantitative analysis. In unilateral vocal cord paralysis, the glottic angle is well correlated with maximum phonation time, jitter and shimmer preoperatively. The postoperative glottic angle is also correlated with preoperative maximum phonation time. In patients with the vocal polyp, the chink is postoperatively decreased, but the size of the chink and the polyp is not correlated with pre and postoperative voice analysis parameters. These findings reveal that glottic an and vocal fold angle are good indicators of e postoperative glottic configuration in unilateral vocal cord paralysis. Vocal fold ratio is also a useful indicator that represents the length of vocal folds. We consider that the computerized analysis through videostroboscopy is one of objective diagnostic methods in many voice disorders if we can measure a distance between the telelaryngoscope and vocal folds.

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Oil Prices and Terms of Trade of Saudi Arabia: An Empirical Analysis

  • HAQUE, Mohammad Imdadul;IMRAN, Mohammad
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.9
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    • pp.201-208
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    • 2020
  • Terms of trade is an important indicator of the welfare gains from international trade to the exporting country. Terms of trade of oil-exporting countries are hypothesized to depend primarily on oil prices. The study assesses the relation between oil prices and the terms of trade of Saudi Arabia. The study uses the Autoregressive Distributed Lag method to determine the cointegration between the country's terms of trade and oil prices for the period 2000-2018. The data for net barter terms of trade is taken from World Development Indicators and oil price is taken from Saudi Arabian Monetary Agency. The results show that oil prices and terms of trade are cointegrated and any disequilibrium between the two variables is corrected by 35% in a year. The study also reports a positive relationship between the two items, both in the short run and long run. Diagnostic tests indicate the model to be fit. The results suggest that, for a primarily oil-producing country like Saudi Arabia, the terms of trade depend on oil prices. The study fills the gap in the literature on the study of terms of trade for Saudi Arabia for the last few years, where there has been a high volatility in oil prices.

Tongue of Fatigue by Classification of Sasang Constitution and Qi Blood Pattern Identification (특발성 피로의 사상체질 및 기혈변증 설진 분석)

  • Choi, Na-Rae;Park, Soo-Jung;Joo, Jong-Cheon;Kwon, Young-Mi
    • Journal of Sasang Constitutional Medicine
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    • v.27 no.4
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    • pp.379-387
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    • 2015
  • Objectives The purpose of this study was to investigate the relevance of Sasang constitution, Qi Blood pattern identification, and tongue diagnosis in subjects complaining of fatigue.Methods Seventy-three subjects who complained of fatigue were assessed using the Chalder Fatigue Scale, tongue diagnosis, pattern identification questionnaire and Sasang constitution diagnosis. The association of tongue diagnosis with Qi Blood pattern identification and Sasang constitution was evaluated.Results 1. There was no significant association between tongue diagnosis and Sasang constitution.2. Tongue color, which is one of the diagnostic indicators in tongue diagnosis, was redder in the Qi stagnation group than in the Qi deficiency and Blood deficiency groups.Conclusions Tongue diagnosis can be utilized in future if proper research regarding Sasang constitution and Sasang constitution pattern identification is conducted.