• 제목/요약/키워드: Diabetic cataract

검색결과 23건 처리시간 0.032초

노인의 가구 소득과 눈 건강과의 관계 (Study on Relationship between Eye Health and Household Income of the Elderly)

  • 박지현;김효진;예기훈
    • 한국안광학회지
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    • 제16권2호
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    • pp.209-217
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    • 2011
  • 목적: 본 연구는 노인의 가구 소득과 눈 건강과의 관계를 확인함으로써 노인의 눈 건강 불평등 정도를 알아보고, 향후 저소득층 노인의 삶의 질 향상을 위한 안보건 정책 수립의 기초자료를 제공하고자 한다. 방법: 국민건강영양조사(2009) 데이터를 이용하여 만 65세 이상의 노인 1,668명을 대상으로 가구 소득에 따른 눈 건강 관련요인(시력, 백내장 유무, 군날개 유무, 안압, 망막이상소견, 나이관련 황반변성, 당뇨망막병증, 근시, 원시, 난시, 부동시 유병률)을 t-test 및 ${\chi}^2$ 검정하였다. 결과: 자동굴절계검사의 굴절이상도와 안압은 저소득군이 낮았고, 나안시력과 교정시력은 0.1~0.5 미만에서 저소득군이 높았고, 원시는 고소득군에서 높았다. 백내장과 최대교정시력 0.8미만인 사람의 백내장 유병여부는 저소득군에서 더 높게 발생하였고, 흡연, 음주, 직업, 교육수준과 유의한 관계가 있었다. 결론: 노인의 가구 소득에 따른 눈 건강 불평등이 존재함을 알 수 있었고, 특히 백내장은 삶의 질과 밀접한 관계가 있는 안질환으로 저소득층 노인의 눈 건강 불평등 해소를 위한 안보건 정책이 필요할 것으로 사료된다.

Ginseng for an eye: effects of ginseng on ocular diseases

  • Kim, Jisu;Han, Su-Young;Min, Hyeyoung
    • Journal of Ginseng Research
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    • 제44권1호
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    • pp.1-7
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    • 2020
  • The sense of vision is the primary means by which we gather information from our surroundings, and vision loss, therefore, severely compromises the life of the affected individuals, their families, and society. Loss of vision becomes more frequent with age, and diabetic retinopathy, age-related macular degeneration, cataracts, and glaucoma are the major causes of vision impairment. To find active pharmacological compounds that might prevent or ameliorate the vision-threatening eye diseases, numerous studies have been performed, and some botanical compounds, including those extracted from ginseng, have been shown to possess beneficial effects in the treatment or prevention of common ocular diseases. In this review, we summarize the recent reports investigating the therapeutic effects of ginseng and ginsenosides on diverse ocular diseases and discuss their therapeutic potential.

Streptozotocin으로 유발한 당뇨병성 쥐에서의 당뇨병성 백내장과 망막병증에 대한 구기자와 황기 혼합 추출물 등의 면역 조절 및 예방 효과 (Effects of Lycii fructus and Astragalus membranaceus Mixed Extracts on Immunomodulators and Prevention of Diabetic Cataract and Retinopathy in Streptozotocin-induced Diabetes Rat Model)

  • 전윤희;문준웅;권혁중;정용준;안치선;김해란;허선진;임병우
    • 한국약용작물학회지
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    • 제18권1호
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    • pp.15-21
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    • 2010
  • This study was conducted to investigate the effects of Lycii fructus and Astragalus membranaceus mixed extracts on immunomodulators and prevention in a streptozotocin-induced diabetes rat model. A total of 28 male rats were divided into four dietary groups and fed a commercial diet (A), commercial diet plus induced diabetes by a streptozotocin (STZ) injection (B), induced diabetes by STZ plus medicinal crop extracts(I&$H^{(R)}$) diet (C), and medicinal crop extracts (I&$H^{(R)}$) diet (D). Immunoblotting analyses revealed cytokine expression, and ELISA analyses revealed immunoglobulin E and nitric oxide production. As a results, the tumor necrosis factor-$\alpha$ (TNF-$\alpha$) and inducible nitric oxide synthase (iNOS) as a inflammatory cytokine were decreased. Interleukin-6 (IL-6) and signal transducer and activation of transcription 3 (STAT3) cytokine related in diabetes expression through JAK/STAT3 pathway were also decreased. Furthermore, immunoglobulin E and nitric oxide production were decreased in the serum and lens, respectively. These results suggest that Lycii fructus and Astragalus membranaceus mixed extracts provide positive effects on immunomodulators and prevention in diabetes and eye disease complications.

Comparison of the outcomes of phacoemulsification versus topical medication alone in canine diabetic cataracts: a retrospective study

  • Eunji Lee;Seonmi Kang;Seonmi Kang;Kangmoon Seo
    • Journal of Veterinary Science
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    • 제24권6호
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    • pp.86.1-86.14
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    • 2023
  • Background: Long-term comparisons of phacoemulsification with topical medication are limited in canine diabetic cataracts. Objectives: To compare outcomes of eyes submitted to phacoemulsification with those of topical medication for canine diabetic cataracts and identify risk factors for complications. Methods: Through medical records review, 150 eyes (76 dogs) with diabetic cataracts were included; 58 eyes (31 dogs) underwent phacoemulsification (phaco-group) and 92 eyes (48 dogs) received ophthalmic solution alone (medication-group). The medication-group was divided into owner-led and vet-led groups depending on who elected not to perform surgery. Comparisons involved time-to-complications, vision, and the number and type of ophthalmic solutions administered. The association between complications and pretreatment clinical findings was investigated. Results: No difference was found in complication risk between the phaco and owner-led medication groups. Conversely, the vet-led medication-group had a higher complication risk than the other groups. At the last follow-up, 94.8% of the phaco-group had vision, whereas 7.6% of the medication-group restored some visual axis. Poor glycemic control in the medication-group and younger age in the phaco-group increased complication risk. At 1-year post-treatment, the average number of ophthalmic solutions administered was 1.7 and 2.6 in the phaco and medication groups, respectively. The medication-group used anti-inflammatories the most throughout the follow-up, whereas the phaco-group used anti-inflammatories the most until 1-year post-treatment and lacrimostimulants at 1.5-year post-treatment. Conclusions: For canine diabetic cataracts, phacoemulsification is recommended because it is superior to topical management alone in terms of maintaining vision and reducing the number of ophthalmic solutions required in the long term.

베트남 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색(II) (Screening of Inhibitory Effect on Aldose Reductase of Vietnam Herbal Medicines (II))

  • 이윤미;김종민;김영숙;장대식;김주환;배기환;김진숙
    • 생약학회지
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    • 제39권4호
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    • pp.324-329
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    • 2008
  • Aldose reductase (AR), the key enzyme in the polyol pathway, plays an important role in the pathogenesis of diabetic complications such as cataract formation. AR inhibitors (ARI) can prevent or reverse early abnormalities in diabetic complications. However, none of ARI has achieved worldwide use because of limited efficacy or undesirable side effects. Therefore, evaluating natural sources for ARI potential may lead to the development of safer and more effective agents against diabetic complications. 49 Vietnam herbal medicines have been investigated with an in vitro evaluation system using aldose reductase inhibitory activities. Of these, 7 herbal medicines, Artemisia annua (leaf, stem), Duranta repens (leaf, stem), Excoecaria cochinchinensis (aerial part), Flueggea virosa (leaf, stem), Khaya senegalensis (leaf), Polygonum orientale (aerial part), Toxicodendron succedanea (leaf, stem) exhibited a significant inhibitory activity against aldose reductase. Particularly, Duranta repens (leaf, stem) and Toxicodendron succedanea (leaf, stem) showed two times more potent inhibitory activity than the positive control, 3.3-tetramethyleneglutaric acid (TMG).

개의 당뇨병에서 Insulin Glargine의 적용 2례 (Use of Insulin Glargine in 2 Dogs with Diabetes Mellitus)

  • 안진옥;서경원;황철용;윤화영
    • 한국임상수의학회지
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    • 제28권1호
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    • pp.139-143
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    • 2011
  • A Spitz (5-years old, castrated male) and a Maltese (9-years old, castrated male) were presented with weight loss, polyuria/polydipsia (PU/PD) and depression. Diabetic ketosis was diagnosed based on clinical signs, physical examinations and screening tests (CBC, serum chemistry and urinalysis). The dogs were treated with NPH initially. However, NPH was inadequate to control blood glucose level due to the short duration of the action (< 5 hours). Because of the poor glycemic control with NPH, the dogs showed diabetic complications including weight loss and cataract. After change to glargine, the duration of insulin action was extended up to 11 hours. As a result, there was significant improvement in clinical signs and serum fructosamine concentrations. This study suggests that glargine is useful as a long-acting insulin in dogs which have poor glycemic control due to the short duration of NPH.

Effect of Byakangelicin from Angelica dahurica and its Semi-synthetic Derivatives on Aldose Reductase, Galactosemic Cataracts, the Polyol Contents and $Na^{+}$, $K^{+}$-ATPase activity in Sciatic Nerves of Streptozotocin-induced Diabetic Rats.

  • Lim, Soon-Sung;Jung, Sang-Hoon;Shin, Kuk-Hyun
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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    • pp.184-184
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    • 1998
  • Aldose reductase(AR), a rate-limiting enzyme in the polyol pathway, has been demonstrated to cause the intracellular accumulation of sorbitol or galactitol and hence to play key roles not only in the cataract formation in the lens but also in the pathogenesis of diabetic complications such as neuropathy, retinopathy and nephropathy, etc. In a series of investigations to evaluate potential AR inhibitors from medicinal plants, we have shown that some hot water extracts exhibited a significant inhibition of a significant inhibition of bovine lens AR in vitro. Among active plants, the roots of Angelica dahuria (Umbelliferae) were shown to have relatively potent AR inhibitory activity. Systematic fractionation of the ether soluble fraction monitored by bioassay led to isolation of two furanocoumarins, byakangelicin(I) and ter-O-methyl byakangelicin( II), were identified as potential AR inhibitors, their $IC_{50}$ values being 6.2 M and 2.8 M, respectively.

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반도체 나노구조를 이용한 SERS기반 바이오센싱 기술 (Surface Enhanced Raman Spectroscopy-based Bio Sensing Technology Using Semiconductor Nanostructures)

  • 유재수;이수현
    • 진공이야기
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    • 제4권3호
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    • pp.12-15
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    • 2017
  • Surface enhanced Raman scattering (SERS) is considered as one of promising medical and diagnostic technologies. The SERS effect is caused by the localized surface plasmon resonance (LSPR) from metal nanoparticles with narrow hot spots. The mechanism of LSPR, development of nanostructure fabrication, and corresponding researches are discussed. The flexible, label-free, low-cost, and highly-sensitive Au/ZnONRs/G is introduced. The Au/ZnONRs/G detects and distinguishes cataract, age-related macular degeneration, and diabetic macular edema from aqueous humor. Comprehension of SERS provides further improvement in bio sensing technology including early diagnosis and prolonged life expectancy.realize highly stretchable electrodes.

Glycation-induced Inactivation of Antioxidant Enzymes and Modulation of Cellular Redox Status in Lens Cells

  • Shin, Ai-Hyang;Oh, Chang-Joo;Park, Jeen-Woo
    • Archives of Pharmacal Research
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    • 제29권7호
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    • pp.577-581
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    • 2006
  • Oxidative mechanisms are thought to have a major role in cataract formation and diabetic complications. Antioxidant enzymes play an essential role in the antioxidant system of the cells that work to maintain low steady-state concentrations of the reactive oxygen species. When HLE-B3 cells, a human lens cell line were exposed to 50-100 mM glucose for 3 days, decrease of viability, inactivation of antioxidant enzymes, and modulation of cellular redox status were observed. Significant increase of cellular oxidative damage reflected by lipid peroxidation and DNA damage were also found. The glycation-mediated inactivation of antioxidant enzymes may result in the perturbation of cellular antioxidant defense mechanisms and subsequently lead to a pro-oxidant condition and may contribute to various pathologies associated with the long term complications of diabetes.