Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Use of Insulin Glargine in 2 Dogs with Diabetes Mellitus

개의 당뇨병에서 Insulin Glargine의 적용 2례

  • Ahn, Jin-Ok (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University and BK21 Program for Veterinary Science) ;
  • Seo, Kyoung-Won (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University and BK21 Program for Veterinary Science) ;
  • Hwang, Cheol-Yong (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University and BK21 Program for Veterinary Science) ;
  • Youn, Hwa-Young (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University and BK21 Program for Veterinary Science)
  • 안진옥 (서울대학교 수의과대학 내과학교실.BK21 수의과학연구인력양성사업단) ;
  • 서경원 (서울대학교 수의과대학 내과학교실.BK21 수의과학연구인력양성사업단) ;
  • 황철용 (서울대학교 수의과대학 내과학교실.BK21 수의과학연구인력양성사업단) ;
  • 윤화영 (서울대학교 수의과대학 내과학교실.BK21 수의과학연구인력양성사업단)
  • Accepted : 2010.09.27
  • Published : 2011.02.28
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Abstract

A Spitz (5-years old, castrated male) and a Maltese (9-years old, castrated male) were presented with weight loss, polyuria/polydipsia (PU/PD) and depression. Diabetic ketosis was diagnosed based on clinical signs, physical examinations and screening tests (CBC, serum chemistry and urinalysis). The dogs were treated with NPH initially. However, NPH was inadequate to control blood glucose level due to the short duration of the action (< 5 hours). Because of the poor glycemic control with NPH, the dogs showed diabetic complications including weight loss and cataract. After change to glargine, the duration of insulin action was extended up to 11 hours. As a result, there was significant improvement in clinical signs and serum fructosamine concentrations. This study suggests that glargine is useful as a long-acting insulin in dogs which have poor glycemic control due to the short duration of NPH.

Keywords

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