• 대한수의학회지
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• 제20권2호
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• pp.123-125
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• 1980

Ununited Anconeal Process (UAP) is defined as a disease of young dogs due to developmental abnormality in which there is a seperation of the anconeal process from the diaphysis of the ulna, leading to a front leg lameness and secondary osteoarthritis. A six -year-old German Shepherd dog was presented because of intermittent right front leg lameness. Diagnosis was made of ununited anconeal process with moderate osteoarthritis by radiographic examination. Surgical removal of ununited anconeal process and curettage of osteoarthritic growth within the elbow joint relieved significant clinical signs despite of size and age of the dog.

• Journal of Pharmaceutical Investigation
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• 제40권spc호
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• pp.19-31
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• 2010

Orally administrated drugs permeate the biological membrane by various transport mechanisms. The oral absorption potential is closely related to the physicochemical properties of the drug and interaction with the physiological factors surrounding the site of absorption. Assessment of the drug membrane permeability is an integral part of the early stage drug developmental process. Appropriate selection of the permeability screening method at the right stage of drug development process is important in achieving successful developmental outcomes. This review aims at introducing currently available in vitro and in vivo screening methods for the membrane permeability assessment.

• 한국과학교육학회지
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• 제15권3호
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• pp.275-283
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• 1995

The purpose of this study was to suggest that the history of science be introduced to students in the secondary school to help understand the developmental process of the scientific concepts, especially the concept 'heat'. Reviewing the national and international researches related to students' concept 'heat' revealed that many students tend to grasp the wrong concept of heat based on the caloric theory. Studies on definitions and explanations of the concept 'heat' and related concepts in secondary school science textbooks indicated that the way 'heat' was described could not help students to correct their misconceptions. In conclusion we need to include the historical and developmental process of scientific concepts such as heat in textbooks.

• 대한수학교육학회지:수학교육학연구
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• 제15권3호
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• pp.353-374
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• 2005

본 연구는 수학교육의 연구 방법론에 대한 많은 변화와 더불어 교과과정 개발의 과학적 접근에 대한 필요성이 증대되는 수학교육 연구 경향에 비추어, RME의 개발연구를 고찰함으로써, 우리나라의 좀더 발전적인 수학 교과과정 개발을 위한 시사점을 제시하는 데 그 목적이 있다. 이러한 목적을 달성하기 위하여 RME 개발연구의 배경과 이론적 틀, 개발연구의 목표, 절차, 자료수집, 자료분석, 정당화 과정을 포함한 개발연구의 방법론에 대해 살펴보았다. 마지막으로 우리나라의 수학 교과과정 개발의 개선을 위해 수학교육의 이론과 실제를 반영한 교육과정 문서의 구성, 교과과정 개발 배경에 대한 충실한 보고, 교과과정 개발 절차 개정의 필요성을 논하였다.

• 한국정보통신학회논문지
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• 제20권8호
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• pp.1561-1568
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• 2016

발달장애청소년은 지적기능과 적응행동에 현저히 제한이 있기 때문에 이들이 고등학교 졸업 후 지역사회의 한 구성원으로서 독립적으로 살아가기 위해서는 개인의 다양성 및 환경적인 차이를 고려한 지속적인 교육이 병행되어야 한다. 컴퓨터교육은 '교육의 평등과 보편성의 확대'라는 측면에서 지역사회적응에 있어 유용한 도구로 활용될 수 있다. 특히, 전환기교육과정으로서의 컴퓨터교육은 성인사회에서 독립적이고 일상적인 삶을 지속하는데 있어 실질적 도움이 된다. 따라서 이 논문은 1)발달장애청소년의 지역사회 적응과 전환기 교육 2) 발달장애청소년을 위한 컴퓨터교육의 중요성과 의의 3)발달장애청소년을 위한 컴퓨터교육의 현황을 살펴보았으며, 이를 통해 발달장애인을 위한 컴퓨터교육의 개선방안을 제시하였다.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2001년도 춘계학술발표대회
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• pp.68-68
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• 2001

Blastocyst formation, consisting of the inner cell mass (ICM) and trophectoderm (TE), is the first differentiation process during embryonic development in mammals. It has been hypothesized that the proportion of ICM to TE in the blastocyst may be crucial for subsequent developmental competence of early embryos, which it may be expressed as a sensitive indicator for evaluating in vitro systems. In this study ICM/total cell ratio of nuclear transfer (NT) embryos was compared with IVF-derived and in vivo embryos. Somatic cell nuclei obtained from a fetus at Day 40 of gestation were transferred into the enucleated oocyte and then cultured in NCSU 23 medium for 6 days as previously described (Koo et al., Biol. Reprod. 2000; 63:986-992). ICM and TE cells of blastocysts were determined by using a differential staining method (Han et al., Biol. Reprod. 1999; 60:1110-1113). Development rate (9.8$\pm$2.5%, 23/225) to the blastocyst stage of NT embryos was lower than IVF embryos (23.8$\pm$2.7%, 53/223). Thus, a difference was detected in the in vitro developmental rate to blastocyst stage between NT and IVF-derived embryos (P<0.05). In the next experiment, we investigated ICM and TE nuclei to assess the quality of blastocysts that produced by NT, IVF and in vivo, respectively. NT blastocysts (27.6$\pm$8.3) showed a smaller total cell number than IVF-derived (42.6$\pm$17.4) and in vivo embryos (283.9$\pm$103.5) (P<0.05). Ratios of ICM/total cells in NT, IVF and in vivo blastocysts were 15.1$\pm$ 18.6% (n=56), 12.3$\pm$9.2% (n=57) and 30.4$\pm$6.8% (n=40), respectively. Individual blastocysts for the ratio of ICM/total cells were assigned to 3 groups (I; <20%, II; 20 to 40% and III;>40%). As the results, most in vivo blastocysts (97.5%, 39/40) were distributed into group II while most NT (78.6%, 44/56) and IVF-derived blastocysts (82.5%, 47/57) were allocated to group I. Thus, our data show that NT or IVF-derived embryos have aberrant morphology during early development in vitro systems, suggesting that these anomalies may result in developmental failures of the NT embryos to term.

• 한국발생생물학회지:발생과생식
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• 제20권3호
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• pp.247-254
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• 2016

Cytological changes of the epithelial cells according to the developmenatal phases of the seminal vesicle related to the spermatogenic stages in the testicular lobules during spermagenesis in male Neptunea (Barbitonia) cumingii (Gastropoda: Buccinidae) were investigated monthly by electron microscopical and histological observations. N. (B) cumingii is dioecious, and an internal fertilization species. The male genital organ is located near the tentacles. The spermatozoon is approximatley $50{\mu}m$ in length. The axoneme of the tail flagellum consists of nine pairs of microtubles at the periphery and one pair at the center. The process of germ cell development during spermatogenesis can be divided into five succesive stages: (1) spermatogonia, (2) primary spermatocytes, (3) secondary spermatocytes, (4) spermatids, and (5) spermatozoa. A considerable amount of spermatozoa make their appearance in the testicular lobules (or acini) and some of them are tranported from the testis towards the seminal vesicles until late July. In this study, the developmental phases of the epithelial cells of the seminal vesicles of N. (B.) cumingii could be classified into four phases: (1) S-I phase (resting), (2) S-IIphase (early accumulating), (3) S-III phase (accumulating), and (4) S-IV phase (spent). However, in case of N. (B.) arthritica cumingii, the developmental phases of the seminal vesicle were devided into three phases: (1) resting, (2) accumulating and (3) spent. Granular bodies in the inner layer of the seminal vesicles are involved in resorption of digestion of residual spermatozoa.

• The Korean Journal of Ecology
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• 제8권4호
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• pp.179-196
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• 1985

By using temperatures as a key variable, a simulation model was constructed to predict the size and developmental speed for the German cockroach population. The following three research steps were conducted to implement the individual simulation technique to represent the basic life system of the cockroach. First, informations on developmental periods and survival rates in each life stage were obtained through rearing experiments at five different temperatures. Secondly, biological parameters needed for modeling were obtained based on these rearing results. The logistic equation was applied to calculating the developmental speed, while the averages of survival rates were utilized as parameters determining population size. And thirdly, a basic life model was constratued in a stimulative framework in FORTRAN for predicting the populating development on the individual basis. For this purpose the biological characteristics, such as life stage, age in days, developmental speed, fecundity, etc., were assigned as an inherent attribute of the transactiion so that they could accompany each individual automatically all through the simulation. This gave the model flexibility and applicability in representing the isnect life system. The save memory space in computer programing, two files were utilized in translocating the individual informations each other as time proceeded. The developed model could be effectively used as a strategic tool in interpreting and managing the cockroach population. It was also suggested in this study that the individual simulation could efficiently serve as a basis to formulate a fundamental framework on which the advanced and complex life process could be built.

• 한국동물생명공학회지
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• 제37권3호
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• pp.176-182
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• 2022

Norflurazon is widely used on agricultural lands and has a high potential to pollute water sources. However, its effects on fish have not been fully elucidated. The purpose of our study was to determine whether norflurazon adversely affects the developmental stage of zebrafish, which are frequently used as a model system to evaluate the environmental impact of pollutants. Norflurazon interfered with the hatching of zebrafish embryos and induced several sublethal deformities including body length reduction, increased yolk sac volume, and enlargement of the pericardial region. We further examined the cardiotoxicity of norflurazon in the flk1:eGFP transgenic zebrafish line. The vascular network, mainly in the brain region, was significantly disrupted in norflurazon-exposed zebrafish. In addition, due to the failure of cardiac looping, norflurazon-exposed zebrafish had an abnormal cardiac structure. These developmental abnormalities were related to the apoptotic process triggered by norflurazon. Overall, the present study demonstrated the non-target toxicity of norflurazon by analyzing the hazardous effects of norflurazon on developing zebrafish.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2004년도 동계학술대회 논문집
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• pp.140-140
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• 2004