• Clinical and Experimental Pediatrics
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• v.45 no.10
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• pp.1278-1282
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• 2002

Glutaric aciduria(type 1) is characterized clinically by progressive dystonia and dyskinesia in childhood, pathologically by degeneration of caudate and putamen, biochemically by tissue deficiency of glutaryl-CoA dehydrogenase(GCDH), and is transmitted as an autosomal recessive traits. Mutations of the GCDH gene on chromosome 19 have been implicated in the causation of glutaric aciduria(type 1). Macrocephaly in infancy and crossing of percentiles for head circumference are real clues to early diagnosis. Acute neuroregression of dystonia following an initial phase of normal or almost normal development is a common mode of presentation, at times preceded by seizures. We experienced a case of glutaric aciduria(type 1) in a 13-month old girl. She was admitted due to development delay and choreoasthetoid movememt that developed after generalized tonic-clonic type seizures. She was diagnosed as having glutaric aciduria(type 1) based on brain MRI and urine organic acid analysis finding.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.8
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• pp.3752-3757
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• 2011

This paper suggests two strategies for the restoration of the Seongbukcheon in Seoul. One is the neighborhood-type development and the other is the construction of the flat open spaces. For the neighborhood-type development, the characteristic of each of the streets which are connected with Seongbukcheon was comprehended and the differentiated approaches for each of them were taken. For the construction of the flat open spaces, the necessity of the flat public open spaces was verified and the strategies for this was suggested.

• Journal of the Korea Institute of Military Science and Technology
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• v.22 no.4
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• pp.536-544
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• 2019

During the assembly and function inspection of missile system, flight simulation process is required. In the conventional flight simulation check of missiles, an inertial navigation system simulator was used to transmit the navigation output data acquired in HILS. There are several disadvantages in terms of check configuration complexity and data synchronization when using the simulator. So we proposed a new flight simulation method that utilizes the nonvolatile built-in memory of the aviation control unit. The data processing procedure and operation procedure of the proposed method for type I and type II missiles are presented. And we analyzed the causes of the difference between proposed method result and the HILS result for type II missile. By comparing the results obtained by the experiments using the proposed method with the results of HILS, the validity of proposed method was confirmed.

• Toxicological Research
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• v.14 no.2
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• pp.123-127
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• 1998

BRCA1 is a tumor suppresser gene in familial cases of breast cancer. It has been controversial whether the subcellular localization of BRCA1 is located in nuclei or cytoplasm in normal human breast cells. We found that a p220 protein was expressed in Type II Normal human breast epithelial cells (NHBEC) but not in Type I NHBEC in Western blot analysis using the 17F8 (3A2) antibody. Immunostaining using the same antibody revealed positive staining in nuclei, cytoplasm and perinuclei of Type II cells and negative staining in Type I NHBEC. The p220 protein, however, was expressed in SV40 immortalized Type I NHBEC and tumorigenic cells derived from them after x-ray and neu oncogene treatment. The subcelluar localization was mostly cytoplasmic and punctate in the nuclei. The breast carcinoma cell lines, MCF-7 and T47D, also expressed the p220 protein. Using RT-PCR, we observed the expression of BRCA1 mRNA in both Type I and Type II NHBEC. This result indicated that there might be mechanisms involved in post-translational or translational regulation of BRCA1 gene. It is speculated that the absence of BRCA1 protein expression in Type I NHBEC might playa role in their susceptibility to neoplastic transformation.

• Journal of Applied Biological Chemistry
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• v.59 no.4
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• pp.317-322
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• 2016

UV exposure induces matrix metalloproteinases (MMPs) and extracellular matrix-degrading enzymes expression. We studied the protective effect of Rubus occidentalis seed against UVB-generated skin photoaging using human fibroblast cells (CCD-986sk). We used an ELISA kit to measure the supernatents of procollagen type I and MMP-1 in CCD-986sk cells after they were exposed to UVB irradiation. The CCD-986sk cells that were used with RC-E/E after the UVB irradiation caused higher levels of type I procollagen and lesser levels of MMP-1 compared with the control group. Furthermore, the RC-E/E treated group showed lesser MMP-1 levels and higher procollagen type I levels than the untreated counterpart. Therefore, it can be concluded that Rubus occidentalis seed can prevent from skin photoaging.

• Journal of fish pathology
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• v.19 no.3
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• pp.243-251
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• 2006

The internal defense system of mollusks consists of circulating haemocytes. In order to understand the morphological characterization of haemocytes, light and electron microscopy were carried out in oyster, Crassostera gigas. Four types of haemocytes were recognized: type Ⅰ small hyalinocytes, type Ⅱ large hyalinocytes, type Ⅲ large granulocytes and type Ⅳ small granulocytes. Additionally, the activities of alkaline phosphatase (ALP), acid phosphatase (ACP), peroxidase (POD), α-naphthyl acetate esterase, β-glucuronidase, PAS, sudan black B and oil red O in haemocytes were analysed by immunocytochemical methods. The results indicate that enzymatic activities were abundant and more active in granulocytes than in hyalinocytes. After incubation with haemoctyes and Vibrio FKC, phagocytic index and percentage of phagocytic cell were and shown to be increased from 15 to 120 min. In addition, the enzymatic activities were higher than those of controls: ALP, ACP, α-naphthyl acetate esterase and β-glcuronidase, indicating that these enzymes can be related with phagocytosis in oyster.

• Journal of the Korean Society of Safety
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• v.33 no.2
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• pp.28-31
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• 2018

In display and semi-conductor manufacturing process, there are numerous unstable factors such as particle concentration, minimal vibration, changes in magnetic field, or electrostatic that becomes an issue to be managed and controlled. In the recent, X-ray ionization is widely used that is neutralized by separating air or gas molecules in the area where the static must be resolved. The mono-type of X-ray ionizer was not capable to be used in $8^{th}$ generation panels manufacturing plant due to its insufficient ionizing coverage since the panel itself is approximately in $2m{\times}3m$. To resolve the current problem, the development of new type called, "Multi-type X-ray ionizer" has resulted in covering enough ionizing space in $8^{th}$ generation panels industry. Comparing mono and multi types with MCNPX code simulation, the multi one indicates more X-ray flux, efficiency, and ionization performance in comparison with either a mono-type or multi-type in array format. In addition, the ionizing efficiency of overlapping area with multi-type showed 30% higher effectiveness rate as to the ordinary mono-type.

• Journal of The Korean Society of Agricultural Engineers
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• v.59 no.5
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• pp.25-30
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• 2017

Hydrologic soil group is one of the important factors to determine runoff potential and curve number. This study was conducted to classify the hydrologic soil groups of Korean soils by considering saturated hydraulic conductivity and depth of impermeable layer. Saturated hydraulic conductivity of Korean soils was estimated by pedotransfer functions developed in the previous studies. Most of paddy soils were classified as D type due to shallow impermeable layer and low saturated hydraulic conductivity in B soil horizon. For upland and forest, soils classified to A and D types increased compared with former classification method because underestimated permeabilities and overestimated drainages were corrected and rock horizon in shallow depth was regarded as impermeable layer. Soils in mountainous land showed the highest distribution in A type, followed by D type. More than 60 % of soils in mountain foot-slope, fan and valley, alluvial plains, and fluvio-marine deposits were classified to D type because of land use such as paddy and upland.

• Educational Technology International
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• v.19 no.1
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• pp.153-173
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• 2018

The purpose of this study was to investigate teaching competence of faculty members based on TPACK which should be examined to ensure high quality in higher education. This study was conducted with a focus on TPACK, which integrate technology knowledge (TK), content knowledge (CK), and pedagogy knowledge (PK). Except insincere responses data from a total of 85 participants were used for data analysis in this study. K-mean cluster analysis method was used to examine how faculty members could be distinguished depending on TPACK type. Study results showed that there were three different types of faculty groups (well-balanced competence type, development required competence type, and lack of technology competence type). First, faculty members defined as well balanced competence type were more than the average level in TPACK. Second, faculty members belonged to development required competence type reported below the average level in TPACK. Thus, faculty members in this type were required to increase teaching competence. Finally, faculty members in lack of technology competence type were needed to enhance competence related to technology because their overall TK level was relatively low. This study examined what distinctive characteristics exited in each type depending on gender, teaching career, nationality, and age. Results from this study offered a basis for better understanding TPACK for enhancing teaching competence at the university level.

• Bulletin of the Korean Space Science Society
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• 2004.10b
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• pp.316-320
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• 2004

This paper describes Ka-band antenna performance analysis of COMS satellite. The key parameters of the antenna system are optimal antenna diameter, feed horn type and horn size, F/D, and the coordinate of offset horns. The paper deals with the method to determine design core parameters of optimal antenna diameter, feed horn type and horn size, F/D, and the coordinate of offset horns, and the performances of design result.