• Journal of the Korean School Mathematics Society
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• v.22 no.4
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• pp.461-482
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• 2019

The purpose of this study was to analyze the elementary pre-service teachers' perspectives on the use of the elementary mathematics textbooks by observing mathematics classes at the schools and to present suggestions on the use of textbooks in the mathematics classes. For this study, let 54 pre-service elementary school teachers observe a total of 54 classes (1,299 students) in the first through sixth grades at 15 areas in Seoul city. With the observations of the mathematics classes, the researcher analyzed the pre-service elementary teachers' perspectives on the use of resources including mathematics textbooks in the elementary mathematics classes. As a result of the study, the pre-service teachers recognized that mathematics textbooks are the main material for mathematics classes, but they think that they need to reconstruct the contents of the textbooks for effective teaching and learning mathematics. In addition, various additional materials need to be used in order to help students learn mathematics more effectively, including by differentiated materials. Also, instruments used in the classes were mainly consisted of TV and PPT data. Pre-service teachers were not much satisfied with the contents of the elementary mathematics textbooks. However, they did not feel the need for development of digital textbooks. The researcher suggested a long term research on how to use study materials such as textbooks within the overall mechanism of teaching and learning processes. Also, practical teacher education programs that include applications of textbooks at schools are necessary in order to improve the quality of mathematics teaching and learning.

• The Korean Journal of Zoology
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• v.32 no.1
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• pp.55-73
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• 1989

The effect of tryptophan or serotonin on the early stage of chick brain development has been morphologically investigated using an electron microscope. The electron micrographs of neural plate cells of 1-day chick embryo treated with tryptophan or serotonin showed irregularity, evagination and disruption of nuclear membrane and nuclear chromatin condenstation, nucleolar margination and segregation. Hypertrophy of stalks, vesicles and vaculoes were seen and dilated and disrupted rough endoplasmic reticulum and underdeveloped neurotubules were also observed. In mesenchyme cells of tryptophan or serotonin administered 18 hr embryo, irregular nuclear membrane, swollen mitochondria, dilated rough endoplasmic reticulum and very large yolk granules were observed. Furthermore, DNA, RNA and protein contents of the embryos treated with typtophan or serotonin were considerably lower than those of control group. The amount of tubulin of the experimental groups was also greatly lower than that of control, suggesting that the impairment of microtubule formation occurred. Tryptophan or serotonin administration might depress the biosynthesis, of nucleic acid and protein including some enzymes tested. It seems that the serotonin formed from exogeneous tryptophan might inhibit the degradation of yolk granule by feedback regulation mechanism so as to impair microtububle and microvilli formation followed by a malformation of chick embryos.

• Food Science and Preservation
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• v.16 no.1
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• pp.1-7
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• 2009

Watermelons (Citrulus vulgaris Schrad) are usually sorted manually by weight, appearance, and acoustic impulse, so grading of maturity and internal quality is subject to inaccuracies. It was necessary to develop a nondestructive evaluation technique of internal watermelon quality to reduce human error. Thus, acoustic characteristics related to internal quality factors were analyzed. Among these factors, three (ripeness, presence of an internal cavity, and blood-colored flesh) were selected for evaluation. The number of peaks and the sum of peak amplitudes for watermelons with blood-colored flesh were lower than for normal fruits. The portable evaluation system has an impact mechanism, a microphone sensor, a signal processing board, an LCD panel, and a battery. A performance test was conducted in the field. The internal quality evaluation model showed 87% prediction accuracy. Validation was conducted on 72 samples. The accuracy of quality evaluation was 83%. The quality of samples was evaluated by an inspector using conventional methods (hitting the watermelon and listening to the sounds), and then compared with prototype results. The quality evaluation accuracy of the prototype was better than that of the inspector. This nondestructive quality evaluation system could be useful in the field, warehouse, and supermarket

• East Asian Journal of Business Economics (EAJBE)
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• v.5 no.4
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• pp.39-49
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• 2017

Purpose - This study is to propose a creative idea for constant business growth and development by examining characteristics of business outcomes by phase, which are "growth" and "erosion and stagnation," respectively. Research design, data, methodology - It is necessary to identify an occurrence of crisis and its diffusion with a dynamic model in order to identify a success and failure of businesses in an organic way, not on a binary structure. The static perspective is to understand a crisis as a simply one-time event or as a linear causation. Thus, it has a limited understanding of the overall situation and has limits to investigating a foundational cause and developing long-term countermeasures. On the contrary, the dynamic perspective is to understand the crisis as circulation process of the overall system. Thus, it divides elements of the crisis as external and internal ones to understand it as the causal relationship of each element. Results - During the growth period of Burger King, the company promoted its brand very successfully with aggressive and creative marketing activities. However, due to the founder's disposal of management rights and the following changes in the management, the company had no choice but to lose focus on its business philosophy and brand management, and eventually it had to face the big crisis (resonance) which was delisting from the stock market because of the external threat; well-being trend. However, Burger King resumed lifting on the stock exchange by making great efforts to clearly identify the current issues and seek solutions. Under the spirit of "perseverance" and its slogan "Have it your way" the company is now going head to head with McDonald's in the North American region and emerging countries. Conclusions - Then, what is the most crucial factor in the success and failure of businesses? Answers may vary, however, as learned from the case study of Burger King, corporations should inspect the present and focus on developing a long-term strategy for the future and actively fulfill the actions. McDonald's may not be able to innovate by itself in the future as it may become routinized to the growth. There will be chances of winning if we change conditions of individuals or organizations to an organic system in terms of being creative. There is a hopeful message here that an individual or small business may have more advantages in the era of the idea and innovation.

• Tuberculosis and Respiratory Diseases
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• v.38 no.1
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• pp.8-15
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• 1991

It has been well known that the integrity of airway epithelium is important in development of bronchial hyperreactivity and bronchial asthma. But the mechanisms involved are still unclear. To evaluate that airway epithelium is able to modulate the contraction of guinea pig tracheal smooth muscle, we investigated the responsiveness of intact and epithelium-denuded tracheal strips to histamine and acetylcholine. And to evaluate whether cyclooxgenase products play a role in this modulatory mechanism, we also investigated the effect of indomethacin pretreatment on the tracheal responsiveness to histamine. Results were as follows: 1) In guinea pig tracheal smooth muscle the presence of airway epithelium significantly reduced the response to histamine. 2) In the presence of indomethacin dose-response curves and $EC_{50}$ values were similar between intact and epithelium-denuded tracheal strips, that is, indomethacin abolished the influence of epithelium on the contracion of tracheal smooth muscle. 3) The response of tracheal smooth muscle to acetylcholine was similar both in the presence and absence of epithelium. These results suggest that airway epithelium of guinea pig may generate an inhibitory signal to decrease the response of tracheal smooth muscle to histamine and cyclooxygenase products may contrbute to the modulation of airway epithelium on the contracion of tracheal smooth muscle.

• Korean Journal of Optics and Photonics
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• v.22 no.6
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• pp.262-268
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• 2011

MIRIS(Multi-purpose Infra-Red Imaging System) is the main payload of the STSAT-3(Korea Science and Technology Satellite. 3), which is being developed by KASI(Korea Astronomy & Space Institute). EOC(Earth Observation Camera), which is one of two infrared cameras in MIRIS, is the camera for observing infrared rays from the Earth in the range of $3{\sim}5{\mu}m$. The optical system of the EOC is a Cassegrain prescription with aspheric primary and secondary mirrors, and its aperture is 100mm. A ring type flexure supports the EOC primary mirror with pre-loading in order to withstand expected load due to the shock and vibration from the launcher. Here we attempt to use the same mechanism by which a retainer supports the lens. Through opto-mechanical analysis it was confirmed that the EOC primary mirror is effectively supported.

• Journal of Ginseng Research
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• v.41 no.3
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• pp.284-289
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• 2017

Background: Compound FK506 is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and inflammatory response mediated by FK506 limit its usefulness. In this study, the protective effect of Korean Red Ginseng (KRG) against FK506-induced damage in LLC-PK1 pig kidney epithelial cells was investigated. Methods: LLC-PK1 cells were exposed to FK506 with KRG and cell viability was measured. Western blotting and RT-PCR analyses evaluated protein expression of MAPKs, caspase-3, and KIM-1. TLR-4 gene expression was assessed. Caspase-3 activities were also determined. The number of apoptotic cells was measured using an image-based cytometric assay. Results: The reduction in LLC-PK1 cell viability by $60{\mu}M$ FK506 was recovered by KRG cotreatment in a dose-dependent manner. The phosphorylation of p38, p44/42 MAPKs (ERK), KIM-1, cleaved caspase-3, and TLR-4 mRNA expression was increased markedly in LLC-PK1 cells treated with $60{\mu}M$ FK506. However, with the exception of p-ERK, elevated levels of p-p38, KIM-1, cleaved caspase-3, and TLR-4 mRNA expression were significantly decreased after cotreatment with KRG. Activity level of caspase-3 was also attenuated by KRG cotreatment. Moreover, image-based cytometric assay showed that apoptotic cell death was increased by $60{\mu}M$ FK506 treatment, whereas it was decreased after cotreatment with KRG. Conclusion: Taken together, these results suggest that the molecular mechanism of KRG in the FK506-induced nephrotoxicity may lead to the development of an adjuvant for the inhibition of adverse effect FK506 in the kidney.

• Journal of Korea Water Resources Association
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• v.45 no.1
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• pp.101-111
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• 2012

In this paper, the feedback loop mechanisms among the operational indices and exogenous variables of a sewerage system that are inherent in the operation and maintenance of a sewerage system were identified using the System Dynamics (SD) modeling methodology. The identified feedback loops were used to develop a SD computer simulation model that can be used to predict future operational conditions of a sewerage system and identified the efficient ways of operation. The data of Busan metropolitan city sewerage system was applied to verify the developed SD model and predict future operational conditions of the system. As a result, it was predicted that sewage treatment efficiency, volume of sewage treatment and cost recovery rate will be gradually increased, whereas service rate which was already very close to the target will remain almost the same as the current value. Furthermore, sensitivity analysis concerning some operational indices was performed in order to discover the policy leverage. As a result, it was found that the exogenous variables related to the pipe maintenance had a great effect on facility using rate, volume of sewage treatment as well as sewage treatment efficiency.

• Korean Journal of Plant Resources
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• v.27 no.1
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• pp.22-28
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• 2014

In this study, we conducted the anti-HIV-1 enzymes assay in vitro and its active components were predicted by QSAR in silico for the elucidation of action mechanism on anti-HIV of natural resources. The extracts of Gardenia jasminoides var. radicans Makino were tested for their inhibitory effects on the reverse transcriptase (RT), protease and ${\alpha}$-glucosidase. In the enzyme inhibition assay, the methanol extracts of Gardenia jasminoides var. radicans Makino stem showed a strong activity of 32.5% on the enzyme activity to cleave an oligopeptide, resembling one of the cleavage sites in the viral polyprotein which can only be processed by HIV-1 protease. Moreover the methanol extracts of stem exhibited alpha-glucosidase inhibitory activities of 26.1%. The methanol extracts ($100{\mu}g/ml$) of stem showed a weak activity of 13.4% on anti-HIV-1 RT using Enzyme Linked Oligonucleotide Sorbent Assay (ELOSA) method. However, all extracts of leaf and stem didn't exhibit the HIV-1-induced cytopathic effects with IC (inhibitory concentration) of $100{\mu}g/ml$ in HIV-1-infected human T-cell line. From these results, it is suggested that Gardenia jasminoides var. radicans Makino extracts may possibly be involved in the inhibition of reverse transcriptase, protease and alpha-glucosidase but can't vitally concerned with the viral replication in vitro.

• Fire Science and Engineering
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• v.34 no.3
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• pp.43-48
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• 2020

The purpose of this study is to develop an earth leakage alarm circuit breaker, equipped with a leakage alarming function (JER-E2S, ETECKOREA Co., Korea), and to analyze its characteristics. The developed mechanism is exclusively used for single-phase and 220 V circuits, with a rated current of 32 A, 20 A, 20 A (for restrooms), 16 A, etc. It satisfies all characteristics of existing earth leakage circuit breakers (ELB). If a fire current, which is a resistive leakage current (Igr), flows through an electric line, the device detects the leakage current in real time and warns against the leakage through a blinking LED lamp. Since the developed device displays a tolerance to a capacitative leakage current (Igc) that inevitably occurs in LED lamps, communication devices, etc., it ensures a stable power supply. In addition, the earth leakage alarm circuit breaker protects against power failure due to a momentary ground fault. Therefore, it can supply power without the risk of the circuit breaker malfunctioning due to a momentary ground fault caused by water droplets, leaves, etc. Moreover, with a standby power of less than 0.1 W, the developed earth leakage alarm circuit breaker exhibits a power saving performance that is 3~8 times greater than that of other ELBs. Installation of approximately 10 earth leakage alarm circuit breakers in one apartment household, with an area of 120 ㎡, can save 2~5 kWh per month. Therefore, the developed earth leakage alarm breaker not only satisfies the characteristics of existing earth leakage breakers, but also exhibits outstanding power supply quality since it has the functions of electric fire prevention and malfunction prevention. Therefore, this device can innovatively contribute to electric fire prevention.