Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Influence of the Epithelium on the Contraction of Guinea Pig Isolated Tracheal Smooth Muscle

Guinea Pig 기도상피세포가 기도 평활근 수축에 미치는 영향

  • Kwon, O.J. (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Cho, S.H. (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Park, I.W. (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Kim, Y.W. (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Han, S.K. (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Shim, Y.S. (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Kim, K.Y. (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Han, Y.C. (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Seoh, S.H. (Department of Physiology, College of Medicine, Seoul National University) ;
  • Kim, K.W. (Department of Physiology, College of Medicine, Seoul National University)
  • 권오정 (서울대학교 의과대학 내과학교실) ;
  • 조상헌 (서울대학교 의과대학 내과학교실) ;
  • 박인원 (서울대학교 의과대학 내과학교실) ;
  • 김영환 (서울대학교 의과대학 내과학교실) ;
  • 한성구 (서울대학교 의과대학 내과학교실) ;
  • 심영수 (서울대학교 의과대학 내과학교실) ;
  • 김건열 (서울대학교 의과대학 내과학교실) ;
  • 한용철 (서울대학교 의과대학 내과학교실) ;
  • 서석효 (서울대학교 의과대학 생리학교실) ;
  • 김기환 (서울대학교 의과대학 생리학교실)
  • Published : 1991.03.31
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Abstract

It has been well known that the integrity of airway epithelium is important in development of bronchial hyperreactivity and bronchial asthma. But the mechanisms involved are still unclear. To evaluate that airway epithelium is able to modulate the contraction of guinea pig tracheal smooth muscle, we investigated the responsiveness of intact and epithelium-denuded tracheal strips to histamine and acetylcholine. And to evaluate whether cyclooxgenase products play a role in this modulatory mechanism, we also investigated the effect of indomethacin pretreatment on the tracheal responsiveness to histamine. Results were as follows: 1) In guinea pig tracheal smooth muscle the presence of airway epithelium significantly reduced the response to histamine. 2) In the presence of indomethacin dose-response curves and $EC_{50}$ values were similar between intact and epithelium-denuded tracheal strips, that is, indomethacin abolished the influence of epithelium on the contracion of tracheal smooth muscle. 3) The response of tracheal smooth muscle to acetylcholine was similar both in the presence and absence of epithelium. These results suggest that airway epithelium of guinea pig may generate an inhibitory signal to decrease the response of tracheal smooth muscle to histamine and cyclooxygenase products may contrbute to the modulation of airway epithelium on the contracion of tracheal smooth muscle.

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