• Korean Journal of Fisheries and Aquatic Sciences
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• v.22 no.6
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• pp.424-428
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• 1990

Mulletts, Mugil cephalus were exposed to artificial sea water containing $50{\mu}g/\iota\;of\;^{14}C-la-belled$ di-2-ethylhexyl phthalate(DEHP) during 15 days and returned to the DEHP free sea water in order to know bioconcentration and depuration of DEHP in the fish. Bioaccumulative process of DEHP in the fish was rather fast, and bioconcentration level of $9.7\~14{\mu}g/g$ and a bioconcentration factor of $220\~270$ were reached after one any of exposure. The biological half-life of DEHP in fish was 1.8 days. Five intermediate metabolites of DEHP were detected in the benzene and ethyl acetate fraction of fish by TLC.

• BMB Reports
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• v.49 no.8
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• pp.403-404
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• 2016

The Wnt/β-catenin signaling is an evolutionarily conserved pathway that plays a pivotal role in embryonic development and adult homeostasis. However, we have limited information about the involvement of Wnt/β-catenin signaling in the lymphatic vascular system that regulates fluid homeostasis by absorbing interstitial fluid and returning it to blood circulation. In this recent publication we report that canonical Wnt/β-catenin signaling is highly active and critical for the formation of lymphovenus valves (LVVs) and lymphatic valves (LVs). β-catenin directly associates with the regulatory elements of the lymphedema-associated transcription factor, FOXC2 and activates its expression in an oscillatory shear stress (OSS)-dependent manner. The phenotype of β-catenin null embryos was rescued by FOXC2 overexpression. These results suggest that Wnt/β-catenin signaling is a mechanotransducer that links fluid force with lymphatic vascular development.

• BMB Reports
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• v.46 no.9
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• pp.429-438
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• 2013

Aging is the strongest risk factor for cancer development, suggesting that molecular crosstalks between aging and tumorigenesis exist in many cellular pathways. Recently, Sirtuins (Sirt1-7), the mammalian homologues of aging-related $sir2{\alpha}$ in yeast, have been shown to modulate several major cellular pathways, such as DNA repair, inflammation, metabolism, cell death, and proliferation in response to diverse stresses, and may serve as a possible molecular link between aging and tumorignenesis. In addition, growing evidence suggests that sirtuins are directly implicated in the development of cancer, and they can act as either a tumor suppressor or promoter, depending on the cellular context and tumor types. While the functions of Sirt1 in tumorigenesis have been reported and reviewed in many studies, the connection between sirtuins 2-7 and the development of cancer is less established. Thus, this review will present the recent updates on the emerging roles of Sirt2-7 members in carcinogenesis.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.877-880
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• 2003

In a competitive and globalized business environment, the need for the green products becomes stronger. To meet these trends, the environmental assessment besides delivery, cost and quality of products should be considered as an important factor in new product development phase. In this paper. a knowledge-based approximate life cycle assessment system (KALCAS) for the collaborative design environment is developed to assess the environmental impacts in context of product concept development. It aims at improving the environmental efficiency of the product using artificial neural networks consisting of high-level product attributes and LCA results. The overall framework of the collaborative environment including KALCAS is proposed. This architecture uses the CO environment to allow users on a wide variety of platforms to access the product data and other related information. It enables us to trade-off the evaluation results between the objectives of the product development including the approximate environmental assessment in the collaborative design environment.

• Journal of the Korean Institute of Navigation
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• v.20 no.3
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• pp.137-162
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• 1996

Today diving activity and technology are indispensable for underwater technology and offshore engineering. And then diving business is still more important to business of subsea. This study surveyed the issue of diving activity in Korea as for compared foreign diving activity. This paper analyzed the status of diving business that include commercial and sport-leisure diving business and development of commercial divers in Korea. This paper reputed the object, the necessity and the character of commercial divers. For the purpose of this study is considered in order to analyze the environment of commercial divers and propose the planning for industrial diving business. Under the present circumstance in Korea this development planning study may be restricted. but the effective planning to activate Korean commercial diving business is abstracted as follows; First, establishment of new course, grade, certificate and licence test for diver is a pre-requisite factor for the successful enactment. Second, the political assistance of concerned government authority is needed. Third, establishment of Korean diving school and medical center for divers are strongly required. Forth, setting up the department of diving activity in university.

• Mycobiology
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• v.47 no.4
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• pp.457-465
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• 2019

MonA is a subunit of a guanine nucleotide exchange factor that is important for vacuole passing and autophagy processes in eukaryotes. In this study, we characterized the function of MonA, an orthologue of Saccharomyces cerevisiae Mon1, in the model fungus Aspergillus nidulans and a toxigenic fungus A. flavus. In A. nidulans, the absence of AnimonA led to decreased fungal growth, reduced asexual reproduction, and defective cleistothecia production. In addition, AnimonA deletion mutants exhibited decreased spore viability, had reduced trehalose contents in conidia, and were sensitive to thermal stress. In A. flavus, deletion of AflmonA caused decreased fungal growth and defective production of asexual spores and sclerotia structures. Moreover, the absence of monA affected vacuole morphology in both species. Taken together, these results indicate that MonA plays conserved roles in controlling fungal growth, development and vacuole morphology in A. nidulans and A. flavus.

• Proceedings of the KSRS Conference
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• 2007.10a
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• pp.482-485
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• 2007

The S-Band SSPA is front-end equipment to transmit both LRIT and HRIT to COMS. To provide the required EIRP, S-Band SSPA is designed to generate maximum 1kW power at its 1dB gain compression point (P1dB). Due to the operation for 24 hours per seven days, the verification on the performance of S-Band SSPA was performed thoroughly. This paper presents that major requirements such as maximum 1kW power, maximum -26dBc of IMD characteristic at 500W output and around -57dBc of coupling factor were verified through proposed test configuration.

• Journal of Aerospace System Engineering
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• v.3 no.1
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• pp.6-11
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• 2009

It is anticipated that quality assurance for the Ka band Communication Payload System(COPS) development program of the communication, Ocean & Meteorological Satellite(COMS) may be a core technical factor to be concerned in order to avoid any failure, and to assure its final performance during the mission lifetime in space. Those can be managed and verified and assessed by performing the Quality Assurance (QA) and risk management which helps to prevent and to reduce the critical fails. This paper introduces the Product Assurance (PA) system and procedures for controlling and monitoring sub-contractors which were participated in Ka band Communication Payload System (COPS) development. Also this paper shows Quality Assurance (QA) procedures and detailed their processes for assured the product performed by local companies from site survey for selecting companies to delivery of their equipment.

• Journal of the Korean housing association
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• v.18 no.5
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• pp.143-150
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• 2007

The purpose of this research is to example the general trend of the service environment evaluation of the silver town and classify based on the service environment evaluation to suggest a effective method and alternatives fur development companies. The survey population of this study focused on 40s and 50s' middle aged both genders living in the Seoul and national capital region, we used random sampling method. The analytical methods used in this study were frequency, mean, standard deviation, factor analysis, Chi-Squae analysis, ANOVA, cluster Analysis, post-hoc estimation (Duncan test), To verify the reliability of each measure, Cronbach's alpha coefficient was used. As a result of classifying the environment evaluation elements, it was classified into 5 groups for the differentiating strategy on each group. The groups are: life support service type, medical and health support service type, cultural support service type, indifference type, and food support service type.

• Journal of the Korea Institute of Military Science and Technology
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• v.15 no.5
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• pp.651-659
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• 2012

Target operational availability setting is the first step to setting up a goal which a weapon system development project have to achieve and doing RAM analysis during whole life of a weapon system. It is important as a key factor to doing RAM analysis in the early phase of weapon system development. This paper present a methodology to set a target operational availability for, especially, a warship when it develop. This methodology uses Operational Mode Summary/Mission Profile(OMS/MP) of the developing warship and RAM analysis results of similar warships to calculate wartime and peacetime target operational availability. It will be used in early phase of not only warship development but also army or aircraft weapon systems when these develop.