• Title/Summary/Keyword: Development factor

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Mast Cells and Vascular Endothelial Growth Factor Expression in Neoangiogenesis of Cervical Intraepithelial Neoplasia and Invasive Squamous Cell Carcinomas of the Uterine Cervix (자궁경부상피내종양과 침윤성 편평상피암종의 혈관신생에서 비만세포와 혈관내피성장인자의 발현)

  • Jekal, Seung-Joo;Lee, Jung-Ah;Rho, Jong-Sup
    • Korean Journal of Clinical Laboratory Science
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    • v.37 no.3
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    • pp.197-206
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    • 2005
  • To determine the correlation between mast cells(MCs) and neoangiogenesis in the growth and progression of cervical cancer, we investigated mast cell density(MCD), microvessel density(MVD) and the expression of vascular epithelial growth factor(VEGF) in cervical intraepithelial neoplasia and invasive suqamous cell carcinoma of the uterine cervix. Forty-five cervical intraepithelial neoplasia(CIN I, II and III), 15 microinvasive carcinomas, 15 invasive squamous cell carcinomas and 20 normal cervical epithelia were included in this study. MCs were stained with anti-c-Kit antibody and alcian blue, microvessels with anti-factor VIII antibody and VEGF with anti-VEGF antibody. The adjacent fields of both normal and neoplastic epithelium were used for counting MCs and microvessels. Computerized image analysis was used to evaluate MCD and MVD. MCD and MVD were the mean numbers per $1mm^2$ counted in 5-10 high and low power fields respectively. In both c-Kit and alcian blue stained sections, MCD progressively increased along the continuum from CIN I to invasive squamous cell carcinoma(p<0.001). MVD increased significantly with cervical neoplasia progression, from CIN to invasive squamous cell carcinoma (p<0.001). In double c-Kit and Factor VIII-stained sections, MCs were mainly present in the areas adjacent to newly formed blood vessels. However, there were no significant differences in MCD and MVD between normal epithelum and CIN I. A strong correlation was also observed between MCD and MVD. In double VEGF and alcian blue-stained sections, VEGF was expressed in only MCs. Strong VEGF-positive MCs were particularly abundant around the tumorous region. Our results suggest that MCs may upregulate neoangiogenesis by VGEF secretion in the development and progression of cervical neoplasia.

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A Theoretical Study on the Compressibility Factor of Hydrogen Gas in the High Pressure Tank (고압탱크에서 수소가스의 압축성 인자에 관한 이론적 연구)

  • JI-QIANG LI;HENG XU;JI-CHAO LI;JEONG-TAE KWON
    • Journal of Hydrogen and New Energy
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    • v.34 no.2
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    • pp.162-168
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    • 2023
  • The fast refueling process of compressed hydrogen has an important impact on the filling efficiency and safety. With the development and use of hydrogen energy, the demand for precision measurement of filling hydrogen thermodynamic parameters is also increasing. In this paper, the compressibility factor calculation model of high-pressure hydrogen gas was studied, and the basic equation of state and thermo-physical parameters were calculated. The hydrogen density data provided by the National Institute of Standards and Technology was compared with the calculation results of each model. Results show that at a pressure of 0.1-100 MPa and a temperature of 233-363 K, the calculation accuracy of the Zheng-Li equation of state was less than 0.5%. In the range of 0.1-70 MPa, the accuracy of Redich-Kwong equation is less than 3%. The hydrogen pressure more influences on the compressibility factor than the hydrogen temperature does. Using the Zheng-Li equation of state to calculate the compressibility factor of on-board high pressure hydrogen can obtain high accuracy.

Development and Validation of Academic Motivation Scale for Medical Students based on Self-Determination Theory (자기 결정성 이론에 근거한 의과대학생 학업 동기 척도 개발과 타당화)

  • Park, Kwi Hwa;Yune, So Jung
    • Journal of Digital Convergence
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    • v.20 no.1
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    • pp.221-229
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    • 2022
  • This study is to develop and validate the academic motivation scale for medical students(AMSMS) based on self-determination theory. After composing preliminary questions from 74 students, a preliminary and main survey were conducted with 148 and 300 students from September to November 2020. Factor analysis, reliability analysis, and correlation analysis were used. As a result of exploratory and confirmatory factor analysis, construct validity was verified. The fitness index of the five-factor model of amotivation, external regulation, introjected regulation, identified regulation, intrinsic motivation was good. The reliability of each factor was ranged from 0.760 to 0.933. The criterion validity of AMSMS was verified by showing a correlation with academic self-efficacy and school life satisfaction. This results show that the AMSMS is both valid and reliable, and it is expected to be used in research related to academic motivation of medical students in the future.

Assessment of growing condition variables on alfalfa productivity

  • Ji Yung Kim;Kun Jun Han;Kyung Il Sung;Byong Wan Kim;Moonju Kim
    • Journal of Animal Science and Technology
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    • v.65 no.5
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    • pp.939-950
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    • 2023
  • This study was conducted to assess the impact of growing condition variables on alfalfa (Medicago sativa L.) productivity. A total of 197 alfalfa yield results were acquired from the alfalfa field trials conducted by the South Korean National Agricultural Cooperative Federation or Rural Development Administration between 1983 and 2008. The corresponding climate and soil data were collected from the database of the Korean Meteorological Administration. Twenty-three growing condition variables were developed as explaining variables for alfalfa forage biomass production. Among them, twelve variables were chosen based on the significance of the partial-correlation coefficients or potential agricultural values. The selected partial correlation coefficients between the variables and alfalfa forage biomass ranged from -0.021 to 0.696. The influence of the selected twelve variables on yearly alfalfa production was summarized into three dominant factors through factor analysis. Along with the accumulated temperature variables, the loading scores of the daily mean temperature higher than 25℃ were over 0.88 in factor 1. The sunshine duration at temperature between 0℃-25℃ was 0.939 in factor 2. Precipitation days were 0.82, which was the greatest in factor 3. Stepwise regression applied with the three dominant factors resulted in the coefficients of factors 1, 2, and 3 for 0.633, 0.485, and 0.115, respectively, and the R-square of the model was 0.602. The environmental conditions limiting alfalfa growth, such as daily temperature higher than 25℃ or daily mean temperature affected annual alfalfa production most substantially among the growing condition variables. Therefore, future cultivar selection should consider the capability of alfalfa to be tolerant to extreme summer weather along with biomass production potential.

A Comparative Study on Chinese Adult women's constitutional components and Somatotype Characteristic (지역별.연령별 중국 성인여성(地域別.年齡別 中國 成人女性)의 체형구성 요인(體型構成 要因)과 유형 비교 연구(類型 比較 硏究))

  • Wee, Hye-Jung;Sohn, Hee-Soon
    • Journal of Fashion Business
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    • v.10 no.5
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    • pp.58-73
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    • 2006
  • The purpose of this study was to improve of fittness and coverage rate of exporting domestic clothing to China for Chinese Adult Female. For study, It was measured 1381 female women aged between 19 and 50 who resident in Beijing and Shanghai in China. as a sample, 1360 female women was seleted for development of apparel sizing system. As for the method of this study was made of 111 items by indirect measures done during Jun. 23 $\sim$ Aug. 7, 2004. Data analysis were processed by SPSS WIN 10.0 Program was used to for technical statistical analysis, correlation analysis, factor analysis, ANOVA(t-test and F-test), duncan's multiple test. The result was as follows: Chinese Adult women's constitutional components determined by factor analysis, six components could be identified: factor 1:constitutional obesty and width size, factor 2: longistudinal body size, factor 3: shoulder form and size, factor 4: longistudinal upper body size, factor 5: under body size, factor 6: shoulder dropping. According to the Women's Wear Specifications(GB/T 1335.2-1997) by drop, body types of Chinese Adult female was classified into six types, it was Y, A, B, C and Z, D. In order, A type as standard somatotype(49.8%), B type(26.9%), Y type (18.8%), C type(2.9%). Y type had the average height and shoulder, bust girth. They were slimmer in overall terms. A type had a normal obesity and body size in height, shoulder, bust girth. They were average Chinese Women. B type had a smaller then A type. They were more obes and thick waist girth. C type had the highest obesity, the widest shoulder and bust girth, and thick waist girth. The characteristics of each body type following the body type structure factor are Y-type for slender type, A-type for standard type, B-type for slightly large type, and C-type for obese type. For each region, the Beijing area had in the order of A-type, Y-type, B-type and C-type, and the Shanghai area had in the order of A-type, B-type, Y-type and C-type.

A Study for Development of Ratio Beale Measuring Pain Using Korean Pain Tersm (통증어휘를 이용한 통증비율척도의 개발연구)

  • 이은옥;윤순녕;송미순
    • Journal of Korean Academy of Nursing
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    • v.14 no.2
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    • pp.93-111
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    • 1984
  • The main purpose of this study is to develop a ratio scale measuring level of pain using Korean pain terms. The specific purposes of this study are to identify the degree of pain of each pain term in each subclass: to classify each subclass in terms of dimensions of pain; and to analyze factors of the Korean pain ratio scale clustering together. One hundred an4 fifty eight pain terms which were originally identified as representative terms and their synonyms were used for data collection. Fifty eight nursing professors ana sixty one medical doctors who have contacted with patients having pain were asked to rate the weight of each pain term on a visual analogue scale. Subclasses in which ranks of pain terms were same f s findings in two previous studies were 1) thermal 3 am 2) cavity pressure, 3) single stimulating pain, 4) radiation pain. and 5) chemical pain. Subclasses in which ranks of pain terms were confused were 1) incisive pressure, and 2) cold pain. Subclasses in which one new pain term was added were 1) inflammatory-repeated pain, 2) punctuate pressure, 3) constrictive pressure, 4) fatigue-related pressure, and 5) suffering-relate4 pain. Subclasses in which two new pain terms were added were 1) traction pressure, 2) peripheral nerve pain, 3) dull pain, 4) pulsation-related pain, 5) digestion-related pain, 6) tract pain, and 7) punishment-related pain. Subclass in which 3 new pain terms were included was fear-related pain. Rating scores of 5 words in 4 subclasses were significantly different between the normal group and the extreme group of subjects in terms of subjective rating. Only one word among 6 words was that newly added to the scale. Rating scores of 12 words in 9 subclasses were significantly different between doctor group and nursing professor group. Among these 12 words, only 3 were those newly added to the scale. In comparison of these 12 words, mean scores of the nursing professors were always 7 to 16 points higher than those of the medical doctors. In the analysis of judgement of subjects in terms of dimensions of pain terms, subclasses of dull pain, cavity pressure, tract pain and cold pain were suggested to be included in the miscellaneous dimension. As a result of factor analysis of the ratings given to 96 pain words using principal components analysis without iteration and with varimax rotation limiting the number of factors to 4, factors of severe pain (factor I) mild-moderate pain (factor II) , causative pain (factor III) and temperature-related pain(factor IV) were extracted with the factor loading above 0.388. When the pain words were re-arranged on the bases of factor loading above 0.368, number of factors decreased to only first two factors. Maximum score of pain word in factor II was 46.17 and the minimum score of the factor I was 45.36. Further studies are needed to identify the validity, reliability, sensitivity and practicability of this ratio scale using patients having various sources of pain.

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A Meta-analysis of The Factors Related to Resilience of Childcare Teachers (보육교사의 회복탄력성 관련 요인에 대한 메타분석)

  • Moon, Dong-Kyu
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.10
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    • pp.222-230
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    • 2020
  • This study verified the effect size of related factors through meta-analysis based on master's theses and doctoral dissertations and academic journal papers studied in Korea for the past 10years in relation to the resilience of childcare teachers. The verification results are as follows. First, the overall effect size of the protection factors was large. In addition, the personality factor group was the largest among the protection factor groups, followed by the job characteristic factor group and the organizational attribute factor group. Second, among the protection factors, all the sub-factors except the organizational characteristic factor group-ledger leadership and job characteristic factor group-emotional labor, which showed the medium effect size, showed a large effect size. Third, the overall effect size of the risk factor showed a large effect size. The organizational characteristic factor group-burnout showed a larger effect size than the job characteristic factor group-job stress. In conclusion, this study is meaningful in that it attempted a quantitative integration to examine objective results by integrating the previous studies in relation to the resilience of childcare teachers over the past 20 years. In addition, it is significant that it provided basic data for the development of policies and policy developments to improve the resilience of childcare teachers.

Development of Actual Measurement Spacing Factor Using Spacing Data of Air Void in Concrete (콘크리트의 공극 간격 데이터를 활용한 실측간격계수 개발)

  • Lee, Jin-Bum;Jeon, Sung-Il;Kwon, Soo-Ahn;An, Ji-Hwan
    • Journal of the Korea Concrete Institute
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    • v.23 no.6
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    • pp.701-709
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    • 2011
  • One of the typical evaluation models of concrete air-void system is spacing factor (SF), which was suggested by Power. Power Spacing Factor (PSF) has a disadvantage of the result being different from the actual case due to the existence of entrapped air, because PSF uses average single spacing factor. Therefore, the Actual Measurement Spacing Factor (AMSF) using actually measured data of air void spacing was developed from this study. PSF and AMSF were compared and evaluated in this study by using the image analysis test result of concrete mixture. This study results showed that PSF and AMSF are generally similar, but AMSF had a larger value when PSF was greater than $400{\mu}m$. The results indicated a possibility of PSF giving false measurement estimation where the measurement is less than the actual value in the concrete mixture containing less air. Also, in the result of PSF and AMSF analysis according to the existence of entrapped air, AMSF showed a larger value in the analysis without entrapped air. But PSF showed a smaller value in the analysis without entrapped air, which was different from the actual case. Because PSF used average single spacing factor, it tended to give a false result. The study results showed that AMSF gave more accurate analysis results.

The Analysis of Assessment Factors for Offshore Wind Port Site Evaluation (해상풍력 전용항만 입지선정 평가항목에 관한 연구)

  • Ko, HyunJeung
    • Journal of Korea Port Economic Association
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    • v.28 no.3
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    • pp.27-44
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    • 2012
  • The offshore wind farm is increasingly attractive as one of future energy sources all over the world. In addition, the capacity of an offshore wind turbine gets larger and its physical characteristics are big and heavy. In this regard, a special port is necessary to assemble, store, and transport the offshore wind systems, supporting to form the offshore wind farms. Thus, this study aims to provide a policy maker which evaluation factors can significantly affect to the optimal site selection of a offshore wind port. For this, Fuzzy-AHP method is applied to capture the relative weights. The results of this study can be summarized as follows. Five criteria in level I was defined such as the accumulation factor, the regional factor, the economic factor, the location factor, and the consortium factor. Of these, the accumulation factor(37.4%), the location factor(34.2%), and the economic factor( 24.5%) were analyzed by major factors. In level II, three assessment items of each factor were selected so that total fifteen items were formed. To sum up, the site selection of offshore wind port should consider the density of the wind industry, cargo volume of securing the economic operation of terminals, the development degree of offshore wind related industry, and the proximity to the offshore wind farms. In other words, the construction of offshore wind port should be paid attention to considering not only the proximity to offshore wind farms but also the preference of turbine manufacturing companies.

Streptochlorin, a Marine Natural Product, Inhibits $NF-{\kappa}B$ Activation and Suppresses Angiogenesis In Vitro

  • Choi, In-Kwon;Shin, Hee-Jae;Lee, Hyi-Seung;Kwon, Ho-Jeong
    • Journal of Microbiology and Biotechnology
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    • v.17 no.8
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    • pp.1338-1343
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    • 2007
  • Angiogenesis is an essential step in tumor progress and metastasis. Accordingly, small molecules that inhibit angiogenesis would appear to be a promising way to cure angiogenesis-related diseases, including cancer. In the present study, we report that streptochlorin, a small molecule from marine actinomycete, exhibits a potent antiangiogenic activity. The compound potently inhibited endothelial cell invasion and tube formation stimulated with vascular endothelial cell growth factor (VEGF) at low micromolar concentrations where it showed no cytotoxicity to the cells. In addition, streptochlorin inhibited TNF-${\alpha}$-induced $NF-{\kappa}B$ activation in the newly developed cell-based reporter gene assay. These data demonstrate that streptochlorin is a new inhibitor of $NF-{\kappa}B$ activation and can be a basis for the development of novel anti-angiogenic agents.