• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.22 no.3
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• pp.88-103
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• 2023

With the recent advancement of 4th Industrial Revolution technology, transportation systems are generating large amounts of mobility data related to the individual movement trajectories of vehicles and people. There are many constraints on utilizing mobility data containing personal information. Thus, in South Korea, the processing and generation of pseudonymized information and the analysis and utilization of this information have been managed in a dual manner by applying separate agencies and technologies through the revision of the Data 3 Act and the enactment of the Data Basic Act. However, this dual approach fails to securely support the entire data lifecycle and suffers from inefficiencies in terms of processing time and cost. Therefore, to compensate for the problems of the existing Expert Data Combination System and Data Safety Zone, this study proposes an Integrated Data Safety Zone Framework that integrates and unifies the process of generating, processing, analyzing, and utilizing mobility data. The integrated process for data processing was redesigned, and common requirements and core technologies were derived. The result is an architecture for a next-generation Integrated Data Safety Zone system that can manage and utilize the entire life cycle of mobility data at one stop.

• The Journal of the Convergence on Culture Technology
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• v.9 no.3
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• pp.817-823
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• 2023

Manufacturing plants face the challenge of reducing energy use in response to climate change. Reducing energy consumption can be seen as one of the most important issues, such as reducing production costs and improving efficiency. Among manufacturing industries, the increase in energy consumption in the food industry is gradually increasing along with the improvement of the standard of living and the increase in population. In order to save energy in food processing plants, it is important to identify and analyze energy consumption characteristics in energy-consuming processes. Prior to this, it is necessary to monitor and analyze existing energy consumption to derive reduction measures. In this study, a small and medium-sized food processing plant producing processed meat products was used as a case study to identify and analyze the energy consumption structure at typical cycle/stage level of the batch heating process. From this, we tried to establish realistic and quantitative goals that can be obtained under individual process operating conditions. The results of this study will be used as basic data for the development of diffusion and pervasive energy saving FEMS technology for common core processes of food factories of small and medium-sized enterprises in the future.

• Asia Marketing Journal
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• v.11 no.1
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• pp.39-72
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• 2009

With the growing importance of accountability, it is getting necessary to test the impact of marketing expenditure on marketing performance. Including recent ROM, we can find a few researches about marketing accountability. But there are a few problems about definitions and metric of marketing expenditure and marketing performance. Therefore, by defining and analyzing the impact of marketing expenditure on marketing performance, we are going to set the classification scheme of marketing expenditure and marketing performance. Based on research findings, new definitions and metrics are proposed as follows. First, we suggest the classification scheme of marketing expenditure. Marketing expenditure is defined as expense accounts in the balance sheet for doing marketing tasks. Marketing expenditures includes many accounts, for example, marketing research, advertising, sales promotion, foreign market development, physical distribution, after services. Among these marketing investment, advertising expenses have a positive effect on marketing performance. Second, we suggest the classification scheme of marketing performance. Already, marketing performance has been defined as financial metrics, customer metrics, market metrics, and corporate social responsibility. But, in this study, we find that the process model is not relevant for explaining association between the performance metrics. The process model is a virtuous cycle: "customer metrics→market metrics→financial metrics→firm valuation metrics." But, in this study, it is not supported or a little significant association between these metrics. Based on these results, we suggest the balance model or flower model as the classification scheme of marketing performance.

• Korean Journal of Poultry Science
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• v.50 no.4
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• pp.193-202
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• 2023

Influenza IAVs are encapsulated negative-strand RNA viruses that infect many bird species' respiratory systems and can spread to other animals, including humans. This work reanalyzed previous microarray datasets to identify common and specific differentially expressed genes (DEGs) in chickens, as well as their biological activities. There were 760 and 405 DEGs detected in HPAIV and LPAIV-infected chicken cells, respectively. HPAIV and LPAIV have 670 and 315 DEGs, respectively, with both viruses sharing 90 DEGs. Because of HPAIV infection, numerous genes were implicated in a fundamental biological function of the cell cycle, according to the functional annotation of DEGs. Of the targeted genes, expressions of CDC Like Kinase 3 (CLK3), Nucleic Acid Binding Protein 1 (NABP1), Interferon-Inducible Protein 6 (IFI6), PIN2 (TERF1) Interacting Telomerase Inhibitor 1 (PINX1), and Cellular Communication Network Factor 4 (WISP1) were altered in DF-1 cells treated with polyinosinic:polycytidylic acid (PIC), a toll-like receptor 3 (TLR3) ligand, suggesting that transcription of these genes be controlled by TLR3 signaling. To gain a better understanding of the pathophysiology of AIVs in chickens, it is crucial to focus more research on unraveling the mechanisms through which AIV infections may manipulate host responses during the infection process. Insights into these mechanisms could facilitate the development of novel therapeutic strategies.

• Journal of Digital Convergence
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• v.22 no.2
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• pp.21-28
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• 2024

This study analyzed the current status of care policies and senior citizen issues in Korea, which has entered a super-aging society, and attempted to suggest improvement measures for desirable convergence policies. The problems of the elderly in Korea have emerged as health problems, poverty problems, loss of roles, and care problems due to changes in the concept of family, values, and socioeconomic structure. In addition, poor seniors need jobs and employment policies, and healthy middle-class seniors need policy development to enable leisure activities and volunteer activities. In particular, it is necessary to establish policies to enable people to spend the rest of their lives in elderly care facilities and elderly care hospitals through community care policies. The super-aging society accounts for more than 20% of the total population among those aged 65 or older, and according to the National Statistical Office, it is expected to become a super-aging society by 2025. Elderly welfare policies must provide various programs and the needs and services of elderly care, and in the future, a super-aging society will need to secure a lot of financial resources and maintain a productive population to cover the financial resources. In other words, the human life cycle is from birth to death, and when the ratio of natural deaths of the elderly and infants born is appropriate, the society and the country can be seen as stable, vibrant, and healthy societies.

• Journal of Life Science
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• v.34 no.6
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• pp.399-407
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• 2024

Angiogenesis is the process by which new blood vessels form from existing blood vessels. This phenomenon occurs during growth, healing, and menstrual cycle changes. Angiogenesis is a complex and multifaceted process that is important for the continued growth of primary tumors, metastasis promotion, the support of metastatic tumors, and cancer progression. Impaired angiogenesis can lead to cancer, autoimmune diseases, rheumatoid arthritis, cardiovascular disease, and delayed wound healing. Currently, there are only a handful of effective antiangiogenic drugs. Recent studies have shown that natural marine products exhibit antiangiogenic effects. In a previous study, we reported that the hexane extract of H. fusiformis (HFH) could inhibit the development of new blood vessels both in vitro and in vivo. The aim of this study was to describe the inhibitory effect of chloroform extracts of H. fusiformis on angiogenesis. To investigate how chloroform extract prevents blood vessel growth, we examined its effects on HUVEC, including cell migration, invasion, and tube formation. In a mouse Matrigel plug assay, H. fusiformis chloroform extract (HFC) also inhibited angiogenesis in vivo. Certain proteins associated with blood vessel growth were reduced after HFC treatment. These proteins include vascular endothelial growth factor (VEGF), mitogen-activated protein kinase (MAPK)/extracellular signal transduction kinase, and serine/threonine kinase 1 (AKT). These studies have shown that the chloroform extract of H. fusiformis can inhibit blood vessel growth both in vitro and in vivo.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.4
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• pp.298-305
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• 2023

Burkitt's lymphoma is a distinct subtype of non-Hodgkin's lymphoma originating from B-cells that is notorious for its aggressive growth and association with immune system impairments, potentially resulting in rapid and fatal outcomes if not addressed promptly. Optimizing the use of Food and Drug Administration-approved medications, such as combining known safe drugs, can lead to time and cost savings. This method holds promise in accelerating the progress of novel treatments, ultimately facilitating swifter access for patients. This study explores the potential of a dual-targeted therapeutic strategy, combining the bruton tyrosine kinase-targeting drug Ibrutinib and the epidermal growth factor receptor/human epidermal growth factor receptor-2-targeting drug Lapatinib. Ramos and Daudi cell lines, well-established models of Burkitt's lymphoma, were used to examine the impact of this combination therapy. The combination of Ibrutinib and Lapatinib inhibited cell proliferation more than using each drug individually. A combination treatment induced apoptosis and caused cell cycle arrest at the S and G2/M phases. This approach is multifaceted in its benefits. It enhances the efficiency of the drug development timeline and maximizes the utility of currently available resources, ensuring a more streamlined and resource-effective research process.

• Korean Journal of Radiology
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• v.24 no.4
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• pp.362-370
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• 2023

Objective: To report the clinical and radiological characteristics of patients with underlying B-cell lymphoma and coronavirus disease 2019 (COVID-19) showing migratory airspace opacities on serial chest computed tomography (CT) with persistent COVID-19 symptoms. Materials and Methods: From January 2020 to June 2022, of the 56 patients with underlying hematologic malignancy who had undergone chest CT more than once at our hospital after acquiring COVID-19, seven adult patients (5 female; age range, 37-71 years; median age, 45 years) who showed migratory airspace opacities on chest CT were selected for the analysis of clinical and CT features. Results: All patients had been diagnosed with B-cell lymphoma (three diffuse large B-cell lymphoma and four follicular lymphoma) and had received B-cell depleting chemotherapy, including rituximab, within three months prior to COVID-19 diagnosis. The patients underwent a median of 3 CT scans during the follow-up period (median 124 days). All patients showed multifocal patchy peripheral ground glass opacities (GGOs) with basal predominance in the baseline CTs. In all patients, follow-up CTs demonstrated clearing of previous airspace opacities with the development of new peripheral and peribronchial GGO and consolidation in different locations. Throughout the follow-up period, all patients demonstrated prolonged COVID-19 symptoms accompanied by positive polymerase chain reaction results from nasopharyngeal swabs, with cycle threshold values of less than 25. Conclusion: COVID-19 patients with B-cell lymphoma who had received B-cell depleting therapy and are experiencing prolonged SARS-CoV-2 infection and persistent symptoms may demonstrate migratory airspace opacities on serial CT, which could be interpreted as ongoing COVID-19 pneumonia.

• Journal of the Microelectronics and Packaging Society
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• v.31 no.3
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• pp.42-49
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• 2024

In the electromagnetic wave shielding material market, superior shielding performance in the high-frequency range, along with flexibility and durability, has emerged as critical requirements. The need for high-performance EMI (Electromagnetic Interference) films to address electromagnetic wave interference issues is growing, particularly in various industrial sectors such as smart electronic devices, automotive electronic systems, and communication equipment. In this study, a trimodal silver paste was developed and fabricated into an EMI film, with its performance evaluated. The developed silver paste, utilizing a modified epoxy binder, exhibited properties suitable for screen printing processes. The film demonstrated excellent shielding performance, with an average attenuation of -99 dB in the high-frequency range of the 5G spectrum (26.5 GHz to 40 GHz), and a shielding effectiveness of -90.3 dB at 33.6 GHz. Flexibility and durability tests showed that the film maintained its flexibility even at a curvature radius of 1 mm. In the bending cycle test, the resistance increased by approximately 25.5% from 0.51 Ω to 0.64 Ω after 10,000 cycles in the outer bending scenario, while in the inner bending scenario, the resistance decreased by about 3.6%, indicating reduced resistance to compressive stress.

• Cartoon and Animation Studies
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• s.29
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• pp.173-207
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• 2012

The four-phased plot which consists of introduction, development, turn and conclusion in the long-story structure tends to be patterned and schematized. The behavior of characters is in line with the beginning of human beings and the plot of comic strips basically has four phases. It is, however, not a simple arrangement but a complex one which was developed by organizing patterns of human power, behavior and emotions. With the results from a survey with college students studying comic strips, this study aims to categorize four characters from the archetypal system by Carol Pearson, four phases of the hero's journey by Joseph Campbell, and the four phases of the plot based on Aristotle's theory, which is the frame of the comic strip structure through supporting evidence extracted from comic strips in an integrated way. In this study, the categorization is performed by simplifying and systemizing a character's life cycle, which is a factor of a story structure in complex comic strips. This study is to identify what comic strip writers express by using the metaphor in the complicated long-story structure of comic strips This study reveals that the structure of introduction, development, turn and conclusion based on the plot theory by Aristotle is the metaphor of human life and fate and that the phases of development in the archetypal system by Carol Pearson, a Jung researcher influenced by Jung's theory are the metaphor of human life and fate. Also, the theories of Joseph Campbell, who also was influenced by Jung, are the metaphor of human life and fate as they projected complex emotions of joy, anger, sorrow, and pleasure onto the archetype of heroes and used the metaphor of the hero's journey. Lastly, the theories are introduced with the approach of 'guide to screenwriters' by Christopher Vogler. Meanwhile, this metaphor is the objective and goal of this study. The comic strips selected for this study seem to have long complex stories which have characters leaving their homes, going through adventures and difficulties, meeting the world in another way, experiencing tension, competition, wars, and hardship and returning home with compensation. They grow mentally and psychologically through their journeys and finally become heroes. They express the meaning of our introspection in a narrative through plots and images of comic strips. This appears complex but the basic structure of long comic strips has four phases of plot. The life style of an extraordinary character traveling for adventures and growing in long comic strips can be divided into four phases symbolizing childhood, adolescence, adulthood, and senescence and it is a psychological growth process. The archetypes of the character can be divided into four phases and the growth process can be explained. The hero's journey symbolized by the character can be also divided into four phases. Through theories, the complex arrangement of four-phased plots in comic strips corresponds with the growth process of introduction, development, turn and conclusion through the stages of life. At the same time, this study found that the characters becoming heroes are the metaphor of introspection and that the characters' growth and life correspond with the four phases in life through long comic strips. Long stories in long comic strips written by comic strip writers show that characters go on their journeys and change their lives through hardship and difficulty by logical construction of plot and their growth processes are presented in archetypal images and they reach introspection as heroes. The readers share time and space through images in comic strips and realize that they had the same experience as the characters emotionally by being moved by the stories.