• Journal of Microbiology and Biotechnology
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• 제23권11호
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• pp.1500-1508
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• 2013

Ebosin, a novel exopolysaccharide produced by Streptomyces sp. 139, has obvious antirheumatic arthritis activity in vivo, and its biosynthesis gene cluster (ste), consisting of 27 open reading frames, has been identified. This paper reports our study of the gene functionality of ste8, the predicted protein product of which is homologous to some bacterial chain length determinant Wzz proteins. For characterization of Ste8, ste8 was cloned and expressed in the mutant strain E. coli 086:H2 (${\Delta}wzz$). The functional complementation of wzz by ste8 was demonstrated by the restoration of wild-type lipopolysaccharide biosynthesis and increased levels of serum resistance of E. coli 086:H2 (${\Delta}wzz$) (pET30a-ste8). To examine the function of ste8 in ebosin biosynthesis, the gene was knocked out with a double crossover via homologous recombination. The molecular weight of the ebosin derivative EPS-8m produced by the mutant Streptomyces sp. 139 ($ste8^-$) was much lower than that of ebosin, and the binding activity of EPS-8m for IL-1R decreased significantly compared with ebosin. These results demonstrate that ste8 encodes a chain length determinant (Wzz) that functions in ebosin biosynthesis.

• 지역사회간호학회지
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• 제9권1호
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• pp.30-39
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• 1998

The purpose of this study was to identify the factors influencing health promoting lifestyle of teachers and to provide the data for efficient health management of teachers. The subjects of this study were eight hundred nine teachers, who were chosen in Choong-Buk province. Survey Questionaires for data analysis were collected through visiting or mailing from September 1 to 30, 1997. The instruments used in this study were HPLP(Health Promoting Lifestyle Profile) by Walker (1987), Internal Health Locus of Control by Walston et al. (1978), Self Esteem by Rogenberg(1965), Importance of Health by Muhlenkamp (1985), Self Efficacy by Sherer & Maddux(1982), and Family Function by Olson & Schellenberg (1985). Data were analyzed by descriptive statistics, unpaired t-test, ANOVA, Pearsons correlation coefficient and stepwise multiple regression using SPSS/PC(v. 4.01) program. The results were as follows; 1. The mean of health promoting lifestyle was total 2.53 on the average, self-actualization 2.97, nutrition 2.90, interpers 52, stress management 2.33, exercise 1.91, and health responsibility 1.82 in order. The index of total health promoting lifestyle was significantly influenced by the factors including sex, age, religion, marital status, duration of work, teaching load, education level and number of family members. 2. The health promoting Lifestyle was significantly positive correlated with Self Efficacy, Family Function, Importance of Health, Internal Health Locus of Control and Self Esteem. 3. Self Efficacy was the most influential determinant predicting health promoting lifestyle of teachers. Self efficacy, Family Function, Importance of Health, Internal Health Locus of Control and Age explained 42% of the health promoting lifestyle. Based on the above findings, it is suggested to develop nursing intervention to improve Self Efficacy, Importance of Health, Family Function of teachers enhance health promoting lifestyle. Further studies are needed to confirm these findings and to determine factors which significantly influence health promoting lifestyle of teachers.

• Journal of Preventive Medicine and Public Health
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• 제24권3호
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• pp.339-355
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• 1991

The concept of workers' participation in occupational health was introduced to Korea recently in relation to primary health care in occupational health. But there is confusion and debate about workers' participation concept. The purpose of this study was to review the concepts of workers' participation and to conduct evaluation the workers' participation status in occupational health and safety, 394 workers and 54 employers (5.6%) in north area of Kyunggi-Do, were selected and interviewed with a questionnaire by a trained interviewer from August to September 1990. In general, the concept of workers' participation is based on industrial domocratisation and Declaration of Human Rights which had been powerful ideologies in labor movement. Contrary to workers' participation, community participation is rooted in the Health Rights. So, it is necessary to consider concept of workers' participation to improve participation. The results of survey were as follows. 1. Most of companies (71.75) carried out occupational health education to workers in study area. 2. The Occupational Safety and Health Committee (OSHC) were set up in 24.1% among the study companies, and 72.7% of workers among respondents thought that OSHC was helpful to workers health. 3. The workers signed his name to personal health report in 43.1% and the rate of participation in occupational environment examination was 54.9%. 4. The workers prefer the OSHC (39.3%), owner (35.1%) and union (25.8%) as a occupation health organisation, but owners prefer OSHC (54.5%), manager (43.2%) and union (2.3%). 5. Among the factors of the general characteristics, the existence of labor union was a major determinant of workers' attitude and level of workers' participation. As we have seen, most levels of workers' participation are low in occupational health. The variable of existence of labor union among the factors was a ma determinant of workers attitude and level of workers' participation. Therefore, in order to promote workers health, it is necessary to ponder long deeply on occupational health care system under the viewpoint of workers' participation.

• 보건교육건강증진학회지
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• 제32권3호
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• pp.23-31
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• 2015

Objectives: The contribution of health behavior is high in the mortality variation. Mortality variation can be decreased through the policies and programs for improving health behavior. We investigated that health behaviors effected with standardized mortality in community. Methods: We examined the distribution of health determinant factors and correlation analyzed between factors and performed multiple linear regression. Data were collected from 2012 Community Health Survey in 253 communities, annual regional statistics, and statistics from Statistics Korea. Results: This study defined that the variation of standardized mortality and there are exist inequality level of health determinant factors in 253 communities. This study showed that the higher standardized mortality explained through health behavior factors of the current smoking rate, walking exercise rate and diagnosis of hypertension or diabetes rate after adjusted other factors(adjusted $R^2=0.709$, p<0.001). Conclusions: Smoking, walking exercise and diagnosis chronic disease affecting on the regional variation of standardized mortality. These factors can be improved by the local residents themselves.

• Journal of Preventive Medicine and Public Health
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• 제48권1호
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• pp.18-27
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• 2015

Objectives: Civic participation, that which directly influences important decisions in our personal lives, is considered necessary for developing a society. We hypothesized that civic participation might be related to self-rated health status. Methods: We constructed a multi-level analysis using data from the World Value Survey (44 countries, n=50 859). Results: People who participated in voting and voluntary social activities tended to report better subjective health than those who did not vote or participate in social activities, after controlling for socio-demographic factors at the individual level. A negative association with unconventional political activity and subjective health was found, but this effect disappeared in a subset analysis of only the 18 Organization for Economic Cooperation and Development (OECD) countries. Moreover, social participation and unconventional political participation had a statistically significant contextual association with subjective health status, but this relationship was not consistent throughout the analysis. In the analysis of the 44 countries, social participation was of borderline significance, while in the subset analysis of the OECD countries unconventional political participation was a stronger contextual determinant of subjective health. The democratic index was a significant factor in determining self-rated health in both analyses, while public health expenditure was a significant factor in analysis of 18 countries. Conclusions: Our investigation suggests that civic participation, including unconventional political activity at the contextual level, might be a significant determinant of health status of a country.

• 가정∙방문간호학회지
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• 제30권2호
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• pp.202-215
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• 2023

Purpose: This study attempted to determine the factors related to behaviors of reducing exposure to endocrine disrupting chemicals (BRE to EDCs) in pregnancy, based on the PRECEDE model. Methods: A cross-sectional survey was conducted with participants (N=239) who met the medical records and eligibility criteria from the Women's Hospital and Public Health Center. Data were collected using a specially-designed questionnaire based on the PRECEDE model and included BRE to EDCs predisposing factors, reinforcing factors, and enabling factors. The data were analyzed using the chi-square test, independent t-test, one way ANOVA, Pearson's correlation coefficients and a hierarchical multiple regression analysis. Results: In Model I it was found that participation in prenatal education influenced the BRE to EDCs significantly; and a regression showed that the determinant variables accounted for 3.4%. In Model II, the predisposing factors of perceived barriers of BRE to EDCs and environmental self-efficacy were added. It was shown that they significantly influenced BRE to EDCs in the order named, and a regression revealed that increases in the determinant variables accounted for 22.5%. In Model III, to which enabling factors were added, the information acquisition experience of BRE to EDCs interacted significantly with BRE to EDCs and a regression showed an increase in the determinant variables accounting for 25.3%. Conclusion: The results of this study, the content of endocrine disruptors must be included in the prenatal care education program for pregnant women, and it should be composed of contents that can reduce the perceived obstacle to BRE to EDCs, enhance the environmental self-efficacy, and provide the information in regard to reducing exposure to EDCs.

• Annals of Occupational and Environmental Medicine
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• 제35권
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• pp.16.1-16.3
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• 2023

• 한국전자통신학회논문지
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• 제10권1호
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• pp.117-124
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• 2015

본 연구는 정보화 시대를 사는 고등학생의 신체적 건강에 영향을 미치는 요인을 인구사회경제학적 특성요인, 학교 요인, 문제행동 요인을 통해 탐색하였다. 이를 위해 본 연구에서는 2012년 제8차 청소년 건강행태 온라인조사 자료 중 고등학생 자료를 활용하여 각 관련변수에 대한 빈도분석, 백분율, 평균 등의 기술 통계분석을 시행하였으며, 독립변인에 따른 고등학생의 신체적 건강 수준의 차이를 t-검증과 F-검증을 통해 분석하였으며, 각 독립변인이 고등학생의 신체적 건강에 미치는 영향을 다중회귀분석을 통해 검증하였다. 결과를 통합 회귀분석에 근거해 제시하면, 인구사회경제학적 요인 중에서는 남학생일수록, 아버지의 학력이 저조한 경우에, 형제가 있는 경우에, 가계의 경제수준이 높을수록, 학교 요인에서는 저학년일 경우에, 성적이 우수할수록, 문제행동 요인에서는 문제음주를 하지 않는 경우에, 약물을 사용하지 않는 경우에 통계학적으로 유의한 수준에서 신체적 건강수준이 더 양호한 것으로 나타났다. 이러한 결과를 근거하여 본 연구는 고등학생의 신체적 건강 증진을 위한 제언을 전달하였다.

• Journal of the Korean Data and Information Science Society
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• 제21권6호
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• pp.1253-1261
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• 2010

본 연구는 국민건강보험공단의 건강검진데이터, 자격 및 보험료, 그리고 진료비 데이터를 활용하여 위암 발생 예측모형을 개발하고자 하였다. 모형개발에는 데이터마이닝 방법론에 의한 로지스틱 회귀모형을 활용하였으며, 모형개발은 남성, 여성 그리고 전체에 대해 각각 개발하여 각 모형에서 위암 발생 결정요인의 차이를 비교하였다. 그 결과 위암 발견 예측에 가장 큰 영향을 미치는 특성은 수검자의 연령이었고, 다음으로 음주, 가족병력 (암) 순으로 나타났다. 남자가 여자보다 위암 발견 가능성이 다소 높은 것으로 나타났으며, 남성의 경우는 연령, 여성의 경우는 음주유무가 위암 발생에 많은 영향을 미치는 것을 확인 할 수 있었다.

• 한국병원경영학회지
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• 제15권2호
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• pp.15-26
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• 2010

Stroke is a high-risk disease. The future of the medical environment is that the proportion of elderly population is increasing, the average life expectancy is being increased, while the fatal rate of stroke will be low. These situation will due to the financial burden on medical insurance. The most important factor that affects on the medical costs of stroke patients is the length of stay. In this study the mean length of hospital for stroke stay was 21.81days(37.97days for intracerebral hemorrhage, 18.89 days for cerebral infarction). The payment per case of stroke was 6.86 million won(12.6 million won for intracerebral hemorrhage, 5.72 million won for cerebral infarction). The payment per case of intracerebral hemorrhage was 2.2 times more than that of cerebral infarction. The payment in the day of hospitalization was the highest and until the second day medical costs was high. After the third day medical costs tended to decline, after that seemed to show an almost constant level. The length of hospital stay was found to be the most important determinant of inpatient charges for stroke. Accordingly rational management of the length of stay will be beneficial to health care consumers, providers, states.