• 제목/요약/키워드: Deterioration factor

검색결과 395건 처리시간 0.025초

The design for therapeutic agents of Leucine Rich Repeat protein using bioinformatics

  • Kim, Seong Yeol;Park, Beom Seok
    • International Journal of Advanced Culture Technology
    • /
    • 제7권4호
    • /
    • pp.156-162
    • /
    • 2019
  • Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by progressive joint deterioration; Furthermore, RA can also affect body tissues, including the skin, eyes, lungs, heart and blood vessels. The early stages of RA can be difficult to diagnose because the signs and symptoms mimic those of many other diseases. It is not known exactly what triggers the onset of RA and how to cure the disease. But recent discoveries indicate that remission of symptoms is more likely when treatment begins early with strong medications known as disease-modifying anti-rheumatic drugs (DMARDs). Tumor necrosis factor (TNF) inhibitors are typical examples of biotherapies that have been developed for RA. The substances may occur naturally in the body or may be made in the laboratory. Other biological therapies care biological response modifiers (BRMs)such as monoclonal antibodies, interferon, interleukin-2 (IL-2) and a protein binder using repeat units. These substances play significant anti-inflammatory roles. Proteins with recurrent, conserved amino acid stretches mediate interactions among proteins for essential biological functions; for example, ankyrin (ANK), Heat repeat protein (HEAT), armadillo repeat protein (ARM) and tetratricopeptide repeats (TPR). Here, we describe Leucine rich repeats (LRR) that ideally fold together to form a solenoid protein domain and is more applicable to our current study than the previously mentioned examples. Although BRMs have limitations in terms of immunogenicity and effector functions, among other factors, in the context therapeutic use and for proteomics research, We has become clear that repeat-unit-derived binding proteins will increasingly be used in biotechnology and medicine.

TNF-α-Induced SOX5 Upregulation Is Involved in the Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Through KLF4 Signal Pathway

  • Xu, Lijun;Zheng, Lili;Wang, Zhifang;Li, Chong;Li, Shan;Xia, Xuedi;Zhang, Pengyan;Li, Li;Zhang, Lixia
    • Molecules and Cells
    • /
    • 제41권6호
    • /
    • pp.575-581
    • /
    • 2018
  • Postmenopausal osteoporosis (PMOP) is a common systemic skeletal disease characterized by reduced bone mass and microarchitecture deterioration. Although differentially expressed SOX5 has been found in bone marrow from ovariectomized mice, its role in osteogenic differentiation in human mesenchymal stem cells (hMSCs) from bone marrow in PMOP remains unknown. In this study, we investigated the biological function of SOX5 and explore its molecular mechanism in hMSCs from patients with PMOP. Our findings showed that the mRNA and protein expression levels of SOX5 were upregulated in hMSCs isolated from bone marrow samples of PMOP patients. We also found that SOX5 overexpression decreased the alkaline phosphatase (ALP) activity and the gene expression of osteoblast markers including Collagen I, Runx2 and Osterix, which were increased by SOX5 knockdown using RNA interference. Furthermore, $TNF-{\alpha}$ notably upregulated the SOX5 mRNA expression level, and SOX5 knockdown reversed the effect of $TNF-{\alpha}$ on osteogenic differentiation of hMSCs. In addition, SOX5 overexpression increased Kruppel-like factor 4 (KLF4) gene expression, which was decreased by SOX5 silencing. KLF4 knockdown abrogated the suppressive effect of SOX5 overexpression on osteogenic differentiation of hMSCs. Taken together, our results indicated that $TNF-{\alpha}$-induced SOX5 upregulation inhibited osteogenic differentiation of hMSCs through KLF4 signal pathway, suggesting that SOX5 might be a novel therapeutic target for PMOP treatment.

송천유역의 수질환경특성 및 효율적 유역관리 (Water Environment Characteristics and Efficient Basin Management of Song Stream)

  • 허인량;신용건;이건호;최지용;김영진;정의호;정명선
    • 한국환경보건학회지
    • /
    • 제27권2호
    • /
    • pp.51-59
    • /
    • 2001
  • Song stream is located in the upstream of the Namhan River. Normal times, the stream flows down to the east sea through the drainage pipe but at rainy season, it flows to the Namhan River. There are large stock farm, leisure town and cultivated land in this basin. The pollutants from these contamination source cause eutrophication at lake Doam and deterioration of water quality in namdai stream. In this case, this study was carried out to evaluate water quality and environmental capacity as well as economical efficiency of each industry. The basin shape factor of subject stream was 0.315, slope is higher than usual basin. The BOD, T-N and T-P productive contamination loading from each contamination source was 2,690, 974 and 194 kg/day, respectively, and major contamination source was stock farm and cultivated land. Annual BOD, T-N, T-P distribution(median value) of Song stream showed 1.0~2.2 mg/L, 3.16~5.85 mg/L and 0.024~0.197 mg/L Doam lake showed 1.1~1.9, 2.51~3.89 and 0.042~0.114 mg/L, respectively. Being compared of water quality at main stream between past and present, it showed that the water quality has improved since last five years. BOD improvement rate was 8~50%. Run off loading of BOD, T-N, T-P was 366, 1129, 17.2 kg/day, and run off rate was 13.6%, 86.2%, 11.3% respectively. Finally, the result of productivity survey of each industry, leisure town, cultivated land and large stock farm was 118, 46, 50 billion won, per T-P 1kg productive, and productivity portion was 100, 39, 42% respectively, and the highest economical efficiency industry was leisure facilities.

  • PDF

제조 및 작동온도에서 평판형 고체연료전지에 발생한 균열 거동 (The Crack Behavior in the Planar Solid Oxide Fuel Cell under the Fabricating and Operating Temperature)

  • 박철준;권오헌;강지웅
    • 한국안전학회지
    • /
    • 제29권4호
    • /
    • pp.34-41
    • /
    • 2014
  • The goal of this study is to investigate some crack behaviors which affect the crack propagation angle at the planar solid oxide fuel cell with cracks under the fabricating and operating temperature and analyze the stresses by 3 steps processing on the solid oxide fuel cell. Currently, there are lots of researches of the performance improvement for fuel cells, and also for the more powerful efficiency. However, the planar solid oxide fuel cell has demerits which the electrode materials have much brittle properties and the thermal condition during the operating process. It brings some problems which have lower reliability owing to the deformation and cracks from the thermal expansion differences between the electrolyte, cathode and anode electrodes. Especially the crack in the corner of the electrodes gives rise to the fracture and deterioration of the fuel cells. Thus it is important to evaluate the behavior of the cracks in the solid oxide fuel cell for the performance and safety operation. From the results, we showed the stress distributions from the cathode to the anode and the effects of the edge crack in the electrolyte and the slant crack in the anode. Futhermore the crack propagation angle was expected according to the crack length and slant angle and the variation of the stress intensity factors for the each fracture mode was shown.

Drying Characteristics of Agricultural Products under Different Drying Methods: A Review

  • Lee, Seung Hyun;Park, Jeong Gil;Lee, Dong Young;Kandpal, Lalit Mohan;Cho, Byoung-Kwan;Hong, Soon-jung;Jun, Soojin
    • Journal of Biosystems Engineering
    • /
    • 제41권4호
    • /
    • pp.389-395
    • /
    • 2016
  • Purpose: Drying is one of the most widely used methods for preserving agricultural products or food. The main purpose of drying agricultural products is to reduce their water content for minimizing microbial spoilage and deterioration reaction during storage. Methods: Although numerous drying methods are successfully applied to dehydrate various agricultural products with little drying time, the final quality of dried samples in terms of appearance and shape cannot be guaranteed. Therefore, based on published literature, this review was conducted to study the drying characteristics of various agricultural products when different drying methods were applied. Results: An increase in the drying power of sources-for example, increase in hot air temperature or velocity, infrared or microwave power-and the combination of drying power levels can reduce the drying time of various agricultural products. In addition, energy efficiency in drying significantly relies on the compositions of the dried samples and drying conditions. Conclusions: The drying power source is the key factor to control entire drying process of different samples and final product quality. In addition, an appropriate drying method should be selected depending on the compositions of the agricultural products.

열분해/GC/MS를 이용한 열화 호박(amber)의 성분 변화 분석 (Analysis of changes in composition of amber with ageing using pyrolysis/GC/MS)

  • 박종서
    • 분석과학
    • /
    • 제26권3호
    • /
    • pp.190-198
    • /
    • 2013
  • 호박은 오래전부터 장식품, 공예품, 부장품 등으로 사용되어 매장문화재 형태로 발굴되고 있다. 발굴 당시 호박은 풍화가 많이 진행되어 표면의 균열, 박락 등이 관찰된다. 풍화에 따른 호박의 성분 변화를 파악하는 것은 보존상태를 진단하고, 적절한 보존방법을 적용하는데 있어 매우 중요하다. 본 연구에서는 열분해/GC/MS로 호박의 열분해 산물을 분석하여 호박을 구성하는 성분을 찾고자 하였다. 또한, 열과 산소가 있는 조건에서 60일 동안 인공열화하여 호박의 열분해 산물의 구성비가 변화하는 것을 관찰하였다. 실험결과 호박의 주요 열분해 산물로 abietic acid가 검출되었고, monoterpene류, alkene류, aromatic hydrocarbon류가 검출되었다. 주요한 23개의 성분에 대해 열화에 따른 상대적인 면적비를 비교하여 열화에 따른 경향성을 파악하였다. 주성분인 abietic acid는 산소와 열이 있는 조건에서 급격하게 감소하였지만, 열만 있는 조건에서는 변화가 크지 않은 것으로 보아 산소가 호박의 열화에 중요한 역할을 하는 것으로 판단된다. 실제 풍화된 호박 원석의 표면에 대해 열화실험 결과를 적용하여 열화상태를 파악하는 시도도 하였다.

Clinical Characteristics and Long-Term Prognosis of Alport Syndrome: A Retrospective Single-Center Study

  • Jang, Hea Min;Baek, Hee Sun;Park, Sun-Hee;Kim, Yong-Lim;Kim, Chan-Duck;Jung, Hee-Yeon;Cho, Jang-Hee;Han, Man Hoon;Kim, Yong Jin;Cho, Min Hyun
    • Childhood Kidney Diseases
    • /
    • 제24권2호
    • /
    • pp.91-97
    • /
    • 2020
  • Purpose: Alport syndrome (AS) is one of the most common inherited renal diseases caused due to mutations of genes encoding specific proteins of the type IV collagen family, and its major clinical manifestations include progressive renal failure, sensorineural deafness, and ocular abnormalities. We investigated the clinical characteristics and long-term prognosis of AS in Korean pediatric and adult populations. Methods: We conducted a retrospective review of medical records of 33 children and adults who had been diagnosed or treated with AS from 1985 to 2019. Results: The mean age of the 33 patients diagnosed with AS was 16.2±13.6 years, and the male-to-female ratio was 2:1. At the first visit, recurrent gross hematuria was the most common initial symptom. In 10 of 33 patients (30.3%), sensorineural hearing loss (SNHL) was diagnosed, but none had ophthalmic problems. Moreover, 11 of 33 patients (33.3%) had advanced to end-stage renal disease (ESRD), and a significant difference was observed in the age of the patients who progressed to ESRD based on the presence or absence of SNHL (P=0.035). Conclusion: SNHL in AS can be an important prognostic factor for long-term deterioration of renal function. Further investigation is required to confirm the clinical course and the genetic characteristics of AS in Korea through prospective national cohort studies.

The Restorative Effect of Gallic Acid on the Experimental Sciatic Nerve Damage Model

  • Gurkan, Gokhan;Erdogan, Mumin Alper;Yigitturk, Gurkan;Erbas, Oytun
    • Journal of Korean Neurosurgical Society
    • /
    • 제64권6호
    • /
    • pp.873-881
    • /
    • 2021
  • Objective : Peripheral nerve injuries occur mostly as a result of mechanical trauma. Due to the microvascular deterioration in peripheral nerve damage, it becomes challenging to remove free oxygen radicals. Gallic acid is a powerful antioxidant with anti-inflammatory effects and a free radical scavenger. The purpose of the study is to show that gallic acid contributes to the restorative effect in mechanical nerve damage, considering its antioxidant and anti-inflammatory effects. Methods : Thirty male Sprague Dawley albino mature rats were included in the study. Ten of them constituted the control group, 10 out of 20 rats for which sciatic nerve damage was caused, constituted the saline group, and 10 formed the gallic acid group. Post-treatment motor functions, histological, immunohistochemical, and biochemical parameters of the rats were evaluated. Results : Compared to the surgery+saline group, lower compound muscle action potential (CMAP) latency, higher CMAP amplitude, and higher inclined plane test values were found in the surgery+gallic acid group. Similarly, a higher nerve growth factor (NGF) percentage, a higher number of axons, and a lower percentage of fibrosis scores were observed in the surgery+gallic acid group. Finally, lower tissue malondialdehyde (MDA) and higher heat shock protein-70 (HSP-70) values were determined in the surgery+gallic acid group. Conclusion : Gallic acid positively affects peripheral nerve injury healing due to its anti-inflammatory and antioxidant effects. It has been thought that gallic acid can be used as a supportive treatment in peripheral nerve damage.

The Fate of Partially Thrombosed Intracranial Aneurysms Treated with Endovascular Intervention

  • Lee, Jeongjun;Cho, Won-Sang;Yoo, Roh Eul;Yoo, Dong Hyun;Cho, Young Dae;Kang, Hyun-Seung;Kim, Jeong Eun
    • Journal of Korean Neurosurgical Society
    • /
    • 제64권3호
    • /
    • pp.427-436
    • /
    • 2021
  • Objective : The fate of partially thrombosed intracranial aneurysms (PTIAs) is not well known after endovascular treatment. The authors aimed to analyze the treatment outcomes of PTIAs. Methods : We retrospectively reviewed the medical records of 27 PTIAs treated with endovascular intervention between January 1999 and March 2018. Twenty-one aneurysms were treated with intraluminal embolization (ILE), and six were treated with parent artery occlusion (PAO) with or without bypass surgery. Radiological results, clinical outcomes and risk factors for major recurrence were assessed. Results : The initial clinical status was similar in both groups; however, the last status was better in the ILE group than in the PAO group (p=0.049). Neurological deterioration resulted from mass effect in one case and rupture in one after ILE, and mass effect in two and perforator infarction in one after PAO. Twenty cases (94.2%) in the ILE group initially achieved complete occlusion or residual neck status. However, 13 cases (61.9%) showed major recurrence, the major causes of which included coil migration or compaction. Seven cases (33.3%) ultimately achieved residual sac status after repeat treatment. In the PAO group, all initially showed complete occlusion or a residual neck, and just one case ultimately had a residual sac. Two cases showed major recurrence, the cause of which was incomplete PAO. Aneurysm wall calcification was the only significantly protective factor against major recurrence (odds ratio, 36.12; 95% confidence interval, 1.85 to 705.18; p=0.018). Conclusion : Complete PAO of PTIAs is the best option if treatment-related complications can be minimized. Simple fluoroscopy is a useful imaging modality because of the recurrence pattern.

글로벌 셰일가스 개발에 따른 플랜트 설비 산업계의 대응 전략 연구 -주조 밸브 산업 중심으로- (Research on the Action Strategies of Plant Facility Industries for Global Shale Gas Development. -A Case of Casting Valve Industry-)

  • 김철;임춘성
    • 융합정보논문지
    • /
    • 제8권6호
    • /
    • pp.389-397
    • /
    • 2018
  • 최근 셰일가스 개발이 확대됨에 따라 셰일가스 생산의 증대로 에너지 시장이 변화되고, 전통에너지 플랜트 설비 축소로 이어지게 됨에 따라 국내 주조 밸브 산업의 경영악화를 극복하고 확대되는 셰일가스 플랜트 진입을 위하여 관련업계 전문가 설문조사와 선행연구를 바탕으로 2차 설문을 통하여 SWOT 요인을 확정하고자 하였다. 강점활용전략으로 국내플랜트사와의 협업 외 3가지 요인을 제시하고, 약점보완전략으로 셰일가스플랜트에 특화된 제품개발 외 4가지 요인을 결과로 제시하였다. 본 연구는 업계의 새로운 에너지설비시장 진입을 위해 내외부 환경요인 분석 및 전략수립을 제언한 것으로 학문적, 실무적인 시사점을 제공한다. 향후 본 연구에서 도출된 전략에 대한 중요도를 분석하고, 중요도의 순위에 따라 기업에 미치는 영향에 대해 연구 하고자 한다.