• Bulletin of the Korean Chemical Society
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• 제33권9호
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• pp.2930-2936
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• 2012

A three-dimensional pharmacophore hypothesis was developed for atypical antipsychotics in order to map common structural features of highly active compounds by using HipHop in CATALYST program. The pharmacophore hypotheses were generated using 12 compounds as training set and validated using 11 compounds as test set. The most predictive hypothesis (Hypo1) comprises five features viz. two hydrophobic regions, two hydrogen bond acceptor lipid and one aromatic ring. In the absence of information like crystallized structure of 5-$HT_{2A}$ receptor and binding mode of antipsychotics with 5-$HT_{2A}$ receptor, this hypothesis will serve as a potentially valuable tool in the design of novel atypical antipsychotics acting primarily at 5-$HT_{2A}$ and $D_2$ receptors.

• 한국초등과학교육학회지:초등과학교육
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• 제35권2호
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• pp.137-149
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• 2016

The purpose of this study is to develop a descriptive paper test item which can evaluate elementary school students' HGA (scientific Hypothesis Generating Ability) and to propose a counting formula that can easily assess student's HGA objectively and quantitatively. To make the test item can possibly evaluate all the students from 6th graders to 3rd graders, the 'rabbit's ear' item is developed. Developed test item was distributed to four different elementary schools in Seoul. Total 280 students who were in the 6th grade solved the item. All the students' reponses to the item were analyzed. Based on the analyzed data evaluation factors and evaluation criteria are extracted to design a Hypothesis Generating ability Quotient (HGQ). As the result 'Explican's Degree of Likeness' and 'Hypothesis' Degree of Explanation' are chosen as evaluation factors. Also precedent evaluation criteria were renewed. At first, Explican's Degree of Likeness evaluation criterion was turned four levels into three levels and each content of evaluation criterion is also modified. Secondly, new evaluation factor 'Hypothesis' Degree of Explanation' was developed as combined three different evaluation criteria, 'level of explican', 'number of explican' and 'structure of explican'. This evaluation factor was designed to assess how the suggested hypothesis can elaborately explain the cause of one phenomenon. Newly designed evaluation factors and evaluation criteria can assess HGA more in detail and reduce the scoring discordant through the markers. Lastly, Developed counting formula is much more simple than precedent Kwon's equation for evaluating the Hypothesis Explanation Quotient. So it could help easily distinguish one student's scientific hypothesis generating ability.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2014년도 추계학술대회 논문집
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• pp.347-349
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• 2014

Model verification and validation (V&V) is a current research topic to build computational models with high predictive capability by addressing the general concepts, processes and statistical techniques. The hypothesis test for validity check is one of the model validation techniques and gives a guideline to evaluate the validity of a computational model when limited experimental data only exist due to restricted test resources (e.g., time and budget). The hypothesis test for validity check mainly employ Type I error, the risk of rejecting the valid computational model, for the validity evaluation since quantification of Type II error is not feasible for model validation. However, Type II error, the risk of accepting invalid computational model, should be importantly considered for an engineered products having high risk on predicted results. This paper proposes a technique named as the response-adaptive experimental design to reduce Type II error by adaptively designing experimental conditions for the validation experiment. A tire tread block problem and a numerical example are employed to show the effectiveness of the response-adaptive experimental design for the validity evaluation.

• 대한간호학회지
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• 제37권6호
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• pp.994-1002
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• 2007

Purpose: This study was to identify the effects of hope intervention on hope and depression of cancer patients staying at home. Methods: The study design was a randomized control group design. The subjects consisted of forty cancer patients randomly selected who were registered at S-Gu Public Health Center. Hope intervention, which was composed of hope assessment, hope objective setting, positive self identity formation, therapeutic relationships, spiritual & transcendental process improvement, positive environmental formation and hope evaluation, was provided from November 20, 2006 to January 26, 2007. Results: The 1-1 hypothesis, "The experimental group which received hope intervention will have a higher score of hope than the control group", was supported(t=-3.253, p= .003). The 1-2 hypothesis, "The experimental group which received hope intervention will have a higher level of hope index than the control group", was supported (t=-4.001, p= .000). Therefore the 1st hypothesis, "The experimental group which received hope intervention will have a higher level of hope than the control group" was supported. The 2nd hypothesis, "The experimental group which received hope intervention will have a lower level of depression than the control group", was not supported (t=1.872, p= .070). Conclusion: Hope intervention is an effective nursing intervention to enhance hope for patient with cancer.

• 한국디자인학회:학술대회논문집
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• 한국디자인학회 2004년도 추계 학술발표대회 논문집
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• pp.10-11
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• 2004

• 동아시아경상학회지
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• 제8권1호
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• pp.1-19
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• 2020

Purpose - This study is to classify quality characteristics of online environment-friendly agricultural products shopping malls into 6 categories and to empirically test their relationship with customer trust, perceived manageability, perceived utility and purchase intention. Research design, data, and methodology - This study targeted adults who have purchased ecofriendly agricultural production online malls for 4 weeks from September 3 to September 30, 2019. The survey type used was a structuralized self-report survey questionnaire made to meet the research purpose in 2019 as the time range. Out of 800 questionnaires, 500 copies are used after excluding surveys with insincere responses. Results - First, results to hypothesis 1, which was about independent variables and customer trust. Analysis showed that health, familiarity, platform reputation, reviews and product quality were found to have significant effect on customer trust; the hypothesis was adopted. On the other hand, system security did not affect customer trust significantly; it was rejected. Second, customer trust was shown to have significant effect on perceived manageability and perceived utility, so the hypothesis was adopted. Third, the hypothesis that perceived manageability moves onto perceived utility was adopted. Moreover, the hypothesis that perceived manageability moves onto purchase intention and the hypothesis that perceived utility moves onto purchase intention were adopted as well. Conclusions - Furthermore, the results of the study imply that it's imperative for online environment-friendly agricultural products shopping malls to consider their characteristics as the means to increase purchase intention of customers.

• 마케팅과학연구
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• 제10권
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• pp.91-110
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• 2002

본 연구에서는 기업이 준거가격 광고의 단서에 대한 이론을 적용하여 소비자들에게 어떻게 효과적으로 커뮤니케이션 해야 할 것인지에 초점을 두고 있다. 여러 서비스산업 중 여행상품을 대상으로 정보유형을 조절변수로 하여, 가격단서(외적 준거가격)와 지식수준의 독립변수가 소비자지각의 종속변수에 어떠한 영향을 미치는지에 대해 살펴보았으며, 이러한 변수들의 관계를 이용하여 외적 준거가격의 제시여부와 지식수준의 높고 낮음, 긍정적 정보와 부정적 정보제공을 통한 8개 집단간의 요인실험설계(factorial design)를 실시하였다. 연구결과 서비스의 준거가격 광고에서 가격단서(외적준거가격)를 제시받은 소비자들이 미제시한 소비자들보다 가격-품질지각이 높아지고, 서비스에 대한 지각가치를 높게 지각한다는 사실이 발견되었다. 또한, 긍정적인 정보보다는 부정적인 정보에 노출되었을 때, 지식수준이 낮은 소비자는 지식수준이 높은 소비자보다 가격-품질지각이 높게 나타나는 것을 확인활 수 있었다.

• 대한안전경영과학회지
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• 제10권2호
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• pp.205-210
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• 2008

The research interprets the principles of sampling error design for quality statistics models such as hypothesis test, interval estimation, control charts and acceptance sampling. Introducing the proper discussions of the design of significance level according to the use of hypothesis test, then it presents two methods to interpret significance by Neyman-Pearson and Fisher. Second point of the study proposes the design of confidence level for interval estimation by Bayesian confidence set, frequentist confidential set and fiducial interval. Third, the content also indicates the design of type I error and type II error considering both productivity and customer claim for control chart. Finally, the study reflects the design of producer's risk with operating charistictics curve, screening and switch rules for the purpose of purchasing and subcontraction.

• 한국디자인학회:학술대회논문집
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• 한국디자인학회 2003년도 가을학술발표대회
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• pp.48-49
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• 2003

• 보건교육건강증진학회지
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• 제15권2호
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• pp.55-66
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• 1998

The purpose of this study was to test whether adhesive taping therapy, one of rehabilitation, helps to relieve chronic low back pain. Sample were selected from 35 outpatients at oriental medicine hospital in the period from April 20 to June 20, 1998. The research design was one-group pretest - posttest design. The pretest included measuring discomfort depending on the scope and types of a range of motion, and their pain by their activity of daily living(ADL). In this research design, a treatment was to expose adhesive taping therapy to samples. The posttest included remeasuring of their discomfort and pain by ADL. The results of this study was as follows: Hypothesis I was that the discomfort score of the post-treatment group had lower than does that of the pre-treatment group. This study accepted the hypothesis (t=2.70, p=.015). Hypothesis II was that the post-treatment group had the pain score by ADL lower than does the pre-treatment group. Empirical results showed statistical significance(t=4.53, p=.000). In summary, the effect measured by the discomfort with a visual analog scale was statistically significant. The degree of pain according to postures in ADL also showed statistical significance. Consequently, these findings showed that the adhesive taping therapy was effective to alleviation of chronic low back pain.