• The Korean Journal of Physiology and Pharmacology
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• v.24 no.4
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• pp.299-310
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• 2020

Alzheimer's disease (AD) is a multi-faceted neurodegenerative disease. Thus, current therapeutic strategies require multitarget-drug combinations to treat or prevent the disease. At the present time, single drugs have proven to be inadequate in terms of addressing the multifactorial pathology of AD, and multitarget-directed drug design has not been successful. Based on these points of views, it is judged that combinatorial drug therapies that target several pathogenic factors may offer more attractive therapeutic options. Thus, we explored that the combination therapy with lower doses of cilostazol and aripiprazole with add-on donepezil (CAD) might have potential in the pathogenesis of AD. In the present study, we found the superior efficacies of donepezil add-on with combinatorial mixture of cilostazol plus aripiprazole in modulation of expression of AD-relevant genes: Aβ accumulation, GSK-3β, P300, acetylated tau, phosphorylated-tau levels, and activation of α-secretase/ADAM 10 through SIRT1 activation in the N2a Swe cells expressing human APP Swedish mutation (N2a Swe cells). We also assessed that CAD synergistically raised acetylcholine release and choline acetyltransferase (CHAT) expression that were declined by increased β-amyloid level in the activated N2a Swe cells. Consequently, CAD treatment synergistically increased neurite elongation and improved cell viability through activations of PI3K, BDNF, β-catenin and α7-nicotinic cholinergic receptors in neuronal cells in the presence of Aβ_1-42. This work endorses the possibility for efficient treatment of AD by supporting the synergistic therapeutic potential of donepezil add-on therapy in combination with lower doses of cilostazol and aripiprazole.

• Korean Journal of Community Nutrition
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• v.22 no.2
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• pp.115-126
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• 2017

Objectives: The purpose of the study was to develop communication strategies for effective nutrition education targeting pregnant women and to create nutrition education contents. Methods: The format and the contents of online resources on nutrition information for pregnant women provided by reliable institutions were analyzed. Possible solutions to overcome barriers of nutrition education as well as communication strategies for effective nutrition education were identified by a brainstorming process. Based on the communication strategies, contents for nutrition education were created. Understandability, level of interest, applicability to daily life, harmony of text and illustration, and overall satisfaction of the contents were evaluated by dietitians and pregnant women. Results: The four communication strategies were developed; (1) to focus on a few important messages, (2) to provide evidence-based information, (3) to create illustrations or infographics with a minimum amount of text, and (4) to provide tips on how to improve the current diet options. Based on these strategies, the contents were focused on three important nutrients for pregnant women, folate, iron, and calcium. The percentages of the recommended nutrient intakes of the three nutrients on selected menu and its improved version by adding a dish or changing a dish into another dish were calculated and provided. Finally, the contents were delivered as illustrations with a minimum amount of text. Overall, dietitians and pregnant women were satisfied with the contents. Conclusions: The contents developed in this study can be used in a pamphlet or a pregnancy diary, or can be shared in social networking services. Further contents on other nutrients and various menu are expected to be developed using these communication strategies.

• The Journal of Engineering Geology
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• v.22 no.2
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• pp.157-171
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• 2012

The slope design of an open-pit mine must ensure slope stability and economic feasibility. The overall slope angle of the pit is therefore the main factor of concern because of limited support or reinforcement options available in such a setting. This study examines the optimal measurement system for monitoring the behavior of the slope in an open-pit mine using displacement measurement, data analysis, and numerical simulations for a coal mine at Pasir, Indonesia. The area of slope to be managed is extensive and the maximum displacement, as calculated by numerical analysis, is about 3,000 mm. The displacement data, measured by inclinometer and GPS, were analyzed, and the applicability of SSR (slope stability radar) was reviewed in comparison with other monitoring systems.

• Nuclear Engineering and Technology
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• v.52 no.11
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• pp.2460-2470
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• 2020

To study the thermophysical and neutronic properties of thorium-plutonium fuel, a conceptual design of a hybrid facility consisting of a subcritical Th-Pu reactor core and a source of additional D-D neutrons that places on the axis of the core is proposed. The source of such neutrons is a column of high-temperature plasma held in a long magnetic trap for D-D fusionreactions. This article presents computer simulation results of generation of thermonuclear neutrons in the plasma, facility neutronic properties and the evolution of a fuel nuclide composition in the reactor core. Simulations were performed for an axis-symmetric radially profiled reactor core consisting of zones with various nuclear fuel composition. Such reactor core containing a continuously operating stationary D-D neutron source with a yield intensity of Y = 2 × 10¹⁶ neutrons per second can operate as a nuclear hybrid system at its effective coefficient of neutron multiplication 0.95-0.99. Options are proposed for optimizing plasma parameters to increase the neutron yield in order to compensate the effective multiplication factor decreasing and plant power in a long operating cycle (3000-day duration). The obtained simulation results demonstrate the possibility of organizing the stable operation of the proposed hybrid 'fusion-fission' facility.

• Nuclear Engineering and Technology
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• v.23 no.2
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• pp.165-173
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• 1991

The recycle of PWR spent fuels in a CANDU reactor, so called the tandem fuel cycle is Investigated in this study. This scheme of utilizing Pm spent fuels will ease the shortage of spent fuel storage capacity as well as will improve the use of uranium resources. The minimum modification to the design of present CANDU reactor is seeked in the recycle. Nine different fuel types are considered in this work and are classified into two categories： refabrication and reconfiguration For refabrication, PWR spent fuels are processed and refabricated into the present 37 rod lattice structure of fuel bundle, and for reconfiguration, meanwhile, spent fuels are simply disassembled and rods are cut to fit into the present grid configuration of fuel bundle without refabrication. For each fuel option, the neutronics calculation of lattice was conducted to evaluate the allowable burnup and power distribution. The fuel cycle cost of each option was also computed to assess the economic justification. The result show that most tandem fuel cycle options considered in this study are technically feasible as well as economically viable.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.15 no.3
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• pp.131-136
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• 2015

The feasibility study is an evaluation and analysis of the potential of a proposed project. It is based on extensive investigation and research to support the process of decision making. A systematic approach to determining the optimum use of scarce resources, involving comparison of two or more alternatives in achieving a specific objective under the given assumptions and constraints. Economic analysis takes into account the opportunity costs of resources employed and attempts to measure in monetary terms the private and social costs and benefits of a project to the community or economy. Cost-benefit analysis (CBA), sometimes called benefit-cost analysis (BCA), is a systematic approach to estimating the strengths and weaknesses of alternatives that satisfy transactions, activities or functional requirements for a business. It is a technique that is used to determine options that provide the best approach for the adoption and practice in terms of benefits in labor, time and cost savings etc. The CBA is also defined as a systematic process for calculating and comparing benefits and costs of a project, decision or government policy and projects.

• Journal of Korea Game Society
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• v.16 no.4
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• pp.25-34
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• 2016

Recent stealth games are mainly action games with frontal confrontation or combat features. In this paper, we designed and implemented an stealth game, where characters are weak person and play is conducted by avoiding the situation, not by frontal confrontation. We chose the light as the key factor for the avoidance. The players can survive and fulfill the missions by blocking the enemy's vision. After implementing the first version, we found that the game using only the avoidance is not as fun as expected. To make the game more interesting, we added limited attack function, provided mini map for better user interface, and this paper describes the options we had and experiences of the decision making process to make the better game.

• Computers and Concrete
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• v.2 no.1
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• pp.31-53
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• 2005

In the present structural codes the safety verification is based on a linear analysis of the structure and the satisfaction of ultimate and serviceability limit states, using a semi-probabilistic security format through the consideration of partial safety factors, which affect the action values and the characteristic values of the material properties. In this context, if a non-linear structural analysis is wanted a difficulty arises, because the global safety coefficient, which could be obtained in a straightforward way from the non-linear analysis, is not directly relatable to the different safety coefficient values usually used for the different materials, as is the case for reinforced concrete structures. The work here presented aims to overcome this difficulty by proposing a methodology that generalises the format of safety verification based on partial safety factors, well established in structural codes within the scope of linear analysis, for cases where non-linear analysis is needed. The methodology preserves the principal assumptions made in the codes as well as a reasonable simplicity in its use, including a realistic definition of the material properties and the structural behaviour, and it is based on the evaluation of a global safety coefficient. Some examples are presented aiming to clarify and synthesise all the options that were taken in the application of the proposed methodology, namely how to transpose the force distributions obtained with a non-linear analysis into design force distributions. One of the most important features of the proposed methodology, the ability for comparing the simplified procedures for second order effects evaluation prescribed in the structural codes, is also presented in a simple and systematic way. The potential of the methodology for the development and assessment of alternative and more accurate procedures to those already established in codes of practice, where non-linear effects must be considered, is also indicated.

• Journal of Biosystems Engineering
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• v.41 no.4
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• pp.294-303
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• 2016

Purpose: This study aimed to evaluate the profitability of four selective mechanization systems in rice cultivation. Methods: Field experiments were conducted in the farmers' field during the wet season (June to November) of 2015 in Bangladesh. Mechanization systems were applied to evaluate four different selective levels (treatment) in eleven consequent operations. Seedlings were raised in a traditional seedbed and trays for manual and mechanical transplanting, respectively. Land preparation, irrigation, fertilizer, pesticide, carrying, and threshing and cleaning operations were performed using the same method in all the experimental plots. The mechanical options in the transplanting, weeding, and harvesting operations were changed. The mechanization systems were $S_1$ = hand transplanting + hand weeding + harvesting by sickle, $S_2$ = mechanical transplanting + Bangladesh Rice Research Institute (BRRI) weeder + reaper, $S_3$ = mechanical transplanting + BRRI power weeder + reaper, and $S_4$ = mechanical transplanting + herbicide + reaper. This experiment was performed in a randomized complete block design with four replications. Power tiller, rice transplanter, BRRI weeder, BRRI power weeder, self-propelled reaper, BRRI open drum thresher, and BRRI winnower were used in the respective operations. Accordingly, the techno-economic performances of the different technologies were calculated and compared with those of the traditional system. Results: The mechanically transplanted plot produced 6-10% more yield than the hand transplanted plot because of the use of tender-aged seedlings. Mechanical transplanting reduced 61% labor and 18% cost compared to manual transplanting. The BRRI weeder, BRRI power weeder, and herbicide application reduced 74, 91, and 98% labor, respectively. The latter also saved 72, 63, and 82% cost, respectively, compared to hand weeding. Herbicide application reduced the substantial amount of labor and cost in the weeding operation. Mechanical harvesting also saved 96% labor and 72% cost compared to the traditional method of harvesting using sickle. Selective mechanization saved 15-17% input cost compared to the traditional method of rice cultivation. Conclusions: Mechanical transplanting with the safe use of herbicide and harvesting by reaper is the most cost- and labor-saving operation. The method might be the recommended set of selective mechanization for enhancing productivity.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.19 no.2
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• pp.113-126
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• 2009

In the recent years, health effect of dimethylformamide(DMF) has been one of critical industrial hygiene issues. There might be many factors to increase the exposure level of DMF. Among those factors, industrial ventilation would be one of the main factors. In this study, industrial ventilation systems of printing processes in synthetic leather factories were thoroughly surveyed and the improved ventilation systems were proposed. 7 synthetic leather factories were selected for this study. After the ventilation systems were visually inspected, each component of the system was tested by using the appropriate instruments. Hood face velocities, fan exhaust flow rates, fan static pressures, fan rotation rates, etc were measured. In addition, flow visualization techniques were used to observe flow patten around hoods and inside the factory buildings. After gathering all qualitative and quantitative information, the test results were analysed to see if any improvement might be necessary. For the system to be improved, the re-design plans were made by using computational fluid dynamics softwares. The softwares used in this study were AIRPAK and STAR-CD. The effectiveness of the several improvement options were tested, then the best cost effective option was selected. Finally, the standard ventilation systems were proposed to minimize the exposure levels of DMF.