• Biomolecules & Therapeutics
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• v.25 no.1
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• pp.12-25
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• 2017

G protein-coupled receptors (GPCRs) are a family of cell-surface proteins that play critical roles in regulating a variety of pathophysiological processes and thus are targeted by almost a third of currently available therapeutics. It was originally thought that GPCRs convert extracellular stimuli into intracellular signals through activating G proteins, whereas ${\beta}$-arrestins have important roles in internalization and desensitization of the receptor. Over the past decade, several novel functional aspects of ${\beta}$-arrestins in regulating GPCR signaling have been discovered. These previously unanticipated roles of ${\beta}$-arrestins to act as signal transducers and mediators of G protein-independent signaling have led to the concept of biased agonism. Biased GPCR ligands are able to engage with their target receptors in a manner that preferentially activates only G protein- or ${\beta}$-arrestin-mediated downstream signaling. This offers the potential for next generation drugs with high selectivity to therapeutically relevant GPCR signaling pathways. In this review, we provide a summary of the recent studies highlighting G protein- or ${\beta}$-arrestin-biased GPCR signaling and the effects of biased ligands on disease pathogenesis and regulation.

• Explosives and Blasting
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• v.25 no.1
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• pp.45-52
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• 2007

When emulsion explosives(1kg/cartridge) are loaded into a long vertical borehole at open blasting site, they undergo an Impact corresponding to 117.6J of shock energy. After shocking. the crystallization of emulsion nay happen immediately. Furthermore, it nay cause a desensitization, arising from increase in the density of emulsion explosive by the breakage of sensitizer. In this paper, some experimental work was performed using PVC pipe equipment(50mm diameter and 12m lengths) to investigate the effects of loading impart of emulsion explosive. It is shown that detonation energy decreases up to 26% of the normal state value and this effect is less than 3% of the total performance of emulsion explosives in borehole blasting.

• The Korean Journal of Physiology and Pharmacology
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• v.4 no.4
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• pp.311-318
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• 2000

We cultured the rabbit inner medullary collecting duct (IMCD) cells as monolayers on collagen-coated membrane filters, and investigated distribution of the P2Y receptors by analyzing nucleotide-induced short circuit current $(I_{sc})$ responses. Exposure to different nucleotides of either the apical or basolateral surface of cell monolayers stimulated $I_{sc}.$ Dose-response relationship and cross-desensitization studies suggested that at least 3 distinct P2Y receptors are expressed asymmetrically on the apical and basolateral membranes. A $P2Y_2-like$ receptor, which responds to UTP and ATP, is expressed on both the apical and basolateral membranes. In addition, a uracil nucleotide receptor, which responds to UDP and UTP, but not ATP, is expressed predominantly on the apical membrane. In contrast, a $P2Y_1-like$ receptor, which responds to ADP and 2-methylthio-ATP, is expressed predominantly on the basolateral membrane. These nucleotides stimulated intracellular cAMP production with an asymmetrical profile, which was comparable to that in the stimulation of $I_{sc}.$ Our results suggest that the adenine and uracil nucleotides can interact with different P2Y nucleotide receptors that are expressed asymmetrically on the apical and basolateral membranes of the rabbit IMCD cells, and that both cAMP- and $Ca^{2+}-dependent$ signaling mechanisms underlie the stimulation of $I_{sc}$.

• Clinical and Experimental Reproductive Medicine
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• v.18 no.2
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• pp.189-196
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• 1991

Long-term administration of luteinizing hormone-releasing hormone(LHRH) agonists, through a process of pituitary desensitization and down-regulation of receptors, inhibits the secretion of gonadotropin and sex-steroids and induces a reversible suppression of gonadal activity. This approach can be used as an effective endocrine therapy for some hormone-dependent tumors. We have used D-Trp6-LHRH, a long acting LHRH agonist, for the treatment of eleven patients with uterine leiomyomas, thereafter myomectomy was performed in seven cases and observed the ultrastructural changes of leiomyoma with an electron microscope. The use of LHRH agonist may be effective in reducing the size of a myoma considerably by primarily inducing medical hypophysectomy and would allow easier surgical removal. Electron microscopic findings of myoma cells after the use of LHRH agonist included the following: loss of cristae and swelling nuclear chromatin, perinuclear vacuolation in cytoplasm. Bone mineral density was slightly decreased, however, the difference was not statistically significant.

• Journal of Haehwa Medicine
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• v.8 no.2
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• pp.341-359
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• 2000

The following result are obtained through that comparative study on the psychotherapy of oriental and occidental medicine. 1. The shamanism(祝由) and active emotion therapy(移精變氣療法) are a primitive form of psychotherapy. It is an opinion that between active emotion therapy(移精變氣療法) and psychoanalytic therapy or supportive psychotherapy are similar. Also, the basic cognition pattern of shamanism(祝由) is projection. 2. Taoism is inseparably related to the psychotherapy of korean oriental medicine, the major thought has become the ideal base of oriental psychotherapy. 3. According to study of clinical document in relation to oriental psychotherapy, psychotherapy had been widely used by medical cure. 4. The five emotion restraint therapy is a high level psychotherapy of oriental medicine. Oriental psychotherapy that disease caused by surprising must be cure by surprising is like to systematic desensitization in western, and that pseudopsychosis must be cure by patient rely on doctor is like to suggestive therapy in western. 5. There are psychotherapy in western that Supportive psychotherapy, Short-term dynamic psychotherapy, Psychoanalytic therapy, Group psychotherapy, Family therapy, Morita therapy, Hypnotherapy, Autogenic training, Behavioral therapy, Milieu therapy, Occupational therapy, Psychodrama, the others. I think that they have wide application to the psychotherapy of korean oriental medicine.

• Journal of Oriental Neuropsychiatry
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• v.8 no.1
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• pp.215-235
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• 1997

according to study of clinical document in relation to Neuropsychiatric disease in Ancient Chinese(Song, Keum, Won, Myung) clinical document the result were obtained as follows. 1. A main point is Jeul-Jin<切診> in diagnosis, that is Hyun-Maeg<弦脈> is liver disease, Whual Mag<滑脈> is gallbladder disease, Sag Mag<數脈> is fever.2. Doctors in Song<宋>, Keum<金>,Won<元> enumerationed many diseases are cause by emotion.3. Oriental psychotherapy that Diseases caused by surprising must be cure by surprising is like to systematic desensitization in Westem.4. Oriental psychotherapy that pseudopsychosis must be cure by patient rely on doctor is like to suggestive therapy in western.5. It is similar to suggestive therapy in western medicine that Sadness ,anguish and frustration induce disease.6. Headache is caused by fever, energy deficience and angry.7. Imsomnia is not caused by hsart disease, but gallbladder or liver.8. Schizophrenia is caused by shocking and a sort of fever.9. Epilepsy is caused by a sort of fever, shocking and fetal disease.10 Schizophrenia(in case of manic state) is caused by fever and shocking, and imaginary pregnancy is considered as schizophrenia.

• Biomolecules & Therapeutics
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• v.24 no.5
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• pp.517-522
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• 2016

${\beta}$-Arrestins are one of the protein families that interact with G protein-coupled receptors (GPCRs). The roles of ${\beta}$-arrestins are multifaceted, as they mediate different processes including receptor desensitization, endocytosis, and G protein-independent signaling. Thus, determining the GPCR regions involved in the interactions with ${\beta}$-arrestins would be a preliminary step in understanding the molecular mechanisms involved in the selective direction of each function. In the current study, we determined the roles of the N-terminus, intracellular loops, and C-terminal tail of a representative GPCR in the interaction with ${\beta}$-arrestin2. For this, we employed dopamine $D_2$ and $D_3$ receptors ($D_2R$ and $D_3R$, respectively), since they display distinct agonist-induced interactions with ${\beta}$-arrestins. Our results showed that the second and third intracellular loops of $D_2R$ are involved in the agonist-induced translocation of ${\beta}$-arrestins toward plasma membranes. In contrast, the N- and C-termini of $D_2R$ exerted negative effects on the basal interaction with ${\beta}$-arrestins.

• Journal of Oriental Neuropsychiatry
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• v.29 no.1
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• pp.1-8
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• 2018

Objectives: The purpose of this study is to compare the Korean-medical and the Western-medical psychotherapy on PTSD for improving the Korean-medical psychotherapy on this issue. Methods: We surveyed recent articles relating to psychotherapy on the incidence of PTSD. Results: Under the circumstances of this study, we note that applying the qigong therapeutics would be helpful when conducting relaxation training on the identified PTSD patients. We understand that taking a systematic desensitization style in the use of the kyungja-pyungji treatment is recommended. It would also be more effective to combine other treatments such as the use of the I-Jeong-Byeon-Gi Therapy and the five minds mutual restriction therapy. We have shown that by using the five minds mutual restriction therapy for the imagery rescripting has a better a synergy effect for optimum patient outcomes for patients who have been diagnosed with PTSD. Conclusions: Our study has shown that by improving the shortcomings of the Korean psychotherapy and utilizing Western psychotherapy's merits, we expect to increase the efficacy of the Korean psychotherapy with these recommendations for changes in this case.

• Anxiety and mood
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• v.5 no.2
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• pp.75-79
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• 2009

In this article, we review the efficacy of early interventions after traumatic incidents and during acute stress disorder (ASD). There are some evidences that psychopharmacological medications such as propronolol, morphine, and hydrocortisone are effective in the prevention of posttraumatic stress disorder (PTSD). Considering the role of selective serotonin reuptake inhibitors in hippocampal neurogenesis and an animal model of PTSD, early administration of selective serotonin reuptake inhibitors is also fairly promising. Other pharmacological treatments including benzodiazepines did not treat ASD nor prevent PTSD. There are good evidences that cognitive behavioral therapy including cognitive therapy and prolonged exposure is a valuable intervention for ASD and the most effective prevention for PTSD. No contolled researches on eye movement desensitization&reprocessing, psychodynamic psychotherapy and hypnotherapy have performed. Recent randomized controlled studies using psychological debriefing did not prove as a useful intervention for the prevention of PTSD until now, although the efficacy of debriefing has been at the centre of controversy.

• Sleep Medicine and Psychophysiology
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• v.2 no.2
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• pp.133-137
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• 1995

The author reviews current knowledge about what REM sleep is and where and how it is generated. REM sleep is the state in which our most vivid dreams occur. REM sleep is identified by the simultaneous presence of a desynchronized cortical EEG, an absence of activity in the antigravity muscles(atonia), and periodic bursts of rapid eye movements. Another characteristic phenomena of REM sleep are the highly synchronized hippocampal EEG of theta frequency and the ponto-geniculo-occipital(PGO) spike. All these phenomena can be explained in terms of changes in neuronal activity. Transection studies have determined that the pons is sufficient for generating REM sleep. Lesion studies have identified a small region in the lateral pontine tegmentum corresponding to lateral portions of the nucleus reticularis pontis oralis(RPO) and the region immediately ventral to the locus coeruleus, which is required for REM sleep. Unit recording studies have found a population of cells within this region that is selectively active in REM sleep. Cholinergic neurons of the giant cell field of pontine tegmentum(ETG), which is 'REM a sleep-on cells', has shown to be critically involved in the generation of REM sleep. Noradrenergic neurons of the locus coeruleus and serotonergic neurons of the dorsal raphe, which are called 'REM sleep-off cells', appear to act in a reciprocal manner to the cholinergic neurons. It is proposed that the periodic cessations of discharge of 'REM sleep-off cells' during REM sleep might be significant for the prevention of the desensitization of receptors of these neurons.