• 대한환경공학회지
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• 제37권2호
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• pp.81-86
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• 2015

수중에 존재하는 포름알데하이드(formaldehyde)를 ${\mu}g/L$ 단위 농도까지 정량할 수 있는 간단한 분석법을 개발하였다. 시료 전처리시 유도체화 시약으로 아세틸아세톤(acetylacetone)을 사용하였고, 기존 분석방법과 달리 추출 및 농축과정을 거치지 않는 것이 장점이다. 시료에 유도체화 시약을 첨가하고 $80^{\circ}C$에서 30분 반응시킨 후 HPLC를 이용하여 포름알데하이드를 분석하였다. 본 방법에 대한 정도보증 결과, 방법검출한계 및 정량한계는 각각 1.6, $5.0{\mu}g/L$로 기존 분석법에 비하여 낮았다. 정밀도 및 정확도는 각각 0.6~3.0%, 91.6~106.3%로 우수하였다. 또한 다양한 환경시료에 대한 회수율 검증에서도 92.0~115.2%로 양호하게 나타났다.

• Bulletin of the Korean Chemical Society
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• 제8권4호
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• pp.313-318
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• 1987

The approximate rate and stoichiometry of the reaction of excess Thexylbromoborane-methyl sulfide, $ThxBHBr{\cdot}SMe_2,$ with selected organic compounds containing representative functional groups under standardized conditions (methylene chloride, $0^{\circ}C)$ were studied in order to characterize the reducing characteristics of the reagent for selective reductions. The selectivity of the reagent was also compared to the selectivity of thexylchloroborane-methyl sulfide. Thexylbromoborane appears to be a much milder and hence more selective reducing agent than thexylchloroborane. The reagent tolerates many organic functionalities. Thus, the reagent shows very little reactivity or no reactivity toward acid chlorides, esters, epoxides, amides, nitro compounds including simple olefins. However, this reagent can reduce aldehydes, ketones, carboxylic acids, nitriles, and sulfoxides. Especially the reagent reduces carboxylic acids including ${\alpha},{\beta}$ -unsaturated ones and nitriles to the corresponding aldehydes. In addition to that, thexylbromoborane shows good stereoselectivity toward cyclic ketones, much better than the chloro-derivative.

• 대한화학회지
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• 제37권1호
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• pp.112-118
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• 1993

수용성 발색시약인 N,N'-oxalylbis(2-pyridyl-3'-sulphobenzoylhydrazone)을 합성하여 분광광도법 및 1, 2차 미분 분광광도법에 의한 구리의 정량법을 개발하였다. 정량은 구리착물 수용액(pH 1.89)의 흡광도 및 1,2차 미분값을 379, 395, 363 그리고 421nm의 파장에서 각각 측정함으로써 수행되었다. 정량 가능한 구리의 농도 범위는 0.12~1.20${\mu}g$ /ml 였으며 이 방법을 알루미늄 합금시료의 분석에 적용하였다. 2차 미분 분광광도법으로 421nm에서 측정했을 때가 가장 좋은 결과를 나타내었다.

• Biomolecules & Therapeutics
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• 제5권2호
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• pp.107-109
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• 1997

For metabolic study of pinusolide, a naturally occurring platelet activating factor antagonist, a synthetic method for preparation of radiolabeled pinusolide was studied. Pinusolide was first oxidized with $OsO_4/NaIO_4 $to 17-nor-8-oxo compound (2), which was subsequently converted to pinusolide by treatment with the Lombardo reagent $(Zn/CH_2Br_2/TiCI_4)$. The Wittily reaction was unsuccessful in the latter carbonyl methylenation of 2.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.407.2-407.2
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• 2002

We have been studing sensitive non-enzymatic chemiluminescence (CL) imaging methods for the detection of DNA. For one of our methods, a unique chemical derivatization reagent. 3'. 4', 5'-trimethoxyphenylglyoxal (TMPG) was utilized. This reagent reacted specifically with guanine bases in nucleic acids to quickly produce a chemiluminescent derivative under mild reaction conditions. (omitted)

• 대한화학회지
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• 제51권4호
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• pp.331-338
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• 2007

분석 시약으로 2-hydroxy-3-methoxy benzaldehyde thiosemicarbazone (HMBATSC)를 사용하여 코발트 (II) 정량을 위하여 빠르고 간단하고 민감한 분광광도법을 개발하였다. 액상에서 금속이온이 pH 6.0에서 HMBATSC와 갈색의 착물을 형성하였다. 이 착물은 375 nm와 390 nm에서 두 개의 최대 흡수 피크를 보였다. 375 nm에서 많은 흡 수를 보였고, 반면 390 nm에서는 분명한 흡수를 보이지 않았다. Beer's 법칙에서 Co(II)는 0.059-2.357 μg ml-1 범위를 보였다. 이 방법의 몰 흡수와 Sandall's 민감도는 각각 2.74×104 l mol-1 cm-1와 0.0024 μg cm-2 였다. 여러 가지 다른 이온들에 간섭에 대해서도 연구하였다. 화학양론적으로 착체는 1:2 [Co(II)- HMBATSC] 이 였다. 이차 유도 분광광도 법에 의한 Co(II)의 정량방법에 대해서도 제안하였다. 제안된 방법을 alloy steels, 비타민 B12와 생물학 시료에 있는 Co(II)의 정량에 적용하였다.

• 약학회지
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• 제37권4호
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• pp.362-364
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• 1993

The sensitive detection of free fatty acids was investigated by using H$_{2}$O$_{2}$-bis(2,4,6-trichlorophenyl) oxalate chemiluminescence system after monodansyl cadaverine labeling. Because dansvl moiety is well excited by this chemiluminescence system, monodansyl cadaverine was a prominent reagent to this system for the determination of free fatty acids. The cluent of 50mM tris-HCI buffer (pH 7.7)-acetonitrile (1:4, v/v) was run through TSK gel ODS 80 TM column. The reagent solutions were mixed with the eluent containing the monodansyl cadaverine derivative of fatty acids from the column. By this system, linolic acid was detected 50 fmol by injected amount.

• 한국염색가공학회지
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• 제33권2호
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• pp.64-71
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• 2021

Large amount of formaldehyde could be released inevitably during the flame-retardant (FR) treatments or from the finished fabrics using Provatex reagent and Proban polymers which have been used as durable FRs for cotton. A water-soluble cyclophosphazene derivative was synthesized as an ecofriendly phosphorus-based FR for cotton fibers. Dichloro tetrakis{N-[3-(Dimethylamino)propyl]methacrylamido} cyclcophosphazene (DCTDCP) was synthesized through the substiutution reaction of Hexachloro cyclophosphazene and N-[3-(Dimethylamino)propyl] methacrylamide at a mole ratio of 1 : 4, which can be cured dually by both alkaline treatment and UV irradiation. More crosslinked networks were produced through the addition of Triacryloyl hexahydrotriazine and Acrylamide as a UV-curable crosslinker and a comonomer respectively. Both flame retardancy and washing durability of the FR cotton were improved synergistically. The durability improvement may be caused by the covalent bond formation of the FR with cellulose and the high degree of polymerization of DCTDCP, which can be verified by the pyrolysis and combustion behaviors analyzed by LOI, TGA, and microcalorimeter.

• Archives of Pharmacal Research
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• 제21권6호
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• pp.651-656
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• 1998

A sensitive high-performance liquid chromatographic (HPLC) method for the determination of aloesin in plasma was developed. After solid-phase extraction from plasma and derivatization of aloesin and compound AD-1, which was prepared from aloesin as a internal standard, with 9-anthroylnitrile in the presence of quinuclidine, the derivatives were separated on a Inertsil ODS-3 column using acetonitrile/methanol/water (3:1:6) as a mobile phase, and detected fluorimetrically at 460nm with excitation at 360nm. The detection limit of aloesin was 3.2ng/ml in plasma (S/N=3).

• Applied Biological Chemistry
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• 제41권8호
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• pp.608-610
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• 1998

To investigate the inhibitory activity of 2-hydroxy-3-amino-4-phenylbutyrate-harboring aminopeptidase N inhibitors, p-nitro-AHPA-peptide derivatives (1 and 2) and an AHPA-peptide derivative (3) were synthesized by chain elongation from C-terminal end using DCC/HOBt as a coupling reagent. The peptides $1{\sim}3$ exerted strong inhibitory activities against aminopeptidase N with $IC_{50}$ values of 1.8, 7.3 and $24.0\;{\mu}g/ml$, respectively, and cytotoxicity on cancer cell lines in vitro.