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Periodontal pathogens and the association between periodontitis and rheumatoid arthritis in Korean adults

  • Kim, Jin-Hee;Choi, In Ah;Lee, Joo Youn;Kim, Kyoung-Hwa;Kim, Sungtae;Koo, Ki-Tae;Kim, Tae-Il;Seol, Yang-Jo;Ku, Young;Rhyu, In-Chul;Song, Yeong Wook;Lee, Yong-Moo
    • Journal of Periodontal and Implant Science
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    • v.48 no.6
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    • pp.347-359
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    • 2018
  • Purpose: Periodontitis and rheumatoid arthritis (RA) share a similar inflammatory pathogenesis. Porphyromonas gingivalis (Pg) can induce anticyclic-citrullinated peptide autoantibodies (anti-CCP antibodies), a key factor in the development of RA. This study aimed at evaluating the relationships between the 2 diseases and identifying the clinical implications thereof, with a focus on periodontal pathogens in Korean adults. Methods: A total of 260 RA patients and 86 age- and sex-matched control patients without arthritis were enrolled in this prospective cross-sectional study. Periodontal indices and the prevalence and amount of periodontal pathogens were compared between the groups. Correlations between periodontal and RA indices were examined, as were correlations between 9 periodontal pathogens and RA indices. Results: The RA group had significantly higher values than the control group for all investigated periodontal indices (P<0.05) except the number of teeth. The gingival index (GI) was correlated with the disease activity score 28 (DAS28) (r=0.125, P=0.049), RA disease duration (r=0.253, P<0.001), erythrocyte sedimentation rate (ESR) (r=0.162, P=0.010), and anti-CCP antibody titer (r=0.205, P=0.004). Probing pocket depth (PPD) was correlated with ESR (r=0.139, P=0.027) and anti-Pg antibody titer (r=0.203, P=0.001). Bleeding on probing (BOP) was correlated with DAS28 (r=0.137, P=0.030), RA disease duration (r=0.202, P=0.001), ESR (r=0.136, P=0.030), anti-Pg antibody titer (r=0.177, P=0.005), and anti-CCP antibody titer (r=0.188, P=0.007). Clinical attachment level (CAL) and periodontitis severity were correlated with anti-Pg antibody titer (the former r=0.201, P=0.002; the latter r=0.175, P=0.006). The quantity of Pg was positively correlated with the serum anti-Pg antibody titer (r=0.148, P=0.020). Conclusions: The GI, BOP, and PPD showed positive relationships with several RA indices. The anti-Pg antibody titer had positive relationships with PPD, BOP, CAL, and periodontitis severity. Thus, increasing values of periodontal indices could be used as a risk indicator of disease development in RA patients, and an increasing anti-Pg antibody titer could be considered as a warning sign in RA patients suffering with periodontitis.

A Study on the Quality of Healthcare Services for Four Critical Illnesses and the Maintenance of Right to Protection and Dignity in a Senior General Hospital (상급종합병원의 4대 중증질환 의료 서비스 품질과 보호받을 권리 및 존엄성 유지에 관한 연구)

  • Woojin Lee;Minsuk Shin
    • Journal of Korean Society for Quality Management
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    • v.51 no.4
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    • pp.531-550
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    • 2023
  • Purpose: The unique nature of life-and-death healthcare services sets them apart from other service industries. While many studies exist on the relationship between healthcare services and customer satisfaction, most of them focus on mildly ill patients, ignoring the differences between critically ill and non-seriously ill patients. This study discusses the actual quality of healthcare services for patients who are facing life-threatening illnesses and are on life support, as well as their right to protection and dignity. Methods: The survey conducted to 149 patients with the four major illnesses: cancer, heart disease, brain disease and rare and incurable disease, those who have experiences with senior general hospitals. Results: The basic statistics of this study are adequate to represent the four major critical illnesses, and the reliability and validity of this study's hypotheses, which were measured by multiple items, were analyzed, and the internal consistency was judged to be high. In addition, it was found that the convergent validity was good and the discriminant validity was also secured. When examining the goodness of fit of the hypotheses, the SRMR, which is the standardized root mean square of residuals that measures the difference between the covariance matrix of the data variables and the theoretical covariance matrix structure of the model, met the optimal criteria. Conclusion: The academic implications of this study are differentiated from other studies by moving away from evaluating the quality of healthcare services for mildly ill patients and focusing on the rights and dignity of patients with life-threatening illnesses in four senior general hospitals. In terms of academic implications, this study enriches the depth of related studies by demonstrating the right to protection and dignity as a factor of patient-centeredness based on physical environment quality, interaction quality, and outcome quality, which are presented as sub-factors of healthcare quality. We found that the three quality factors classified by Brady and Cronin (2001) are optimized for healthcare quality assessment and management, and that the results of patients' interaction quality assessment can be used to provide a comprehensive quality rating for hospitals. Health and human rights are inextricably linked, so assessing the degree to which rights and dignity are protected can be a superior and more comprehensive measurement tool than traditional health level measures for healthcare organizations. Practical implications: Improving the quality of the physical environment and the quality of outcomes is an important challenge for hospital managers who attract patients with life and death conditions, but given the scale and economics of time, money, and human inputs, improving the quality of interactions and defining them as performance indicators in hospital quality management is an efficient way to create maximum value in the short term.

Applications of the Scanning Electron Microscope (주사형(走査型) 전자현미경(電子顯微鏡)의 응용분야(應用分野))

  • Kim, Yong-Nak
    • Applied Microscopy
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    • v.2 no.1
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    • pp.39-46
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    • 1972
  • There are many kinds of microscopes suitable for general studies; optical microscopes(OM), conventional transmission electron microscopes (TEM), and scanning electron microscopes(SEM). The optical microscopes and the conventional transmission electron microscopes are very familiar. The images of these microscopes are directly formed on an image plane with one or more image forming lenses. On the other hand, the image of the scanning electron microscope is formed on a fluorescent screen of a cathode ray tube using a scanning system similar to television technique. In this paper, the features and some applications of the scanning electron microscope will be discussed briefly. The recently available scanning electron microscope, combining a resolution of about $200{\AA}$ with great depth of field, is favorable when compared to the replica technique. It avoids the problem of specimen damage and the introduction of artifacts. In addition, it permits the examination of many samples that can not be replicated, and provides a broader range of information. The scanning electron microscope has found application in diverse fields of study including biology, chemistry, materials science, semiconductor technology, and many others. In scanning electron microscopy, the secondary electron method. the backscattererd electron method, and the electromotive force method are most widely used, and the transmitted electron method will become more useful. Change-over of magnification can be easily done by controlling the scanning width of the electron probe. It is possible. to continuously vary the magnification over the range from 100 times to 1.00,000 times without readjustment of focusing. Conclusion: With the development of a scanning. electron microscope, it is now possible to observe almost all-information produced through interactions between substances and electrons in the form of image. When the probe is properly focused on the specimen, changing magnification of specimen orientation does not require any change in focus. This is quite different from the conventional transmission electron microscope. It is worthwhile to note that the typical probe currents of $10^{-10}$ to $10^{-12}\;{\AA}$ are for below the $10^{-5}$ to $10^{-7}\;{\AA}$ of a conventional. transmission microscope. This reduces specimen contamination and specimen damage due to heatings. Outstanding features of the scanning electron microscope include the 'stereoscopic observation of a bulky or fiber specimen in high resolution' and 'observation of potential distribution and electromotive force in semiconductor devices'.

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Optical Design of a Modified Catadioptric Omnidirectional Optical System for a Capsule Endoscope to Image Simultaneously Front and Side Views on a RGB/NIR CMOS Sensor (RGB/NIR CMOS 센서에서 정면 영상과 측면 영상을 동시에 결상하는 캡슐 내시경용 개선된 반사굴절식 전방위 광학계의 광학 설계)

  • Hong, Young-Gee;Jo, Jae Heung
    • Korean Journal of Optics and Photonics
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    • v.32 no.6
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    • pp.286-295
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    • 2021
  • A modified catadioptric omnidirectional optical system (MCOOS) using an RGB/NIR CMOS sensor is optically designed for a capsule endoscope with the front field of view (FOV) in visible light (RGB) and side FOV in visible and near-infrared (NIR) light. The front image is captured by the front imaging lens system of the MCOOS, which consists of an additional three lenses arranged behind the secondary mirror of the catadioptric omnidirectional optical system (COOS) and the imaging lens system of the COOS. The side image is properly formed by the COOS. The Nyquist frequencies of the sensor in the RGB and NIR spectra are 90 lp/mm and 180 lp/mm, respectively. The overall length of 12 mm, F-number of 3.5, and two half-angles of front and side half FOV of 70° and 50°-120° of the MCOOS are determined by the design specifications. As a result, a spatial frequency of 154 lp/mm at a modulation transfer function (MTF) of 0.3, a depth of focus (DOF) of -0.051-+0.052 mm, and a cumulative probability of tolerance (CPT) of 99% are obtained from the COOS. Also, the spatial frequency at MTF of 170 lp/mm, DOF of -0.035-0.051 mm, and CPT of 99.9% are attained from the front-imaging lens system of the optimized MCOOS.

A Study on the Development of "Bufo gargarizans" Habitat Suitability Index(HSI) (두꺼비 서식지 적합성 지수(HSI) 모델개발을 위한 연구)

  • Cho, Gun-Young;Koo, Bon-Hak
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.25 no.2
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    • pp.23-38
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    • 2022
  • This study investigates the characteristics and physical habitat requirements for each Bufo gargarizans life history through a literature survey. After deriving variables for each component of Bufo gargarizans, in order to reduce regional deviations from eight previously studied literature research areas for deriving the criteria for variables, a total of 12 natural habitats of Bufo gargarizanss are selected as spatial ranges by selecting four additional sites such as Umyeonsan Ecological Park in Seoul, Wonheungibangjuk in Cheongju in the central region, Changnyeong Isan Reservoir in the southern region, and Mangwonji in Daegu. This study presents Bufo gargarizans SI, a species endemic to Korea, whose population is rapidly declining due to large-scale housing site development and road development, and develops a Bufo gargarizans HSI model accordingly to improve the function of the damaged Bufo gargarizans habitat and to present an objective basis for site selection of alternative habitat. At the same time, it provides basic data for adaptive management and follow-up monitoring. The three basic habitat requirements of amphibians, the physical habitat requirements of Bufo gargarizans, synthesized with shelter, food, and water, and the characteristics of each life history, are classified into five components by adding space and threats through literature research and expert advice. Variables are proposed by synthesizing and comparing the general characteristics of amphibians, among the previously studied single species of amphibians, the components of HSI of goldfrogs and Bufo gargarizans, and the ecological and physical environmental characteristics of Bufo gargarizans. Afterwards, through consultation with an amphibian expert, a total of 10 variables are finally presented by adjacent forest area(ha), the distance between spawning area and the nearest forest land(m), the soil, the distance from the wetland(m), the forest layered structure, the low grassland space, the permanent wetland area(ha), shoreline slope(%), PH, presence of predators, distance from road(m), presence or absence of obstacles. n order to derive the final criteria for each of the 10 variables, the criteria(alternative) for each variable are presented through geographic information analysis of the site survey area and field surveys of the previously studied literature research area. After a focus group interview(FGI) of 30 people related to the Bufo gargarizans colony in Cheongju, a questionnaire and in-depth interviews with three amphibians experts are conducted to verify and supplement the criteria for each final variable. Based on the finally developed Bufo gargarizans HSI, the Bufo gargarizans habitat model is presented through the SI graph model and the drawing centering on the Bufo gargarizans spawning area

Current Barriers of Obesity Management of Children Using Community Child Care Centers and Potential Possibility of Utilizing Mobile Phones: A Qualitative Study for Children and Caregivers (지역아동센터 이용 어린이의 비만관리의 한계점과 모바일폰의 잠재적인 활용 가능성: 어린이와 보호자 대상의 질적 연구)

  • Lee, Bo Young;Park, Mi-Young;Kim, Kirang;Shim, Jea Eun;Hwang, Ji-Yun
    • Korean Journal of Community Nutrition
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    • v.25 no.3
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    • pp.189-203
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    • 2020
  • Objectives: This study was performed to identify the current barriers of obesity management for children using Community Child Care Centers and their caregivers (parents and teachers working in the Centers). Further, this study explored the possibility of utilizing a mobile phone application for tailored obesity prevention and management programs to overcome the current difficulties associated with children's obesity management. Methods: The qualitative data were collected through in-depth interviews with 20 obese and overweight children or children who wanted to participate in this study using Community Child Care Centers, 12 teachers working at the Centers, and a focus group interview with five parents of children using the Centers. Data were analyzed with a thematic approach categorizing themes and sub-themes based on the transcripts. Results: The current barriers of obesity management of obese and overweight children using Community Child Care Centers were lack of self-directed motivation regarding obesity management (chronic obesity-induced lifestyles and reduced self-confidence due to stigma) and lack of support from households and Community Child Care Centers (latchkey child, inconsistency in dietary guidance between the Center and household, repetitive pressure to eat, and absence of regular nutrition education). Mobile phone applications may have potential to overcome the current barriers by providing handy and interesting obesity management based on visual media (real-time tracking of lifestyles using behavior records and social support using gamification), environmental support (supplementation of parental care and network-based education between the Community Child Care Center and household), and individualized intervention (encouragement of tailored and gradual changes in eating habits and tailored goal setting). It is predicted that the real-time mobile phone program will provide information for improving nutritional knowledge and behavioral skills as well as lead to sustainable children's coping strategies regarding obesity management. In addition, it is expected that environmental factors may be improved by network-based education between the Community Child Care Centers and households using the characteristics of mobile phones, which are free from space and time constraints. Conclusions: The tailored education program for children using Community Child Care Centers based on mobile phones may prevent and reduce childhood obesity by overcoming the current barriers of obesity management for children, providing environmental and individualized support to promote healthy lifestyles and quality of life in the future.

Mechanism-based View of Innovative Capability Building in POSCO (메커니즘 관점에서 본 조직변신과 포스코의 혁신패턴 연구)

  • Kim, So-Hyung
    • Journal of Distribution Science
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    • v.11 no.6
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    • pp.59-65
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    • 2013
  • Purpose - Studies of mechanism as a competitive strategy, a relatively new field in the study of strategic management research, has recently drawn the attention of the business management scholars. The literature has so far proposed the subjective-based view, environment-based view, and the resource-based view in its analyses of firm management. Hence, it is highly likely for the firm management to be reasonably thought of as a combination of and interaction among the three key elements of subject, environment, and resources this is the mechanism-based view (MBV). It is reasonable to consider firm management to be the combination of and interaction among the three key elements of subject, environment, and resources. The overall dynamic process that integrates these three elements and creates functional harmony is identified as the mechanism, the principle of firm management. Much of the extant literatures on MBV has mainly focused on case studies, a qualitative approach prone to subjectivity of the researcher, although the intuition from the study may lead to meaningful insights into a firm-specific mechanism. This study's focus is also on case analysis, but it still attempts a quantitative approach in order to reach a scientific and systematic understanding of the MBV. Research design, data, and methodology - I used both a qualitative and quantitative approach to a single model, given the complexity of the innovation processes. I conducted in-depth interviews with POSCO employees-20 from general management, two from human resources, eight from information technology, five from finance and accounting, and five from production and logistics management. Once the innovative events were selected, the interview results were double-checked by the interviewees themselves to ensure the accuracy of the answers recorded. Based on the interview, I then conducted statistical validation using the survey results as well. Results - This study analyzes the building process of innovation and the effect of the mechanism pattern on innovation by examining the case of POSCO, which has survived over the past 21 years. I apply a new analytical tool to study mechanism innovation types, perform a new classification, and describe the interrelationships among the mechanism factors. This process allows me to see how the "Subject"factor interacts with the other factors. I found that, in the innovation process of the adoption stage, Subject had a mediating effect but that the mediating effect of resource and performance was smaller than the effect of Subject on performance alone. During the implementation stage, the mediating effect of Subject increased. Conclusion - Therefore, I have confirmed that the subject utilizes resources reasonably and efficiently. I have also advanced mechanism studies: whereas the field's research methods have been largely confined to single case studies, I have used both qualitative and quantitative methods to examine the relationships among mechanisms.

A Proposition on Landscape Restoration of Joseon Dynasty's Palace Gardens (조선시대 궁궐정원의 원형경관 복원을 위한 제안)

  • Ahn, Gye-Bog;Lee, Won-Ho
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.32 no.3
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    • pp.10-20
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    • 2014
  • The purpose of this study is to define criteria for landscape restoration of palace gardens. The case study on Gyeongbokgung and Changdeokgung was used not only to evaluate effectiveness of the criteria, but also to propose solutions to issues of current restoration process of both palace gardens. Following three pairs of different concepts were chosen as criteria to determine on the original form: Diachrony vs. Synchrony, Originality vs. Contemporary Characteristics, and Invariance vs. Deformability. Gyeongbokgung has been restored based on its contemporary characteristics of Year 1888 and the main focus is on its architectural features rather than both architecture and landscape. However, in-depth complementary work on landscape restoration is necessary to restore its originality in Year 1395 such as analyzing photos of Gyeongbokgung taken in modern era. In case of Changdeokgung, we analyzed separately by region or landmark such as Jondeok-Pavilion(尊德亭), Yeonkyung-Hall(演慶堂), and Okryu-Stream(玉流川). Original form of Jondeok-Pavilion Area was changed in 1884. Since diachronic invariance that lasted for 240 years is more important criterion than its contemporary characteristics, it should be restored as how it was painted in Donggwoldo(東闕圖). In Yeonkyung-Hall Area, both original characteristics at the time of Hyomyung Crown Prince and contemporary characteristics of Emperor Kojong Era appear. Therefore, different solution is required for such area to be restored appropriately. Starting from era of King Injo(1636), diachrony and invariance of Okryu-Stream Area were continued throughout the era of King Sukjong and King Jeongjo(1800). It is more than 250 years before Okryu-Stream Area was altered under the rule of Emperor Kojong in 1884. In fact, alterations made to Okryu-Stream Area after 1884 doesn't hold much significance. Therefore, water landscape of Okryu-Stream Area, which was altered in the era of Emperor Kojong, needs to be restored based on Donggwoldo.

Development of Revegetation Measures using Boring Technique in Rock Slopes - Focus on Lespedeza cyrtobotrya - (암반비탈면에 있어서 천공기법에 의한 녹화공법의 개발 - 참싸리를 중심으로 -)

  • Ma, Ho-Seop;Kang, Won-Seok;Park, Jin-Won
    • Journal of Korean Society of Forest Science
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    • v.100 no.4
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    • pp.558-564
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    • 2011
  • This study was conducted to evaluate the effects of early revegetation by analyzing the characteristics of germination and growth of Lespedeza cyrtobotrya using boring technique in rock slopes. After making up a growing basis of approximately 20 cm depth and 10 cm diameter by using a boring machine, the surface of rock slopes was planted with vegetation-plant. The number of germinating populations by soil media was 23 in H.s, 22 in T.s, 12 in M.s, and 1 in M.g.s. The germination rate (%) by soil media was 19.2% in H.s, 18.3% in T.s, 10.0% in M.s and 0.8% in M.g.s. In monthly changes of growth rate, the aspect was northwest direction, the soil media was M.s, and the treatment was microorganism plot. The main factors affecting survivorship and growth of population were soil media and treatment plot. The interaction between each factor had a good effects in bearing ${\times}$ soil media, bearing ${\times}$ treatment plot, soil media ${\times}$ treatment plot. but, it is recommended that the mulching of vegetation plant is highly needed to help the germination of seed and growth of vegetation because of loss of seed and soil media occurred due to rainfall. Therefore, The result suggests that the revegetation technique using boring in rock slope was very efficient in respect of the early revegetation and the landscape.

Remarks for Basic Medical Education Quality Improvement of Yonsei University in Korea (기본의학 교육과정 개선 방안 - 연세의대 광혜교육과정을 중심으로 -)

  • Ryue, Sook-Hee;Ahn, Duk Sun;Lee, Won Taek;Park, Jeon Han;Jung, Hyun Su;Park, Mu Seuk;Yang, Eun Bae
    • Korean Medical Education Review
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    • v.11 no.2
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    • pp.15-24
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    • 2009
  • Medical Students' competencies depend on the medical school curriculum. Basic medical education, in particular, is an important starting point for further medical competency development. We aimed to identify the most important areas of reform in the basic medical education curriculum of Yonsei Medical School. To accomplish this, we sought case studies of different medical schools and discussion points for quality improvement methods. A qualitative comparison method saturated through the systematic discussions on the emerging thematic approaches to determine the current directions in medical school curriculum reform. The discussions, which involved 7 experts, spanned 8 months and were based on a literature review, with focus on the 7 selected case studies. From the discussions, we concluded that in order to improve basic medical education curriculum, the following measures need to be carried out. First, an outcome-based curriculum is to be designed. The expected outcome is to be deliberately and succinctly defined and should be expressed as teaching and learning objectives. Second, the core subjects and elective subjects are to be classified on the basis of the aim, content, and passage level of the subjects. Hence, the core curriculum must be treated as a standard part of medical knowledge, and the elective curriculum must be richer and more in-depth. Third, universities should institutionalize regular evaluation of their departments. Appropriate and just evaluations should be made, and feedback given to the school's administrative department. Fourth, the departmental and administrative management of the basic medical education curriculum should be harmonized with each other. Finally, teaching and learning resources are to be increased and diversified and made available to professors and students for basic medical education.