• Title/Summary/Keyword: Deprivation

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The Neuroprotective Mechanism of Sunghyangjunggisan Water Extracts on Apoptosis of PC 12 Cell (PC 12 세포의 Apoptosis에 대한 성향정기산의 방어효과 및 작용기전 연구)

  • 최철원;이인;이기상;조남수;문병순
    • The Journal of Korean Medicine
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    • v.23 no.1
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    • pp.50-60
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    • 2002
  • Objectives: Sunghyangjunggisan (SHJS) is a commonly prescribed drug with a wide neuropharmacological spectrum. The water extracts of SHJS were found to be protective against neurotoxicity elicited by deprivation of serum and glucose. Methods: The morphological examination and Hoechst staining of nucleus also clearly showed that the extracts attenuated the cell shrinkage, membrane blebbing, representing typical neuronal apoptotic phenomena and nucleosome-sized fragmentation under the microscope in PC 12 rat pheochromocytoma cells. Results: Activation of protein kinase A (PKA) with dibutyl-cAMP and forskolin also protected during glucose deprivation, although it was not additive with the effect provided by phorbol ester. Interestingly, treatment with the protein kinase A inhibitor, KT5720, was not neuroprotective in the presence of SHJS. Electrophoretic mobility shift assays were used to characterize the neuroprotective binding of nuclear proteins to consensus sequences for AP-l, nuclear factor kappa B ($NF-{\kappa}B$) after glucose deprivation. When PC 12 cells are induced to undergo apoptosis by serum deprivation, AP-l and $NF-{\kappa}B$ DNA binding activity transiently increases to a slight degree. This stimulation is blocked by the water extracts of SHJS. The site of action of the drugs appeared to involve specific inhibition of AP-1 and nuclear factor kB binding activity. Conclusions: Taken together, these results suggested the possibility that the extracts of SHJS might provide a neurotrophic-like activity in PC 12 cells.

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The Effect of Visual Deprivation on Trunk and Lower Extremity Muscle Activity on an Unstable Surface (불안정면에서 시각차단이 체간과 하지의 근활성도에 미치는 영향)

  • Han, Jin-Tae
    • PNF and Movement
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    • v.16 no.3
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    • pp.433-439
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    • 2018
  • Purpose: Visual information is one of the most important factors for postural balance. The purpose of this study was to investigate the effect of visual deprivation on the lower extremities and trunk muscle activity on an unstable surface during quiet standing. Methods: Fifteen healthy males from a university population participated in this study. Surface electromyography of the rectus abdominis, the erector spinalis, the vastus femoris oblique, the semitendinosis, the tibialis anterior, and the medial gastrocnemius was measured using EMG equipment (Telemyo 2400, Noraxon, USA). The participants were asked to maintain postural balance on an unstable surface (Balance pad, Airex, USA) for 30 seconds with eyes open and with eyes closed during quiet standing. The Wilcoxon test was used to compare the muscle activity of the lower extremities and the trunk between open and closed eyes on an unstable surface. Results: The muscle activity of the trunk and the lower extremities was increased more with eyes closed than with eyes open on the unstable surface during quiet standing. Conclusion: The findings from this study suggest that visual information could alter lower extremity and trunk muscle activity. Therefore, visual deprivation can be used as a method to improve postural balance.

The Influence of Consumers' Emotions on Brand Disappointment Caused by the Nepo-Baby Issue in Fashion Brands -Focusing on Powerlessness, Unfairness, Relative Deprivation, and Loneliness-

  • Ha Youn Kim;Woojin Choi
    • Journal of the Korean Society of Clothing and Textiles
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    • v.48 no.1
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    • pp.157-171
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    • 2024
  • The term 'Nepo-baby' refers to someone whose career benefits from family connections. Criticism of the so-called Nepo-baby issue is growing, especially among the MZ generation, who highly value fairness. In this study, we explored how fashion consumers perceive the Nepo-baby issue and its impact on fashion brands. Consumers are more likely to compare themselves to Nepo babies and may experience feelings of powerlessness, unfairness, relative deprivation, and loneliness. These perceptions can lead to negative feelings toward the brand, resulting in disappointment. Our research hypotheses were tested using SPSS 26.0 and AMOS 23.0. Fashion brands promoting Nepo babies affect consumers' self-perceptions of powerlessness, unfairness, relative deprivation, loneliness, and negative feelings. Brand disappointment was tested using a structural equation model. Using a multi-group path analysis, we investigated consumers' perceptions of the Nepo-baby issue and general brand stories. Our research results reveal the significant impact of controversial Nepo babies on negative feelings toward fashion brands and brand disappointment.

A Justification on the Evil of Death (죽음의 나쁨에 관한 정당화)

  • Kwon, Su-Hyeon
    • The Journal of the Convergence on Culture Technology
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    • v.3 no.4
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    • pp.27-33
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    • 2017
  • Epicurus and Lucretius expressed that death is neither evil to the living nor the dead. On the contrary, our everyday perception of death is that death is evil. Such everyday perception might seem in lack of introspection and blind but our living environment and form of life are strongly supporting this perception. This paper argues that there is reasonable cause for believing death is evil. In order to justify this argue, this paper critically supports Thomas Nagel's 'Deprivation Theory', which identifies the cause of death being in evil in the deprivation of life. This paper investigates the main substances of 'Deprivation Theory, suggests the related problems and therefore reconstitutes the main arguments of 'Deprivation Theory, resulting in the investigation of the following facts; that we cannot avoid the fate of death, but that our existence is headed towards the future, and that as independent individuals we have infinite possibilities of life. Death is natural to humanity as species, but as independent individuals death deprives us from possible life and future. Therefore, death we encounter in our living environment and form of life is evil. As species, we can agree with Epicurus and Lecretius' view, but as independent individuals we cannot share them.

The Effects of Balance and Trunk Repositioning Sense with Multisensorial Training using Visual Cue Deprivation in Subacute Stroke Patients (시각 통제를 이용한 다중감각 훈련이 아급성 뇌졸중 환자의 균형 및 체간위치감각에 미치는 효과)

  • So, Dong-Hak;Lee, Wan-Hee;Yun, Mi-Jung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.14 no.2
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    • pp.737-743
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    • 2013
  • This study was to investigate the effects of balance and trunk repositioning sense through multisensorial training using visual cue deprivation in subacute stroke patients. Multisensorial training group practiced after visual deprivation, control group practiced in the same training except visual deprivation with thirty subjects. Both groups were conducted training programs on sixty minutes a day, five days a week during four weeks. The subjects were evaluated by static balance, dynamic balance and trunk repositioning sense in the pre-posttest. There was significant improvement by multisensorial training that static balance, dynamic balance and the trunk repositioning sense between pretest and post test (p<.05). There were significantly differences in the amount of change of dynamic balance, trunk repositioning sense between the two groups(p<.05). Through this study, multisensorial training suggest that is effective in the improvement of dynamic balance and trunk repositioning sense.

Compensatory Growth of Grower Olive Flounder (Paralichthys olivaceus) with Different Feeding Regime at Suboptimal Temperature

  • Cho, S.H.;Kim, K.T.;Choi, I.C.;Jeon, G.H.;Kim, D.S.
    • Asian-Australasian Journal of Animal Sciences
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    • v.25 no.2
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    • pp.272-277
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    • 2012
  • Compensatory growth of grower olive flounder (Paralichthys olivaceus) was determined at suboptimal temperature ($13.0{\pm}1.9^{\circ}C$). Fifteen fish averaging 201.1 g per tank were distributed into 18 of 300 L flow-through tanks. Six treatments were prepared in triplicate: fish were hand-fed with an extruded pellet to apparent satiation once a day for 16 weeks (16 WF); and the other five groups of fish were hand-fed for 15, 14, 13, 12 and 10 weeks after 1-, 2-, 3-, 4- and 6-week feed deprivation, referred to as 15 WF, 14 WF, 13 WF, 12 WF and 10 WF, respectively. A linear relationship between body weight of fish and feed deprivation was observed: Y (Body weight of fish) = -1.81X (Weeks of feed deprivation)+201.07, $R^2$ = 0.83. Weight gain of grower olive flounder in 15 WF, 14 WF, 13 WF and 12 WF treatments was comparable to that of fish in 16 WF treatment, but lower than that of fish in 10 WF treatment. Specific growth rate of fish in 15 WF treatment was higher than that of fish in 16 WF, 14 WF and 10 WF treatments. Feed consumption of fish was not affected by feeding regime. Feed and protein efficiency ratios of fish in 15 WF treatment were higher than those of fish in 13 WF, 12 WF and 10 WF treatments. Grower olive flounder could achieve full compensatory growth when fish were daily fed for 12 weeks after 4-week feed deprivation at suboptimal temperature.

Effects of Total Sleep Deprivation on Auditory Event-Related Potentials (전수면박탈이 정상인의 청각 사건관련전위에 미치는 영향)

  • Lee, Heon-Jeong;Chun, Ho-Seok;Kim, Leen;Suh, Kwang-Yoon
    • Sleep Medicine and Psychophysiology
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    • v.10 no.2
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    • pp.108-112
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    • 2003
  • Objectives: The purpose of this study is to investigate the psychophysiological effects of total sleep deprivation by using auditory event-related potentials. Methods: Twenty four healthy college students (18 men, 6 women) participated in this study. The subjects remained awake for 37 hours under continuous surveillance. In the morning and the evening of two consecutive study days, auditory event-related potentials were checked. Results: The latencies of P300 and N200 were significantly prolonged (p<0.001) and their amplitudes decreased (p<0.05) as a consequence of sleep deprivation. The amplitude of P200 was significantly increased during sleep deprivation (p<0.05). However, there was no significant change in the latency and amplitude of N100. Conclusion: Among the components of auditory event-related potentials, P300 and N200 are good indicators of sleep-deprived status. Further investigation is necessary to elucidate the neurophysiological mechanisms of these findings.

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The Multilevel Effects of Regional Deprivation on Perceived Upward Social Mobility of Residents (지역박탈이 주민의 계층상승 가능성에 대한 인식에 미치는 영향 - 서울시를 대상으로 -)

  • Song, Taesoo;Lim, Up
    • Journal of the Korean Regional Science Association
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    • v.36 no.3
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    • pp.3-16
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    • 2020
  • The causes and effects of intra-urban spatial inequality have received much scholarly attention. However, the effects of urban spatial inequality on resident perceptions and the mechanisms through which it is sustained and reproduced remain mostly unknown. This study aimed to investigate whether regional deprivation, the relative socioeconomic standing of a region, affects the residents' perceptions of upward social mobility. By employing the ordinal logistic multilevel model to analyze nested data collected from Seoul, South Korea, this study found that the regional deprivation has a significant negative effect on residents' perception of upward social mobility. The results of this study suggest that one way in which spatial inequality is sustained and reproduced is by the effects of regional deprivation, having negative impacts on the aspirations and socioeconomic activities of residents. This study is expected to provide meaningful implications for planning and policy aimed to combat spatial inequality.

The Relationship between Sleep Pattern, Eating Habit, and the Perceived Skin Health among Female Adults (여성의 수면습관 및 식습관과 지각된 피부건강 간의 관계)

  • Yang, Mi-Young;Suh, Kyung-Hyun
    • Korean Journal of Health Education and Promotion
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    • v.26 no.4
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    • pp.11-22
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    • 2009
  • Objectives: The researchers investigated the relationship between sleep pattern (circadian rhythm/sleep deprivation), eating habit, and the perceived skin condition of female adults, in orders to provide valuable information to women who want to maintain healthy skin and professionals in health promotion. Methods: The participants were 297 female adults whose ages ranged from 20 to 60 (M=35.14, SD=10.37). The questionnaires and psychological tests used in this research included the following: Circadian Rhythm Questionnaire, Sleep Deprivation Scale, Eating Habit Questionnaire, Skin Condition Questionnaire, Scale for Perceived Skin Health. Results: Results indicated that evening type women had more fatty skin and felt their skins less healthier than morning type. Although women who did not deprived their sleep had more fatty and sensitive skin and felt their skins less healthier than women who deprived their sleep, sleep deprivation was positively related to the morningness, and the morningness was negatively related to the preference of fatty and spicy foods. Only the preference of fatty foods among eating habit was positively related to the fatty and sensitive skin, and negatively to the perceived skin health. Regression analyses with circadian rhythm and the preference of fatty foods revealed that only circadian rhythm was significant predictor for the fatty skin, while the preference of fatty foods was only significant predictor for the sensitive skin and the perceived skin health. And, circadian rhythm and the preference of fatty foods accounted for around 12.0% variance of the fatty skin. Conclusion: This study reiterates the roles of fatty foods on skin health, and found the role of circadian rhythm on skin health, and it is needed to explore the relationship between sleep deprivation and skin condition further. These results may provide useful information for health practitioners.

Effect of Environmental Factors on Depressive-like Behavior and Memory Function in Adolescent Rats

  • Song, Min Kyung;Lee, Jae-Min;Kim, Yoon Ju;Lee, Joo Hee;Kim, Youn-Jung
    • Journal of Korean Biological Nursing Science
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    • v.19 no.4
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    • pp.276-283
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    • 2017
  • Purpose: The aim of this study was to identify the effects of environmental factors on depressive-like behavior and memory function during adolescence. We performed behavior tests in adolescent rats exposed to environmental enrichment, handling, and social deprivation for eight weeks. Methods: Wistar rats were randomly assigned to control, environmental enrichment, handling, and social deprivation groups at the age of four weeks. Results: In the forced swim test, the immobility time in the environmental enrichment group was decreased than that in the control group (p=.038), while the immobility time in the social deprivation group was increased than that in the control group (p=.035), the environmental enrichment group (p<.001), and the handling group (p=.001). In the Morris water maze test, the social deprivation group had an increased latency time than the control group (p=.013) and the environmental enrichment group (p=.001). In the passive avoidance test, the environmental enrichment group had an increased latency time than the control group (p=.005). However, the social deprivation group had reduced latency time than the socially housed groups (control: p=.030; environmental enrichment: p<.001; handling: p<.001). Conclusion: These findings suggest that environmental factors play an important role in emotion and memory function during adolescence.