• Proceedings of the KSRS Conference
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• 2007.03a
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• pp.76-81
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• 2007

융설 모형의 중요 매개변수인 적설분포면적은 실제 우리나라에서 적설과 관련한 관측 자료의 부족으로 인해 매개변수 추정이 어렵다. 이러한 문제점 해결을 위해 원격탐사기법을 활용하여 적설분포면적을 추출하였다. 본 연구에서는 1997년 부터 2006년 까지의 겨울철 NOAA (National Oceanic and Atmospheric Administration)의 AVHRR(Advanced Very High Resolution Radiometer) 위성영상의 8 sets의 총 108개 영상을 이용하여 적설분포면적을 추출하였고，기상청의 지상기상관측소의 최섬적설심 자료를 이용하여 GIS 자료를 구축함으로써 적설심의 공간적 분포를 추출하였다. 이를 국내 5대유역인 한강，낙동강，금강，영산강，섬진강 유역에 대하여 융설모형의 주요 매개변수인 적설분포면적，유역 평균， 최대 적설심과 적설분포감소비곡선을 구축하였다. 그 중 적설분포면적감소곡선 (SDC : Snow cover Depletion Curve)는 적설분포면적의 감소형태를 나타내 주는 지표로써 융설의 가장 민감한 매개변수이다. 이를 국내 5대 강 유역에 대해 구축하여 정량화 하였다.

• Journal of the Korean Magnetics Society
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• v.3 no.3
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• pp.221-228
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• 1993

The general requirements of recording media include recording performance, environmental stability, runnability on the drive or deck, and manufacturability. CoCrMo thin films were prepared using RF sputtering system for a study on chemical stability. Surface degradation of the CoCrMo thin film was studied by SEM, XPS and AES. Surface degradation was found to be dependent of sputtering condition and Mo content. Addition of Mo to CoCr thin film improved dramatically its surface degradation resistance in dilute sulfuric acid, as indicated by active-passive transition appeared in electrochemical polarization curve. Futhermore, the passive current density was decreased with increasing Mo content. The reduction in a number density of corrosion sites by Mo addition vms observed, after accelerated corrosion test. AES survey indicated that corrosion occured on the site with Cr depletion and highly concentrated chloride ions.

• 한국정보디스플레이학회:학술대회논문집
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• 2005.07b
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• pp.1284-1287
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• 2005

Peripheral pentacene region gives a significant influence on C-V characteristics of metal-oxide-pentacene capacitor structure. When the gate voltage goes toward negative, the effect of peripheral pentacene region becomes larger. Remaining gate DC bias constant and changing small signal frequency, the capacitance of peripheral pentacene changes along with frequency so that the total capacitance value also changes. The influence of peripheral pentacene region should be removed to measure accurate C-V characteristics, because it is hard to take into account the effect of the region quantitatively. After removing the influence of peripheral pentacene region, acceptor concentration, flat band voltage and depletion width of pentacene thin film are extracted from an accurate C-V curve as $1.58{\times}10^{17}cm^{-3}$, -1.54 V and 39.4 nm, respectively.

• Journal of Advanced Marine Engineering and Technology
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• v.30 no.6
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• pp.709-715
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• 2006

The effects of thermal cycle condition and applied stress on the intergranular corrosion in austenitic 316 type stainless steels were investigated. Specimens were solution-treated at 1100$^{\circ}C$ for one hour and then sensitized in the temperature range of $500{\sim}800^{\circ}C$ by holding $2{\sim}300s$ with a various applied stresses of $0{\sim}8kg/mm^2$. Degree of sensitization. DOS %, was measured through polarization curve by electrochemical DL-EPR test. Microstructural observations were also conducted DOS % increased with an increase of sensitization temperature and/or holding time. Increase of applied stress resulted in increase of DOS % and more corroded surface because of acceleration of intergranular corrosion and fine grain size due to the stress. Cr depleted zone near grain boundary was observed. The amount of depletion was profounded with an increase of sensitization temperature, holding time and applied stress. $M_{23}C_6$ carbides were precipitated discontinuously at grain boundary. However, its amount was relatively small in the thermal cycle condition of 800$^{\circ}C$, 300sec and 4kg/mm$^2$.

• Journal of Preventive Veterinary Medicine
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• v.42 no.4
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• pp.171-176
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• 2018

A study of the tissue depletion of florfenicol (FFC) administered orally to pigs at a dose of 0.05 kg/ton feed for 7 days was performed. Sixteen healthy cross swine were administered with FFC. Four treated animals were arbitrarily selected to be sacrificed 1, 3 and 5 days after the end of treatment. FFC residue concentrations in muscle, liver, kidney, and fat were determined using high-performance liquid chromatography (HPLC) with ultraviolet photometric detector at 230 nm. The correlation coefficient ($R^2$) of the calibration curve for florfenicol amine (FFCa) was > 0.997 and the limits of detection and quantification were 0.012 and $0.040{\mu}g/mL$, respectively. Recovery rates in swine edible tissues ranged from 79.1 to 93.5%. In the FFC-treated group, FFC residues at 3 days post-treatment were below the maximum residue limits (MRLs) in muscle, kidney and fat, and those at 5 days post-administration were below the MRLs in all edible tissues. These results suggest that the withdrawal period of FFC after the drug treatment might be 5 days, which is a sufficient amount of time for reduction of the FFC residues below the MRLs in all edible tissues.

• Journal of Plant Biology
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• v.16 no.3_4
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• pp.17-34
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• 1973

The physico-chemical factors, the distribution of chlorophyll and the primary production of the lakes Hwajinpo, Yongrangho, Chunchonho, Uiamho, Soyangho and Changjamot have been studied in order to make ecological comparison among these lakes during summer stagnation period of August to September of 1973. On the basis of the characteristics of these lakes, the lake types have been discussed. Thermocline is observed at 3-4m zone in the lake Changjamot and 4-5m zone in the lake Yongrangho. In the case of lake Hwajinpo and impoundments, the distinct thermal stratification is not observed at the summer stagnation period. As to vertical distribution of dissolved oxygen, a positive heterograde curve is obtained in the lakes Hwajinpo and Yongrangho. In the lake Changjamot the typical clinograde curve and the oxygen depletion in hypolimnion are observed. In the case of impoundments, however, the orthograde curve is observed in the lakes Chunchonho and Uiamho. While in the lake Soyangho, any stratification of the disssolved oxygen is not found. In the brackish lakes, such as lakes Hwajinpo and Yongragho, the salinity of hypolimnion is found to be much higher than that of epilimnion. In the lake Hwajinpo, the salinity of hypolimnion is exhibited 32.7$\textperthousand$, which is nearly the same as sea water. The distribution of nitrogenous compounds and phosphates is found to be high in the lake Changjmot. The silicate is also found in high concentration in the lake Chunchonho, and the distribution of nutrients in the brackish lakes is generally low. As to the vertical distribution of chlorophyll level, the lake Changjamot shows a stratum type and the brackish lakes L-type stratification. In the impoundments, lakes Chunchonho and Uiamho appear to be homogeneous type. Seasonal variation of chlorophyll level in the lake Changjamot is examined from January to September 1973. The vertical distribution of chlorophyll during the period of circulation from January to April is homogeneous type and is stratum type thereafter. The maximum chlorophyll level is 277.4mg/$m^2$ on June 23 and the pattern of seasonal variation of chlorophyll level is comparable to the type of eutrophy. The horizontal distribution of chlorophyll level is studied in the brackish lakes, Hwajinpo and Yongrangho. The pattern of distribution is found to be an irregular type. On the basis of measurements of primary production by means of the carbon-14 method and the distribution of chlorophyll level, it is concluded that the interior part of the lake Hwajinpo and Changjamot are eutrophic and the exterior part of the lake Hwajinpo, lake Yongrangho and the impoundments, lake Uiambo and Soyangho are mesotrophic.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.40 no.1
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• pp.1-10
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• 2003

Device characteristics of the Metal-Ferroclecric-Semiconductor FET(MFSFET) are simulated in this study. The field-dependent polarization model and the square-law FET model are employed in our simulation. C-V$_{G}$ curves generated from our MFSFET simulation exhibit the accumulation, the depletion and the inversion regions clearly. The capacitance, the subthreshold and the drain current characteristics as a function of gate bias exhibit the memory windows are 1 and 2 V, when the coercive voltages of ferroelectric are 0.5 and 1 V respectively. I$_{D}$-V$_{D}$ curves are composed of the triode and the saturation regions. The difference of saturation drain currents of the MFSFET device at the dual threshold voltages in I$_{D}$-V$_{D}$ curve is 1.5, 2.7, 4.0, and 5.7 ㎃, when the gate biases are 0, 0.1, 0.2 and 0.3V respectively. As the drain current is demonstrated after time delay, PLZT(10/30/70) thin film shows excellent reliability as well as the decrease of saturation current is about 18 % after 10 years. Our simulation model is expected to be very useful in the estimation of the behaviour of MFSFET devices.T devices.

• Archives of Pharmacal Research
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• v.22 no.2
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• pp.165-172
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• 1999

In the present work , the transport mechanism of a capsaicin derivative, DA-5018, through blood-brain barrier (BBB) has been investigated to evaluate the feasibility of potential drug development. The result of pharmacokinetic parameters obtained from the intravenous injection of plasma volume marker,$[3^H]RSA$ and $[{14}^C]DA-5018$, indicated that both AUC, area under the plasma concentration curve and VD, volume of distribution in brain of $[3^H]RSA$ agreed with those reported ($1620{\pm}10 $percentage injected dose minute per milliliter (%IDmin/ml) and $12.0{\pm}0.1{\mu}l/g$, respectively). Elimination half-life and AUC of $[{14}^C]DA-5018$is corrected by the PHLC analysis, 19.6$\pm$1.2 min and 7.69$\pm$0.85% IDmin/ml, respectively. The metabolic rate of $[{14}^C]DA-5018$was very rapid. The blood-brain barrier permeability surface area (PS) product of $[{14}^C]DA-5018$ was calculated to be 0.24$\pm$0.05 $\mu$l/min/g. The result of internal carotid artery perfusion and capillary depletion suggested that [14C]DA-5018 pass through BBB with the time increasingly. Investigation of transport mechanism of $[{14}^C]DA-5018$ using agonist and antagonist suggested that vanilloid (capsaicin) receptor did not exist in the BBB, and nutrient carrier system in the BBB has no effect on the transport of DA-5018. In conclusion, despite the fact that penetration of DA-5018 through BBB is significant, the intact drug found in the brain tissue is small because of a rapid metabolism. Therefore, for the central analgesic effect of DA-5018, the method to increase the metabolic stability in plasma and the brain permeability should be considered.

• Journal of Wetlands Research
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• v.23 no.2
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• pp.173-182
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• 2021

It is important to extract and assess low-flow recession characteristics for water resources management in the upper reaches of a stream. It is difficult to express the groundwater flow recession characteristics for streamflow synthetically. The linear recession model has been widely used by baseflow recession analysis for reason of simplicity and convenience, but recent studies show that nonlinear recession models fit well, and the relationship between the reservoir storage of shallow unconfined aquifers and the groundwater discharge was to be identified as nonlinear in the literature based on the analysis of numerous streamflow recession curves. The objective of the study is to decode these nonlinear characteristics, including evaporation loss, storage, and recharge of groundwater using streamflow. By analyzing the observed time series of streamflow from the study area, which is the Pyeongchang River basin in Korea, the main components of the underlying groundwater balance, namely, discharge, evaporation loss, storage, and recharge, can be identified and quantified. As a result of the study, depletion of groundwater by evapotranspiration losses through the water uptake of tree roots was found to bias the recession curves and the estimated reservoir parameters. The seasonality of both rainfall and potential evaporation, analysis of the recession curves, stratified according to time of the year, allowed the quantification of evapotranspiration loss as a function of a calendar month and stored groundwater storage.

• BMB Reports
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• v.56 no.6
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• pp.347-352
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• 2023

The protein family of poly (ADP-ribose) polymerases (PARPs) is comprised of multifunctional nuclear enzymes. Several PARP inhibitors have been developed as new anticancer drugs to combat resistance to chemotherapy. Herein, we characterized PARP4 mRNA expression profiles in cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines. PARP4 mRNA expression was significantly upregulated in cisplatin-resistant ovarian cancer cell lines, and this upregulation was associated with the hypomethylation of specific cytosine-phosphate-guanine (CpG) sites (cg18582260 and cg17117459) on its promoter. Reduced PARP4 expression was restored by treating cisplatin-sensitive cell lines with a demethylation agent, implicating the epigenetic regulation of PARP4 expression by promoter methylation. Depletion of PARP4 expression in cisplatin-resistant cell lines reduced cisplatin chemoresistance and promoted cisplatin-induced DNA fragmentation. The differential mRNA expression and DNA methylation status at specific PARP4 promoter CpG sites (cg18582260 and cg17117459) according to cisplatin responses, was further validated in primary ovarian tumor tissues. The results showed significantly increased PARP4 mRNA expressions and decreased DNA methylation levels at specific PARP4 promoter CpG sites (cg18582260 and cg17117459) in cisplatin-resistant patients. Additionally, the DNA methylation status at cg18582260 CpG sites in ovarian tumor tissues showed fairly clear discrimination between cisplatin-resistant patients and cisplatin-sensitive patients, with high accuracy (area under the curve = 0.86, P = 0.003845). Our findings suggest that the DNA methylation status of PARP4 at the specific promoter site (cg18582260) may be a useful diagnostic biomarker for predicting the response to cisplatin in ovarian cancer patients.